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  1. Article ; Online: The potential of electronic nose technology in lung transplantation

    Nynke Wijbenga / Rogier A.S. Hoek / Bas J. Mathot / Leonard Seghers / Joachim G.J.V. Aerts / Olivier C. Manintveld / Merel E. Hellemons

    ERJ Open Research, Vol 8, Iss

    a proof of principle

    2022  Volume 3

    Keywords Medicine ; R
    Language English
    Publishing date 2022-07-01T00:00:00Z
    Publisher European Respiratory Society
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: A Lung Cancer Patient with Dyspnea

    Pruis, Melinda A. / Hussain, Burhan / Bakker, Marleen / Hoek, Rogier A.S. / Miedema, Jelle R. / Dingemans, Anne-Marie C. / Paats, Marthe S.

    Cancer Cell

    Diagnostic Difficulties during the COVID-19 Pandemic

    2020  Volume 38, Issue 5, Page(s) 611–612

    Keywords Cell Biology ; Cancer Research ; Oncology ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ZDB-ID 2078448-X
    ISSN 1878-3686 ; 1535-6108
    ISSN (online) 1878-3686
    ISSN 1535-6108
    DOI 10.1016/j.ccell.2020.10.005
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  3. Article ; Online: High torque tenovirus (TTV) load before first vaccine dose is associated with poor serological response to COVID-19 vaccination in lung transplant recipients.

    Hoek, Rogier As / Verschuuren, Erik Am / de Vries, Rory D / Vonk, Judith M / van Baarle, Debbie / van der Heiden, Marieke / van Gemert, Johanna P / Gore, Edmund J / Niesters, Hubert Gm / Erasmus, Michiel / Hellemons, Merel E / Scherbeijn, Sandra Mj / Wijbenga, Nynke / Mahtab, Edris A F / GeurtsvanKessel, Corine H / Buter, Coretta Van Leer

    The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation

    2022  Volume 41, Issue 6, Page(s) 765–772

    Abstract: Background: Serological responses to COVID-19 vaccination are diminished in recipients of solid organ transplants, especially in lung transplant recipients (LTR), probably as result of immunosuppressive treatment. There is currently no marker of ... ...

    Abstract Background: Serological responses to COVID-19 vaccination are diminished in recipients of solid organ transplants, especially in lung transplant recipients (LTR), probably as result of immunosuppressive treatment. There is currently no marker of immunosuppression that can be used to predict the COVID-19 vaccination response. Here, we study whether torque tenovirus (TTV), a highly prevalent virus can be used as an indicator of immunosuppression.
    Methods: The humoral response to the mRNA 1273 vaccine was assessed in 103 LTR, who received a transplant between 4 and 237 months prior to vaccination, by measuring Spike (S)-specific IgG levels at baseline, 28 days after first, and 28 days after the second vaccination. TTV loads were determined by RT-PCR and Pearson's correlation coefficient was calculated to correlate serological responses to TTV load.
    Results: Humoral responses to COVID-19 vaccination were observed in 41 of 103 (40%) LTR at 28 days after the second vaccination. Sixty-two of 103 (60%) were non-responders. Lower TTV loads at baseline (significantly) correlated with higher S-specific antibodies and a higher percentage of responders. Lower TTV loads also strongly correlated with longer time since transplantation, indicating that participants with lower TTV loads were longer after transplantation.
    Conclusions: This study shows a better humoral response to the SARS-CoV-2 vaccine in subjects with a lower TTV load pre-vaccination. In addition, TTV load correlates with the time after transplantation. Further studies on the use of TTV load in vaccination efficacy studies in immunocompromised cohorts should provide leads for the potential use of this marker for optimizing vaccination response.
    MeSH term(s) 2019-nCoV Vaccine mRNA-1273 ; COVID-19/prevention & control ; COVID-19 Vaccines ; Humans ; Lung ; SARS-CoV-2 ; Torque ; Torque teno virus/genetics ; Transplant Recipients ; Vaccination
    Chemical Substances COVID-19 Vaccines ; 2019-nCoV Vaccine mRNA-1273 (EPK39PL4R4)
    Language English
    Publishing date 2022-03-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1062522-7
    ISSN 1557-3117 ; 1053-2498
    ISSN (online) 1557-3117
    ISSN 1053-2498
    DOI 10.1016/j.healun.2022.03.006
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  4. Article ; Online: BNT162b2 mRNA Covid-19 Vaccine in a Nationwide Mass Vaccination Setting.

    Roest, Stefan / Hoek, Rogier A S / Manintveld, Olivier C

    The New England journal of medicine

    2021  Volume 384, Issue 20, Page(s) 1968–1970

    MeSH term(s) COVID-19 ; COVID-19 Vaccines ; Humans ; Mass Vaccination ; RNA, Messenger ; SARS-CoV-2
    Chemical Substances COVID-19 Vaccines ; RNA, Messenger ; BNT162 vaccine (N38TVC63NU)
    Language English
    Publishing date 2021-04-21
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMc2104281
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  5. Article ; Online: Severe COPD: Multidisciplinary Consultation to Get the Right Care at the Right Place.

    Hekking, Pieter-Paul / van Meggelen, Monique / Lie, W Johan / Hoek, Rogier Arnaud Sebastiaan / van Ranst, Dirk / van der Kleij, Stephan Cornelis Johan / Seghers, Leonard / Kappen, Jasper / Braunstahl, Gert-Jan / In 't Veen, Johannes

    International journal of chronic obstructive pulmonary disease

    2024  Volume 19, Page(s) 749–752

    MeSH term(s) Humans ; Pulmonary Disease, Chronic Obstructive/diagnosis ; Pulmonary Disease, Chronic Obstructive/therapy ; Referral and Consultation
    Language English
    Publishing date 2024-03-14
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 2212419-6
    ISSN 1178-2005 ; 1176-9106
    ISSN (online) 1178-2005
    ISSN 1176-9106
    DOI 10.2147/COPD.S434011
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  6. Article ; Online: Clinical characteristics and outcome of immunocompromised patients with COVID-19 caused by the Omicron variant: a prospective observational study

    Malahe, S. Reshwan K. / Hoek, Rogier A.S. / Dalm, Virgil A.S.H. / Broers, Annoek E.C. / den Hoed, Caroline M. / Manintveld, Olivier C. / Baan, Carla C. / van Deuzen, Charlotte M. / Papageorgiou, Grigorios / Bax, Hannelore I. / van Kampen, Jeroen J. / Hellemons, Merel E. / Kho, Marcia M.L. / de Vries, Rory D. / Molenkamp, Richard / Reinders, Marlies E.J. / Rijnders, Bart J.A.

    medRxiv

    Abstract: Summary Background In the general population, illness after infection with the SARS-CoV-2 Omicron variant is less severe compared with previous variants. Data on the disease burden of Omicron in immunocompromised patients are lacking. We investigated the ...

    Abstract Summary Background In the general population, illness after infection with the SARS-CoV-2 Omicron variant is less severe compared with previous variants. Data on the disease burden of Omicron in immunocompromised patients are lacking. We investigated the clinical characteristics and outcome of a cohort of immunocompromised patients with COVID-19 caused by Omicron. Methods Solid organ transplant recipients, patients on anti-CD20 therapy, and allogenic hematopoietic stem cell transplantation recipients on immunosuppressive therapy infected with the Omicron variant, were included. Patients were contacted regularly until symptom resolution. Clinical characteristics of consenting patients were collected through their electronic patient files. To identify possible risk factors for hospitalization, a univariate logistic analysis was performed. Findings A total of 114 consecutive immunocompromised patients(88% after a solid organ transplant) were enrolled. Eighty-nine percent had previously received three mRNA vaccinations. While only one patient died, 23(20%) required hospital admission for a median of 11 days. A low SARS-CoV-2 IgG antibody response(<300 BAU/mL) at diagnosis, higher age, being a lung transplant recipient, more comorbidities and a higher frailty were associated with hospital admission(all p<0.01). At the end of follow-up, 25% had still not fully recovered. Of the 23 hospitalized patients, 70% had a negative and 92% a low IgG (<300 BAU/mL) antibody response at admission. Sotrovimab was administered to 17 of them, of which one died. Interpretation While the mortality in immunocompromised patients infected with Omicron was low, hospital admission was frequent and the duration of symptoms often prolonged. Besides vaccination, other interventions are needed to limit the morbidity from COVID-19 in immunocompromised patients. Funding None.
    Keywords covid19
    Language English
    Publishing date 2022-04-27
    Publisher Cold Spring Harbor Laboratory Press
    Document type Article ; Online
    DOI 10.1101/2022.04.25.22273197
    Database COVID19

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  7. Article: The potential of electronic nose technology in lung transplantation: a proof of principle.

    Wijbenga, Nynke / Hoek, Rogier A S / Mathot, Bas J / Seghers, Leonard / Aerts, Joachim G J V / Manintveld, Olivier C / Hellemons, Merel E

    ERJ open research

    2022  Volume 8, Issue 3

    Abstract: Exhaled breath analysis using eNose technology holds promise as a point-of-care indicator of clinical status after lung transplantation. This case study invites further exploration of eNose technology in the field of lung transplantation. ...

    Abstract Exhaled breath analysis using eNose technology holds promise as a point-of-care indicator of clinical status after lung transplantation. This case study invites further exploration of eNose technology in the field of lung transplantation.
    Language English
    Publishing date 2022-07-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 2827830-6
    ISSN 2312-0541
    ISSN 2312-0541
    DOI 10.1183/23120541.00048-2022
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  8. Article: Insights from the European Respiratory Society 2018 Annual International Congress in the fields of thoracic surgery and lung transplantation.

    Hoek, Rogier A S / Gaitanakis, Stelios / Hellemons, Merel E

    Journal of thoracic disease

    2018  Volume 10, Issue Suppl 25, Page(s) S3005–S3009

    Language English
    Publishing date 2018-10-04
    Publishing country China
    Document type Editorial
    ZDB-ID 2573571-8
    ISSN 2077-6624 ; 2072-1439
    ISSN (online) 2077-6624
    ISSN 2072-1439
    DOI 10.21037/jtd.2018.09.08
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  9. Article: Aspergillus

    Yusuf, Erlangga / Seghers, Leonard / Hoek, Rogier A S / van den Akker, Johannes P C / Bode, Lonneke G M / Rijnders, Bart J A

    Journal of clinical medicine

    2021  Volume 10, Issue 11

    Abstract: Several reports have been published ... ...

    Abstract Several reports have been published on
    Language English
    Publishing date 2021-06-02
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm10112469
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  10. Article ; Online: Pneumomediastinum Due to Traumatic Rectal Perforation.

    Bots, Eva M T / Hoek, Rogier A S

    American journal of respiratory and critical care medicine

    2019  Volume 201, Issue 5, Page(s) e15–e16

    MeSH term(s) Adult ; Fractures, Bone/complications ; Humans ; Intestinal Perforation/complications ; Intestinal Perforation/diagnosis ; Intestinal Perforation/surgery ; Male ; Mediastinal Emphysema/diagnostic imaging ; Mediastinal Emphysema/etiology ; Pelvic Bones/injuries ; Rectal Diseases/complications ; Rectal Diseases/diagnosis ; Rectal Diseases/surgery ; Rectum/injuries ; Subcutaneous Emphysema/diagnostic imaging ; Subcutaneous Emphysema/etiology ; Wounds, Penetrating/complications
    Language English
    Publishing date 2019-09-26
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.201902-0276IM
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