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Article ; Online: Current status of high-intensity focused ultrasound for prostate cancer: technology, clinical outcomes, and future.

Murat, François-Joseph L / Gelet, Albert

2008 Volume 9, Issue 2, Page(s) 113–121

Abstract: Based on a review of recently published articles, we evaluated the current status of high-intensity focused ultrasound (HIFU) as a primary treatment option for localized prostate cancer and as a salvage therapy when radiation has failed. With mid- and ... ...

Abstract	Based on a review of recently published articles, we evaluated the current status of high-intensity focused ultrasound (HIFU) as a primary treatment option for localized prostate cancer and as a salvage therapy when radiation has failed. With mid- and long-term progression-free survival rates around 70%, negative postoperative prostate biopsies almost 90%, and an excellent morbidity profile, primary HIFU appears to be a valid alternative to active surveillance protocols in low-risk patients and standard therapies in patients with life expectancies of 10 or fewer years. Moreover, HIFU has a considerable potential for local-only recurrence after radiation failure. HIFU is a recent technology, and many improvements will undoubtedly expand its future indications and use for the management of prostate cancer.
MeSH term(s)	Humans ; Male ; Neoplasm Recurrence, Local/etiology ; Neoplasm Recurrence, Local/therapy ; Prostatic Neoplasms/therapy ; Treatment Outcome ; Ultrasonic Therapy/adverse effects ; Ultrasonic Therapy/methods ; Ultrasonic Therapy/trends ; Ultrasound, High-Intensity Focused, Transrectal
Language	English
Publishing date	2008-04-18
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2057354-6
ISSN	1534-6285 ; 1527-2737
ISSN (online)	1534-6285
ISSN	1527-2737
DOI	10.1007/s11934-008-0022-3
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Free-floating organized fat necrosis: rare presentation of pelvic mass managed with laparoscopic techniques.

Murat, François-Joseph L / Gettman, Matthew T

Urology

2004 Volume 63, Issue 1, Page(s) 176–177

Abstract: Free-floating intraperitoneal pelvic masses are exceedingly rare. These abnormalities, typically composed of organized fat necrosis, are most commonly thought to occur after spontaneous torsion and subsequent infarction of an appendix epiploica. Most of ... ...

Abstract	Free-floating intraperitoneal pelvic masses are exceedingly rare. These abnormalities, typically composed of organized fat necrosis, are most commonly thought to occur after spontaneous torsion and subsequent infarction of an appendix epiploica. Most of these loose bodies are incidentally discovered. Surgical removal is recommended because cross-sectional imaging typically cannot accurately make the diagnosis. Laparoscopy offers a minimally invasive tool to simultaneously inspect the abdominal cavity, assess the pelvic mass diagnosis, and treat the patient. We describe the case of a patient followed up for pudendal neuropathy in which organized fat necrosis was diagnosed and treated by laparoscopy.
MeSH term(s)	Diagnosis, Differential ; Fat Necrosis/diagnosis ; Fat Necrosis/diagnostic imaging ; Fat Necrosis/surgery ; Humans ; Incidental Findings ; Laparoscopy ; Male ; Middle Aged ; Neuralgia/complications ; Pelvic Pain/etiology ; Peritoneal Cavity ; Tomography, X-Ray Computed
Language	English
Publishing date	2004-01
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	192062-5
ISSN	1527-9995 ; 0090-4295
ISSN (online)	1527-9995
ISSN	0090-4295
DOI	10.1016/j.urology.2003.09.080
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Zs.A 1142: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 275: Show issues

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Article: Techniques mini-invasives dans les tumeurs localisées du rein de l'adulte de moins de 40 mm: aspects techniques et résultats.

Murat, François-Joseph / Lezrek, Mohamed / Martin, Xavier

Progres en urologie : journal de l'Association francaise d'urologie et de la Societe francaise d'urologie

2004 Volume 14, Issue 2, Page(s) 237–242

Abstract: Partial nephrectomy has recently become the reference treatment for localized renal cancer, less than 40 mm in diameter, in adults. The development of laparoscopy remains limited by the difficulties of haemostasis in these indications. "Minimally ... ...

Title translation	Minimally invasive techniques in localized renal tumours less than 40 mm in diameter in adults: technical aspects and results.
Abstract	Partial nephrectomy has recently become the reference treatment for localized renal cancer, less than 40 mm in diameter, in adults. The development of laparoscopy remains limited by the difficulties of haemostasis in these indications. "Minimally invasive techniques" have therefore been developed in this context, in order to achieve two objectives: parenchyma sparing and low morbidity. Various approaches, using cryotherapy, radiofrequency, microwaves or high intensity focused ultrasound, are under investigation. The preliminary clinical results appear to be promising, but the efficacy endpoints of these treatments still need to be evaluated, as well as the survival results based on longer term follow-up. However, if the good initial results are confirmed, these techniques could constitute, in the future, an alternative to surgery for the management of renal cancers less than 40 mm in diameter The objective of this article is to review these various techniques, to summarize the studies published in the literature and to discuss the preliminary oncological results.
MeSH term(s)	Catheter Ablation ; Cryosurgery ; Humans ; Kidney Neoplasms/pathology ; Kidney Neoplasms/therapy ; Microwaves/therapeutic use ; Ultrasonic Therapy
Language	French
Publishing date	2004-04
Publishing country	France
Document type	English Abstract ; Journal Article ; Review
ZDB-ID	1186190-3
ISSN	1166-7087
ISSN	1166-7087
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Article: High-intensity focused ultrasound (HIFU) for prostate cancer.

Murat, Francois-Joseph / Poissonnier, Laura / Pasticier, Gilles / Gelet, Albert

Cancer control : journal of the Moffitt Cancer Center

2007 Volume 14, Issue 3, Page(s) 244–249

Abstract: Background: The growing interest in high-intensity focused ultrasound (HIFU) is mainly due to its potential applications as a minimally invasive therapy. HIFU has been assessed for its role in the treatment of localized prostate cancer in patients who ... ...

Abstract	Background: The growing interest in high-intensity focused ultrasound (HIFU) is mainly due to its potential applications as a minimally invasive therapy. HIFU has been assessed for its role in the treatment of localized prostate cancer in patients who otherwise would not have benefited from surgery and in local recurrences after radiation failure. Methods: Relevant information on HIFU treatment was identified through a MEDLINE search using specified terms. Papers that presented original outcomes were included in the present review. Results: High biochemical efficacy, excellent tumor local control and favorable mid-term oncological data with a low morbidity rate have been proven in many series of patients. Conclusions: Although HIFU is a recent and emerging technology, it has been well studied and developed to a point that HIFU will undoubtedly be an effective alternative to radiation therapy.
MeSH term(s)	Humans ; Male ; Prostatic Neoplasms/diagnostic imaging ; Prostatic Neoplasms/therapy ; Treatment Outcome ; Ultrasonography/adverse effects ; Ultrasonography/instrumentation ; Ultrasonography/methods
Language	English
Publishing date	2007-07
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1328503-8
ISSN	1526-2359 ; 1073-2748
ISSN (online)	1526-2359
ISSN	1073-2748
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Zs.A 4467: Show issues

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Article: Infarctus partiel du rein par dissection spontanée idiopathique de l'artère rénale.

Dahmani, Laurent / Murat, François-Joseph / Ouaki, Frédéric / Irani, Jacques / Dore, Bertrand

Progres en urologie : journal de l'Association francaise d'urologie et de la Societe francaise d'urologie

2003 Volume 13, Issue 4, Page(s) 670–672

Abstract: Idiopathic spontaneous renal artery dissection (SRAD) is a rare disease and must be taken into account in the differential diagnosis of low back pain. It may be due to various aetiologies, secondary to degenerative or traumatic diseases, or it may be ... ...

Title translation	Partial infarction of the kidney caused by spontaneous idiopathic dissection of the renal artery.
Abstract	Idiopathic spontaneous renal artery dissection (SRAD) is a rare disease and must be taken into account in the differential diagnosis of low back pain. It may be due to various aetiologies, secondary to degenerative or traumatic diseases, or it may be idiopathic. Intravenous urography is usually normal. Abdominal CT usually visualizes the renal infarction and selective arteriography confirms the diagnosis of renal artery dissection. Medical treatment and surveillance provide effective management of the disease. However, surgical management may be proposed either immediately or secondarily. SRAD usually has a favourable course, but, in the longer term, may be complicated by organic renal failure and renovascular hypertension.
MeSH term(s)	Adult ; Aneurysm, Dissecting/complications ; Humans ; Infarction/etiology ; Kidney/blood supply ; Male ; Renal Artery
Language	French
Publishing date	2003-09
Publishing country	France
Document type	Case Reports ; English Abstract ; Journal Article
ZDB-ID	1186190-3
ISSN	1166-7087
ISSN	1166-7087
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Article: Efficacy of the InVance male sling in men with stress urinary incontinence.

Fassi-Fehri, Hakim / Badet, Lionel / Cherass, Arnaud / Murat, François-Joseph / Colombel, Marc / Martin, Xavier / Gelet, Albert

European urology

2007 Volume 51, Issue 2, Page(s) 498–503

Abstract: Objectives: To evaluate the efficacy and safety of the InVance bulbourethral sling in male stress urinary incontinence.: Materials and methods: Between June 2003 and April 2005, the InVance bulbourethral sling was implanted into 50 patients with ... ...

Abstract	Objectives: To evaluate the efficacy and safety of the InVance bulbourethral sling in male stress urinary incontinence. Materials and methods: Between June 2003 and April 2005, the InVance bulbourethral sling was implanted into 50 patients with urinary incontinence after prostate surgery in 49 cases and pelvic trauma in 1 case. The patients were monitored and evaluated in a prospective manner (continence, tolerance, and satisfaction). The treatment was considered to be successful if the patient stopped wearing any kind of continence pad (patient cured) or only one pad per day (patient improved), with no de novo urinary disorders and without significant postvoid residual urine. Patient satisfaction with the procedure was assessed. Results: After a median follow-up of 6 mo, 50% of patients were dry, 26% had improved, and 24% suffered treatment failure. The success rates for the patients with severe incontinence and those who had undergone radiation therapy were 50% and 25%, respectively. All patients who were dry or had improved were satisfied and presented no obstructive or irritative de novo urinary disorders. The overall success rate for the 51 procedures conducted was 74.5%. Six cases of transitory acute urine retention and six cases of persistent perineal pain were reported. Explantation was necessary because of suppuration of the sling in three patients and of a de novo irritative urinary disorder in one patient. No cases of pubic osteitis or urethral erosion were reported. Conclusions: The InVance bulbourethral sling procedure makes it possible to treat stress urinary incontinence after prostate surgery with satisfactory and lasting short-term results. Severe incontinence and a past history of pelvic radiation therapy seem to be factors contributing to the failure of this procedure.
MeSH term(s)	Aged ; Aged, 80 and over ; Follow-Up Studies ; Humans ; Male ; Middle Aged ; Prostheses and Implants ; Urinary Incontinence, Stress/surgery ; Urologic Surgical Procedures, Male/methods
Language	English
Publishing date	2007-02
Publishing country	Switzerland
Document type	Clinical Trial ; Journal Article
ZDB-ID	193790-x
ISSN	1421-993X ; 0302-2838
ISSN (online)	1421-993X
ISSN	0302-2838
DOI	10.1016/j.eururo.2006.08.042
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Zs.A 1247: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 294: Show issues

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Article: Spongioplastie et "déjantage" des corps caverneux. Intérêt dans la correction des hypospadias.

Dodat, Hubert / Landry, Jean-Luc / Szwarc, Caroline / Culem, Stéphane / Murat, François-Joseph / Dubois, Rémi

Progres en urologie : journal de l'Association francaise d'urologie et de la Societe francaise d'urologie

2002 Volume 12, Issue 3, Page(s) 522–526

Abstract: Hypospadias is a frequent malformation and its treatment is not devoid of complications, particularly fistulas. The authors describe the department's surgical technique (modified Duplay technique). Urethroplasty is no longer performed by simple ... ...

Title translation	Urethroplasty and separation of the corpora cavernosa for hypospadias repair.
Abstract	Hypospadias is a frequent malformation and its treatment is not devoid of complications, particularly fistulas. The authors describe the department's surgical technique (modified Duplay technique). Urethroplasty is no longer performed by simple approximation of the urethral plate without dissection. The inferior surface of corpora cavernosa is exposed as far as the lateral border and as far as the summit in the glans, allowing tension-free suture of urethral tissues with a lengthening effect of this intermediate plane. This completes correction of chordee and especially "bucket-handle" glans and protects the reconstructed urethra and proximal urethra. The risk of fistula is therefore reduced (2 cases out of 51). This technical modification can be used to treat all forms of distal hypospadias (glanular, glanulo-preputial, and anterior penile). It has also been used for several cases of more severe hypospadias. These good results must be confirmed in a larger series of patients.
MeSH term(s)	Child ; Child, Preschool ; Humans ; Hypospadias/surgery ; Infant ; Male ; Penis/surgery ; Treatment Outcome ; Urethra/surgery
Language	French
Publishing date	2002-06
Publishing country	France
Document type	English Abstract ; Journal Article
ZDB-ID	1186190-3
ISSN	1166-7087
ISSN	1166-7087
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Article: Oxygénothérapie hyperbare et cystite hémorragique post-radique.

Pires, Christophe / Irani, Jacques / Ouaki, Frédéric / Murat, François-Joseph / Doré, Bertrand

Progres en urologie : journal de l'Association francaise d'urologie et de la Societe francaise d'urologie

2002 Volume 12, Issue 6, Page(s) 1188–1193

Abstract: Radiotherapy alone or in combination with other modalities is used in the treatment of a large number of pelvic tumours of urological or gynaecological origin. Despite constant progress in this field, medium-term and long-term complications remain ... ...

Title translation	Hyperbaric oxygen therapy and radiation-induced hemorrhagic cystitis.
Abstract	Radiotherapy alone or in combination with other modalities is used in the treatment of a large number of pelvic tumours of urological or gynaecological origin. Despite constant progress in this field, medium-term and long-term complications remain frequent and often require difficult long-term management. Radiation cystitis is one of the most frequent complications and directly concerns urologists. Among the various treatment options for haemorrhagic cystitis, hyperbaric oxygen therapy appears to give good short-term and medium-term results. It is currently reserved for cases refractory to the standard treatments for radiation cystitis.
MeSH term(s)	Cystitis/etiology ; Cystitis/therapy ; Hemorrhage/etiology ; Hemorrhage/therapy ; Humans ; Hyperbaric Oxygenation ; Radiation Injuries/complications ; Radiation Injuries/therapy
Language	French
Publishing date	2002-12
Publishing country	France
Document type	English Abstract ; Journal Article ; Review
ZDB-ID	1186190-3
ISSN	1166-7087
ISSN	1166-7087
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Article: Efficacité hémostatique d'un applicateur a ultrasons collimatés de haute intensité dans la néphrectomie partielle sous hilaire chez le porc.

Murat, François-Joseph / Lafon, Cyril / Cathignol, Dominique / Theillère, Yves / Gelet, Albert / Chapelon, Jean-Yves / Martin, Xavier

Progres en urologie : journal de l'Association francaise d'urologie et de la Societe francaise d'urologie

2005 Volume 15, Issue 4, Page(s) 684–688

Abstract: Objective: To evaluate the haemostatic property of a high intensity focused ultrasound (HIFU) applicator in lower pole partial nephrectomy in a porcine model.: Materials and methods: An applicator with a flat HIFU transducer operating at a frequency ... ...

Title translation	Haemostatic efficacy of a high intensity focused ultrasound applicator in lower pole partial nephrectomy in the pig.
Abstract	Objective: To evaluate the haemostatic property of a high intensity focused ultrasound (HIFU) applicator in lower pole partial nephrectomy in a porcine model. Materials and methods: An applicator with a flat HIFU transducer operating at a frequency of 3.78 MHz was designed. Nine female pigs weighing between 35 and 39 kg were used. The kidneys of 5 pigs were used to characterize basic lesions, study haemostatic efficacy and measure the temperature rise in treated tissues. The following 4 pigs were treated by HIFU prior to bilateral lower pole partial nephrectomy. Treatment consisted of circumferential juxtaposition of basic lesions in the lower pole with vascular clamping. Haemostatic efficacy was evaluated immediately and 30 minutes after lower pole resection. Results: A 50-second ultrasound pulse with an intensity of 26 W/cm2 induced a full thickness lesion of the kidney, between 22 and 36 mm. Lesions were reproducible. The temperature rise observed in treated tissues was 62 +/- 12, 59 +/- 9 and 58 +/- 11 degrees C at distances of 15, 20 and 25 mm from the transducer, respectively. All lower pole partial nephrectomies were exsanguinated, except for one case (12.5%), in which a central renal artery was not controlled. Conclusions: Our HIFU applicator is an excellent haemostatic tool ensuring effective coagulation of the renal parenchyma, allowing dry lower pole partial nephrectomy. Improvement of the ergonomics of this applicator and adaptation to laparoscopy are currently under investigation.
MeSH term(s)	Animals ; Female ; Hemostatic Techniques ; Nephrectomy/methods ; Swine ; Ultrasonic Therapy
Language	French
Publishing date	2005-09
Publishing country	France
Document type	English Abstract ; Evaluation Studies ; Journal Article
ZDB-ID	1186190-3
ISSN	1166-7087
ISSN	1166-7087
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Article ; Online: Mid-term results demonstrate salvage high-intensity focused ultrasound (HIFU) as an effective and acceptably morbid salvage treatment option for locally radiorecurrent prostate cancer.

Murat, Francois-Joseph / Poissonnier, Laura / Rabilloud, Muriel / Belot, Aurélien / Bouvier, Raymonde / Rouviere, Olivier / Chapelon, Jean-Yves / Gelet, Albert

European urology

2009 Volume 55, Issue 3, Page(s) 640–647

Abstract: Background: Local occurrence of prostate cancer (PCa) after external beam radiation (EBRT) may benefit from definitive local therapy.: Objective: To evaluate the safety and efficacy of salvage high-intensity focal ultrasound (HIFU) in local PCa ... ...

Abstract	Background: Local occurrence of prostate cancer (PCa) after external beam radiation (EBRT) may benefit from definitive local therapy. Objective: To evaluate the safety and efficacy of salvage high-intensity focal ultrasound (HIFU) in local PCa recurrence after EBRT and to determine prognostic factors for optimal patient selection. Design, setting, and participants: Between 1995 and 2006, patients with a local PCa recurrence after EBRT were retrospectively included. Intervention: All patients received salvage HIFU with the Ablatherm device. Measurements: Prognostic factors (pre-EBRT risk group, androgen-deprivation [AD] use, pre-HIFU prostate-specific antigen [PSA], Gleason score and positive biopsy percentage) were studied in univariate and multivariate analyses. Progression was defined as positive biopsy and/or last PSA > nadir + 2 ng/ml and/or adjuvant therapy introduction. All complications were recorded. Results and limitations: Some 194 HIFU sessions for 167 patients were performed. Local cancer control was achieved with negative biopsy results in 122 (73%) patients. The median PSA nadir was 0.19 ng/ml. The mean follow-up period was 18.1 mo (range: 3-121 mo). Seventy-four patients required no hormone therapy. The actuarial 5-yr overall survival rate was 84%. The actuarial 3-yr progression-free survival rate was significantly lower in three circumstances: (1) worsening of the pre-EBRT stage with 53%, 42%, and 25% for low-, intermediate-, and high-risk patients, respectively, (2) increase in the pre-HIFU PSA, and (3) use of AD during PCa management. In multivariate analyses, the risk ratio for intermediate- and high-risk patients were 1.32 and 1.96, respectively. The risk ratio was 2.8 if patients had received AD. No rectal complications were observed. Urinary incontinence accounted for 49.5% of the urinary sphincter implantations required in 11% of patients. This is a retrospective study in which the role of the PSA doubling time and the time until recurrence was not evaluated. Conclusions: Salvage HIFU is a curative treatment option for local relapse after EBRT with acceptable morbidity. Careful patient selection is imperative depending upon the aforementioned prognostic factors.
MeSH term(s)	Humans ; Male ; Middle Aged ; Neoplasm Recurrence, Local/therapy ; Prostatic Neoplasms/radiotherapy ; Prostatic Neoplasms/therapy ; Retrospective Studies ; Salvage Therapy/methods ; Time Factors ; Treatment Failure ; Treatment Outcome ; Ultrasonic Therapy
Language	English
Publishing date	2009-03
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	193790-x
ISSN	1873-7560 ; 1421-993X ; 0302-2838
ISSN (online)	1873-7560 ; 1421-993X
ISSN	0302-2838
DOI	10.1016/j.eururo.2008.04.091
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Zs.MO 294: Show issues

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