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  1. Article ; Online: High rates of stillbirth and preterm delivery in women with covid-19 and the efficacy of ECMO in pregnancy.

    Kingston, Elizabeth V

    BMJ (Clinical research ed.)

    2020  Volume 370, Page(s) m2921

    MeSH term(s) COVID-19 ; Coronavirus Infections/complications ; Coronavirus Infections/therapy ; Extracorporeal Membrane Oxygenation/methods ; Female ; Humans ; Pandemics ; Pneumonia, Viral/complications ; Pneumonia, Viral/therapy ; Pregnancy ; Pregnancy Complications, Infectious/epidemiology ; Pregnancy Complications, Infectious/therapy ; Pregnancy Complications, Infectious/virology ; Premature Birth/epidemiology ; Premature Birth/virology ; Stillbirth/epidemiology ; Treatment Outcome
    Keywords covid19
    Language English
    Publishing date 2020-07-27
    Publishing country England
    Document type Letter
    ZDB-ID 1362901-3
    ISSN 1756-1833 ; 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    ISSN (online) 1756-1833
    ISSN 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    DOI 10.1136/bmj.m2921
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ua VI Zs.10: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  3. Book ; Online: High rates of stillbirth and preterm delivery in women with covid-19 and the efficacy of ECMO in pregnancy

    Kingston, Elizabeth V

    2020  

    Keywords LETTERS ; covid19
    Language English
    Publishing date 2020-07-27 06:56:21.0
    Publisher BMJ Publishing Group Ltd
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: High rates of stillbirth and preterm delivery in women with covid-19 and the efficacy of ECMO in pregnancy

    Kingston, Elizabeth V

    BMJ

    2020  , Page(s) m2921

    Keywords covid19
    Language English
    Publisher BMJ
    Publishing country uk
    Document type Article ; Online
    ZDB-ID 1362901-3
    ISSN 1756-1833 ; 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    ISSN (online) 1756-1833
    ISSN 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    DOI 10.1136/bmj.m2921
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: The trauma call.

    Mercer, Simon J / Kingston, Elizabeth V / Jones, Clinton P L

    BMJ (Clinical research ed.)

    2018  Volume 361, Page(s) k2272

    MeSH term(s) Emergency Service, Hospital/organization & administration ; Humans ; Patient Care Team/organization & administration ; Wounds and Injuries/diagnosis ; Wounds and Injuries/therapy
    Language English
    Publishing date 2018-06-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 1362901-3
    ISSN 1756-1833 ; 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    ISSN (online) 1756-1833
    ISSN 0959-8154 ; 0959-8146 ; 0959-8138 ; 0959-535X ; 1759-2151
    DOI 10.1136/bmj.k2272
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ua VI Zs.10: Show issues Location:
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  6. Article ; Online: Accounting for population structure in genetic studies of cystic fibrosis.

    Kingston, Hanley / Stilp, Adrienne M / Gordon, William / Broome, Jai / Gogarten, Stephanie M / Ling, Hua / Barnard, John / Dugan-Perez, Shannon / Ellinor, Patrick T / Gabriel, Stacey / Germer, Soren / Gibbs, Richard A / Gupta, Namrata / Rice, Kenneth / Smith, Albert V / Zody, Michael C / Blackman, Scott M / Cutting, Garry / Knowles, Michael R /
    Zhou, Yi-Hui / Rosenfeld, Margaret / Gibson, Ronald L / Bamshad, Michael / Fohner, Alison / Blue, Elizabeth E

    HGG advances

    2022  Volume 3, Issue 3, Page(s) 100117

    Abstract: ... ...

    Abstract CFTR
    Language English
    Publishing date 2022-05-12
    Publishing country United States
    Document type Journal Article
    ISSN 2666-2477
    ISSN (online) 2666-2477
    DOI 10.1016/j.xhgg.2022.100117
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Vaccination recommendations for adults receiving biologics and oral therapies for psoriasis and psoriatic arthritis: Delphi consensus from the medical board of the National Psoriasis Foundation.

    Chat, Vipawee S / Ellebrecht, Christoph T / Kingston, Paige / Gondo, George / Bell, Stacie / Cordoro, Kelly M / Desai, Seemal R / Duffin, Kristina C / Feldman, Steven R / Garg, Amit / Gelfand, Joel M / Gladman, Dafna / Green, Lawrence J / Gudjonsson, Johann / Han, George / Hawkes, Jason E / Kircik, Leon / Koo, John / Langley, Richard /
    Lebwohl, Mark / Michael Lewitt, G / Liao, Wilson / Martin, George / Orbai, Ana-Maria / Reddy, Soumya M / Richardson, Veronica / Ritchlin, Christopher T / Schwartzman, Sergio / Siegel, Evan L / Van Voorhees, Abby S / Wallace, Elizabeth B / Weinberg, Jeffrey M / Winthrop, Kevin L / Yamauchi, Paul / Armstrong, April W

    Journal of the American Academy of Dermatology

    2024  

    Abstract: Background: For psoriatic patients who need to receive nonlive or live vaccines, evidence-based recommendations are needed regarding whether to pause or continue systemic therapies for psoriasis and/or psoriatic arthritis.: Objective: To evaluate ... ...

    Abstract Background: For psoriatic patients who need to receive nonlive or live vaccines, evidence-based recommendations are needed regarding whether to pause or continue systemic therapies for psoriasis and/or psoriatic arthritis.
    Objective: To evaluate literature regarding vaccine efficacy and safety and to generate consensus-based recommendations for adults receiving systemic therapies for psoriasis and/or psoriatic arthritis receiving nonlive or live vaccines.
    Methods: Using a modified Delphi process, 22 consensus statements were developed by the National Psoriasis Foundation Medical Board and COVID-19 Task Force, and infectious disease experts.
    Results: Key recommendations include continuing most oral and biologic therapies without modification for patients receiving nonlive vaccines; consider interruption of methotrexate for nonlive vaccines. For patients receiving live vaccines, discontinue most oral and biologic medications before and after administration of live vaccine. Specific recommendations include discontinuing most biologic therapies, except for abatacept, for 2-3 half-lives before live vaccine administration and deferring next dose 2-4 weeks after live vaccination.
    Limitations: Studies regarding infection rates after vaccination are lacking.
    Conclusion: Interruption of antipsoriatic oral and biologic therapies is generally not necessary for patients receiving nonlive vaccines. Temporary interruption of oral and biologic therapies before and after administration of live vaccines is recommended in most cases.
    Language English
    Publishing date 2024-02-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 603641-7
    ISSN 1097-6787 ; 0190-9622
    ISSN (online) 1097-6787
    ISSN 0190-9622
    DOI 10.1016/j.jaad.2023.12.070
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1540: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Understanding the cognitive impact of the contraceptive estrogen Ethinyl Estradiol: tonic and cyclic administration impairs memory, and performance correlates with basal forebrain cholinergic system integrity.

    Mennenga, Sarah E / Gerson, Julia E / Koebele, Stephanie V / Kingston, Melissa L / Tsang, Candy W S / Engler-Chiurazzi, Elizabeth B / Baxter, Leslie C / Bimonte-Nelson, Heather A

    Psychoneuroendocrinology

    2015  Volume 54, Page(s) 1–13

    Abstract: Ethinyl Estradiol (EE), a synthetic, orally bio-available estrogen, is the most commonly prescribed form of estrogen in oral contraceptives, and is found in at least 30 different contraceptive formulations currently prescribed to women as well as hormone ...

    Abstract Ethinyl Estradiol (EE), a synthetic, orally bio-available estrogen, is the most commonly prescribed form of estrogen in oral contraceptives, and is found in at least 30 different contraceptive formulations currently prescribed to women as well as hormone therapies prescribed to menopausal women. Thus, EE is prescribed clinically to women at ages ranging from puberty to reproductive senescence. Here, in two separate studies, the cognitive effects of cyclic or tonic EE administration following ovariectomy (Ovx) were evaluated in young female rats. Study I assessed the cognitive effects of low and high doses of EE, delivered tonically via a subcutaneous osmotic pump. Study II evaluated the cognitive effects of low, medium, and high doses of EE administered via a daily subcutaneous injection, modeling the daily rise and fall of serum EE levels with oral regimens. Study II also investigated the impact of low, medium and high doses of EE on the basal forebrain cholinergic system. The low and medium doses utilized here correspond to the range of doses currently used in clinical formulations, and the high dose corresponds to doses prescribed to a generation of women between 1960 and 1970, when oral contraceptives first became available. We evaluate cognition using a battery of maze tasks tapping several domains of spatial learning and memory as well as basal forebrain cholinergic integrity using immunohistochemistry and unbiased stereology to estimate the number of choline acetyltransferase (ChAT)-producing cells in the medial septum and vertical/diagonal bands. At the highest dose, EE treatment impaired multiple domains of spatial memory relative to vehicle treatment, regardless of administration method. When given cyclically at the low and medium doses, EE did not impact working memory, but transiently impaired reference memory during the learning phase of testing. Of the doses and regimens tested here, only EE at the highest dose impaired several domains of memory; tonic delivery of low EE, a dose that corresponds to the most popular doses used in the clinic today, did not impact cognition on any measure. Both medium and high injection doses of EE reduced the number of ChAt-immunoreactive cells in the basal forebrain, and cell population estimates in the vertical/diagonal bands negatively correlated with working memory errors.
    MeSH term(s) Animals ; Basal Forebrain/drug effects ; Cholinergic Neurons/drug effects ; Cognition/drug effects ; Contraceptives, Oral/administration & dosage ; Contraceptives, Oral/toxicity ; Dose-Response Relationship, Drug ; Drug Administration Schedule ; Ethinyl Estradiol/administration & dosage ; Ethinyl Estradiol/toxicity ; Female ; Maze Learning/drug effects ; Memory/drug effects ; Memory Disorders/chemically induced ; Random Allocation ; Rats ; Rats, Inbred F344
    Chemical Substances Contraceptives, Oral ; Ethinyl Estradiol (423D2T571U)
    Language English
    Publishing date 2015-01-12
    Publishing country England
    Document type Comparative Study ; Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 197636-9
    ISSN 1873-3360 ; 0306-4530
    ISSN (online) 1873-3360
    ISSN 0306-4530
    DOI 10.1016/j.psyneuen.2015.01.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1235: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  9. Article: A Polycomb domain found in committed cells impairs differentiation when introduced into PRC1 in pluripotent cells

    Jaensch, Elizabeth S. / Zhu, Jinjin / Cochrane, Jesse C. / Marr, Sharon K. / Oei, Theresa A. / Damle, Manashree / McCaslin, Ethan Z. / Kingston, Robert E.

    Molecular cell. 2021 Nov. 18, v. 81, no. 22

    2021  

    Abstract: The CBX family of proteins is central to proper mammalian development via key roles in Polycomb-mediated maintenance of repression. CBX proteins in differentiated lineages have chromatin compaction and phase separation activities that might contribute to ...

    Abstract The CBX family of proteins is central to proper mammalian development via key roles in Polycomb-mediated maintenance of repression. CBX proteins in differentiated lineages have chromatin compaction and phase separation activities that might contribute to maintaining repressed chromatin. The predominant CBX protein in pluripotent cells, CBX7, lacks the domain required for these activities. We inserted this functional domain into CBX7 in embryonic stem cells (ESCs) to test the hypothesis that it contributes a key epigenetic function. ESCs expressing this chimeric CBX7 were impaired in their ability to properly form embryoid bodies and neural progenitor cells and showed reduced activation of lineage-specific genes across differentiation. Neural progenitors exhibited a corresponding inappropriate maintenance of Polycomb binding at neural-specific loci over the course of differentiation. We propose that a switch in the ability to compact and phase separate is a central aspect of Polycomb group function during the transition from pluripotency to differentiated lineages.
    Keywords chromatin ; epigenetics ; mammals ; separation
    Language English
    Dates of publication 2021-1118
    Size p. 4677-4691.e8.
    Publishing place Elsevier Inc.
    Document type Article
    ZDB-ID 1415236-8
    ISSN 1097-4164 ; 1097-2765
    ISSN (online) 1097-4164
    ISSN 1097-2765
    DOI 10.1016/j.molcel.2021.09.018
    Database NAL-Catalogue (AGRICOLA)

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  10. Article ; Online: Publisher Correction: A meta-analysis of genome-wide association studies identifies multiple longevity genes.

    Deelen, Joris / Evans, Daniel S / Arking, Dan E / Tesi, Niccolò / Nygaard, Marianne / Liu, Xiaomin / Wojczynski, Mary K / Biggs, Mary L / van der Spek, Ashley / Atzmon, Gil / Ware, Erin B / Sarnowski, Chloé / Smith, Albert V / Seppälä, Ilkka / Cordell, Heather J / Dose, Janina / Amin, Najaf / Arnold, Alice M / Ayers, Kristin L /
    Barzilai, Nir / Becker, Elizabeth J / Beekman, Marian / Blanché, Hélène / Christensen, Kaare / Christiansen, Lene / Collerton, Joanna C / Cubaynes, Sarah / Cummings, Steven R / Davies, Karen / Debrabant, Birgit / Deleuze, Jean-François / Duncan, Rachel / Faul, Jessica D / Franceschi, Claudio / Galan, Pilar / Gudnason, Vilmundur / Harris, Tamara B / Huisman, Martijn / Hurme, Mikko A / Jagger, Carol / Jansen, Iris / Jylhä, Marja / Kähönen, Mika / Karasik, David / Kardia, Sharon L R / Kingston, Andrew / Kirkwood, Thomas B L / Launer, Lenore J / Lehtimäki, Terho / Lieb, Wolfgang / Lyytikäinen, Leo-Pekka / Martin-Ruiz, Carmen / Min, Junxia / Nebel, Almut / Newman, Anne B / Nie, Chao / Nohr, Ellen A / Orwoll, Eric S / Perls, Thomas T / Province, Michael A / Psaty, Bruce M / Raitakari, Olli T / Reinders, Marcel J T / Robine, Jean-Marie / Rotter, Jerome I / Sebastiani, Paola / Smith, Jennifer / Sørensen, Thorkild I A / Taylor, Kent D / Uitterlinden, André G / van der Flier, Wiesje / van der Lee, Sven J / van Duijn, Cornelia M / van Heemst, Diana / Vaupel, James W / Weir, David / Ye, Kenny / Zeng, Yi / Zheng, Wanlin / Holstege, Henne / Kiel, Douglas P / Lunetta, Kathryn L / Slagboom, P Eline / Murabito, Joanne M

    Nature communications

    2021  Volume 12, Issue 1, Page(s) 2463

    Language English
    Publishing date 2021-04-23
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-021-22613-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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