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Article: Effectiveness and Safety of Sofosbuvir-Velpatasvir in Patients with Cirrhosis Associated with Genotype 3 Hepatitis C Infection in Xinjiang, China.

Abulitifu, Yilihamu / Lian, Jiangshan / Adilijiang, Munire / Liu, Lan / Zhao, Fengcong / Qian, Wen / Zhang, Yongping

2022 Volume 15, Page(s) 6463–6470

Abstract: Purpose: Patients with cirrhosis from genotype 3 (GT3) hepatitis C virus (HCV) infection are difficult to cure. This study investigated the effectiveness and safety of sofosbuvir-velpatasvir (SOF/VEL) with and without ribavirin (RBV) in patients with ... ...

Abstract	Purpose: Patients with cirrhosis from genotype 3 (GT3) hepatitis C virus (HCV) infection are difficult to cure. This study investigated the effectiveness and safety of sofosbuvir-velpatasvir (SOF/VEL) with and without ribavirin (RBV) in patients with GT3 HCV-infection-related cirrhosis from Xinjiang, China. Patients and methods: This study included 33 patients with GT3 HCV infected cirrhosis, who were treated with either SOF/VEL+RBV for 12 weeks (n = 27) or SOF/VEL alone for 24 weeks (n = 6) between January 2019 and June 2021. The primary endpoint was a sustained virological response at 12 weeks (SVR12), post-treatment. Secondary endpoints included changes from baseline in Child-Pugh-Turcotte scores, clinical results, hepatic-encephalopathy status, ascites, and gastrointestinal bleeding at 12 weeks, post-treatment. Results: Out of the 33 patients, 18 (54.6%) were diagnosed with GT3a, 15 (45.4%) with GT3b, 16 (48.5%) with compensated cirrhosis, and 17 (51.5%) with decompensated cirrhosis. SVR12 was 87.9% (compensated cirrhosis: 93.8%, decompensated cirrhosis: 82.4%). The Child-Pugh-Turcotte scores improved at 12 weeks (p < 0.05). Total bilirubin, albumin, and alanine transaminase levels, as well as hepatic-encephalopathy were significantly improved among patients with compensated and decompensated cirrhosis (p < 0.05). The blood cell count and serum creatinine levels did not deteriorate. Conclusion: SOF/VEL, with and without RBV, was effective, safe, and well-tolerated as a treatment for GT3 HCV associated cirrhosis.
Language	English
Publishing date	2022-11-03
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2494856-1
ISSN	1178-6973
ISSN	1178-6973
DOI	10.2147/IDR.S385071
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Article ; Online: Neonatal outcomes after neuraminidase inhibitor use during pregnancy: A meta-analysis of cohort studies.

Lian, Jiangshan / Adilijiang, Munire / Chang, Caihua / Jiang, Haiyin / Zhang, Yongping

British journal of clinical pharmacology

2021 Volume 88, Issue 3, Page(s) 911–918

Abstract: Aim: Influenza infection poses a severe threat to pregnant mothers, and antiviral treatment is recommended. However, the safety of neuraminidase-inhibitor antiviral medications during pregnancy has not been well described.: Methods: A systematic ... ...

Abstract	Aim: Influenza infection poses a severe threat to pregnant mothers, and antiviral treatment is recommended. However, the safety of neuraminidase-inhibitor antiviral medications during pregnancy has not been well described. Methods: A systematic review and meta-analysis were performed to evaluate the adverse neonatal outcomes associated with exposure to neuraminidase inhibitors during pregnancy. The PubMed, Embase and Cochrane Library databases were searched to identify potential studies for inclusion. Results: Nine cohort studies that estimated adverse neonatal outcomes associated with exposure to neuraminidase-inhibitor medication during pregnancy were included. Exposure to a neuraminidase inhibitor during pregnancy was not associated with an increased risk of congenital malformation (odds ratio [OR] 0.9, 95% confidence interval [CI] 0.72-1.12, P = .341), low Apgar score (OR 0.96, 95% CI 0.77-1.2, P = .733) or preterm birth (OR 0.99, 95% CI 0.89-1.09, P = .771) compared with no exposure. However, exposure to a neuraminidase inhibitor was associated with a reduced risk of low birth weight (OR 0.79, 95% CI 0.68-0.92, P = .002) and giving birth to a small-for-gestational-age infant (OR 0.78, 95% CI 0.69-0.88, P < .001). Further analyses limited to oseltamivir exposure were consistent with the overall results. Conclusion: Exposure to neuraminidase-inhibitor medication during pregnancy does not appear to be associated with adverse neonatal outcomes. We recommend further studies to investigate this association, which will help clinicians determine whether to prescribe a neuraminidase inhibitor during pregnancy.
MeSH term(s)	Antiviral Agents/adverse effects ; Cohort Studies ; Enzyme Inhibitors/adverse effects ; Female ; Humans ; Infant ; Infant, Newborn ; Neuraminidase ; Pregnancy ; Pregnancy Outcome/epidemiology ; Premature Birth/chemically induced
Chemical Substances	Antiviral Agents ; Enzyme Inhibitors ; Neuraminidase (EC 3.2.1.18)
Language	English
Publishing date	2021-09-02
Publishing country	England
Document type	Journal Article ; Meta-Analysis ; Review ; Systematic Review
ZDB-ID	188974-6
ISSN	1365-2125 ; 0306-5251 ; 0264-3774
ISSN (online)	1365-2125
ISSN	0306-5251 ; 0264-3774
DOI	10.1111/bcp.15033
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Article ; Online: Landscape factors influencing bird nest site selection in urban green spaces

Zhenhui Ding / Ao Guo / Meng Lian / Yan Wang / Wenjia Ying / Hao Jiang / Xingyu Zhou / Cheng Qian / Jiangshan Lai / Jiajie Cao

Frontiers in Ecology and Evolution, Vol

2023 Volume 11

Abstract: IntroductionUnderstanding the birds’ breeding strategies in urban habitats is vital for ensuring their continued existence. Therefore, more research must be conducted on bird breeding and urban adaptation strategies in urban green spaces. This study ... ...

Abstract	IntroductionUnderstanding the birds’ breeding strategies in urban habitats is vital for ensuring their continued existence. Therefore, more research must be conducted on bird breeding and urban adaptation strategies in urban green spaces. This study aimed to address this gap by investigating the influence of landscape factors on the selection of bird nest sites. MethodsData on the presence and absence of magpie (Pica pica) and gray magpie (Cyanopica cyana) nests were collected through field surveys conducted in the campus of Nanjing Forestry University during the 2023 breeding season. Generalized additive models (GAMs) incorporating landscape variables were employed to assess the effects of these predictors on nest occurrence. The model with the lowest Akaike’s information criterion value was selected among the candidate GAMs.ResultsBelow is a summary of the main results. Nest tree height (TH), distance from the central lawn (D), and tree coverage (TC) within the sampled area were identified as the primary landscape factors influencing nest site choice. Conversely, factors such as the shortest distance to the water source, herb coverage, shrub coverage, percentage of buildings, and percentage of hard pavement did not significantly impact on nest site selection. Furthermore, the nesting potential of magpies and grey magpies initially increased with tree height, reaching a maximum at ca. TH=25 meters after which it began to decline. The nesting occurrence rate showed an initial decrease tendency with increasing distance from the central lawn, reaching a minimum at D=400 meters, and then increased with further distance. Additionally, nesting potential decreased initially with increasing of TC in the range of 0–20%, fluctuated evenly between 20–60% TC, and decreased rapidly when TC exceeded 60%.DiscussionThis study provides valuable insights into the selection of nest sites by birds in urban habitats, specifically with respect to landscape factors. The understanding of the impact of urban green spaces on urban birds ...
Keywords	landscape factors ; magpie and gray magpie ; nesting site selection ; tree height ; urban habitats ; Evolution ; QH359-425 ; Ecology ; QH540-549.5
Subject code	710
Language	English
Publishing date	2023-08-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
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Article: Metagenomic Next-Generation Sequencing for Accurate Diagnosis of Acute HIV Infection with Aseptic Meningitis: A Case Report.

Zhou, Jing / Fu, Miao / Zhang, Dehe / Xu, Yejin / Lian, Jiangshan / Xu, Hanglu / Zhang, Yang / Chen, Haijun

Infection and drug resistance

2022 Volume 15, Page(s) 2529–2536

Abstract: Background: Although individuals infected with HIV for the first time manifest a series of acute syndromes, most patients show mild or no symptoms, which complicates the initial clinical diagnosis. Early diagnosis is important for effective prevention ... ...

Abstract	Background: Although individuals infected with HIV for the first time manifest a series of acute syndromes, most patients show mild or no symptoms, which complicates the initial clinical diagnosis. Early diagnosis is important for effective prevention and management of patients. Metagenomic next-generation sequencing technology (mNGS) can rapidly detect a wide range of pathogenic microorganisms, even in atypical cases. However, to date, few studies have reported the application of mNGS to diagnose acute HIV infection with aseptic meningitis. Case presentation: A 38-year-old man was admitted to the Department of Infectious Diseases due to repeated fever, headache, and scattered rashes on his limbs. Routine blood analysis revealed elevated absolute lymphocytes and monocytes. Moreover, monocytes were found to be significantly increased following a lumbar puncture and cerebrospinal fluid detection. mNGS results revealed the presence of the human immunodeficiency virus (HIV-1), with HIV RNA of 910 copies/mL in his cerebrospinal fluid. The HIV antigen/antibody test was negative. According to a study by Fie Big et al, a clear diagnosis of acute HIV infection at Fiebig stage I. The patient's condition improved after treatment, and he was prescribed antiretroviral therapy (ART) after discharge. Conclusion: Aseptic meningitis is easily misdiagnosed during the initial stages of acute HIV infection. mNGS can be used to identify the pathogen early, rapidly, and accurately, thereby improving the treatment of acute HIV infections.
Language	English
Publishing date	2022-05-16
Publishing country	New Zealand
Document type	Case Reports
ZDB-ID	2494856-1
ISSN	1178-6973
ISSN	1178-6973
DOI	10.2147/IDR.S361049
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Article ; Online: Comparative analysis of elderly hospitalized patients with COVID-19 or influenza A H1N1 virus infections.

Lv, Yan / Yu, Guodong / Zhang, Xiaoli / Gu, Jueqing / Ye, Chanyuan / Lian, Jiangshan / Lu, Xiaoqing / Lu, Yingfeng / Yang, Yida

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases

2022 Volume 125, Page(s) 278–284

Abstract: Objectives: This study aimed to investigate the differences between elderly patients hospitalized with COVID-19 or influenza A H1N1 virus infections.: Methods: We contrasted two absolute groups of patients (age ≥60 years) infected with either COVID- ... ...

Abstract	Objectives: This study aimed to investigate the differences between elderly patients hospitalized with COVID-19 or influenza A H1N1 virus infections. Methods: We contrasted two absolute groups of patients (age ≥60 years) infected with either COVID-19 (n = 222) or influenza A H1N1 virus infections (n = 96). Propensity score matching was used to reduce the imbalance between the two matched groups. The clinical features, imaging presentations, therapies, and prognosis data were compared between the two groups. Results: The patients with influenza showed higher proportions of cough, expectoration, fatigue, and shortness of breath. Higher counts of lymphocytes, hemoglobin, and creatine kinase and lower counts of white blood cells, neutrophils, blood urea nitrogen, and C-reactive protein were found in the patients with COVID-19. Regarding the imaging characteristics, bilateral pneumonia was the most abnormal pattern in the two groups of patients. The incidence of acute respiratory distress syndrome or death was lower among the patients with COVID-19. Conclusion: The clinical manifestations of patients with COVID-19 are more concealed than those of patients with influenza. Fewer symptoms of sputum production, fatigue, and shortness of breath, combined with lower counts of white blood cells, neutrophils, and C-reactive protein are the possible predictive factors of COVID-19 among elderly patients.
Language	English
Publishing date	2022-11-09
Publishing country	Canada
Document type	Journal Article
ZDB-ID	1331197-9
ISSN	1878-3511 ; 1201-9712
ISSN (online)	1878-3511
ISSN	1201-9712
DOI	10.1016/j.ijid.2022.11.008
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Article: Impact of short-term ambient air pollution exposure on the risk of severe COVID-19.

Feng, Baihuan / Lian, Jiangshan / Yu, Fei / Zhang, Dan / Chen, Weizhen / Wang, Qi / Shen, Yifei / Xie, Guoliang / Wang, Ruonan / Teng, Yun / Lou, Bin / Zheng, Shufa / Yang, Yida / Chen, Yu

Journal of environmental sciences (China)

2022 Volume 135, Page(s) 610–618

Abstract: Ecological studies suggested a link between air pollution and severe COVID-19 outcomes, while studies accounting for individual-level characteristics are limited. In the present study, we aimed to investigate the impact of short-term ambient air ... ...

Abstract	Ecological studies suggested a link between air pollution and severe COVID-19 outcomes, while studies accounting for individual-level characteristics are limited. In the present study, we aimed to investigate the impact of short-term ambient air pollution exposure on disease severity among a cohort of 569 laboratory confirmed COVID-19 patients admitted to designated hospitals in Zhejiang province, China, from January 17 to March 3, 2020, and elucidate the possible biological processes involved using transcriptomics. Compared with mild cases, severe cases had higher proportion of medical conditions as well as unfavorable results in most of the laboratory tests, and manifested higher air pollution exposure levels. Higher exposure to air pollutants was associated with increased risk of severe COVID-19 with odds ratio (OR) of 1.89 (95% confidence interval (CI): 1.01, 3.53), 2.35 (95% CI: 1.20, 4.61), 2.87 (95% CI: 1.68, 4.91), and 2.01 (95% CI: 1.10, 3.69) for PM
MeSH term(s)	Humans ; Nitrogen Dioxide/analysis ; Particulate Matter/analysis ; COVID-19/epidemiology ; Air Pollution/adverse effects ; Air Pollution/analysis ; Air Pollutants/toxicity ; Air Pollutants/analysis ; China/epidemiology ; Environmental Exposure/analysis
Chemical Substances	Nitrogen Dioxide (S7G510RUBH) ; Particulate Matter ; Air Pollutants
Language	English
Publishing date	2022-10-11
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1092300-7
ISSN	1878-7320 ; 1001-0742
ISSN (online)	1878-7320
ISSN	1001-0742
DOI	10.1016/j.jes.2022.09.040
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Article ; Online: Expression and Significance of LncRNA-MINCR and CDK2 mRNA in Primary Hepatocellular Carcinoma.

Lian, Jiangshan / Zhang, Xiaolin / Lu, Yingfeng / Hao, Shaorui / Zhang, Zhe / Yang, Yida

Combinatorial chemistry & high throughput screening

2019 Volume 22, Issue 3, Page(s) 201–206

Abstract: Objective: To investigate the expression of long-chain non-coding RNA MINCR (LncRNAMINCR) and Cyclin-Dependent Kinase 2 (CDK2) mRNA in primary hepatocellular carcinoma, and to analyze the relationship between its expression and clinical pathological ... ...

Abstract	Objective: To investigate the expression of long-chain non-coding RNA MINCR (LncRNAMINCR) and Cyclin-Dependent Kinase 2 (CDK2) mRNA in primary hepatocellular carcinoma, and to analyze the relationship between its expression and clinical pathological parameters and prognosis of hepatocellular carcinoma. Methods: Seventy-five surgically resected primary hepatocellular carcinoma tissues and paracancerous tissues were selected. Real-time PCR was used to detect the expression of LncRNA-MINCR and CDK2 mRNA in hepatocellular carcinoma tissues and adjacent tissues. The relationship of clinicopathological parameters and prognosis between hepatocellular carcinoma and LncRNA-MINCR and CDK2 mRNA were analyzed. Pearson correlation coefficient describes the correlation between LncRNA-MINCR and CDK2 mRNA. Results: The expression of LncRNA-MINCR and CDK2 mRNA in primary hepatocellular carcinoma tissues was higher than that in the adjacent tissues [(5.51±0.62) vs (1.62±0.51), (4.52±0.73) vs (1.85±0.95), P<0.05]. The expression of LncRNA-MINCR in the primary hepatocellular carcinoma group was positively correlated with CDK2 mRNA (r=0.352, P<0.05), and the expression of LncRNA-MINCR in the paracancerous tissue group was not correlated with CDK2 mRNA (r=0.024, P>0.05). LncRNA-MINCR expression was associated with TNM staging, lymph node metastasis, and cirrhosis (P<0.05). CDK2 mRNA expression was associated with tumor diameter, TNM stage, lymph node metastasis, and serum alpha-fetoprotein levels (P<0.05). The 3-year survival rate of patients with high expression of LncRNAMINCR was lower than that of LncRNA-MINCR low expression group [53.49% vs 77.38%, 2=13.024, P<0.05). The 3-year survival rate of patients with high CDK2 mRNA expression was lower than that of CDK2 mRNA low expression group [51.29] % vs 80.38%, 2 = 10.15, P < 0.05]. Conclusion: The expression of LncRNA-MINCR and CDK2 mRNA in primary hepatocellular carcinoma tissues increased significantly. The two play a synergistic role in the invasion, invasion and metastasis of hepatocarcinoma cells. High expression of LncRNA-MINCR and CDK2 mRNA indicates poor prognosis in patients with hepatocellular carcinoma.
MeSH term(s)	Adult ; Aged ; Carcinoma, Hepatocellular/physiopathology ; Cyclin-Dependent Kinase 2/genetics ; Female ; Gene Expression Regulation, Neoplastic/genetics ; Humans ; Liver Neoplasms/physiopathology ; Lymph Nodes/metabolism ; Male ; Middle Aged ; Neoplasm Metastasis/physiopathology ; Neoplasm Staging ; Prognosis ; RNA, Long Noncoding/metabolism ; RNA, Messenger/metabolism ; alpha-Fetoproteins/metabolism
Chemical Substances	RNA, Long Noncoding ; RNA, Messenger ; alpha-Fetoproteins ; CDK2 protein, human (EC 2.7.11.22) ; Cyclin-Dependent Kinase 2 (EC 2.7.11.22)
Language	English
Publishing date	2019-04-01
Publishing country	United Arab Emirates
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2064785-2
ISSN	1875-5402 ; 1386-2073
ISSN (online)	1875-5402
ISSN	1386-2073
DOI	10.2174/1386207322666190404151020
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Article ; Online: Immunomodulatory and Antiviral Therapy Improved Functional Cure Rate in CHB Patients with High HBsAg Level Experienced NA.

Jia, Hongyu / Yu, Guodong / Yu, Jiong / Zhang, Xiaoli / Yang, Lisha / Wang, Bin / Zhang, Jiming / Bai, Lang / Zhang, Xinxin / Wang, Kai / Zhao, Ping / Yang, Dongliang / Zhao, Yingren / Yu, Yanyan / Zhang, Yimin / Gu, Jueqing / Ye, Chanyuan / Cai, Huan / Lu, Yingfeng /

Xiang, Dairong / Yu, Liang / Lian, Jiangshan / Hu, Jianhua / Zhang, Shanyan / Jin, Ciliang / Yang, Yida

Journal of clinical and translational hepatology

2023 Volume 11, Issue 5, Page(s) 1003–1010

Abstract: Background and aims: A functional cure, or hepatitis B virus (HBV) surface antigen (HBsAg) loss, is difficult to achieve in patients with hepatitis B virus e antigen (HBeAg)-positive chronic hepatitis B. The HBV vaccine and granulocyte-macrophage colony- ...

Abstract	Background and aims: A functional cure, or hepatitis B virus (HBV) surface antigen (HBsAg) loss, is difficult to achieve in patients with hepatitis B virus e antigen (HBeAg)-positive chronic hepatitis B. The HBV vaccine and granulocyte-macrophage colony-stimulating factor (GM-CSF) have been reported to help reduce HBsAg levels and promote HBsAg loss. In this prospective randomized trial, we evaluated HBsAg loss in patients receiving pegylated interferon-α2b (PEGIFN-α2b) and tenofovir disoproxil fumarate (TDF), with and without GM-CSF and HBV vaccination. Methods: A total of 287 patients with HBeAg positive chronic hepatitis B and seroconversion after nucleot(s)ide analog treatment were assigned randomly to three treatment groups for 48 weeks, TDF alone (control), PEGIFN-α2b + TDF, and PEGIFN-α2b + TDF + GM-CSF + HBV vaccine. The primary endpoints were the proportions of patients with HBsAg loss and seroconversion at 48 and 72 weeks. Results: The cumulative HBsAg loss rates in the control, PEGIFN-α2b + TDF, and PEGIFN-α2b + TDF + GM-CSF + HBV vaccine groups at week 48 were 0.0%, 28.3%, and 41.1%, respectively. The cumulative HBsAg seroconversion rates in these groups at week 48 were 0.0%, 21.7%, and 33.9%, respectively. Multivariate regression analysis showed that GM-CSF use plus HBV vaccination was significantly associated with HBsAg loss ( Conclusions: In patients with HBeAg-positive chronic hepatitis B and seroconversion after nucleot(s)ide analog treatment, immunomodulatory/antiviral treatment regimens effectively improved HBsAg loss, and the regimen including GM-CSF and HBV vaccination was most effective.
Language	English
Publishing date	2023-03-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	3019822-7
ISSN	2310-8819 ; 2225-0719
ISSN (online)	2310-8819
ISSN	2225-0719
DOI	10.14218/JCTH.2022.00413
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Article: Prophylactic antiviral treatment reduces the incidence of liver failure among patients coinfected with Mycobacterium tuberculosis and hepatitis B virus

Lian, Jiangshan / Hu, Ping / Jia, Hongyu / Liu, Yueying / Lu, Yingfeng / Wang, Xiaoxiao / Yang, Yida / Zhang, Yimin

Virus research. 2019 Sept., v. 270

2019

Abstract: China has a high prevalence of tuberculosis and hepatitis B virus infection. The purpose of this study was to determine whether HBV coinfection increases the risk of incidence of drug-induced hepatotoxicity among patients on anti-tuberculosis therapy ... ...

Abstract	China has a high prevalence of tuberculosis and hepatitis B virus infection. The purpose of this study was to determine whether HBV coinfection increases the risk of incidence of drug-induced hepatotoxicity among patients on anti-tuberculosis therapy.This retrospective study was carried out at the First Affiliated Hospital, School of Medicine, Zhejiang University, from 2013 to 2017. All enrolled patients were confirmed HBsAg-positive for a duration of at least 6 months and coinfected with mycobacterium tuberculosis.A cohort of 90 patients was analyzed. The incidence of liver damage and liver failure was 51.11% (n = 46) and 22.22% (n = 20), respectively. By multivariate analysis, initial albumin <35 g/l (P = 0.004, odds ratio 6.162, 95% confidence interval 1.767–21.486) was an independent risk factor for liver failure, but prophylactic antiviral treatment (P < 0.001, odds ratio 0.033, 95% confidence interval 0.007–0.154) was an independent protective factor for liver failure. Of the 90 patients, 20 developed liver failure, none of the patients with liver failure received prophylactic antiviral therapy, and 6 of those patients died of liver failure.Prophylactic antiviral treatment reduces the incidence of liver failure in patients coinfected with Mycobacterium tuberculosis and hepatitis B virus; therefore, it is recommended that prophylactic antiviral treatment be administered while receiving anti-tuberculosis treatment in patients coinfected with Mycobacterium tuberculosis and hepatitis B virus.
Keywords	albumins ; confidence interval ; hepatitis B ; Hepatitis B virus ; hepatotoxicity ; hospitals ; liver ; liver failure ; medicine ; mixed infection ; multivariate analysis ; Mycobacterium tuberculosis ; odds ratio ; patients ; retrospective studies ; risk factors ; therapeutics ; tuberculosis ; China
Language	English
Dates of publication	2019-09
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	605780-9
ISSN	1872-7492 ; 0168-1702
ISSN (online)	1872-7492
ISSN	0168-1702
DOI	10.1016/j.virusres.2019.197664
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Article ; Online: Dynamic metabolic profiles for HBeAg seroconversion in chronic hepatitis B (CHB) patients by gas chromatography-mass spectrometry (GC-MS).

Lu, Yingfeng / Zhou, Chiyan / Yan, Ren / Lian, Jiangshan / Cai, Huan / Yu, Jiong / Chen, Deyin / Su, Xiaoling / Qian, Jiajie / Yang, Yida / Li, Lanjuan

Journal of pharmaceutical and biomedical analysis

2021 Volume 206, Page(s) 114349

Abstract: Chronic hepatitis B (CHB) remains a major public health problem globally. HBeAg seroconversion is a vital hallmark for the improvement of CHB. The plasma metabolic profile has not been clear in CHB patients and searching metabolic candidates to represent ...

Abstract	Chronic hepatitis B (CHB) remains a major public health problem globally. HBeAg seroconversion is a vital hallmark for the improvement of CHB. The plasma metabolic profile has not been clear in CHB patients and searching metabolic candidates to represent HBeAg seroconversion is also difficult currently. In this study, CHB patients were recruited, followed and divided into the HBeAg-positive (HBeAg-pos.) group (n = 29) and the HBeAg-negative (HBeAg-neg.) group (n = 29) based on HBeAg seroconversion or not. The plasma metabolic profiles were measured by gas chromatography-mass spectrometry (GC-MS) at 0 week (0w), 24 weeks (24w) and 48 weeks (48w) after administration. The acquired data was analyzed using orthogonal partial least squares discriminate analysis (OPLS-DA) and the differential metabolites were further assessed by self and group comparison. No differences of age, gender and serological characteristics were observed between two groups at 0w and 48w separately. The OPLS-DA score plots depending on administration time displayed robust metabolic differences no matter HBeAg turned to be negative or not. According to VIP> 1.0, a total of 15 differential metabolites were same in the two groups, 7 differential metabolites (glycolic acid, D-talose, L-proline, L-(-)-arabitol, ethyl-alpha-D-glucopyranoside, L-leucine and dihydroxybutanoic acid) were derived from one group alone and considered as metabolic candidates. At 0w versus (vs.) 24w, only 3 of 7 candidates (L-proline, L-(-)-arabitol, dihydroxybutanoic acid) showed nonuniform in the two groups, while at 0w vs. 48w, all of them varied inconsistently. Conclusively the dynamic metabolic profiles assayed by GC-MS were different between CHB patients with and without HBeAg seroconversion. The 7 metabolic candidates probably had the ability to reflect the CHB progression for HBeAg seroconversion and 3 of them showed strong relationship with HbeAg seroconversion early.
MeSH term(s)	Antiviral Agents/therapeutic use ; Gas Chromatography-Mass Spectrometry ; Hepatitis B e Antigens/therapeutic use ; Hepatitis B virus ; Hepatitis B, Chronic/diagnosis ; Hepatitis B, Chronic/drug therapy ; Humans ; Interferon-alpha ; Metabolome ; Seroconversion ; Treatment Outcome
Chemical Substances	Antiviral Agents ; Hepatitis B e Antigens ; Interferon-alpha
Language	English
Publishing date	2021-09-06
Publishing country	England
Document type	Journal Article
ZDB-ID	604917-5
ISSN	1873-264X ; 0731-7085
ISSN (online)	1873-264X
ISSN	0731-7085
DOI	10.1016/j.jpba.2021.114349
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