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Article ; Online: High mortality is expected in patients who have COVID-19 during the postoperative period.

Huang, Gengwen

CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne

2020 Volume 192, Issue 29, Page(s) E847

MeSH term(s)	Betacoronavirus ; COVID-19 ; COVID-19 Testing ; Clinical Laboratory Techniques ; Coronavirus Infections/diagnosis ; Coronavirus Infections/mortality ; Humans ; Mass Screening ; Pandemics ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/mortality ; Postoperative Complications/mortality ; Preoperative Care ; Prognosis ; SARS-CoV-2
Keywords	covid19
Language	English
Publishing date	2020-05-04
Publishing country	Canada
Document type	Letter
ZDB-ID	215506-0
ISSN	1488-2329 ; 0008-4409 ; 0820-3946
ISSN (online)	1488-2329
ISSN	0008-4409 ; 0820-3946
DOI	10.1503/cmaj.75781
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Article: High mortality is expected in patients who have COVID-19 during the postoperative period

Huang, Gengwen

CMAJ

Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #656430
Database	COVID19

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Article ; Online: Diagnostic performance of plasma metagenomic next-generation sequencing for infected pancreatic necrosis: A prospective multicenter study.

Shen, Dingcheng / Lin, Chiayen / Hong, Xiaoyue / Li, Jiarong / Huang, Gengwen

The Journal of infection

2023 Volume 87, Issue 6, Page(s) e104–e106

MeSH term(s)	Humans ; Pancreatitis, Acute Necrotizing ; Prospective Studies ; High-Throughput Nucleotide Sequencing ; Intraabdominal Infections
Language	English
Publishing date	2023-10-28
Publishing country	England
Document type	Multicenter Study ; Letter
ZDB-ID	424417-5
ISSN	1532-2742 ; 0163-4453
ISSN (online)	1532-2742
ISSN	0163-4453
DOI	10.1016/j.jinf.2023.10.014
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Article: Novel insights into biomarkers of progression in Desmoid tumor.

Liu, Baiqi / Sun, Zefang / Zhou, Rui / Shen, Dingcheng / Zhu, Shuai / Chen, Lu / Huang, Gengwen

Frontiers in oncology

2023 Volume 13, Page(s) 1206800

Abstract: Desmoid tumor (DT) is a rare neoplasm characterized by the proliferation of myofibroblastic cells that infiltrates and invades adjacent tissues. Due to its locally aggressive and recurrent nature, DT often causes local symptoms and can be challenging to ... ...

Abstract	Desmoid tumor (DT) is a rare neoplasm characterized by the proliferation of myofibroblastic cells that infiltrates and invades adjacent tissues. Due to its locally aggressive and recurrent nature, DT often causes local symptoms and can be challenging to manage clinically. Therefore, identifying biomarkers that can predict the progression of DT and guide treatment decisions is critical. This review summarizes several biomarkers that have been implicated in active surveillance (AS) and the prediction of postoperative recurrence and attempts to elucidate their underlying mechanisms. Some of these novel markers could provide prognostic value for clinicians, and ultimately help facilitate optimal and accurate therapeutic decisions for DT.
Language	English
Publishing date	2023-08-03
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2649216-7
ISSN	2234-943X
ISSN	2234-943X
DOI	10.3389/fonc.2023.1206800
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Article ; Online: Is Contemporary Open Pancreatic Necrosectomy Still Useful In The Minimally Invasive Era?

Ning, Caihong / Sun, Zefang / Shen, Dingcheng / Lin, Chiayen / Li, Jiarong / Wei, Qin / Chen, Lu / Huang, Gengwen

Surgery

2024 Volume 175, Issue 5, Page(s) 1394–1401

Abstract: Background: Previous studies have shown that open pancreatic necrosectomy for infected pancreatic necrosis was associated with high morbidity and mortality. However, these results were mostly concluded from historical cohorts with traditional early ... ...

Abstract	Background: Previous studies have shown that open pancreatic necrosectomy for infected pancreatic necrosis was associated with high morbidity and mortality. However, these results were mostly concluded from historical cohorts with traditional early necrosectomy in the absence of a minimally invasive step-up approach. Objective: To explore the value of contemporary open pancreatic necrosectomy for infected pancreatic necrosis in the minimally invasive era. Methods: A post hoc analysis was performed in a prospective maintained database of 320 patients with infected pancreatic necrosis from January 2011 to December 2022 at a large Chinese tertiary hospital. Results: A total of 320 patients with infected pancreatic necrosis received either a minimally invasive step-up approach (245, 76.6%) or open pancreatic necrosectomy (75, 23.4%), which included upfront open pancreatic necrosectomy (32, 10.0%) and salvage open pancreatic necrosectomy (43, 13.4%). Upfront open pancreatic necrosectomy was associated with similar morbidity and mortality rates but fewer surgical interventions compared with a minimally invasive step-up approach. However, salvage open pancreatic necrosectomy was associated with significantly higher mortality (48.8% vs 18.8%, P = .007), gastrointestinal fistula (44.2% vs 18.8%, P = .021), hemorrhage (48.8% vs 15.6%, P = .003), and intensive care unit stay (25 vs 7 days, P = .040) compared with upfront open pancreatic necrosectomy. Multivariate analysis suggested that multiple organ failure (hazard ratio = 5.1; 95% confidence interval, 1.4-18.2, P = .013) and synchronous critical acute pancreatitis (hazard ratio = 3.0; 95% confidence interval, 1.1-8.6, P = .040) were 2 independent risk factors of death for patients who received open pancreatic necrosectomy. Conclusion: Patients undergoing upfront open pancreatic necrosectomy received fewer surgical interventions with comparable efficacy compared to the minimally invasive step-up approach. Salvage open pancreatic necrosectomy was potentially lifesaving, though it carried high morbidity and mortality. Multiple organ failure and synchronous critical acute pancreatitis were 2 independent risk factors of death for patients who received open pancreatic necrosectomy.
MeSH term(s)	Humans ; Pancreatitis, Acute Necrotizing/surgery ; Multiple Organ Failure ; Treatment Outcome ; Acute Disease ; Prospective Studies ; Drainage/methods ; Minimally Invasive Surgical Procedures/methods
Language	English
Publishing date	2024-02-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	202467-6
ISSN	1532-7361 ; 0039-6060
ISSN (online)	1532-7361
ISSN	0039-6060
DOI	10.1016/j.surg.2024.01.021
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Article ; Online: Soft pancreas should be assessed histopathologically for fibrosis to predict postoperative pancreatic fistula after pancreaticoduodenectomy.

Cao, Xintong / Zhu, Shuai / Luo, Gengqiu / Huang, Gengwen

Asian journal of surgery

2020 Volume 44, Issue 1, Page(s) 421–422

MeSH term(s)	Female ; Fibrosis ; Forecasting ; Humans ; Male ; Pancreas/pathology ; Pancreatic Fistula/epidemiology ; Pancreatic Fistula/etiology ; Pancreaticoduodenectomy/adverse effects ; Postoperative Complications/epidemiology ; Postoperative Complications/etiology ; Prospective Studies ; Risk Factors ; Severity of Illness Index ; Time Factors
Language	English
Publishing date	2020-11-24
Publishing country	China
Document type	Letter
ZDB-ID	1068461-x
ISSN	0219-3108 ; 1015-9584
ISSN (online)	0219-3108
ISSN	1015-9584
DOI	10.1016/j.asjsur.2020.10.025
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Article ; Online: Macrophage migration inhibitory factor is an early marker of severe acute pancreatitis based on the revised Atlanta classification.

Shen, Dingcheng / Tang, Caixi / Zhu, Shuai / Huang, Gengwen

BMC gastroenterology

2021 Volume 21, Issue 1, Page(s) 34

Abstract: Background: Various serum markers for early identification of severe acute pancreatitis (SAP) have been studied. Serum macrophage migration inhibitory factor (MIF) was reported to be correlated with severity of acute pancreatitis (AP) based on the 1992 ... ...

Abstract	Background: Various serum markers for early identification of severe acute pancreatitis (SAP) have been studied. Serum macrophage migration inhibitory factor (MIF) was reported to be correlated with severity of acute pancreatitis (AP) based on the 1992 Atlanta classification. However, MIF has never been proven to be predictive of disease severity based on the revised Atlanta classification (RAC). The potential predictive value of MIF needs to be further validated. Methods: Consecutive patients with AP within 48 h after symptom onset and 10 healthy control volunteers were enrolled prospectively. Serum MIF levels were measured by enzyme-linked immunosorbent assay (ELISA). The predictive value of MIF, clinical scores and other serum markers were determined. Results: Among 143 patients with AP, there were 52 (36.4%), 65 (45.5%) and 26 (18.1%) with mild, moderate and severe disease based on the RAC respectively. Compared with healthy volunteers, serum levels of MIF were significantly higher in AP patients, especially those with SAP (P < 0.001). Multivariate regression analysis indicated that increased serum MIF (cut-off 2.30 ng/ml, OR = 3.16, P = 0.008), IL-6 (cut-off 46.8 pg/ml, OR = 1.21, P = 0.043), APACHE II score (cut-off 7.5, OR = 2.57, P = 0.011) and BISAP score (cut-off 1.5, OR = 1.01, P = 0.038) were independent risk factors for predicting SAP (P < 0.05). By using the area under the receiver operating characteristic (ROC) curve (AUC), MIF (AUC 0.950) demonstrated more excellent discriminative power for predicting SAP than APACHE II (AUC 0.899), BISAP (AUC 0.886), and IL-6 (AUC 0.826). Conclusions: Serum MIF is a valuable early marker for predicting the severity of AP based on the RAC.
MeSH term(s)	APACHE ; Acute Disease ; Biomarkers ; Humans ; Macrophage Migration-Inhibitory Factors ; Pancreatitis/diagnosis ; Predictive Value of Tests ; Prognosis ; ROC Curve ; Severity of Illness Index
Chemical Substances	Biomarkers ; Macrophage Migration-Inhibitory Factors
Language	English
Publishing date	2021-01-22
Publishing country	England
Document type	Journal Article
ISSN	1471-230X
ISSN (online)	1471-230X
DOI	10.1186/s12876-020-01598-0
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Article: Classification of emphysematous pancreatitis and its relation to prognosis.

Li, Jiarong / Zhu, Shuai / Cao, Xintong / Lin, Chiayen / Ning, Caihong / Huang, Gengwen

Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences

2022 Volume 45, Issue 11, Page(s) 1348–1354

Abstract: Objectives: Emphysematous pancreatitis (EP) is a subtype of infectious pancreatic necrosis (IPN). It is characterized by the accumulation of gas inside or around the pancreatic necrotic tissue. This study aims to investigate the relation between ... ...

Title translation	气肿型胰腺炎的分类及其与预后的关系.
Abstract	Objectives: Emphysematous pancreatitis (EP) is a subtype of infectious pancreatic necrosis (IPN). It is characterized by the accumulation of gas inside or around the pancreatic necrotic tissue. This study aims to investigate the relation between classification and prognosis of EP, and to provide guidance for clinical diagnosis and treatment of IPN. Methods: A prospective cohort of 228 cases of IPN from January 2010 to June 2020 in the Department of General Surgery of Xiangya Hospital, Central South University were analyzed. Among them, 120 cases without peritoneal/retroperitoneal surgical intervention before admission were included. The 120 cases of IPN were classified into the EP group and the non-EP group. The general clinical information and results of pathogenic microorganism between the EP and the non-EP group were compared. EP patients were divided into early-EP (within 2 weeks of onset) and late-EP (after 2 weeks of onset) according to the presence timing of air bubble sign, and they were divided into extensive-EP and common-EP according to the distribution characteristics of bubble sign. The clinical characteristics between the survivors and non-survivors of both IPN and EP were compared. Results: Among the 120 IPN patients, 25 (20.8%) were EP patients and 95 (79.2%) were non-EP patients. According to the classifications, 8 were early-EP (32.0%) and 17 were late-EP (68.0%); 15 were common-EP (60.0%) and 10 were extensive-EP (40.0%). There was no significant difference in gender, age, etiology, and mortality between the EP group and the non-EP group (all Conclusions: Air bubble sign is not associated with the prognosis of IPN. Early- and extensive-EP often indicate worse prognosis. Aggressive surgical intervention based on step-up approach should be considered with priority.
Language	Chinese
Publishing date	2022-06-26
Publishing country	China
Document type	Journal Article
ZDB-ID	2168533-2
ISSN	1672-7347
ISSN	1672-7347
DOI	10.11817/j.issn.1672-7347.2020.200678
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Article ; Online: CONSTRUCTION OF SEPSIS DIAGNOSTIC MODELS AND IDENTIFICATION OF MACROPHAGE SUBPOPULATIONS BASED ON PYROPTOSIS-RELATED GENES.

Sun, Zefang / Zhang, Tao / Ning, Caihong / Shen, Dingcheng / Pei, Wenwu / Zhou, Rui / Zhu, Shuai / Huang, Gengwen

Shock (Augusta, Ga.)

2023 Volume 60, Issue 1, Page(s) 1–10

Abstract: Abstract: Background: Numerous studies have shown that pyroptosis is associated with sepsis progression, which can lead to dysregulated host immune responses and organ dysfunction. Therefore, investigating the potential prognostic and diagnostic values ... ...

Abstract	Abstract: Background: Numerous studies have shown that pyroptosis is associated with sepsis progression, which can lead to dysregulated host immune responses and organ dysfunction. Therefore, investigating the potential prognostic and diagnostic values of pyroptosis in patients with sepsis is essential. Methods: We conducted a study using bulk and single-cell RNA sequencing (scRNA-seq) from the Gene Expression Omnibus database to examine the role of pyroptosis in sepsis. Univariate logistic analysis, least absolute shrinkage, and selection operator regression analysis were used to identify pyroptosis-related genes (PRGs), construct a diagnostic risk score model, and evaluate the selected genes' diagnostic value. Consensus clustering analysis was used to identify the PRG-related sepsis subtypes with varying prognoses. Functional and immune infiltration analyses were used to explain the subtypes' distinct prognoses, and scRNA-seq data were used to differentiate immune-infiltrating cells and macrophage subsets and study cell-cell communication. Results: A risk model was established based on 10 key PRGs ( NAIP , ELANE , GSDMB , DHX9 , NLRP3 , CASP8 , GSDMD , CASP4 , APIP , and DPP9 ), of which four ( ELANE , DHX9 , GSDMD , and CASP4 ) were associated with prognosis. Two subtypes with different prognoses were identified based on the key PRG expressions. Functional enrichment analysis revealed diminished nucleotide oligomerization domain-like receptor pathway activity and enhanced neutrophil extracellular trap formation in the subtype with a poor prognosis. Immune infiltration analysis suggested a different immune status between the two sepsis subtypes, with the subtype with a poor prognosis exhibiting stronger immunosuppression. The single-cell analysis identified a macrophage subpopulation characterized by gasdermin D (GSDMD) expression that may be involved in pyroptosis regulation, which was associated with the prognosis of sepsis. Conclusion: We developed and validated a risk score for sepsis identification based on 10 PRGs, four of which also have potential value in the prognosis of sepsis. We identified a subset of gasdermin D macrophages associated with poor prognosis, providing new insights into the role of pyroptosis in sepsis.
Language	English
Publishing date	2023-05-16
Publishing country	United States
Document type	Journal Article
ZDB-ID	1185432-7
ISSN	1540-0514 ; 1073-2322
ISSN (online)	1540-0514
ISSN	1073-2322
DOI	10.1097/SHK.0000000000002137
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Article ; Online: Outcomes of infected pancreatic necrosis complicated with duodenal fistula in the era of minimally invasive techniques.

Shen, Dingcheng / Ning, Caihong / Huang, Gengwen / Liu, Zhiyong

Scandinavian journal of gastroenterology

2019 Volume 54, Issue 6, Page(s) 766–772

Abstract: Background: ...

Abstract	Background:
MeSH term(s)	Adult ; China ; Drainage ; Duodenal Diseases/etiology ; Duodenal Diseases/surgery ; Female ; Humans ; Intestinal Fistula/etiology ; Intestinal Fistula/surgery ; Length of Stay ; Male ; Middle Aged ; Minimally Invasive Surgical Procedures ; Pancreatitis, Acute Necrotizing/complications ; Pancreatitis, Acute Necrotizing/mortality ; Pancreatitis, Acute Necrotizing/surgery ; Retrospective Studies ; Tomography, X-Ray Computed
Language	English
Publishing date	2019-05-28
Publishing country	England
Document type	Journal Article
ZDB-ID	82042-8
ISSN	1502-7708 ; 0036-5521
ISSN (online)	1502-7708
ISSN	0036-5521
DOI	10.1080/00365521.2019.1619831
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