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  1. Article ; Online: High oligoclonality of immunoglobulins in SARS-CoV2 positive patients.

    Kolopp-Sarda, Marie / Miossec, Pierre

    Annals of the rheumatic diseases

    2020  Volume 80, Issue 3, Page(s) 402–403

    MeSH term(s) COVID-19 ; Humans ; Immunoglobulins ; Immunologic Tests ; RNA, Viral ; SARS-CoV-2
    Chemical Substances Immunoglobulins ; RNA, Viral
    Keywords covid19
    Language English
    Publishing date 2020-08-10
    Publishing country England
    Document type Letter
    ZDB-ID 7090-7
    ISSN 1468-2060 ; 0003-4967
    ISSN (online) 1468-2060
    ISSN 0003-4967
    DOI 10.1136/annrheumdis-2020-218316
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  2. Article ; Online: Key points to consider for an improved detection and characterization of cryoglobulins.

    Kolopp-Sarda, Marie N / Miossec, Pierre

    Autoimmunity reviews

    2021  Volume 20, Issue 11, Page(s) 102948

    MeSH term(s) Cryoglobulins ; Humans
    Chemical Substances Cryoglobulins
    Language English
    Publishing date 2021-09-09
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 2144145-5
    ISSN 1873-0183 ; 1568-9972
    ISSN (online) 1873-0183
    ISSN 1568-9972
    DOI 10.1016/j.autrev.2021.102948
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  3. Article ; Online: Practical Details for the Detection and Interpretation of Cryoglobulins.

    Kolopp-Sarda, Marie-Nathalie / Miossec, Pierre

    Clinical chemistry

    2021  Volume 68, Issue 2, Page(s) 282–290

    Abstract: Background: Cryoglobulins are immunoglobulins that precipitate at low temperature. Strict preanalytical and analytical conditions are critical for the detection of cryoglobulins.: Content: This review will focus on practical recommendations for ... ...

    Abstract Background: Cryoglobulins are immunoglobulins that precipitate at low temperature. Strict preanalytical and analytical conditions are critical for the detection of cryoglobulins.
    Content: This review will focus on practical recommendations for detection and characterization of cryoglobulins and the technical problems that may be encountered. A laboratory report format is proposed for presentation of these results that includes the parameters necessary for an optimal interpretation by clinicians. The first step of detection of cryoglobulins can be performed in any laboratory that has a 37 °C incubator and temperature-controlled centrifuge. The second step is the characterization of cryoglobulins, and this often must be performed in more specialized laboratories. Characterization includes immunoglobulin typing, for the classification of cryoglobulins and potential underlying disease(s); quantification of immunoglobulins and rheumatoid factor in the cryoprecipitate to define the pathogenicity; and quantification of serum complement, which is useful for diagnosis.
    Summary: These practical recommendations will be useful for the accurate detection of cryoglobulins, an essential step for the diagnosis of cryoglobulinemic vasculitis, a rare but severe clinical manifestation of cryoglobulins.
    MeSH term(s) Cryoglobulinemia/diagnosis ; Cryoglobulins ; Humans ; Immunoglobulins ; Laboratories
    Chemical Substances Cryoglobulins ; Immunoglobulins
    Language English
    Publishing date 2021-11-16
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 80102-1
    ISSN 1530-8561 ; 0009-9147
    ISSN (online) 1530-8561
    ISSN 0009-9147
    DOI 10.1093/clinchem/hvab195
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  4. Article ; Online: Reply.

    Kolopp-Sarda, Marie-Nathalie / Miossec, Pierre

    Arthritis & rheumatology (Hoboken, N.J.)

    2020  Volume 72, Issue 11, Page(s) 1956–1957

    MeSH term(s) Cryoglobulins ; Humans
    Chemical Substances Cryoglobulins
    Language English
    Publishing date 2020-09-22
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2756371-6
    ISSN 2326-5205 ; 2326-5191
    ISSN (online) 2326-5205
    ISSN 2326-5191
    DOI 10.1002/art.41433
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  6. Article ; Online: Contribution of Hepatitis C Infection to a Large Cohort of Cryoglobulin-Positive Patients: Detection and Characteristics.

    Kolopp-Sarda, Marie N / Miossec, Pierre

    Frontiers in immunology

    2020  Volume 11, Page(s) 1183

    Abstract: Cryoglobulins (CGs) are cold precipitating immunoglobulins, and hepatitis C virus (HCV) infection is its most common cause. The purpose of the study was to determine the contribution of HCV in a large cohort of CG. Biological characteristics and ... ...

    Abstract Cryoglobulins (CGs) are cold precipitating immunoglobulins, and hepatitis C virus (HCV) infection is its most common cause. The purpose of the study was to determine the contribution of HCV in a large cohort of CG. Biological characteristics and specificity of CGs in HCV patients were compared to non-HCV subjects. Cryoglobulin analysis included isotype, clonality, concentration, and rheumatoid factor (RF) in cryoprecipitate and serum complement and RF. This study is an extension of the study carried out on a cohort of 13,439 patients tested for CGs from all medical units, in which 1,675/13,439 (12.5%) patients had a CG, and 680/1,675 (40.6%) had HCV serology or viral load determination (HCV RNA). Among these 680 CG patients tested for HCV, 325 of 680 (47.8%) HCV patients (272 HCV RNA
    MeSH term(s) Adult ; Aged ; Cohort Studies ; Cryoglobulinemia/etiology ; Cryoglobulinemia/immunology ; Cryoglobulins/analysis ; Cryoglobulins/immunology ; Female ; Hepatitis C/complications ; Hepatitis C/immunology ; Humans ; Male ; Middle Aged ; Retrospective Studies
    Chemical Substances Cryoglobulins
    Language English
    Publishing date 2020-06-30
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2020.01183
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  7. Article ; Online: Cryoglobulinemic vasculitis: pathophysiological mechanisms and diagnosis.

    Kolopp-Sarda, Marie N / Miossec, Pierre

    Current opinion in rheumatology

    2020  Volume 33, Issue 1, Page(s) 1–7

    Abstract: Purpose of review: Cryoglobulins (CG) are immunoglobulins that precipitate in the cold, and dissolve at 37°C. In vivo, in cold exposed tissues and organs, they can induce vasculitis and occlusive vasculopathy after deposition on vascular endothelium ... ...

    Abstract Purpose of review: Cryoglobulins (CG) are immunoglobulins that precipitate in the cold, and dissolve at 37°C. In vivo, in cold exposed tissues and organs, they can induce vasculitis and occlusive vasculopathy after deposition on vascular endothelium under low temperature and high concentration conditions. Clinical manifestations are cutaneous (purpura, ulcers, vasomotor symptoms, and livedo reticularis), rheumatological (arthralgia and arthritis), and peripheral neuropathy (paresthesia and pain in the lower limbs). In profound organs such as the kidneys, CG deposition is less temperature-dependent, favored by local protein and anion concentrations, and can lead to glomerulonephritis. This review will focus on cryoglobulinemic vasculitis and vascular lesion, and their diagnosis.
    Recent findings: The mechanisms of vascular lesions of pathogenic CG in function of CG type and their characteristics are better defined. Optimal conditions for CG detection are critical. The importance of looking for underlying diseases, especially hepatitis C virus status in mixed CG, is reminded.
    Summary: A decision diagram for CG vasculitis diagnosis based on clinical and biological parameters is proposed.
    MeSH term(s) Cold Temperature ; Cryoglobulinemia/complications ; Cryoglobulinemia/diagnosis ; Cryoglobulinemia/physiopathology ; Cryoglobulins/analysis ; Glomerulonephritis/complications ; Hepacivirus/immunology ; Hepatitis C/complications ; Humans ; Kidney/pathology ; Rheumatoid Factor ; Skin/pathology ; Vasculitis/complications ; Vasculitis/diagnosis ; Vasculitis/physiopathology
    Chemical Substances Cryoglobulins ; Rheumatoid Factor (9009-79-4)
    Language English
    Publishing date 2020-09-15
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1045317-9
    ISSN 1531-6963 ; 1040-8711
    ISSN (online) 1531-6963
    ISSN 1040-8711
    DOI 10.1097/BOR.0000000000000757
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  8. Article ; Online: High oligoclonality of immunoglobulins in SARS-CoV2 positive patients

    Kolopp-Sarda, Marie / Miossec, Pierre

    Annals of the Rheumatic Diseases

    2020  , Page(s) annrheumdis–2020–218316

    Keywords Immunology ; General Biochemistry, Genetics and Molecular Biology ; Immunology and Allergy ; Rheumatology ; covid19
    Language English
    Publisher BMJ
    Publishing country uk
    Document type Article ; Online
    ZDB-ID 7090-7
    ISSN 1468-2060 ; 0003-4967
    ISSN (online) 1468-2060
    ISSN 0003-4967
    DOI 10.1136/annrheumdis-2020-218316
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  9. Article ; Online: IgG subclasses in cryoglobulins: link to composition and clinical manifestations.

    Kolopp-Sarda, Marie N / Azevedo, Pedro Ming / Miossec, Pierre

    Arthritis research & therapy

    2020  Volume 22, Issue 1, Page(s) 267

    Abstract: Background: Cryoglobulins (CG) are immunoglobulins which precipitate at low temperature. The analysis of IgG subclass composition of CG is poorly reported. The aim of this study was to determine the subclasses of IgG-containing type I and mixed type II ... ...

    Abstract Background: Cryoglobulins (CG) are immunoglobulins which precipitate at low temperature. The analysis of IgG subclass composition of CG is poorly reported. The aim of this study was to determine the subclasses of IgG-containing type I and mixed type II and III CG in relation to clinical manifestations.
    Methods: Out of a previous series of 1675 patients, inclusion criteria were a cryoprecipitate > 1 mL and a total IgG > 300 mg/L. IgG subclasses were quantified by immunoturbidimetry, rheumatoid factor (RF), and C4 by immunonephelometry. Clinical parameters were collected from hospital charts.
    Results: CG samples from 86 patients were included, 10 type I CG and 76 mixed CG. Type I CG subclasses were IgG1 (6/10) and IgG2/IgG3 (4/10), never IgG4. IgG subclass in type II vs. III CG were 73.3 ± 15.2% vs. 52.5 ± 20.7% for IgG1 (p < 0.0001), 15.4 ± 8.2% vs. 25.9 ± 14% for IgG2 (p < 0.0001), 8.4 ± 12.4 vs. 21.2 ± 14% for IgG3 (p < 0.0001), and 3 ± 5.2% vs. 0.5 ± 1.2 for IgG4 (p < 0.0001). In mixed CG, the higher proportion of IgG4 was associated with RF positive CG (p = 0.01) and low C4 (p = 0.01). In type I CG, IgG1 were associated with severe vasculitis manifestations, IgG2/IgG3 with cutaneous or renal manifestations. In mixed CG, IgG2 was the only subclass associated with CG manifestations, with a higher concentration in asymptomatic (162.6 ± 29.5 mg/L) vs. symptomatic patients with cutaneous (103 ± 17.8 mg/L, p = 0.04) and neurological (108 ± 24 mg/L, p = 0.04) manifestations.
    Conclusion: In type I IgG CG, IgG1 was the main CG subclass associated with CG vasculitis. In mixed CG, low IgG2 concentration was linked to CG cutaneous and neurological manifestations.
    MeSH term(s) Cryoglobulins ; Humans ; Immunoglobulin G ; Rheumatoid Factor ; Skin ; Vasculitis/immunology
    Chemical Substances Cryoglobulins ; Immunoglobulin G ; Rheumatoid Factor (9009-79-4)
    Language English
    Publishing date 2020-11-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 2107602-9
    ISSN 1478-6362 ; 1478-6354
    ISSN (online) 1478-6362
    ISSN 1478-6354
    DOI 10.1186/s13075-020-02364-z
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  10. Article ; Online: Accréditation des cryoglobulines : retour d’expérience du CHU de Lyon.

    Dechomet, Magali / Kolopp-Sarda, Marie-Nathalie / Dimet, Isabelle / Lombard, Christine

    Annales de biologie clinique

    2021  Volume 79, Issue 2, Page(s) 190–195

    Abstract: Research and identification of a serum cryoglobulin is a current laboratory test. This analysis is complex to accredit due to, firstly, very strict pre-analytical requirements, secondly, lack of standardization between laboratories in carrying out the ... ...

    Title translation Accreditation of cryoglobulins: Experience of CHU of Lyon.
    Abstract Research and identification of a serum cryoglobulin is a current laboratory test. This analysis is complex to accredit due to, firstly, very strict pre-analytical requirements, secondly, lack of standardization between laboratories in carrying out the different phases of sampling until results validation. The method validation of this analysis, carried out to meet requirements of the NF EN ISO 15189 standard, is a complex process divided into three sub-processes: cryoglobulin research including detection and isolation of cryoprecipitate, typing by immunofixation and quantification of cryoglobulin by immunoglobulin assays. This work made it possible, thanks to the development of a risk matrix taking into account all pre-analytical, analytical and post-analytical phases, to stress the importance of technical proficiency and management of critical equipment . With this approach, the laboratory also checked homogeneity of results validation practices.
    MeSH term(s) Accreditation ; Cryoglobulins ; Humans ; Laboratories ; Reference Standards ; Research Design
    Chemical Substances Cryoglobulins
    Language French
    Publishing date 2021-03-26
    Publishing country France
    Document type Journal Article
    ZDB-ID 418098-7
    ISSN 1950-6112 ; 0003-3898
    ISSN (online) 1950-6112
    ISSN 0003-3898
    DOI 10.1684/abc.2021.1631
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