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  1. Book ; Thesis: Kontrollierte Teilbelastung unter Benutzung einer Einlegesohle mit integrierter Druckmessung

    Bodechtel, Roland Krug

    2002  

    Author's details vorgelegt von Roland Krug Bodechtel
    Language German
    Size 57 Bl., Ill., graph. Darst.
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Erlangen, Nürnberg, Univ., Diss., 2002
    HBZ-ID HT013453843
    Database Catalogue ZB MED Medicine, Health

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    2002 E 3808 order for loan Magazin

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  2. Book ; Online ; Thesis: Implementierung von CSR im Einkauf unter Berücksichtigung situativer Führung von Agents und Stewards

    Krug, Mathias [Verfasser] / Bogaschewsky, Roland [Gutachter]

    2017  

    Author's details Mathias Krug ; Gutachter: Roland Bogaschewsky
    Keywords Wirtschaft ; Economics
    Subject code sg330
    Language German
    Publisher Universität Würzburg
    Publishing place Würzburg
    Document type Book ; Online ; Thesis
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  3. Article ; Online: CT-like MRI: a qualitative assessment of ZTE sequences for knee osseous abnormalities.

    Bharadwaj, Upasana Upadhyay / Coy, Adam / Motamedi, Daria / Sun, Dong / Joseph, Gabby B / Krug, Roland / Link, Thomas M

    Skeletal radiology

    2022  Volume 51, Issue 8, Page(s) 1585–1594

    Abstract: Objective: To qualitatively evaluate the utility of zero echo-time (ZTE) MRI sequences in identifying osseous findings and to compare ZTE with optimized spoiled gradient echo (SPGR) sequences in detecting knee osseous abnormalities.: Materials and ... ...

    Abstract Objective: To qualitatively evaluate the utility of zero echo-time (ZTE) MRI sequences in identifying osseous findings and to compare ZTE with optimized spoiled gradient echo (SPGR) sequences in detecting knee osseous abnormalities.
    Materials and methods: ZTE and standard knee MRI sequences were acquired at 3T in 100 consecutive patients. Three radiologists rated confidence in evaluating osseous abnormalities and image quality on a 5-grade Likert scale in ZTE compared to standard sequences. In a subset of knees (n = 57) SPGR sequences were also obtained, and diagnostic confidence in identifying osseous structures was assessed, comparing ZTE and SPGR sequences. Statistical significance of using ZTE over SPGR was characterized with a paired t-test.
    Results: Image quality of the ZTE sequences was rated high by all reviewers with 278 out of 299 (100 studies, 3 radiologists) scores ≥ 4 on the Likert scale. Diagnostic confidence in using ZTE sequences was rated "very high confidence" in 97%, 85%, 71%, and 73% of the cases for osteophytosis, subchondral cysts, fractures, and soft tissue calcifications/ossifications, respectively. In 74% of cases with osseous findings, reviewer scores indicated confidence levels (score ≥ 3) that ZTE sequences improved diagnostic certainty over standard sequences. The diagnostic confidence in using ZTE over SPGR sequences for osseous structures as well as abnormalities was favorable and statistically significant (p < 0.01).
    Conclusion: Incorporating ZTE sequences in the standard knee MRI protocol was technically feasible and improved diagnostic confidence for osseous findings in relation to standard MR sequences. In comparison to SPGR sequences, ZTE improved assessment of osseous abnormalities.
    MeSH term(s) Bone and Bones ; Humans ; Magnetic Resonance Imaging/methods ; Tomography, X-Ray Computed/methods
    Language English
    Publishing date 2022-01-28
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 527592-1
    ISSN 1432-2161 ; 0364-2348
    ISSN (online) 1432-2161
    ISSN 0364-2348
    DOI 10.1007/s00256-021-03987-2
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    Zs.A 1304: Show issues Location:
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  4. Article ; Online: Systematic P2Y receptor survey identifies P2Y11 as modulator of immune responses and virus replication in macrophages.

    Andersen, Line Lykke / Huang, Yiqi / Urban, Christian / Oubraham, Lila / Winheim, Elena / Stafford, Che / Nagl, Dennis / O'Duill, Fionan / Ebert, Thomas / Engleitner, Thomas / Paludan, Søren Riis / Krug, Anne / Rad, Roland / Hornung, Veit / Pichlmair, Andreas

    The EMBO journal

    2023  Volume 42, Issue 23, Page(s) e113279

    Abstract: The immune system is in place to assist in ensuring tissue homeostasis, which can be easily perturbed by invading pathogens or nonpathogenic stressors causing tissue damage. Extracellular nucleotides are well known to contribute to innate immune ... ...

    Abstract The immune system is in place to assist in ensuring tissue homeostasis, which can be easily perturbed by invading pathogens or nonpathogenic stressors causing tissue damage. Extracellular nucleotides are well known to contribute to innate immune signaling specificity and strength, but how their signaling is relayed downstream of cell surface receptors and how this translates into antiviral immunity is only partially understood. Here, we systematically investigated the responses of human macrophages to extracellular nucleotides, focusing on the nucleotide-sensing GPRC receptors of the P2Y family. Time-resolved transcriptomic analysis showed that adenine- and uridine-based nucleotides induce a specific, immediate, and transient cytokine response through the MAPK signaling pathway that regulates transcriptional activation by AP-1. Using receptor trans-complementation, we identified a subset of P2Ys (P2Y1, P2Y2, P2Y6, and P2Y11) that govern inflammatory responses via cytokine induction, while others (P2Y4, P2Y11, P2Y12, P2Y13, and P2Y14) directly induce antiviral responses. Notably, P2Y11 combined both activities, and depletion or inhibition of this receptor in macrophages impaired both inflammatory and antiviral responses. Collectively, these results highlight the underappreciated functions of P2Y receptors in innate immune processes.
    MeSH term(s) Humans ; Cytokines ; Immunity ; Macrophages/metabolism ; Nucleotides/metabolism ; Signal Transduction ; Virus Replication
    Chemical Substances Cytokines ; Nucleotides ; P2RY11 protein, human
    Language English
    Publishing date 2023-10-26
    Publishing country England
    Document type Journal Article
    ZDB-ID 586044-1
    ISSN 1460-2075 ; 0261-4189
    ISSN (online) 1460-2075
    ISSN 0261-4189
    DOI 10.15252/embj.2022113279
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    Zs.A 1808: Show issues Location:
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  5. Article ; Online: Thresholding approaches for estimating paraspinal muscle fat infiltration using T1- and T2-weighted MRI: Comparative analysis using water-fat MRI.

    Ornowski, Jessica / Dziesinski, Lucas / Hess, Madeline / Krug, Roland / Fortin, Maryse / Torres-Espin, Abel / Majumdar, Sharmila / Pedoia, Valentina / Bonnheim, Noah B / Bailey, Jeannie F

    JOR spine

    2023  Volume 7, Issue 1, Page(s) e1301

    Abstract: Background: Paraspinal muscle fat infiltration is associated with spinal degeneration and low back pain, however, quantifying muscle fat using clinical magnetic resonance imaging (MRI) techniques continues to be a challenge. Advanced MRI techniques, ... ...

    Abstract Background: Paraspinal muscle fat infiltration is associated with spinal degeneration and low back pain, however, quantifying muscle fat using clinical magnetic resonance imaging (MRI) techniques continues to be a challenge. Advanced MRI techniques, including chemical-shift encoding (CSE) based water-fat MRI, enable accurate measurement of muscle fat, but such techniques are not widely available in routine clinical practice.
    Methods: To facilitate assessment of paraspinal muscle fat using clinical imaging, we compared four thresholding approaches for estimating muscle fat fraction (FF) using T1- and T2-weighted images, with measurements from water-fat MRI as the ground truth: Gaussian thresholding, Otsu's method, K-mean clustering, and quadratic discriminant analysis. Pearson's correlation coefficients (
    Results: We found that for all muscles combined, FF measurements from T1- and T2-weighted images were strongly positively correlated with measurements from the water-fat images for all thresholding techniques (
    Conclusion: We conclude that muscle FF can be quantified using thresholded T1- and T2-weighted MRI images with relatively low bias and absolute error in relation to water-fat MRI, particularly in the MF and ES, and the choice of thresholding technique should depend on the muscle and clinical MRI sequence of interest.
    Language English
    Publishing date 2023-12-01
    Publishing country United States
    Document type Journal Article
    ISSN 2572-1143
    ISSN (online) 2572-1143
    DOI 10.1002/jsp2.1301
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: A Colonic Organoid Model Challenged with the Large Toxins of

    Schneemann, Martina / Heils, Lucas / Moos, Verena / Weiß, Franziska / Krug, Susanne M / Weiner, January / Beule, Dieter / Gerhard, Ralf / Schulzke, Jörg-Dieter / Bücker, Roland

    Toxins

    2023  Volume 15, Issue 11

    Abstract: Background: Clostridioides difficile: Methods: Human adult colon organoids were cultured on membrane inserts. Tight junction (TJ) proteins and actin cytoskeleton were analyzed for expression via Western blotting and via confocal laser-scanning ... ...

    Abstract Background: Clostridioides difficile
    Methods: Human adult colon organoids were cultured on membrane inserts. Tight junction (TJ) proteins and actin cytoskeleton were analyzed for expression via Western blotting and via confocal laser-scanning microscopy for subcellular localization.
    Results: Polarized intestinal organoid monolayers were established from stem cell-containing colon organoids to apply toxins from the apical side and to perform functional measurements in the organoid model. The toxins caused a reduction in transepithelial electrical resistance in human colonic organoid monolayers with sublethal concentrations. Concomitantly, we detected increased paracellular permeability fluorescein and FITC-dextran-4000. Human colonic organoid monolayers exposed to the toxins exhibited redistribution of barrier-forming TJ proteins claudin-1, -4 and tricellulin, whereas channel-forming claudin-2 expression was increased. Perijunctional F-actin cytoskeleton organization was affected.
    Conclusions: Adult stem cell-derived human colonic organoid monolayers were applicable as a colon infection model for electrophysiological measurements. The TJ changes noted can explain the epithelial barrier dysfunction and diarrhea in patients, as well as increased entry of luminal antigens triggering inflammation.
    MeSH term(s) Humans ; Tight Junction Proteins/metabolism ; Bacterial Toxins/toxicity ; Bacterial Toxins/metabolism ; Clostridioides difficile/metabolism ; Tight Junctions/metabolism ; Clostridioides ; Colon ; Diarrhea ; Inflammation/metabolism ; Organoids ; Intestinal Mucosa
    Chemical Substances Tight Junction Proteins ; Bacterial Toxins
    Language English
    Publishing date 2023-11-04
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2518395-3
    ISSN 2072-6651 ; 2072-6651
    ISSN (online) 2072-6651
    ISSN 2072-6651
    DOI 10.3390/toxins15110643
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  7. Article ; Online: ISSLS Prize in Bioengineering Science 2023: Age- and sex-related differences in lumbar intervertebral disc degeneration between patients with chronic low back pain and asymptomatic controls.

    Bonnheim, Noah B / Lazar, Ann A / Kumar, Anika / Akkaya, Zehra / Zhou, Jiamin / Guo, Xiaojie / O'Neill, Conor / Link, Thomas M / Lotz, Jeffrey C / Krug, Roland / Fields, Aaron J

    European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society

    2023  Volume 32, Issue 5, Page(s) 1517–1524

    Abstract: Purpose: Clinical management of disc degeneration in patients with chronic low back pain (cLBP) is hampered by the challenge of distinguishing pathologic changes relating to pain from physiologic changes related to aging. The goal of this study was to ... ...

    Abstract Purpose: Clinical management of disc degeneration in patients with chronic low back pain (cLBP) is hampered by the challenge of distinguishing pathologic changes relating to pain from physiologic changes related to aging. The goal of this study was to use imaging biomarkers of disc biochemical composition to distinguish degenerative changes associated with cLBP from normal aging.
    Methods: T1ρ MRI data were acquired from 133 prospectively enrolled subjects for this observational study (80 cLBP, 53 controls; mean ± SD age = 43.9 ± 13.4 years; 61 females, 72 males). The mean T1ρ relaxation time in the nucleus pulposus (NP-T1ρ; n = 650 discs) was used as a quantitative biomarker of disc biochemical composition. Linear regression was used to assess associations between NP-T1ρ and age, sex, spinal level, and study group, and their interactions.
    Results: NP-T1ρ values were lower in cLBP patients than controls (70.8 ± 22.8 vs. 76.4 ± 22.2 ms, p = 0.009). Group differences were largest at L5-S1 (ΔT1ρ
    Conclusion: Aging effects on the biochemical composition of the L5-S1 disc may involve a relatively uniform set of factors from which many cLBP patients deviate. NP-T1ρ values at L5-S1 may be highly relevant to clinical phenotyping, particularly in younger individuals.
    MeSH term(s) Male ; Female ; Humans ; Adult ; Middle Aged ; Intervertebral Disc Degeneration/diagnostic imaging ; Intervertebral Disc Degeneration/pathology ; Low Back Pain/pathology ; Intervertebral Disc/diagnostic imaging ; Intervertebral Disc/pathology ; Magnetic Resonance Imaging/methods ; Lumbar Vertebrae/diagnostic imaging ; Lumbar Vertebrae/pathology ; Bioengineering
    Language English
    Publishing date 2023-02-18
    Publishing country Germany
    Document type Observational Study ; Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 1115375-1
    ISSN 1432-0932 ; 0940-6719
    ISSN (online) 1432-0932
    ISSN 0940-6719
    DOI 10.1007/s00586-023-07542-6
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    Zs.A 3437: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article: Deep-learning-based biomarker of spinal cartilage endplate health using ultra-short echo time magnetic resonance imaging.

    Bonnheim, Noah B / Wang, Linshanshan / Lazar, Ann A / Chachad, Ravi / Zhou, Jiamin / Guo, Xiaojie / O'Neill, Conor / Castellanos, Joel / Du, Jiang / Jang, Hyungseok / Krug, Roland / Fields, Aaron J

    Quantitative imaging in medicine and surgery

    2023  Volume 13, Issue 5, Page(s) 2807–2821

    Abstract: Background: T2* relaxation times in the spinal cartilage endplate (CEP) measured using ultra-short echo time magnetic resonance imaging (UTE MRI) reflect aspects of biochemical composition that influence the CEP's permeability to nutrients. Deficits in ... ...

    Abstract Background: T2* relaxation times in the spinal cartilage endplate (CEP) measured using ultra-short echo time magnetic resonance imaging (UTE MRI) reflect aspects of biochemical composition that influence the CEP's permeability to nutrients. Deficits in CEP composition measured using T2* biomarkers from UTE MRI are associated with more severe intervertebral disc degeneration in patients with chronic low back pain (cLBP). The goal of this study was to develop an objective, accurate, and efficient deep-learning-based method for calculating biomarkers of CEP health using UTE images.
    Methods: Multi-echo UTE MRI of the lumbar spine was acquired from a prospectively enrolled cross-sectional and consecutive cohort of 83 subjects spanning a wide range of ages and cLBP-related conditions. CEPs from the L4-S1 levels were manually segmented on 6,972 UTE images and used to train neural networks utilizing the u-net architecture. CEP segmentations and mean CEP T2* values derived from manually- and model-generated segmentations were compared using Dice scores, sensitivity, specificity, Bland-Altman, and receiver-operator characteristic (ROC) analysis. Signal-to-noise (SNR) and contrast-to-noise (CNR) ratios were calculated and related to model performance.
    Results: Compared with manual CEP segmentations, model-generated segmentations achieved sensitives of 0.80-0.91, specificities of 0.99, Dice scores of 0.77-0.85, area under the receiver-operating characteristic curve values of 0.99, and precision-recall (PR) AUC values of 0.56-0.77, depending on spinal level and sagittal image position. Mean CEP T2* values and principal CEP angles derived from the model-predicted segmentations had low bias in an unseen test dataset (T2* bias =0.33±2.37 ms, angle bias =0.36±2.65°). To simulate a hypothetical clinical scenario, the predicted segmentations were used to stratify CEPs into high, medium, and low T2* groups. Group predictions had diagnostic sensitivities of 0.77-0.86 and specificities of 0.86-0.95. Model performance was positively associated with image SNR and CNR.
    Conclusions: The trained deep learning models enable accurate, automated CEP segmentations and T2* biomarker computations that are statistically similar to those from manual segmentations. These models address limitations with inefficiency and subjectivity associated with manual methods. Such techniques could be used to elucidate the role of CEP composition in disc degeneration etiology and guide emerging therapies for cLBP.
    Language English
    Publishing date 2023-03-10
    Publishing country China
    Document type Journal Article
    ZDB-ID 2653586-5
    ISSN 2223-4306 ; 2223-4292
    ISSN (online) 2223-4306
    ISSN 2223-4292
    DOI 10.21037/qims-22-729
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Book ; Online ; Thesis: Die Rolle des Chemokins CCL17 in der Pathogenese chronisch-entzündlicher Darmerkrankungen

    Jandl, Lisa [Verfasser] / Krug, Anne [Akademischer Betreuer] / Krug, Anne [Gutachter] / Schmid, Roland M. [Gutachter]

    2019  

    Author's details Lisa Jandl ; Gutachter: Anne Krug, Roland M. Schmid ; Betreuer: Anne Krug
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Universitätsbibliothek der TU München
    Publishing place München
    Document type Book ; Online ; Thesis
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  10. Article: "Guided Endodontics" nach Zahntrauma

    Connert, Thomas / Kühl, Sebastian / Krug, Ralf / Weiger, Roland / Krastl, Gabriel

    Quintessenz Zahnmedizin

    2019  Volume 70, Issue 9, Page(s) 1066

    Language German
    Document type Article
    ZDB-ID 2956701-4
    ISSN 0033-6580 ; 2627-9088
    Database Current Contents Medicine

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