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  1. Article ; Online: Evaluating the risk-benefit ratio of immunotherapy according to liver-functional reserve in advanced HCC: the dark side of the moon.

    Cabibbo, Giuseppe / Celsa, Ciro / Alimenti, Eleonora / Iavarone, Massimo

    Hepatology (Baltimore, Md.)

    2023  Volume 77, Issue 4, Page(s) 1074–1077

    MeSH term(s) Humans ; Carcinoma, Hepatocellular/therapy ; Liver Neoplasms/therapy ; Moon ; Immunotherapy/adverse effects
    Language English
    Publishing date 2023-01-03
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 604603-4
    ISSN 1527-3350 ; 0270-9139
    ISSN (online) 1527-3350
    ISSN 0270-9139
    DOI 10.1097/HEP.0000000000000205
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1660: Show issues Location:
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  2. Article ; Online: The Authors' Reply.

    Invernizzi, Federica / Iavarone, Massimo

    Transplantation

    2020  Volume 104, Issue 8, Page(s) e244

    MeSH term(s) Carcinoma, Hepatocellular ; Humans ; Liver Neoplasms ; Liver Transplantation ; Neoplasm Recurrence, Local ; Sorafenib ; TOR Serine-Threonine Kinases
    Chemical Substances Sorafenib (9ZOQ3TZI87) ; TOR Serine-Threonine Kinases (EC 2.7.1.1)
    Language English
    Publishing date 2020-07-23
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 208424-7
    ISSN 1534-6080 ; 0041-1337
    ISSN (online) 1534-6080
    ISSN 0041-1337
    DOI 10.1097/TP.0000000000003229
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Hepatic splenosis mimicking hepatocellular carcinoma in metabolic associated fatty liver disease.

    Pessarelli, Tommaso / Crespi, Silvia / Antonelli, Barbara / Maggioni, Marco / Iavarone, Massimo

    Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver

    2022  Volume 54, Issue 12, Page(s) 1725–1726

    MeSH term(s) Humans ; Carcinoma, Hepatocellular/diagnosis ; Carcinoma, Hepatocellular/complications ; Splenosis/diagnostic imaging ; Splenosis/complications ; Liver Neoplasms/diagnosis ; Liver Neoplasms/complications ; Liver Cirrhosis/complications ; Diagnosis, Differential
    Language English
    Publishing date 2022-07-11
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1459373-7
    ISSN 1878-3562 ; 1125-8055
    ISSN (online) 1878-3562
    ISSN 1125-8055
    DOI 10.1016/j.dld.2022.06.018
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    Zs.A 1134: Show issues Location:
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  4. Article ; Online: Indolent cancer and pattern of progression: Two missing parameters in trial design for hepatology.

    Iavarone, Massimo / Nault, Jean-Charles / Cabibbo, Giuseppe / Torres, Ferran / Reig, Maria

    Hepatology (Baltimore, Md.)

    2023  

    Abstract: The indolent and aggressive behaviors of HCC might have a role in clinical trial (CT) results; however, the indolent HCC is less analyzed compared to others cancer. Indolent profile could be characterized as follows: (1) patients with low risk of ... ...

    Abstract The indolent and aggressive behaviors of HCC might have a role in clinical trial (CT) results; however, the indolent HCC is less analyzed compared to others cancer. Indolent profile could be characterized as follows: (1) patients with low risk of progression itself due to the HCC molecular profile and/or due to the interaction between cancer cell their microenvironment; (2) patients who achieve objective response or present spontaneous regression; and (3) patients who develop radiological progression with no consequence on either the liver function or general status, and without trigger a change in the tumor stage. Patients with "indolent HCC" generally never develop cancer-related symptoms neither die for HCC-related causes. Thus, we hypothesize that the imbalance in the proportion of "indolent" versus "aggressive HCC" between arms or the underestimation/overestimation of HCC behavior at baseline in single-arm CT could be associated with CT failure or under-overestimation of trial results. The "indolent progression" may also explain the discrepancy between radiological progression-based end points and survival. Moreover, we discuss the related causes that explain the indolent profile of HCC and propose (1) refining the progression-related end point by the pattern of progression to minimize the limitations of the current end points; (2) considering alternative statistical tools for survival analysis such as milestone survival, or restricted mean survival time to capture the value of indolent HCC. According to these considerations, we propose incorporating novel end points into the single arm of phase I/II CT as exploratory analysis or as a secondary end point in phase III CT.
    Language English
    Publishing date 2023-07-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 604603-4
    ISSN 1527-3350 ; 0270-9139
    ISSN (online) 1527-3350
    ISSN 0270-9139
    DOI 10.1097/HEP.0000000000000527
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Hydrogen-Deuterium Exchange Mass Spectrometry Identifies Local and Long-Distance Interactions within the Multicomponent Radical SAM Enzyme, PqqE.

    Zhu, Wen / Iavarone, Anthony T / Klinman, Judith P

    ACS central science

    2024  Volume 10, Issue 2, Page(s) 251–263

    Abstract: ... SAM (rSAM) enzyme, PqqE. We describe the use of hydrogen-deuterium exchange mass spectrometry (HDX-MS ...

    Abstract Interactions among proteins and peptides are essential for many biological activities including the tailoring of peptide substrates to produce natural products. The first step in the production of the bacterial redox cofactor pyrroloquinoline quinone (PQQ) from its peptide precursor is catalyzed by a radical SAM (rSAM) enzyme, PqqE. We describe the use of hydrogen-deuterium exchange mass spectrometry (HDX-MS) to characterize the structure and conformational dynamics in the protein-protein and protein-peptide complexes necessary for PqqE function. HDX-MS-identified hotspots can be discerned in binary and ternary complex structures composed of the peptide PqqA, the peptide-binding chaperone PqqD, and PqqE. Structural conclusions are supported by size-exclusion chromatography coupled to small-angle X-ray scattering (SEC-SAXS). HDX-MS further identifies reciprocal changes upon the binding of substrate peptide and S-adenosylmethionine (SAM) to the PqqE/PqqD complex: long-range conformational alterations have been detected upon the formation of a quaternary complex composed of PqqA/PqqD/PqqE and SAM, spanning nearly 40 Å, from the PqqA binding site in PqqD to the PqqE active site Fe
    Language English
    Publishing date 2024-01-17
    Publishing country United States
    Document type Journal Article
    ISSN 2374-7943
    ISSN 2374-7943
    DOI 10.1021/acscentsci.3c01023
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  6. Article ; Online: Combination of CLIF-OF and CCI predicts survival in patients with cirrhosis and COVID-19.

    Iavarone, Massimo / D'Ambrosio, Roberta / Lampertico, Pietro

    Gut

    2020  Volume 70, Issue 9, Page(s) 1798–1799

    MeSH term(s) Acute-On-Chronic Liver Failure ; COVID-19 ; Fibrosis ; Humans ; Liver Cirrhosis/complications ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-10-07
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 80128-8
    ISSN 1468-3288 ; 0017-5749
    ISSN (online) 1468-3288
    ISSN 0017-5749
    DOI 10.1136/gutjnl-2020-322929
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    Zs.A 160: Show issues Location:
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  7. Article ; Online: Reply to: Correspondence on "High rates of 30-day mortality in patients with cirrhosis and COVID-19".

    Iavarone, Massimo / D'Ambrosio, Roberta / Lampertico, Pietro

    Journal of hepatology

    2020  Volume 73, Issue 6, Page(s) 1570–1571

    MeSH term(s) COVID-19 ; Carcinoma, Hepatocellular ; Humans ; Liver Cirrhosis/epidemiology ; Liver Neoplasms ; Pandemics ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-08-07
    Publishing country Netherlands
    Document type Letter ; Comment
    ZDB-ID 605953-3
    ISSN 1600-0641 ; 0168-8278
    ISSN (online) 1600-0641
    ISSN 0168-8278
    DOI 10.1016/j.jhep.2020.08.001
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    Zs.A 2027: Show issues Location:
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  8. Article ; Online: Liver transplant for hepatocellular carcinoma: A heavyweight therapeutic option in need of a new policy on liver graft allocation.

    Iavarone, Massimo / Invernizzi, Federica

    Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver

    2018  Volume 50, Issue 12, Page(s) 1351–1352

    MeSH term(s) Carcinoma, Hepatocellular ; Humans ; Liver Neoplasms ; Liver Transplantation ; Tissue and Organ Procurement
    Language English
    Publishing date 2018-09-27
    Publishing country Netherlands
    Document type Editorial ; Comment
    ZDB-ID 1459373-7
    ISSN 1878-3562 ; 1125-8055
    ISSN (online) 1878-3562
    ISSN 1125-8055
    DOI 10.1016/j.dld.2018.09.018
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  9. Article: Impact of Sarcopenia on the Survival of Patients with Hepatocellular Carcinoma Treated with Sorafenib.

    Biselli, Maurizio / Reggidori, Nicola / Iavarone, Massimo / Renzulli, Matteo / Lani, Lorenzo / Granito, Alessandro / Piscaglia, Fabio / Lorenzini, Stefania / Alimenti, Eleonora / Vara, Giulio / Caraceni, Paolo / Sangiovanni, Angelo / Marignani, Massimo / Gigante, Elia / Brandi, Nicolò / Gramenzi, Annagiulia / Trevisani, Franco

    Cancers

    2024  Volume 16, Issue 6

    Abstract: Background and aims: Sarcopenia has been associated with poor outcomes in patients with cirrhosis and hepatocellular carcinoma. We investigated the impact of sarcopenia on survival in patients with advanced hepatocellular carcinoma treated with ... ...

    Abstract Background and aims: Sarcopenia has been associated with poor outcomes in patients with cirrhosis and hepatocellular carcinoma. We investigated the impact of sarcopenia on survival in patients with advanced hepatocellular carcinoma treated with Sorafenib.
    Methods: A total of 328 patients were retrospectively analyzed. All patients had an abdominal CT scan within 8 weeks prior to the start of treatment. Two cohorts of patients were analyzed: the "Training Group" (215 patients) and the "Validation Group" (113 patients). Sarcopenia was defined by reduced skeletal muscle index, calculated from an L3 section CT image.
    Results: Sarcopenia was present in 48% of the training group and 50% of the validation group. At multivariate analysis, sarcopenia (HR: 1.47,
    Language English
    Publishing date 2024-03-07
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers16061080
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  10. Article ; Online: Thymosin fraction 5 re-evaluated after 35 years by high-resolution mass spectrometry.

    Hannappel, Ewald / Iavarone, Federica / Castagnola, Massimo

    Expert opinion on biological therapy

    2018  Volume 18, Issue sup1, Page(s) 199–203

    Abstract: ... Results: We detected more than 100 monoisotopic masses corresponding to thymosin β4 and truncated forms ... at room temperature, by high-resolution mass spectrometry in terms of stability and yet uncharacterized ... on high-performance liquid chromatography (HPLC) coupled to high-resolution LTQ-Orbitrap mass ...

    Abstract Objectives: We reevaluated a lyophilized sample of thymosin fraction 5, stored for 37 years at room temperature, by high-resolution mass spectrometry in terms of stability and yet uncharacterized polypeptides that could be biological important substances.
    Methods: A top-down proteomic platform based on high-performance liquid chromatography (HPLC) coupled to high-resolution LTQ-Orbitrap mass spectrometry (MS) was applied to molecular characterization of polypeptides present in thymosin fraction 5.
    Results: We detected more than 100 monoisotopic masses corresponding to thymosin β4 and truncated forms of ubiquitin, prothymosin α, thymosin β4, and thymosin β9. Additionally, we discovered a new polypeptide present in thymosin fraction 5 and identified it as intact SH3 domain-binding glutamic acid-rich-like protein 3.
    Conclusion: In spite of the well-known proteolytic processes inherent to the preparation of thymosin fraction 5, still uncharacterized polypeptides as well as truncated forms of already well-known thymosins are present in fraction 5 after long-term storage. Therefore, continuing characterization of thymosin fraction 5 is even nowadays highly promising.
    MeSH term(s) Animals ; Chromatography, High Pressure Liquid ; Drug Stability ; Drug Storage ; Freeze Drying ; Humans ; Mass Spectrometry/methods ; Protein Precursors/analysis ; Protein Precursors/isolation & purification ; Proteomics/methods ; Thymosin/analogs & derivatives ; Thymosin/analysis ; Thymosin/chemistry ; Thymosin/isolation & purification ; Time Factors ; Ubiquitin/analysis ; Ubiquitin/isolation & purification
    Chemical Substances Protein Precursors ; Ubiquitin ; prothymosin alpha ; thymosin fraction 5 ; thymosin beta(4) (549LM7U24W) ; Thymosin (61512-21-8) ; thymosin beta(9) (81775-04-4)
    Language English
    Publishing date 2018-07-31
    Publishing country England
    Document type Journal Article
    ZDB-ID 2052501-1
    ISSN 1744-7682 ; 1471-2598
    ISSN (online) 1744-7682
    ISSN 1471-2598
    DOI 10.1080/14712598.2018.1474196
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6094: Show issues Location:
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