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  1. Book: Imaging in rheumatic diseases

    Weiss, Pamela F.

    (Rheumatic disease clinics of North America ; volume 42, number 4 (November 2016))

    2016  

    Author's details editor Pamela F. Weiss
    Series title Rheumatic disease clinics of North America ; volume 42, number 4 (November 2016)
    Collection
    Language English
    Size xvi Seiten, Seite 562-796, Illustrationen
    Publisher Elsevier
    Publishing place Philadelphia, Pennsylvania
    Publishing country United States
    Document type Book
    HBZ-ID HT019189908
    ISBN 978-0-323-47694-2 ; 0-323-47694-5
    Database Catalogue ZB MED Medicine, Health

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  2. Article ; Online: When to stop medication in juvenile idiopathic arthritis.

    Abel, Dori / Weiss, Pamela F

    Current opinion in rheumatology

    2023  Volume 35, Issue 5, Page(s) 265–272

    Abstract: Purpose of review: Disease-modifying antirheumatic drugs (DMARDs) have dramatically improved patient outcomes in juvenile idiopathic arthritis (JIA). However, these medications may also result in physical, psychologic, and economic burden, which must be ...

    Abstract Purpose of review: Disease-modifying antirheumatic drugs (DMARDs) have dramatically improved patient outcomes in juvenile idiopathic arthritis (JIA). However, these medications may also result in physical, psychologic, and economic burden, which must be balanced with risk of flare off treatment. Although some children remain in remission after medication discontinuation, evidence is sparse for if, when, and how medications should be de-escalated once achieving clinically inactive disease (CID). We review the data on medication discontinuation and the role of serologic and imaging biomarkers in JIA.
    Recent findings: The literature uniformly supports early biologic DMARD initiation, although the optimal timing and strategy for medication withdrawal in patients with sustained CID remains unclear. In this review, we present the current data on flare frequency and time to flare, clinical factors associated with flare, and recapture data for each JIA category. We also summarize the current knowledge on the role of imaging and serologic biomarkers in guiding these treatment decisions.
    Summary: JIA is a heterogenous disease for which prospective clinical trials are needed to address the question of when, how, and in whom to withdraw medication. Research investigating the roles of serologic and imaging biomarkers may help improve the ability to ascertain which children can successfully de-escalate medications.
    MeSH term(s) Child ; Humans ; Arthritis, Juvenile/diagnostic imaging ; Arthritis, Juvenile/drug therapy ; Prospective Studies ; Antirheumatic Agents/therapeutic use ; Remission Induction ; Biomarkers ; Treatment Outcome
    Chemical Substances Antirheumatic Agents ; Biomarkers
    Language English
    Publishing date 2023-05-03
    Publishing country United States
    Document type Review ; Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 1045317-9
    ISSN 1531-6963 ; 1040-8711
    ISSN (online) 1531-6963
    ISSN 1040-8711
    DOI 10.1097/BOR.0000000000000948
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  3. Article ; Online: Association of Infant Breastfeeding and Juvenile Spondyloarthritis: A Case-Control Study.

    Baggett, Katelyn H / Brandon, Timothy G / Xiao, Rui / Weiss, Pamela F

    The Journal of rheumatology

    2024  

    Abstract: Objective: Given the multifactorial pathogenesis of juvenile spondyloarthritis (JSpA) and evidence of a protective effect in phenotypically similar diseases, we aimed to test whether breastfeeding is associated with the development and disease activity ... ...

    Abstract Objective: Given the multifactorial pathogenesis of juvenile spondyloarthritis (JSpA) and evidence of a protective effect in phenotypically similar diseases, we aimed to test whether breastfeeding is associated with the development and disease activity of JSpA.
    Methods: This single-center retrospective case-control study included children with JSpA and age- and sex-matched controls with a 1:1 ratio. Univariable and multivariable conditional logistic regression modeling for matched pairs was used to test the association of infant factors with the development of JSpA, including infant nutrition and form of delivery. Linear regression was used to assess the association of JSpA disease activity (JSpA Disease Activity Index with 6 elements [JSpADA6]) at presentation with breastfeeding exposure, form of delivery, and antibiotic exposure.
    Results: For the 195 case-control matched pairs, the mean age was 13.0 years and 47.7% were female. For breastfeeding, 88.7% of controls and 69.2% of JSpA cases were exposed to breastfeeding of any duration, respectively (
    Conclusion: This study suggests that infant factors that affect the microbiome may be associated with the occurrence and disease activity of JSpA at presentation.
    Language English
    Publishing date 2024-05-01
    Publishing country Canada
    Document type Journal Article
    ZDB-ID 194928-7
    ISSN 1499-2752 ; 0315-162X
    ISSN (online) 1499-2752
    ISSN 0315-162X
    DOI 10.3899/jrheum.2023-1203
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  4. Article ; Online: Imaging in pediatric spondyloarthritis.

    Carol, Hallie A / Chauvin, Nancy A / Weiss, Pamela F

    Current opinion in rheumatology

    2023  Volume 35, Issue 4, Page(s) 226–234

    Abstract: Purpose of review: Imaging is used in the diagnosis of peripheral and axial disease in juvenile spondyloarthritis (JSpA). Imaging of the joints and entheses in children and adolescents can be challenging for those unfamiliar with the appearance of the ... ...

    Abstract Purpose of review: Imaging is used in the diagnosis of peripheral and axial disease in juvenile spondyloarthritis (JSpA). Imaging of the joints and entheses in children and adolescents can be challenging for those unfamiliar with the appearance of the maturing skeleton. These differences are key for rheumatologists and radiologists to be aware of.
    Recent findings: In youth, skeletal variation during maturation makes the identification of arthritis, enthesitis, and sacroiliitis difficult. A great effort has been put forward to define imaging characteristics seen in healthy children in order to more accurately identify disease. Additionally, there are novel imaging modalities on the horizon that are promising to further differentiate normal physiologic changes versus disease.
    Summary: This review describes the current state of imaging, limitations, and future imaging modalities in youth, with key attention to differences in imaging interpretation of the peripheral joints, entheses, and sacroiliac joint in youth and adults.
    MeSH term(s) Adult ; Adolescent ; Humans ; Child ; Magnetic Resonance Imaging/methods ; Spondylarthritis/diagnostic imaging ; Sacroiliitis/diagnostic imaging ; Sacroiliac Joint/diagnostic imaging ; Arthritis, Juvenile/diagnostic imaging
    Language English
    Publishing date 2023-04-14
    Publishing country United States
    Document type Review ; Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 1045317-9
    ISSN 1531-6963 ; 1040-8711
    ISSN (online) 1531-6963
    ISSN 1040-8711
    DOI 10.1097/BOR.0000000000000942
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  5. Article ; Online: Underutilization of ambulatory blood pressure monitoring in locally and nationally representative samples of patients with childhood-onset systemic lupus erythematosus.

    Chang, Joyce C / Son, Mary Beth F / Alonzi, Gabrielle / Weiss, Pamela F / Daga, Ankana

    Clinical rheumatology

    2023  Volume 43, Issue 3, Page(s) 1265–1268

    MeSH term(s) Humans ; Child ; Blood Pressure Monitoring, Ambulatory ; Lupus Erythematosus, Systemic ; Case-Control Studies ; Age of Onset
    Language English
    Publishing date 2023-11-22
    Publishing country Germany
    Document type Letter
    ZDB-ID 604755-5
    ISSN 1434-9949 ; 0770-3198
    ISSN (online) 1434-9949
    ISSN 0770-3198
    DOI 10.1007/s10067-023-06819-x
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  6. Article ; Online: Imaging: Enhanced Evaluation of Children and Adults with Rheumatic Disease.

    Weiss, Pamela F

    Rheumatic diseases clinics of North America

    2016  Volume 42, Issue 4, Page(s) xv–xvi

    Language English
    Publishing date 2016-11
    Publishing country United States
    Document type Editorial
    ZDB-ID 92118-x
    ISSN 1558-3163 ; 0889-857X
    ISSN (online) 1558-3163
    ISSN 0889-857X
    DOI 10.1016/j.rdc.2016.09.001
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  7. Article ; Online: Juvenile-Versus Adult-Onset Spondyloarthritis: Similar, but Different.

    Weiss, Pamela F / Roth, Johannes

    Rheumatic diseases clinics of North America

    2020  Volume 46, Issue 2, Page(s) 241–257

    Abstract: This article provides an overview of juvenile spondyloarthritis and important differences in the classification criteria, clinical presentation, outcomes, and pathology in juvenile versus adult-onset disease. Key differences in classification criteria ... ...

    Abstract This article provides an overview of juvenile spondyloarthritis and important differences in the classification criteria, clinical presentation, outcomes, and pathology in juvenile versus adult-onset disease. Key differences in classification criteria between children and adults with spondyloarthritis are important to understand, as they can make transition from pediatric to adult care challenging. MRI and ultrasonography are increasingly relied on for the assessment of adult-onset disease activity and change over time in the pediatric population. The unique features of the maturing axial and peripheral skeleton are described for each modality, as they are key to understand for accurate interpretation of pathology in the pediatric population.
    MeSH term(s) Adolescent ; Adult ; Arthritis, Juvenile/classification ; Arthritis, Juvenile/diagnosis ; Child ; Humans ; Spondylarthritis/classification ; Spondylarthritis/diagnosis ; Transition to Adult Care
    Language English
    Publishing date 2020-04-23
    Publishing country United States
    Document type Comparative Study ; Journal Article ; Review
    ZDB-ID 92118-x
    ISSN 1558-3163 ; 0889-857X
    ISSN (online) 1558-3163
    ISSN 0889-857X
    DOI 10.1016/j.rdc.2020.01.003
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  8. Article ; Online: Imaging in the diagnosis and management of axial spondyloarthritis in children.

    Weiss, Pamela F / Chauvin, Nancy A

    Best practice & research. Clinical rheumatology

    2020  Volume 34, Issue 6, Page(s) 101596

    Abstract: Imaging is often used at the time of diagnosis to exclude conditions other than arthritis, to confirm the physical examination if equivocal, and to assess the degree of inflammation and baseline damage. Plain radiography is helpful in the evaluation of ... ...

    Abstract Imaging is often used at the time of diagnosis to exclude conditions other than arthritis, to confirm the physical examination if equivocal, and to assess the degree of inflammation and baseline damage. Plain radiography is helpful in the evaluation of damage from chronic inflammation, while ultrasound and magnetic resonance imaging (MRI) are helpful in the assessment of early disease and active inflammation. Multiple studies have shown that tenderness on physical examination of the sacroiliac joint is often discordant with imaging results, so MRI is increasingly relied upon to assess for objective evidence of inflammation. There are no widely accepted, validated tools for the pediatric population using ultrasound or MRI assessment of the peripheral joints. Validated tools exist for objective assessment of pediatric hip disease on radiographs and axial disease on MRI, but not on other imaging modalities. The utility of these scoring systems in clinical care and clinical trials remains untested.
    MeSH term(s) Child ; Humans ; Magnetic Resonance Imaging ; Radiography ; Sacroiliac Joint/diagnostic imaging ; Sacroiliitis/diagnostic imaging ; Spondylarthritis/diagnostic imaging ; Spondylarthritis/therapy
    Language English
    Publishing date 2020-10-07
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 2052323-3
    ISSN 1532-1770 ; 1521-6942
    ISSN (online) 1532-1770
    ISSN 1521-6942
    DOI 10.1016/j.berh.2020.101596
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  9. Article: Evaluation and Treatment of Enthesitis-Related Arthritis.

    Weiss, Pamela F

    Current medical literature. Rheumatology

    2014  Volume 32, Issue 2, Page(s) 33–41

    Language English
    Publishing date 2014-01-08
    Publishing country England
    Document type Journal Article
    ISSN 0261-3360
    ISSN 0261-3360
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  10. Article ; Online: Update on enthesitis-related arthritis.

    Weiss, Pamela F

    Current opinion in rheumatology

    2016  Volume 28, Issue 5, Page(s) 530–536

    Abstract: Purpose of review: This review provides a detailed update regarding the genetics, pathogenesis, disease phenotype evaluation, therapies and expected outcomes for children with enthesitis-related arthritis (ERA).: Recent findings: Recent studies ... ...

    Abstract Purpose of review: This review provides a detailed update regarding the genetics, pathogenesis, disease phenotype evaluation, therapies and expected outcomes for children with enthesitis-related arthritis (ERA).
    Recent findings: Recent studies evaluated human leukocyte antigen (HLA)-B27 subtypes and non-major histocompatibility complex genes including toll like receptor 4, NLRP3, CXCR4 and PTPN12 in children with ERA. The microbiome and γδ-T cells have also been an area of active investigation. Several studies focus on the imaging phenotype of children with ERA, including the use of ultrasonography and MRI. MRI techniques studied in this population include dedicated MRI, whole-body MRI and diffusion-weighted imaging. Conventional and biologic disease-modifying agents continue to be the mainstay of therapy, though the past 2 years have witnessed several greatly needed randomized controlled trials to study the efficacy of these medications in ERA. Finally, long-term effectiveness studies of biologics in children with ERA have helped inform provider and patient expectations of disease response and prognosis.
    Summary: Further evaluation of the role of the microbiome and the interleukin 17/interleukin 23 axis, techniques to optimize evaluation of disease features, and efficacy and effectiveness of newer medications are greatly needed in this understudied population of children.
    MeSH term(s) Adolescent ; Antirheumatic Agents/therapeutic use ; Arthritis, Juvenile/diagnostic imaging ; Arthritis, Juvenile/drug therapy ; Arthritis, Juvenile/genetics ; Arthritis, Juvenile/immunology ; Biological Products/therapeutic use ; Child ; Diffusion Magnetic Resonance Imaging ; Gastrointestinal Microbiome/immunology ; HLA-B27 Antigen/genetics ; Humans ; Immunity, Humoral/immunology ; Magnetic Resonance Imaging ; NLR Family, Pyrin Domain-Containing 3 Protein/genetics ; Phenotype ; Prognosis ; Protein Tyrosine Phosphatase, Non-Receptor Type 12/genetics ; Receptors, Antigen, T-Cell, gamma-delta/immunology ; Receptors, CXCR4/genetics ; T-Lymphocytes/immunology ; Toll-Like Receptor 4/genetics ; Ultrasonography
    Chemical Substances Antirheumatic Agents ; Biological Products ; CXCR4 protein, human ; HLA-B27 Antigen ; NLR Family, Pyrin Domain-Containing 3 Protein ; NLRP3 protein, human ; Receptors, Antigen, T-Cell, gamma-delta ; Receptors, CXCR4 ; TLR4 protein, human ; Toll-Like Receptor 4 ; PTPN12 protein, human (EC 3.1.3.48) ; Protein Tyrosine Phosphatase, Non-Receptor Type 12 (EC 3.1.3.48)
    Language English
    Publishing date 2016-09
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1045317-9
    ISSN 1531-6963 ; 1040-8711
    ISSN (online) 1531-6963
    ISSN 1040-8711
    DOI 10.1097/BOR.0000000000000313
    Database MEDical Literature Analysis and Retrieval System OnLINE

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