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Article ; Online: Evaluating the docetaxel effect in an animal model of polyarthritis.

Alghulami, Omar Mustafa / Jasim, Ghaith Ali / Jasim, Suzan Yousif

2024

Abstract: Rheumatoid arthritis (RA) is immune-mediated, inflammatory disease that affects synovial joints, and characterized by inflammatory changes in synovial tissue, cartilage, bone, and less commonly in extra-articular structures. Docetaxel (DTX) is a semi- ... ...

Abstract	Rheumatoid arthritis (RA) is immune-mediated, inflammatory disease that affects synovial joints, and characterized by inflammatory changes in synovial tissue, cartilage, bone, and less commonly in extra-articular structures. Docetaxel (DTX) is a semi-synthetic anti-neoplastic medication. Peptidyl-arginine deiminase type 4 (PAD4) is expressed in macrophages and neutrophils in RA synovial membrane. Their effectiveness is in producing anti-cyclic citrullinated peptide antibodies (ACPA)-targeted citrullinated neoepitopes. Aim: To evaluate the anti-inflammatory effects of DTX in RA and the effect of methotrexate on PAD4 to investigate its potential as an RA biomarker. Methods: Forty male Wistar rats were divided into five groups of eight rats. Healthy rats formed the control group. The Second Group to Fifth group were induced with Complete Freund's adjuvant. The third group received DTX at a dosage of 1 mg/kg on alternate days, as determined by a preliminary experiment. The fourth group was given 1 mg/kg/week of methotrexate intraperitoneally. The fifth group was treated with a half dose of DTX and methotrexate simultaneously. Results: Significant Arthritis index and knee joint circumference decrease in the DTX group. No significant difference in body weight, platelet-lymphocyte ratio, and white blood cell count between the groups. Neutrophile lymphocyte ratio showed weak correlation with ACPA, while PAD4 showed good correlation with RA markers. Level of ACPA, PAD4, TNF-α, IL-1β, and VEGF significantly decreased in the DTX group than induction group (p < 0.05). Conclusion: DTX reduces the progression and joint destruction in rats induced by Complete Freund's Adjuvant which may due to inhibition of PAD4, TNF-α, IL-1β, VEGF, and ACPA. Also, methotrexate exhibited anti PAD4 effect.
Language	English
Publishing date	2024-04-15
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1080058-x
ISSN	1568-5608 ; 0925-4692
ISSN (online)	1568-5608
ISSN	0925-4692
DOI	10.1007/s10787-024-01459-2
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Article ; Online: Correction to: Macular microvascular changes in children with transfusion-dependent beta-thalassemia.

AttaAllah, Heba Radi / Mousa, Suzan Omar / Omar, Ismail Ahmed Nagib

Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie

2022 Volume 260, Issue 4, Page(s) 1431

Language	English
Publishing date	2022-01-11
Publishing country	Germany
Document type	Published Erratum
ZDB-ID	8435-9
ISSN	1435-702X ; 0721-832X
ISSN (online)	1435-702X
ISSN	0721-832X
DOI	10.1007/s00417-022-05555-3
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Article ; Online: Effects of Noise Pollution on Zakho University Students at Two Faculty of Science Buildings

Thabit Elias Basheer / Omar Salih Omar / Suzan Khalid Hashim

Science Journal of University of Zakho, Vol 10, Iss

2022 Volume 2

Abstract: Noise is a type of pollution that has a negative impact on human health and well-being. Because of population growth and urbanization, the magnitude and severity of noise pollutionare increasing. This study examines the level of noise throughout Zakho ... ...

Abstract	Noise is a type of pollution that has a negative impact on human health and well-being. Because of population growth and urbanization, the magnitude and severity of noise pollutionare increasing. This study examines the level of noise throughout Zakho university-faculty of science buildings. Noise levels were measured using a sound level meter at two campus buildings at five different times (9:00 AM –2:00 PM). A total of 180 students (98 females, 82 males) were questioned to collect data. The noise levels were highest at the ground floor of building one were at (11:00AM-12:00PM) and (12:00-1:00 PM), respectively, changing from 60.6 to 73.7 dB at (11:00 AM-12:00 PM) and 63.3-73.8 dB at (12:00-1:00 PM) (12-1:00 PM). These results could be due to students taking a lunch hour after 12:00PM and visiting a café at this site. The most prevalent direct impact of noise on students was feeling annoyed, which affected 23% of students, followed by headache (18%) and so on. Noise has psychological effects on students such as anxiety (6%) and sleep problems (4%) which all have a low percentage. Lastly, memory lapse (2%) and fatigue (3%) impact on students had a lower proportion when compared to other impacts. However, there was 22% of students did not affect by noise.
Keywords	Noise pollution ; Physical and Psychological effects ; Sound pressure level ; Science ; Q
Subject code	333
Language	English
Publishing date	2022-04-01T00:00:00Z
Publisher	University of Zakho
Document type	Article ; Online
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Article: Nasopharyngeal Branchial Cleft Cyst: A Rare Case Report and Literature Review.

Alzaidi, Suzan / Alsulami, Omar A / Alqarni, Saad / Alqurashi, Alshema / Ghafouri, Abdullah / Bin Abbas, Elham S

Cureus

2023 Volume 15, Issue 8, Page(s) e43432

Abstract: Branchial cleft cysts are birth defects that happen when the first through fourth pharyngeal clefts do not close properly and most of these cysts develop from the second cleft. Second branchial cleft cysts are almost always in the neck, so it is rare for ...

Abstract	Branchial cleft cysts are birth defects that happen when the first through fourth pharyngeal clefts do not close properly and most of these cysts develop from the second cleft. Second branchial cleft cysts are almost always in the neck, so it is rare for them to present in the nasopharynx. We report an extremely rare case of a branchial cleft cyst that is located in an unusual site in the nasopharynx in a 36-year-old male with no prior medical history. Computed tomography scan findings showed non-enhancing thickening of the right side mucosal-pharyngeal space, obliterating the fossa of Rosenmuller with no invasion or erosion. The patient was admitted for nasopharyngeal mass excision, and the mass was sent for histopathology. When a cystic lesion is noted in the lateral nasopharynx, branchial cleft cysts should be on the list of possible diagnoses. Surgery is primarily the treatment. The marsupialization approach is a simple way to treat nasopharyngeal branchial cleft cysts as it is safe and has limited complications.
Language	English
Publishing date	2023-08-13
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.43432
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Article ; Online: Percutaneous Coronary Intervention with Procedural Unfractionated Heparin without Activated Clotting Time Guidance: A Unique Opportunity to Assess Thrombotic and Bleeding Events.

Zgheib, Ali Z / Jdaidani, Jennifer / Akl, Elie / Khalil, Suzan / Chaabo, Omar / Piazza, Nicolo / Sawaya, Fadi J / Rebeiz, Abdallah G

International journal of clinical practice

2024 Volume 2024, Page(s) 6219301

Abstract: Background: Rates of major bleeding and intraprocedural thrombotic events (IPTE) in the setting of percutaneous coronary intervention (PCI) using weight-adjusted unfractionated heparin (UFH) without activated clotting time (ACT) monitoring are not known. ...

Abstract	Background: Rates of major bleeding and intraprocedural thrombotic events (IPTE) in the setting of percutaneous coronary intervention (PCI) using weight-adjusted unfractionated heparin (UFH) without activated clotting time (ACT) monitoring are not known. Methods: We reviewed 2,748 consecutive patients who underwent coronary angiography at our tertiary care university hospital between January 2017 and December 2020. All patients who underwent PCI with weight-adjusted UFH without ACT guidance were considered for further analysis. Major bleeding complications occurring within 48 hours of PCI were collected from patients' medical records. IPTE were collected independently by two interventional cardiologists after review of coronary angiograms. Results: There were 718 patients included in the analysis (65.4 ± 12.2 years old; 81.3% male). In total, 45 patients (7.8%) experienced a major bleed or IPTE. The most common IPTE were slow/no reflow (1.5%) and coronary artery dissection with decreased flow (1.1%). Other IPTE occurred in <1% of cases. Major bleeding occurred in 11 patients (1.5%), of whom 8 required blood transfusion and 3 required vascular intervention. Bleeding complications were more common with femoral compared with radial access (6.6% vs. 0.2%, Conclusion: Weight-adjusted UFH use during PCI without ACT monitoring was related to low rates of major bleeding or IPTE.
MeSH term(s)	Humans ; Male ; Middle Aged ; Aged ; Female ; Heparin/adverse effects ; Percutaneous Coronary Intervention/adverse effects ; Treatment Outcome ; Hemorrhage/chemically induced ; Thrombosis ; Anticoagulants/adverse effects
Chemical Substances	Heparin (9005-49-6) ; Anticoagulants
Language	English
Publishing date	2024-02-15
Publishing country	India
Document type	Review ; Journal Article
ZDB-ID	1386246-7
ISSN	1742-1241 ; 1368-5031
ISSN (online)	1742-1241
ISSN	1368-5031
DOI	10.1155/2024/6219301
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Article ; Online: Imaging of COVID-19 simulators

Abdelghany Mohammed Motawea / Suzan Omar / Rabab Yasin

The Egyptian Journal of Radiology and Nuclear Medicine, Vol 52, Iss 1, Pp 1-

2021 Volume 17

Abstract: Abstract Background Coronavirus (COVID-19) pneumonia emerged in Wuhan, China, in December 2019. It was highly contagious spreading all over the world, with a rapid increase in the number of deaths. The reported cases have reached more than 14 million ... ...

Abstract	Abstract Background Coronavirus (COVID-19) pneumonia emerged in Wuhan, China, in December 2019. It was highly contagious spreading all over the world, with a rapid increase in the number of deaths. The reported cases have reached more than 14 million with more than 600,000 deaths around the world. So, the pandemic of COVID-19 became a surpassing healthcare crisis with an intensive load on the healthcare resources. In this study, the aim was to differentiate COVID-19 pneumonia from its mimickers as atypical infection, interstitial lung diseases, and eosinophilic lung diseases based on CT, clinical, and laboratory findings. Results This retrospective study included 260 patients, of which 220 were confirmed as COVID-19 positive by two repeated RT-PCR test and 40 were classified as non-COVID by two repeated negative RT-PCR test or identification of other pathogens, other relevant histories, or clinical findings. In this study, 158 patients were male (60.7 %) and 102 patients were female (39.3%). There was 60.9% of the COVID-19 group were male and 39.1% were female. Patients in the non-COVID group were significantly older (the mean age was 46.4) than those in the confirmed COVID-19 group (35.2y). In the COVID-19 group, there was exposure history to positive cases in 84.1% while positive exposure history was 20% in the non-COVID group. Conclusion The spectrum of CT imaging findings in COVID-19 pneumonia is wide that could be contributed by many other diseases making the interpretation of chest CTs nowadays challenging to differentiate between different diseases having the same signs and act as deceiving simulators in the era of COVID-19.
Keywords	COVID-19 coronavirus infections ; CT computed tomography ; Atypical pneumonia ; Interstitial lung diseases ; Medical physics. Medical radiology. Nuclear medicine ; R895-920
Subject code	610
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	SpringerOpen
Document type	Article ; Online
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Article ; Online: The mosquitoes (Diptera: Culicidae) of the Mexican Yucatan Peninsula: a comprehensive review on the use of taxonomic names.

Talaga, Stanislas / le Goff, Gilbert / Arana-Guardia, Roger / Baak-Baak, Carlos Marcial / García-Rejón, Julián Everardo / García-Suárez, Omar / Rodríguez-Valencia, Víctor Manuel / Tolsá-García, María José / Suzán, Gerardo / Roiz, David

Journal of medical entomology

2023 Volume 61, Issue 2, Page(s) 274–308

Abstract: The Yucatan Peninsula is a biogeographic province of the Neotropical region which is mostly encompassed by the 3 Mexican states of Campeche, Quintana Roo, and Yucatán. During the development of the International Joint Laboratory ELDORADO (Ecosystem, ... ...

Abstract	The Yucatan Peninsula is a biogeographic province of the Neotropical region which is mostly encompassed by the 3 Mexican states of Campeche, Quintana Roo, and Yucatán. During the development of the International Joint Laboratory ELDORADO (Ecosystem, bioLogical Diversity, habitat mOdifications and Risk of emerging PAthogens and Diseases in MexicO), a French-Mexican collaboration between the IRD (Institut de Recherche pour le Développement) and UNAM (Universidad Nacional Autónoma de México) in Mérida, it became evident that many putative mosquito species names recorded in the Mexican Yucatan Peninsula were misidentifications/misinterpretations or from the uncritical repetition of incorrect literature records. To provide a stronger foundation for future studies, the mosquito fauna of the Mexican Yucatan Peninsula is here comprehensively reviewed using current knowledge of taxonomy, ecology, and distribution of species through extensive bibliographic research, and examination of newly collected specimens. As a result, 90 mosquito species classified among 16 genera and 24 subgenera are recognized to occur in the Mexican Yucatan Peninsula, including 1 new peninsula record and 3 new state records.
MeSH term(s)	Animals ; Culicidae ; Ecosystem ; Mexico ; Biodiversity ; Ecology
Language	English
Publishing date	2023-12-30
Publishing country	England
Document type	Review ; Journal Article
ZDB-ID	410635-0
ISSN	1938-2928 ; 0022-2585
ISSN (online)	1938-2928
ISSN	0022-2585
DOI	10.1093/jme/tjad168
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Article ; Online: An industrial procedure for the intestinal permeability enhancement of acyclovir: in-vitro and histological evidence.

Mady, Omar Y / Thabit, Sara Mohsen / Abo Elnasr, Suzan E / Hedaya, Asmaa A

Scientific reports

2023 Volume 13, Issue 1, Page(s) 20067

Abstract: Acyclovir, an antiviral drug, has low bioavailability due to its low permeability. Consequently, high drug doses and frequent administration are required. This study investigates the use of span 60, at different concentrations, as a granulating agent to ... ...

Abstract	Acyclovir, an antiviral drug, has low bioavailability due to its low permeability. Consequently, high drug doses and frequent administration are required. This study investigates the use of span 60, at different concentrations, as a granulating agent to enhance drug permeability using an industrial procedure on a pilot scale. The micromeritics, drug content, drug crystallinity, drug partition coefficient, and drug release of the produced formulations were examined. The findings revealed an enhanced drug partition coefficient, suggesting drug entrapment in the polar portion of span 60. The drug release profiles exhibited rapid and complete drug release. The improvement of the drug permeability was evaluated using a modified non-everted sac technique. Notably, drug permeability through the rabbit intestine significantly improved, as evidenced by various calculated permeation parameters, providing insights into the drug absorption mechanism. The widening of the paracellular pathway was observed through histological examination of the rabbit intestinal segment, which aligns with the drug absorption mechanism. The utilization of a paracellular pathway enhancer as a granulating agent holds promise as a strategy to enhance the oral bioavailability of class III drugs. Overall, this study presents a novel drug delivery approach to enhance drug permeation and bioavailability, with potential implications for other medications.
MeSH term(s)	Animals ; Rabbits ; Acyclovir/pharmacology ; Antiviral Agents/pharmacology ; Pharmaceutical Preparations ; Intestines ; Biological Availability ; Permeability ; Intestinal Absorption ; Administration, Oral
Chemical Substances	Acyclovir (X4HES1O11F) ; Antiviral Agents ; Pharmaceutical Preparations
Language	English
Publishing date	2023-11-16
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-47306-2
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Article ; Online: Association of Thrombotic Markers With Severity of Pediatric-Onset Systemic Lupus Erythematosus.

Maher, Sheren Esam / Abdul-Badia, Ahmed Ragab / Abu El-Ela, Mostafa Ahmed / Mousa, Suzan Omar

Indian pediatrics

2023 Volume 60, Issue 9, Page(s) 736–738

Abstract: Objective: To assess the relation of thrombotic markers, thrombomodulin and D-dimer levels to the disease severity in pediatric onset systemic lupus erythematosus (p-SLE) measured by the Systemic Lupus Erythematous Disease Activity Index (SLEDAI).: ... ...

Abstract	Objective: To assess the relation of thrombotic markers, thrombomodulin and D-dimer levels to the disease severity in pediatric onset systemic lupus erythematosus (p-SLE) measured by the Systemic Lupus Erythematous Disease Activity Index (SLEDAI). Methods: 40 children with p-SLE were grouped according to SLEDAI into: low activity SLE group (laSLE) and moderate-high activity SLE group (mhaSLE). 40 healthy children were included as control group. Serum thrombomodulin, and D-dimer levels were measured for all enrolled children. Results: The low activity and moderate-high activity SLE groups had significantly higher mean (SD) thrombomodulin [7.2 (1.83) mg/mL and 9.86 (3.29) mg/mL, respectively vs 5.85 (1.41) mg/mL; P<0.001] and D-dimer (r=0.42, P=0.006) levels than controls. Furthermore, the mhaSLE group had significantly higher thrombomodulin levels and D-dimer (r = 0.42, P= 0.006) levels than the laSLE group (P=0.008 and 0.006). Thrombomodulin and D-dimer had significant positive correlations with SLEDAI. Conclusion: Thrombomodulin and D-dimer are valuable markers for p-SLE activity, discriminating children with severe disease activity from those with low disease activity.
MeSH term(s)	Child ; Humans ; Thrombomodulin ; Lupus Erythematosus, Systemic/diagnosis ; Thrombosis/diagnosis
Chemical Substances	Thrombomodulin
Language	English
Publishing date	2023-07-20
Publishing country	India
Document type	Journal Article
ZDB-ID	402594-5
ISSN	0974-7559 ; 0019-6061
ISSN (online)	0974-7559
ISSN	0019-6061
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Article ; Online: Macular microvascular changes in children with transfusion-dependent beta-thalassemia.

AttaAllah, Heba Radi / Mousa, Suzan Omar / Omar, Ismail Ahmed Nagib

Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie

2021 Volume 259, Issue 11, Page(s) 3283–3293

Abstract: Background: To investigate the effect of iron overload on macular perfusion among transfusion-dependent thalassemia (TDT) patients using optical coherence tomography angiography (OCTA) METHODS: The study is a prospective observational case-control study. ...

Abstract	Background: To investigate the effect of iron overload on macular perfusion among transfusion-dependent thalassemia (TDT) patients using optical coherence tomography angiography (OCTA) METHODS: The study is a prospective observational case-control study. It included 27 eyes from 27 children with transfusion-dependent β-thalassemia and 25 eyes from 25 age-matched controls. All participants were evaluated clinically and with OCTA Avanti RTVue-XR system (Optovue) to assess macular microvascular changes, by measuring vessels density (VDs) and foveal avascular zone (FAZ) area, at both superficial and deep retinal plexuses and at choriocapillaris level. Results: Foveal and parafoveal zones were significantly thinner among thalassemia patients, with significantly larger FAZ area at the level of both superficial and deep retinal plexuses when compared with control group. The thalassemia group showed significant lower values compared with the controls regarding whole-image, foveal, and parafoveal deep VD. There were significant negative correlations between serum ferritin and deep (whole image and parafoveal) VD (r = - 0.429, P = 0.026, and r = - 0.452, P = 0.018, respectively). Choriocapillaris VDs (whole image and foveal) showed significant negative correlations with serum ferritin levels (r = - 0.390, P = 0.044 and r = - 0.401, P = 0.038, respectively) CONCLUSIONS: Macular microvascular changes were detected by OCTA examination in patients with TDT, mostly due to iron overload effect, as we selected patients on iron-chelating agent with the least harmful effect on the retina. The most affected layer is the DCP. Changes at the deep layer could be used as a sensitive biomarker for early macular perfusion changes in those patients. Trial registration: Study registration number is UMIN000042657, date of registration: 2020/12/04 (retrospectively registered).
MeSH term(s)	Case-Control Studies ; Child ; Fluorescein Angiography ; Fovea Centralis ; Humans ; Retinal Vessels/diagnostic imaging ; Tomography, Optical Coherence ; beta-Thalassemia/complications ; beta-Thalassemia/diagnosis
Language	English
Publishing date	2021-06-14
Publishing country	Germany
Document type	Journal Article ; Observational Study
ZDB-ID	8435-9
ISSN	1435-702X ; 0721-832X
ISSN (online)	1435-702X
ISSN	0721-832X
DOI	10.1007/s00417-021-05275-0
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