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  1. Article ; Online: Impaired neutrophil extracellular trap-forming capacity contributes to susceptibility to chronic vaginitis in a mouse model of vulvovaginal candidiasis.

    Yano, Junko / Fidel, Paul L

    Infection and immunity

    2024  Volume 92, Issue 3, Page(s) e0035023

    Abstract: Vulvovaginal candidiasis (VVC), caused ... ...

    Abstract Vulvovaginal candidiasis (VVC), caused by
    MeSH term(s) Female ; Humans ; Animals ; Mice ; Candidiasis, Vulvovaginal/microbiology ; Extracellular Traps ; Antifungal Agents/pharmacology ; Disease Models, Animal ; Mice, Inbred C3H ; Candida albicans/genetics
    Chemical Substances Antifungal Agents
    Language English
    Publishing date 2024-01-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 218698-6
    ISSN 1098-5522 ; 0019-9567
    ISSN (online) 1098-5522
    ISSN 0019-9567
    DOI 10.1128/iai.00350-23
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 684: Show issues Location:
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  2. Article ; Online: Deciphering Photoinduced Catalytic Reaction Mechanisms in Natural and Artificial Photosynthetic Systems on Multiple Temporal and Spatial Scales Using X-ray Probes.

    Chen, Lin X / Yano, Junko

    Chemical reviews

    2024  Volume 124, Issue 9, Page(s) 5421–5469

    Abstract: Utilization of renewable energies for catalytically generating value-added chemicals is highly desirable in this era of rising energy demands and climate change impacts. Artificial photosynthetic systems or photocatalysts utilize light to convert ... ...

    Abstract Utilization of renewable energies for catalytically generating value-added chemicals is highly desirable in this era of rising energy demands and climate change impacts. Artificial photosynthetic systems or photocatalysts utilize light to convert abundant CO
    Language English
    Publishing date 2024-04-25
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 207949-5
    ISSN 1520-6890 ; 0009-2665
    ISSN (online) 1520-6890
    ISSN 0009-2665
    DOI 10.1021/acs.chemrev.3c00560
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  3. Article ; Online: Methods Related to the Immunopathogenesis of Vulvovaginal Candidiasis and Associated Neutrophil Anergy.

    Yano, Junko / Fidel, Paul L

    Methods in molecular biology (Clifton, N.J.)

    2022  Volume 2542, Page(s) 193–218

    Abstract: Vulvovaginal candidiasis (VVC) is a common mucosal disease, caused primarily by Candida albicans that affects up to 75% of women of childbearing age. The pathogenesis of VVC and recurrent VVC (RVVC) is largely understood after decades of research. In ... ...

    Abstract Vulvovaginal candidiasis (VVC) is a common mucosal disease, caused primarily by Candida albicans that affects up to 75% of women of childbearing age. The pathogenesis of VVC and recurrent VVC (RVVC) is largely understood after decades of research. In this regard, an immunopathological response involving the migration of neutrophils that become dysfunctional (anergic) in the vaginal environment leads to the symptomatic conditions. However, immunotherapeutic strategies to correct the immunopathogenesis are still elusive. Much of the mechanistic discoveries have been uncovered using the established mouse model of chronic VVC. This chapter details the methods widely used for the mouse model of experimental VVC and associated outcome measures of the immunopathologic response and resulting symptomatic condition and focuses further on assays used to demonstrate "neutrophil anergy" in the model. These methods may serve as a source or resource for further experimentation with the ultimate goal to reduce or eliminate VVC/RVVC.
    MeSH term(s) Animals ; Candida albicans ; Candidiasis, Vulvovaginal/drug therapy ; Candidiasis, Vulvovaginal/pathology ; Disease Models, Animal ; Female ; Humans ; Mice ; Neutrophils/pathology ; Vagina
    Language English
    Publishing date 2022-08-25
    Publishing country United States
    Document type Journal Article
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-2549-1_14
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  4. Article ; Online: Room temperature crystallography and X-ray spectroscopy of metalloenzymes.

    Makita, Hiroki / Zhang, Miao / Yano, Junko / Kern, Jan

    Methods in enzymology

    2023  Volume 688, Page(s) 307–348

    Abstract: The ultrashort (10s of femtoseconds) X-ray pulses generated by X-ray free electron lasers enable the measurement of X-ray diffraction and spectroscopic data from radiation-sensitive metalloenzymes at room temperature while mostly avoiding the effects of ... ...

    Abstract The ultrashort (10s of femtoseconds) X-ray pulses generated by X-ray free electron lasers enable the measurement of X-ray diffraction and spectroscopic data from radiation-sensitive metalloenzymes at room temperature while mostly avoiding the effects of radiation damage usually encountered when performing such experiments at synchrotron sources. Here we discuss an approach to measure both X-ray emission and X-ray crystallographic data at the same time from the same sample volume. The droplet-on-tape setup described allows for efficient sample use and the integration of different reaction triggering options in order to conduct time-resolved studies with limited sample amounts. The approach is illustrated by two examples, photosystem II that catalyzes the light-driven oxidation of water to oxygen, and isopenicillin N synthase, an enzyme that catalyzes the double ring cyclization of a tripeptide precursor into the β-lactam isopenicillin and can be activated by oxygen exposure. We describe the necessary steps to obtain microcrystals of both proteins as well as the operation procedure for the drop-on-tape setup and details of the data acquisition and processing involved in this experiment. At the end, we present how the combination of time-resolved X-ray emission spectra and diffraction data can be used to improve the knowledge about the enzyme reaction mechanism.
    MeSH term(s) X-Rays ; Temperature ; Metalloproteins ; Spectrum Analysis ; Crystallography, X-Ray ; Oxygen
    Chemical Substances Metalloproteins ; Oxygen (S88TT14065)
    Language English
    Publishing date 2023-08-16
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
    ISSN 1557-7988
    ISSN (online) 1557-7988
    DOI 10.1016/bs.mie.2023.07.009
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  5. Article: Erratum to "Crossing double stent retriever technique for refractory terminal internal carotid artery occlusion" [Radiology Case Reports 17 (2022) 1848-1852].

    Sasaki, Isao / Imahori, Taichiro / Yano, Tatsuya / Gomi, Masanori / Kuroda, Junko / Kobayashi, Norikata / Sato, Kimitoshi / Niwa, Yoji / IwasaKi, Koichi / Hasegawa, Hiroshi

    Radiology case reports

    2024  Volume 19, Issue 4, Page(s) 1658

    Abstract: This corrects the article DOI: 10.1016/j.radcr.2022.03.023.]. ...

    Abstract [This corrects the article DOI: 10.1016/j.radcr.2022.03.023.].
    Language English
    Publishing date 2024-01-12
    Publishing country Netherlands
    Document type Published Erratum
    ZDB-ID 2406300-9
    ISSN 1930-0433
    ISSN 1930-0433
    DOI 10.1016/j.radcr.2023.12.036
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  6. Article ; Online: Combining on-line spectroscopy with synchrotron and X-ray free electron laser crystallography.

    Makita, Hiroki / Simon, Philipp S / Kern, Jan / Yano, Junko / Yachandra, Vittal K

    Current opinion in structural biology

    2023  Volume 80, Page(s) 102604

    Abstract: With the recent advances in serial crystallography methods at both synchrotron and X-ray free electron laser sources, more details of intermediate or transient states of the catalytic reactions are being revealed structurally. These structural studies of ...

    Abstract With the recent advances in serial crystallography methods at both synchrotron and X-ray free electron laser sources, more details of intermediate or transient states of the catalytic reactions are being revealed structurally. These structural studies of reaction dynamics drive the need for on-line in crystallo spectroscopy methods to complement the crystallography experiment. The recent applications of combined spectroscopy and crystallography methods enable on-line determination of in crystallo reaction kinetics and structures of catalytic intermediates, sample integrity, and radiation-induced sample modifications, if any, as well as heterogeneity of crystals from different preparations or sample batches. This review describes different modes of spectroscopy that are combined with the crystallography experiment at both synchrotron and X-ray free-electron laser facilities, and the complementary information that each method can provide to facilitate the structural study of enzyme catalysis and protein dynamics.
    MeSH term(s) Synchrotrons ; Electrons ; Crystallography, X-Ray ; Spectrum Analysis ; Lasers
    Language English
    Publishing date 2023-05-04
    Publishing country England
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 1068353-7
    ISSN 1879-033X ; 0959-440X
    ISSN (online) 1879-033X
    ISSN 0959-440X
    DOI 10.1016/j.sbi.2023.102604
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    In stock of ZB MED Cologne/Königswinter

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  7. Article ; Online: High-Spin and Reactive Fe

    Scott, Anna G / Alves Galico, Diogo / Bogacz, Isabel / Oyala, Paul H / Yano, Junko / Suturina, Elizaveta A / Murugesu, Muralee / Agapie, Theodor

    Angewandte Chemie (International ed. in English)

    2023  Volume 62, Issue 49, Page(s) e202313880

    Abstract: Atomically defined large metal clusters have applications in new reaction development and preparation of materials with tailored properties. Expanding the synthetic toolbox for reactive high nuclearity metal complexes, we report a new class of Fe ... ...

    Abstract Atomically defined large metal clusters have applications in new reaction development and preparation of materials with tailored properties. Expanding the synthetic toolbox for reactive high nuclearity metal complexes, we report a new class of Fe clusters, Tp*
    Language English
    Publishing date 2023-11-07
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2011836-3
    ISSN 1521-3773 ; 1433-7851
    ISSN (online) 1521-3773
    ISSN 1433-7851
    DOI 10.1002/anie.202313880
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  8. Article: Leukotrienes Are Dispensable for Vaginal Neutrophil Recruitment as Part of the Immunopathological Response During Experimental Vulvovaginal Candidiasis.

    Yano, Junko / White, David J / Sampson, Anthony P / Wormley, Floyd L / Fidel, Paul L

    Frontiers in microbiology

    2021  Volume 12, Page(s) 739385

    Abstract: Recruitment of polymorphonuclear neutrophils (PMNs) into the vaginal lumen is the hallmark of an acute immunopathologic inflammatory response during vulvovaginal candidiasis (VVC) caused ... ...

    Abstract Recruitment of polymorphonuclear neutrophils (PMNs) into the vaginal lumen is the hallmark of an acute immunopathologic inflammatory response during vulvovaginal candidiasis (VVC) caused by
    Language English
    Publishing date 2021-11-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2021.739385
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  9. Article ; Online: Applying the Host-Microbe Damage Response Framework to

    Fidel, Paul L / Yano, Junko / Esher, Shannon K / Noverr, Mairi C

    Journal of fungi (Basel, Switzerland)

    2020  Volume 6, Issue 1

    Abstract: Disease is a complex outcome that can occur as a result of pathogen-mediated damage, host-mediated damage or both. This has led to the revolutionary concept of the damage response framework (DRF) that defines microbial virulence as a function of host ... ...

    Abstract Disease is a complex outcome that can occur as a result of pathogen-mediated damage, host-mediated damage or both. This has led to the revolutionary concept of the damage response framework (DRF) that defines microbial virulence as a function of host immunity. The DRF outlines six scenarios (classes) of host damage or beneficial outcomes, depending on the microbe and the strength of the immune response.
    Language English
    Publishing date 2020-03-11
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2784229-0
    ISSN 2309-608X ; 2309-608X
    ISSN (online) 2309-608X
    ISSN 2309-608X
    DOI 10.3390/jof6010035
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  10. Article ; Online: Attenuated cerebellar phenotypes in Inpp4a truncation mutants with preserved phosphatase activity

    Dang Minh Tran / Nozomu Yoshioka / Norihisa Bizen / Yukiko Mori-Ochiai / Masato Yano / Shogo Yanai / Junya Hasegawa / Satoshi Miyashita / Mikio Hoshino / Junko Sasaki / Takehiko Sasaki / Hirohide Takebayashi

    Disease Models & Mechanisms, Vol 16, Iss

    2023  Volume 7

    Keywords phosphoinositide ; cerebellar atrophy ; inositol polyphosphate-4-phosphatase type i ; pain-induced epilepsy ; neurodegeneration ; mouse model ; Medicine ; R ; Pathology ; RB1-214
    Language English
    Publishing date 2023-07-01T00:00:00Z
    Publisher The Company of Biologists
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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