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Article ; Online: False positive Herpes Simplex IgM serology in COVID-19 patients correlates with SARS-CoV-2 IgM/IgG seropositivity.

Vandervore, Laura / Van Mieghem, Eugénie / Nowé, Vicky / Schouwers, Sofie / Steger, Charlotte / Abrams, Pascale / Van Schaeren, Jozef / Meskal, Anissa / Vandamme, Timon

Diagnostic microbiology and infectious disease

2022 Volume 103, Issue 1, Page(s) 115653

Abstract: Differentiating COVID-19 from other causes of viral pneumonia, like herpes simplex (HSV), can be complicated by shared clinical and laboratory features. Viral pneumonia is mostly diagnosed based on molecular or serological techniques. Serological ... ...

Abstract	Differentiating COVID-19 from other causes of viral pneumonia, like herpes simplex (HSV), can be complicated by shared clinical and laboratory features. Viral pneumonia is mostly diagnosed based on molecular or serological techniques. Serological immunoassay interferences, often attributed to concurrent appearance of heterologous (viral) immunoglobulins, is well-known, but has not been studied in COVID-19 patients. Following false positive HSV immunoglobulin M (IgM) results in our index patient, 25 other COVID-19 patients were tested for HSV-1/2 IgM with the chemiluminescent Liaison assay and Euroimmun enzyme-linked immunosorbent assay. Forty-five percent of COVID-19 patients tested positive for HSV IgM with Liaison. No HSV indices were positive with Euroimmun enzyme-linked immunosorbent assay, suggesting immunoassay interference. Significant correlation between HSV IgM and SARS-CoV-2 IgM/IgG positivity was found. Adding 0.5% polyvinylpyrrolidone, inhibiting non-specific solid-phase adsorption, abolished interference in 22% of false positive cases, suggesting interference caused by solid-phase reactive IgM. Hence, serologic immunoassay results should be interpreted with caution in COVID-19 patients.
MeSH term(s)	Antibodies, Viral ; COVID-19/diagnosis ; Herpes Simplex/diagnosis ; Humans ; Immunoassay/methods ; Immunoglobulin G ; Immunoglobulin M ; Pneumonia, Viral/diagnosis ; SARS-CoV-2 ; Sensitivity and Specificity
Chemical Substances	Antibodies, Viral ; Immunoglobulin G ; Immunoglobulin M
Language	English
Publishing date	2022-01-31
Publishing country	United States
Document type	Journal Article
ZDB-ID	604920-5
ISSN	1879-0070 ; 0732-8893
ISSN (online)	1879-0070
ISSN	0732-8893
DOI	10.1016/j.diagmicrobio.2022.115653
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Article ; Online: Systemic lupus erythematosus presenting as non-resolving pneumonia: a case report.

Stappers, Sofie / van der Graaff, Denise / Hoffman, Ilse / Moorkens, Walter / Hantson, Inge / Stappaerts, Inge / Nowé, Vicky / Vervliet, Liesbeth

Acta clinica Belgica

2021 Volume 77, Issue 3, Page(s) 616–623

Abstract: BackgroundSystemic lupus erythematosus (SLE) is a rheumatological disorder with a heterogeneous clinical presentation and disease course. Case presentationWe report a case concerning a young woman with pleuropneumonia, non-responsive to conventional ... ...

Abstract	BackgroundSystemic lupus erythematosus (SLE) is a rheumatological disorder with a heterogeneous clinical presentation and disease course. Case presentationWe report a case concerning a young woman with pleuropneumonia, non-responsive to conventional antibiotic therapy, who was, upon further inquiry and passage of time, diagnosed with SLE. Key pointsBy means of this case, we would like to emphasize the clinical implications and prognostic significance of lymphopenia in patients with SLE. Moreover, we attempt to make the reader aware of some of the protean manifestations of SLE and we would like to raise suspicion of acute lupus pneumonitis by demonstrating a case of a young female with non-resolving pneumonia.
MeSH term(s)	Anti-Bacterial Agents/therapeutic use ; Female ; Humans ; Lupus Erythematosus, Systemic/complications ; Lupus Erythematosus, Systemic/diagnosis ; Pneumonia/diagnosis ; Pneumonia/etiology
Chemical Substances	Anti-Bacterial Agents
Language	English
Publishing date	2021-05-22
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	390201-8
ISSN	2295-3337 ; 0001-5512 ; 1784-3286
ISSN (online)	2295-3337
ISSN	0001-5512 ; 1784-3286
DOI	10.1080/17843286.2021.1925817
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Article ; Online: Outbreak of Silicosis in Workers Producing Artificial Stone Skirting Boards: A Novel Application of Silica-Based Composites.

Ronsmans, Steven / Goeminne, Pieter / Jerjir, Naïm / Nowé, Vicky / Vandebroek, Eline / Keirsbilck, Stephan / Weynand, Birgit / Hoet, Peter H M / Vanoirbeek, Jeroen A J / Wuyts, Wim A / Yserbyt, Jonas / Nemery, Benoit

Chest

2022 Volume 162, Issue 2, Page(s) 406–409

MeSH term(s)	Disease Outbreaks ; Dust ; Humans ; Occupational Exposure/adverse effects ; Silicon Dioxide ; Silicosis/epidemiology
Chemical Substances	Dust ; Silicon Dioxide (7631-86-9)
Language	English
Publishing date	2022-04-02
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1032552-9
ISSN	1931-3543 ; 0012-3692
ISSN (online)	1931-3543
ISSN	0012-3692
DOI	10.1016/j.chest.2022.03.039
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Article ; Online: Outbreak of silicosis in workers producing silica-based artificial kerbstones

Steven Ronsmans / Pieter Goeminne / Vicky Nowé / Eline Vandebroek / Stephan Keirsbilck / Birgit Weynand / Peter HM. Hoet / Jeroen AJ. Vanoirbeek / Wim A. Wuyts / Jonas Yserbyt / Benoit Nemery

Safety and Health at Work, Vol 13, Iss , Pp S255- (2022)

2022

Keywords	Public aspects of medicine ; RA1-1270
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
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Article ; Online: The short-term effects of ORKAMBI (lumacaftor/ivacaftor) on regional and distal lung structures using functional respiratory imaging.

Lauwers, Eline / Belmans, Dennis / Mignot, Benjamin / Ides, Kris / Van Hoorenbeeck, Kim / Snoeckx, Annemiek / Van Holsbeke, Cedric / Nowé, Vicky / Van Braeckel, Eva / De Backer, Wilfried / De Backer, Jan / Verhulst, Stijn

Therapeutic advances in respiratory disease

2021 Volume 15, Page(s) 17534666211046774

Abstract: Background: Lumacaftor/ivacaftor (LUM/IVA) has shown modest benefits in previous research, but the exact effects in the cystic fibrosis (CF) lung remain unclear. This study aims to offer novel information on the mode of action of the cystic fibrosis ... ...

Abstract	Background: Lumacaftor/ivacaftor (LUM/IVA) has shown modest benefits in previous research, but the exact effects in the cystic fibrosis (CF) lung remain unclear. This study aims to offer novel information on the mode of action of the cystic fibrosis transmembrane conductance regulator (CFTR)-modulating drug by assessing lung structure and function using functional respiratory imaging (FRI). Methods: CF patients aged ⩾12 years homozygous for Results: Of the 12 patients enrolled in the study, 11 completed all study visits. Concerning the FRI parameters, hyperinflation of the lung decreased, indicated by a reduction in air trapping and lobar volume at expiration. Also, a decrease in airway wall volume and a redistribution of pulmonary blood volume were noted, which might be related to a decrease in mucus impaction. Airway resistance, airway volume, internal airflow distribution and aerosol deposition pattern did not show significant changes. No significant improvements were found in any of the CF-CT scores or in the spirometric parameters. Other secondary outcomes showed similar results compared with previous research. Correlations at baseline were found between FRI and conventional outcomes, including physical functioning, spirometry and CF-CT scores. Conclusions: LUM/IVA decreased lung hyperinflation in combination with a potential decrease in mucus impaction, which can be related to an improved mucociliary transport. These results indicate that several FRI parameters, reflecting regional and distal lung structures, are more sensitive to changes caused by LUM/IVA than conventional respiratory outcomes.
MeSH term(s)	Adolescent ; Adult ; Aminophenols/therapeutic use ; Aminopyridines/therapeutic use ; Benzodioxoles/therapeutic use ; Child ; Cystic Fibrosis/diagnostic imaging ; Cystic Fibrosis/drug therapy ; Cystic Fibrosis/physiopathology ; Drug Combinations ; Humans ; Quinolones/therapeutic use ; Treatment Outcome
Chemical Substances	Aminophenols ; Aminopyridines ; Benzodioxoles ; Drug Combinations ; Quinolones ; lumacaftor, ivacaftor drug combination
Language	English
Publishing date	2021-09-20
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2476459-0
ISSN	1753-4666 ; 1753-4658
ISSN (online)	1753-4666
ISSN	1753-4658
DOI	10.1177/17534666211046774
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Zs.A 6753: Show issues

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Article ; Online: Pulsatile tinnitus and the intrameatal vascular loop: why do we not hear our carotids?

De Ridder, Dirk / De Ridder, Leo / Nowé, Vicky / Thierens, Hubert / Van de Heyning, Paul / Møller, Aage

Neurosurgery

2005 Volume 57, Issue 6, Page(s) 1213–7; discussion 1213–7

Abstract: Objective: Pulsatile tinnitus is characterized by hearing the heart beat or respiration in one or both ears. In 15% of patients with pulsatile tinnitus, no cause can be found. Other investigators have suggested that a vascular loop entering the internal ...

Abstract	Objective: Pulsatile tinnitus is characterized by hearing the heart beat or respiration in one or both ears. In 15% of patients with pulsatile tinnitus, no cause can be found. Other investigators have suggested that a vascular loop entering the internal auditory meatus can be another cause of arterial, pulse synchronous tinnitus. If so, we should constantly hear the arterial pulsations of the carotid arteries passing through the petrous bone. Methods: Using magnetic resonance imaging, 17 patients with unilateral pulsatile tinnitus and 46 with non-pulsatile tinnitus were analyzed for the presence of a vascular loop entering into the internal acoustic meatus. Four temporal bones were sectioned to find structural differences between the internal acoustic meatus and the pericarotid area. Four patients with intrameatal vascular loops and ipsilateral pulsatile tinnitus underwent surgery by Teflon interpositioning between the loop and the cochlea. Results: In unilateral pulsatile tinnitus, a statistically highly significant amount of intrameatal vascular loops was noted in comparison to non-pulsatile tinnitus. A well-developed pericarotid venous plexus was found histologically. Three of the four patients who underwent surgery were initially tinnitus free, but pulsations recurred after 3 months in one patient. Conclusion: Vascular loops in the internal auditory canal may generate pulsatile tinnitus. It may be treated by placing Teflon between the cochlea and the intrameatal vascular loop. One then does not hear the pulsation of the carotids due to a dampening effect of a pericarotid venous plexus.
MeSH term(s)	Adolescent ; Adult ; Aged ; Aged, 80 and over ; Arteries/physiopathology ; Carotid Arteries/pathology ; Carotid Arteries/physiopathology ; Case-Control Studies ; Ear, Inner/blood supply ; Ear, Inner/pathology ; Ear, Inner/surgery ; Female ; Humans ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Petrous Bone/blood supply ; Polytetrafluoroethylene ; Prostheses and Implants ; Recurrence ; Temporal Bone/pathology ; Tinnitus/diagnosis ; Tinnitus/physiopathology ; Tinnitus/surgery ; Treatment Outcome ; Veins/pathology
Chemical Substances	Polytetrafluoroethylene (9002-84-0)
Language	English
Publishing date	2005-10-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	135446-2
ISSN	1524-4040 ; 0148-396X
ISSN (online)	1524-4040
ISSN	0148-396X
DOI	10.1227/01.neu.0000186035.73828.34
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Zs.A 1424: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article: The interutricular distance determined from external landmarks.

Nowé, Vicky / Wuyts, Floris L / Hoppenbrouwers, Mieke / Van de Heyning, Paul H / De Schepper, Arthur M / Parizel, Paul M

Journal of vestibular research : equilibrium & orientation

2003 Volume 13, Issue 1, Page(s) 17–23

Abstract: Knowledge of the exact distance between the utricles is important in new vestibular tests, such as the unilateral centrifugation (UC) test for the unilateral examination of the utricles. During this test, subjects are rotated at constant velocity and ... ...

Abstract	Knowledge of the exact distance between the utricles is important in new vestibular tests, such as the unilateral centrifugation (UC) test for the unilateral examination of the utricles. During this test, subjects are rotated at constant velocity and simultaneously laterally displaced along an interaural axis so that one labyrinth becomes aligned with the axis of rotation. When the axis of rotation crosses precisely through one labyrinth, only the opposite labyrinth is stimulated. To achieve this setup, precise knowledge of the interutricular distance is needed. The purpose of this study is to investigate the correlation between the interutricular distance (IUD), measured on T2-weighted magnetic resonance images, and specific external measures of head dimensions such as distance nasion-inion, intermastoid distance (IMD), distances between the temporomandibular joints and between the lateral margins of the orbits. Data have been collected in a series of 50 subjects (25 men and 25 women). On MR images we found a mean IUD of 7.22 cm (SD = 0.42 cm). There was a strong correlation between the IUD measured on MR images and the intermastoid distance. A linear combination of the IMD, nasion-inion distance and height of the subjects could predict the IUD very satisfactory (R = 0.85, adjusted R2=0.723). We also determined a measure of eccentricity of the vestibular labyrinths. The 95% prediction interval for the asymmetry appeared to be less than 4.3%.
MeSH term(s)	Adolescent ; Adult ; Aged ; Aged, 80 and over ; Echo-Planar Imaging ; Female ; Head/anatomy & histology ; Humans ; Male ; Mastoid/anatomy & histology ; Middle Aged ; Predictive Value of Tests ; Saccule and Utricle/anatomy & histology ; Vestibule, Labyrinth/anatomy & histology
Language	English
Publishing date	2003
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1051840-x
ISSN	1878-6464 ; 0957-4271
ISSN (online)	1878-6464
ISSN	0957-4271
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Article: Functional anatomy of the human cochlear nerve and its role in microvascular decompressions for tinnitus.

De Ridder, Dirk / Ryu, Hiroshi / Møller, Aage R / Nowé, Vicky / Van de Heyning, Paul / Verlooy, Jan

Neurosurgery

2003 Volume 54, Issue 2, Page(s) 381–8; discussion 388–90

Abstract: Objective: The functional anatomy (i.e., tonotopy) of the human cochlear nerve is unknown. A better understanding of the tonotopy of the central nervous system segment of the cochlear nerve and of the pathophysiology of tinnitus might help to ameliorate ...

Abstract	Objective: The functional anatomy (i.e., tonotopy) of the human cochlear nerve is unknown. A better understanding of the tonotopy of the central nervous system segment of the cochlear nerve and of the pathophysiology of tinnitus might help to ameliorate the disappointing results obtained with microvascular decompressions in patients with tinnitus. Methods: We assume that vascular compression of the cochlear nerve can induce a frequency-specific form of hearing loss and that when the nerve is successfully decompressed, this hearing loss can recuperate. Thirty-one patients underwent a microvascular decompression of the vestibulocochlear nerve for vertigo or tinnitus. Preoperative audiograms were subtracted from postoperative audiograms, regardless of the surgical result with regard to the tinnitus and vertigo, because the hearing improvement could be the only sign of the vascular compression. The frequency of maximal improvement was then correlated to the site of vascular compression. A tonotopy of the cochlear nerve was thus obtained. Results: A total of 18 correlations can be made between the site of compression and postoperative maximal hearing improvement frequency when 5-dB hearing improvement is used as threshold, 13 when 10-dB improvement is used as threshold. A clear distribution can be seen, with clustering of low frequencies at the posterior and inferior side of the cochlear nerve, close to the brainstem, and close to the root exit zone of the facial nerve. High frequencies are distributed closer to the internal acoustic meatus and more superiorly along the posterior aspect of the cochlear nerve. Conclusion: The tonotopic organization of the cisternal segment of the cochlear nerve has an oblique rotatory structure as a result of the rotatory course of the cochlear nerve in the posterior fossa. Knowledge of this tonotopic organization of the auditory nerve in its cisternal course might benefit surgeons who perform microvascular decompression operations for the vestibulocochlear compression syndrome, especially in the treatment of unilateral severe tinnitus.
MeSH term(s)	Adult ; Aged ; Cochlear Nerve/blood supply ; Cochlear Nerve/pathology ; Cochlear Nerve/physiopathology ; Decompression, Surgical ; Female ; Humans ; Male ; Microcirculation/surgery ; Middle Aged ; Nerve Compression Syndromes/pathology ; Nerve Compression Syndromes/physiopathology ; Nerve Compression Syndromes/surgery ; Retrospective Studies ; Tinnitus/pathology ; Tinnitus/physiopathology ; Tinnitus/surgery ; Treatment Outcome
Language	English
Publishing date	2003-07-11
Publishing country	United States
Document type	Journal Article
ZDB-ID	135446-2
ISSN	1524-4040 ; 0148-396X
ISSN (online)	1524-4040
ISSN	0148-396X
DOI	10.1227/01.neu.0000103420.53487.79
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Article: High-resolution virtual MR endoscopy of the cerebellopontine angle.

Nowé, Vicky / Michiels, Johan L P / Salgado, Rodrigo / De Ridder, Dirk / Van de Heyning, Paul H / De Schepper, Arthur M / Parizel, Paul M

AJR. American journal of roentgenology

2004 Volume 182, Issue 2, Page(s) 379–384

MeSH term(s)	Cerebellopontine Angle/anatomy & histology ; Humans ; Image Enhancement ; Imaging, Three-Dimensional ; Magnetic Resonance Imaging ; Neuroendoscopy ; Neurosurgical Procedures ; Preoperative Care ; Reference Values ; User-Computer Interface
Language	English
Publishing date	2004-02
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	82076-3
ISSN	1546-3141 ; 0361-803X ; 0092-5381
ISSN (online)	1546-3141
ISSN	0361-803X ; 0092-5381
DOI	10.2214/ajr.182.2.1820379
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