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Article ; Online: The component of the m

Miranda-Gonçalves, Vera / Lobo, João / Guimarães-Teixeira, Catarina / Barros-Silva, Daniela / Guimarães, Rita / Cantante, Mariana / Braga, Isaac / Maurício, Joaquina / Oing, Christoph / Honecker, Friedemann / Nettersheim, Daniel / Looijenga, Leendert H J / Henrique, Rui / Jerónimo, Carmen

Journal of experimental & clinical cancer research : CR

2021 Volume 40, Issue 1, Page(s) 268

Abstract: ... to investigate the role of N6-methyladenosine (m: Methods: Four cell lines representative of GCTs (three ... its phenotypic effect in vivo.: Results: We demonstrated the differential expression of the various m ... target elements of the m ...

Abstract	Background: Germ cell tumors (GCTs) are developmental cancers, tightly linked to embryogenesis and germ cell development. The recent and expanding field of RNA modifications is being increasingly implicated in such molecular events, as well as in tumor progression and resistance to therapy, but still rarely explored in GCTs. In this work, and as a follow-up of our recent study on this topic in TGCT tissue samples, we aim to investigate the role of N6-methyladenosine (m Methods: Four cell lines representative of GCTs (three testicular and one mediastinal), including an isogenic cisplatin resistant subline, were used. CRISPR/Cas9-mediated knockdown of VIRMA was established and the chorioallantoic membrane assay was used to study its phenotypic effect in vivo. Results: We demonstrated the differential expression of the various m Conclusions: VIRMA has an oncogenic role in GCTs confirming our previous tissue-based study and is further involved in response to cisplatin by interfering with DNA repair. These data contribute to our better understanding of the emergence of cisplatin resistance in GCTs and support recent attempts to therapeutically target elements of the m
MeSH term(s)	Adenosine/analogs & derivatives ; Adenosine/physiology ; Antineoplastic Agents/therapeutic use ; Cell Line, Tumor ; Cisplatin/therapeutic use ; DNA Damage ; Drug Resistance, Neoplasm/physiology ; Gene Knockdown Techniques ; Humans ; Male ; Methyltransferases/physiology ; Neoplasms, Germ Cell and Embryonal/drug therapy ; Neoplasms, Germ Cell and Embryonal/genetics ; Neoplasms, Germ Cell and Embryonal/pathology ; RNA-Binding Proteins/genetics ; RNA-Binding Proteins/physiology
Chemical Substances	Antineoplastic Agents ; RNA-Binding Proteins ; VIRMA protein, human ; N-methyladenosine (CLE6G00625) ; Methyltransferases (EC 2.1.1.-) ; METTL3 protein, human (EC 2.1.1.62) ; Adenosine (K72T3FS567) ; Cisplatin (Q20Q21Q62J)
Language	English
Publishing date	2021-08-25
Publishing country	England
Document type	Journal Article
ZDB-ID	803138-1
ISSN	1756-9966 ; 0392-9078
ISSN (online)	1756-9966
ISSN	0392-9078
DOI	10.1186/s13046-021-02072-9
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Article ; Online: m

Lobo, João / Costa, Ana Laura / Cantante, Mariana / Guimarães, Rita / Lopes, Paula / Antunes, Luís / Braga, Isaac / Oliveira, Jorge / Pelizzola, Mattia / Henrique, Rui / Jerónimo, Carmen

Journal of translational medicine

2019 Volume 17, Issue 1, Page(s) 79

Abstract: Background: Covalent RNA modifications, such as N-6-methyladenosine (m: Methods: In silico ... as immunohistochemistry for VIRMA, YTHDF3 and m: Results: In our cohort, VIRMA and YTHDF3 mRNA expression levels ... m: Conclusion: Abundance of m ...

Abstract	Background: Covalent RNA modifications, such as N-6-methyladenosine (m Methods: In silico analysis of TCGA data disclosed altered expression of VIRMA (52%) and YTHDF3 (48%), prompting subsequent validation. Formalin-fixed paraffin-embedded tissues from 122 TGCTs (2005-2016) were selected. RNA extraction, cDNA synthesis and real-time qPCR (Taqman assays) for VIRMA and YTHDF3 were performed, as well as immunohistochemistry for VIRMA, YTHDF3 and m Results: In our cohort, VIRMA and YTHDF3 mRNA expression levels differed among TGCT subtypes, with Seminomas (SEs) depicting higher levels than Non-Seminomatous tumors (NSTs) (p < 0.01 for both). A positive correlation was found between VIRMA and YTHDF3 expression levels. VIRMA discriminated SEs from NSTs with AUC = 0.85 (Sensitivity 77.3%, Specificity 81.1%, PPV 71.6%, NPV 85.3%, Accuracy 79.7%). Immunohistochemistry paralleled transcript findings, as patients with strong m Conclusion: Abundance of m
MeSH term(s)	Adenosine/analogs & derivatives ; Adenosine/metabolism ; Adult ; Animals ; Cohort Studies ; Computer Simulation ; Gene Expression Regulation, Neoplastic ; Humans ; Male ; Mice ; Neoplasm Metastasis ; Neoplasms, Germ Cell and Embryonal/genetics ; Neoplasms, Germ Cell and Embryonal/pathology ; Phenotype ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; RNA-Binding Proteins/genetics ; RNA-Binding Proteins/metabolism ; Reproducibility of Results ; Seminoma/genetics ; Seminoma/pathology ; Testicular Neoplasms/genetics ; Testicular Neoplasms/pathology ; Young Adult
Chemical Substances	RNA, Messenger ; RNA-Binding Proteins ; VIRMA protein, human ; YTHDF3 protein, human ; N-methyladenosine (CLE6G00625) ; Adenosine (K72T3FS567)
Language	English
Publishing date	2019-03-12
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1479-5876
ISSN (online)	1479-5876
DOI	10.1186/s12967-019-1837-z
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Article ; Online: Impact of reducing lipid content during in vitro embryo production: A systematic review and meta-analysis.

Vasconcelos, Erlandia M / Braga, Rachel F / Leal, Gabriela R / Carvalho, Renner P R / Machado-Neves, Mariana / Sudano, Mateus J / Souza-Fabjan, Joanna M G

Theriogenology

2024 Volume 222, Page(s) 31–44

Abstract: There is still no consensus regarding the role of lipid modulators during in vitro embryo production. Thus, we investigated how lipid reducers during the in vitro maturation of oocytes (IVM) or in vitro culture (IVC) of embryos impact their cryotolerance. ...

Abstract	There is still no consensus regarding the role of lipid modulators during in vitro embryo production. Thus, we investigated how lipid reducers during the in vitro maturation of oocytes (IVM) or in vitro culture (IVC) of embryos impact their cryotolerance. A literature search was performed using three databases, recovering 43 articles for the systematic review, comprising 75 experiments (13 performed in IVM, 62 in IVC) and testing 13 substances. In 39 % of the experiments, an increase in oocyte and/or embryo survival after cryopreservation was reported, in contrast to 48 % exhibiting no effect, 5 % causing negative effects, and 8 % influencing in a dose-dependent manner. Of the 75 experiments extracted during IVM and IVC, 41 quantified the lipid content. Of those that reduced lipid content (n = 26), 50 % increased cryotolerance, 34 % had no effect, 8 % harmed oocyte/embryo survival, and 8 % had different results depending on the concentration used. Moreover, 28 out of the 43 studies were analyzed under a meta-analytical approach at the IVC stage in cattle. There was an improvement in the cryotolerance of bovine embryos when the lipid content was reduced. Forskolin, l-carnitine, and phenazine ethosulfate positively affected cryotolerance, while conjugated linoleic acid had no effect and impaired embryonic development. Moreover, fetal bovine serum has a positive impact on cryotolerance. SOF and CR1aa IVC media improved cryotolerance, while mSOF showed no effect. In conclusion, lipid modulators did not unanimously improve cryotolerance, especially when used in IVM, but presented positive effects on cryotolerance during IVC when reaching lipid reduction.
MeSH term(s)	Animals ; Cryopreservation/veterinary ; Cryopreservation/methods ; Embryo Culture Techniques/veterinary ; Lipids/chemistry ; In Vitro Oocyte Maturation Techniques/veterinary ; In Vitro Oocyte Maturation Techniques/methods ; Fertilization in Vitro/veterinary ; Cattle/embryology ; Lipid Metabolism ; Embryo, Mammalian/physiology
Chemical Substances	Lipids
Language	English
Publishing date	2024-04-09
Publishing country	United States
Document type	Journal Article ; Systematic Review ; Meta-Analysis
ZDB-ID	189232-0
ISSN	1879-3231 ; 0093-691X
ISSN (online)	1879-3231
ISSN	0093-691X
DOI	10.1016/j.theriogenology.2024.04.003
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 3929: Show issues

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Book ; Online: New Translational Insights on Metabolic Syndrome: Obesity, Hypertension, Diabetes and Beyond

Braga, Valdir A. / Balarini, Camille M.

2016

Abstract: Metabolic syndrome (MetS) can be considered as a clustering of several risk factors such as obesity, hypertension, insulin resistance and dyslipidemia, which could lead to the development of diabetes and cardiovascular diseases (CVD). There are several ... ...

Abstract	Metabolic syndrome (MetS) can be considered as a clustering of several risk factors such as obesity, hypertension, insulin resistance and dyslipidemia, which could lead to the development of diabetes and cardiovascular diseases (CVD). There are several underlying causes for MetS including overweight, physical inactivity and genetic factors. However, the underlying mechanisms that leads to MetS are still poorly understood. Therefore, the aim of this E-book is to provide a space where researchers holding different backgrounds could shed some light onto the pathophysiology of different risk factors involved in MetS, mostly from translational research worldwide
Keywords	Science (General) ; Physiology
Size	1 electronic resource (114 p.)
Publisher	Frontiers Media SA
Document type	Book ; Online
Note	English ; Open Access
HBZ-ID	HT020090644
ISBN	9782889199242 ; 288919924X
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article: Scintillation light detection in the 6-m drift-length ProtoDUNE Dual Phase liquid argon TPC.

Abud, A Abed / Abi, B / Acciarri, R / Acero, M A / Adames, M R / Adamov, G / Adamowski, M / Adams, D / Adinolfi, M / Aduszkiewicz, A / Aguilar, J / Ahmad, Z / Ahmed, J / Aimard, B / Ali-Mohammadzadeh, B / Alion, T / Allison, K / Monsalve, S Alonso / AlRashed, M /

Alt, C / Alton, A / Alvarez, R / Amedo, P / Anderson, J / Andreopoulos, C / Andreotti, M / Andrews, M / Andrianala, F / Andringa, S / Anfimov, N / Ankowski, A / Antoniassi, M / Antonova, M / Antoshkin, A / Antusch, S / Aranda-Fernandez, A / Arellano, L / Arnold, L O / Arroyave, M A / Asaadi, J / Asquith, L / Aurisano, A / Aushev, V / Autiero, D / Lara, V Ayala / Ayala-Torres, M / Azfar, F / Back, A / Back, H / Back, J J / Backhouse, C / Bagaturia, I / Bagby, L / Balashov, N / Balasubramanian, S / Baldi, P / Baller, B / Bambah, B / Barao, F / Barenboim, G / Alzas, P Barham / Barker, G / Barkhouse, W / Barnes, C / Barr, G / Monarca, J Barranco / Barros, A / Barros, N / Barrow, J L / Basharina-Freshville, A / Bashyal, A / Basque, V / Batchelor, C / Chagas, E Batista das / Battat, J B R / Battisti, F / Bay, F / Bazetto, M C Q / Alba, J L L Bazo / Beacom, J F / Bechetoille, E / Behera, B / Beigbeder, C / Bellantoni, L / Bellettini, G / Bellini, V / Beltramello, O / Benekos, N / Montiel, C Benitez / Neves, F Bento / Berger, J / Berkman, S / Bernardini, P / Berner, R M / Bersani, A / Bertolucci, S / Betancourt, M / Rodríguez, A Betancur / Bevan, A / Bezawada, Y / Bezerra, T J C / Bhardwaj, A / Bhatnagar, V / Bhattacharjee, M / Bhattarai, D / Bhuller, S / Bhuyan, B / Biagi, S / Bian, J / Biassoni, M / Biery, K / Bilki, B / Bishai, M / Bitadze, A / Blake, A / Blaszczyk, F / Blazey, G C / Blucher, E / Boissevain, J / Bolognesi, S / Bolton, T / Bomben, L / Bonesini, M / Bongrand, M / Bonilla-Diaz, C / Bonini, F / Booth, A / Boran, F / Bordoni, S / Borkum, A / Bostan, N / Bour, P / Bourgeois, C / Boyden, D / Bracinik, J / Braga, D / Brailsford, D / Branca, A / Brandt, A / Bremer, J / Breton, D / Brew, C / Brice, S J / Brizzolari, C / Bromberg, C / Brooke, J / Bross, A / Brunetti, G / Brunetti, M / Buchanan, N / Budd, H / Butorov, I / Cagnoli, I / Cai, T / Caiulo, D / Calabrese, R / Calafiura, P / Calcutt, J / Calin, M / Calvez, S / Calvo, E / Caminata, A / Campanelli, M / Caratelli, D / Carber, D / Carceller, J C / Carini, G / Carlus, B / Carneiro, M F / Carniti, P / Terrazas, I Caro / Carranza, H / Carroll, T / Forero, J F Castaño / Castillo, A / Castromonte, C / Catano-Mur, E / Cattadori, C / Cavalier, F / Cavallaro, G / Cavanna, F / Centro, S / Cerati, G / Cervelli, A / Villanueva, A Cervera / Chalifour, M / Chappell, A / Chardonnet, E / Charitonidis, N / Chatterjee, A / Chattopadhyay, S / Neyra, M S S Chavarry / Chen, H / Chen, M / Chen, Y / Chen, Z / Chen-Wishart, Z / Cheon, Y / Cherdack, D / Chi, C / Childress, S / Chirco, R / Chiriacescu, A / Chisnall, G / Cho, K / Choate, S / Chokheli, D / Chong, P S / Christensen, A / Christian, D / Christodoulou, G / Chukanov, A / Chung, M / Church, E / Cicero, V / Clarke, P / Cline, G / Coan, T E / Cocco, A G / Coelho, J A B / Colton, N / Conley, E / Conley, R / Conrad, J / Convery, M / Copello, S / Cova, P / Cremaldi, L / Cremonesi, L / Crespo-Anadón, J I / Crisler, M / Cristaldo, E / Crnkovic, J / Cross, R / Cudd, A / Cuesta, C / Cui, Y / Cussans, D / Dalager, O / da Motta, H / Da Silva Peres, L / David, C / David, Q / Davies, G S / Davini, S / Dawson, J / De, K / De, S / Debbins, P / De Bonis, I / Decowski, M P / De Gouvêa, A / De Holanda, P C / De Icaza Astiz, I L / Deisting, A / De Jong, P / Delbart, A / Delepine, D / Delgado, M / Dell'Acqua, A / Delmonte, N / De Lurgio, P / de Mello Neto, J R T / DeMuth, D M / Dennis, S / Densham, C / Deptuch, G W / De Roeck, A / De Romeri, V / De Souza, G / Devi, R / Dharmapalan, R / Dias, M / Diaz, F / Díaz, J S / Domizio, S Di / Giulio, L Di / Ding, P / Noto, L Di / Dirkx, G / Distefano, C / Diurba, R / Diwan, M / Djurcic, Z / Doering, D / Dolan, S / Dolek, F / Dolinski, M / Domine, L / Donon, Y / Douglas, D / Douillet, D / Dragone, A / Drake, G / Drielsma, F / Duarte, L / Duchesneau, D / Duffy, K / Dunne, P / Dutta, B / Duyang, H / Dvornikov, O / Dwyer, D / Dyshkant, A / Eads, M / Earle, A / Edmunds, D / Eisch, J / Emberger, L / Emery, S / Englezos, P / Ereditato, A / Erjavec, T / Escobar, C / Eurin, G / Evans, J J / Ewart, E / Ezeribe, A C / Fahey, K / Falcone, A / Fani', M / Farnese, C / Farzan, Y / Fedoseev, D / Felix, J / Feng, Y / Fernandez-Martinez, E / Menendez, P Fernandez / Morales, M Fernandez / Ferraro, F / Fields, L / Filip, P / Filthaut, F / Fiorini, M / Fischer, V / Fitzpatrick, R S / Flanagan, W / Fleming, B / Flight, R / Fogarty, S / Foreman, W / Fowler, J / Fox, W / Franc, J / Francis, K / Franco, D / Freeman, J / Freestone, J / Fried, J / Friedland, A / Robayo, F Fuentes / Fuess, S / Furic, I K / Furman, K / Furmanski, A P / Gabrielli, A / Gago, A / Gallagher, H / Gallas, A / Gallego-Ros, A / Gallice, N / Galymov, V / Gamberini, E / Gamble, T / Ganacim, F / Gandhi, R / Gandrajula, R / Gao, F / Gao, S / Garcia-Gamez, D / García-Peris, M Á / Gardiner, S / Gastler, D / Gauvreau, J / Ge, G / Geffroy, N / Gelli, B / Gendotti, A / Gent, S / Ghorbani-Moghaddam, Z / Giammaria, P / Giammaria, T / Giangiacomi, N / Gibin, D / Gil-Botella, I / Gilligan, S / Girerd, C / Giri, A K / Gnani, D / Gogota, O / Gold, M / Gollapinni, S / Gollwitzer, K / Gomes, R A / Bermeo, L V Gomez / Fajardo, L S Gomez / Gonnella, F / Gonzalez-Diaz, D / Gonzalez-Lopez, M / Goodman, M C / Goodwin, O / Goswami, S / Gotti, C / Goudzovski, E / Grace, C / Gran, R / Granados, E / Granger, P / Grant, A / Grant, C / Gratieri, D / Green, P / Greenler, L / Greer, J / Grenard, J / Griffith, W C / Groh, M / Grudzinski, J / Grzelak, K / Gu, W / Guardincerri, E / Guarino, V / Guarise, M / Guenette, R / Guerard, E / Guerzoni, M / Guffanti, D / Guglielmi, A / Guo, B / Gupta, A / Gupta, V / Guthikonda, K K / Gutierrez, R / Guzowski, P / Guzzo, M M / Gwon, S / Ha, C / Haaf, K / Habig, A / Hadavand, H / Haenni, R / Hahn, A / Haiston, J / Hamacher-Baumann, P / Hamernik, T / Hamilton, P / Han, J / Harris, D A / Hartnell, J / Hartnett, T / Harton, J / Hasegawa, T / Hasnip, C / Hatcher, R / Hatfield, K W / Hatzikoutelis, A / Hayes, C / Hayrapetyan, K / Hays, J / Hazen, E / He, M / Heavey, A / Heeger, K M / Heise, J / Henry, S / Morquecho, M A Hernandez / Herner, K / Hewes, J / Hilgenberg, C / Hill, T / Hillier, S J / Himmel, A / Hinkle, E / Hirsch, L R / Ho, J / Hoff, J / Holin, A / Hoppe, E / Horton-Smith, G A / Hostert, M / Hourlier, A / Howard, B / Howell, R / Hoyos, J / Hristova, I / Hronek, M S / Huang, J / Hulcher, Z / Iles, G / Ilic, N / Iliescu, A M / Illingworth, R / Ingratta, G / Ioannisian, A / Irwin, B / Isenhower, L / Itay, R / Jackson, C M / Jain, V / James, E / Jang, W / Jargowsky, B / Jediny, F / Jena, D / Jeong, Y S / Jesús-Valls, C / Ji, X / Jiang, L / Jiménez, S / Jipa, A / Johnson, R / Johnson, W / Johnston, N / Jones, B / Jones, S / Judah, M / Jung, C K / Junk, T / Jwa, Y / Kabirnezhad, M / Kaboth, A / Kadenko, I / Kakorin, I / Kalitkina, A / Kalra, D / Kamiya, F / Kaneshige, N / Kaplan, D M / Karagiorgi, G / Karaman, G / Karcher, A / Karolak, M / Karyotakis, Y / Kasai, S / Kasetti, S P / Kashur, L / Kazaryan, N / Kearns, E / Keener, P / Kelly, K J / Kemp, E / Kemularia, O / Ketchum, W / Kettell, S H / Khabibullin, M / Khotjantsev, A / Khvedelidze, A / Kim, D / King, B / Kirby, B / Kirby, M / Klein, J / Klustova, A / Kobilarcik, T / Koehler, K / Koerner, L W / Koh, D H / Kohn, S / Koller, P P / Kolupaeva, L / Korablev, D / Kordosky, M / Kosc, T / Kose, U / Kostelecký, V A / Kothekar, K / Kralik, R / Kreczko, L / Krennrich, F / Kreslo, I / Kropp, W / Kroupova, T / Kubota, S / Kudenko, Y / Kudryavtsev, V A / Kulagin, S / Kumar, J / Kumar, P / Kunze, P / Kurita, N / Kuruppu, C / Kus, V / Kutter, T / Kvasnicka, J / Kwak, D / Lambert, A / Land, B / Lane, C E / Lang, K / Langford, T / Langstaff, M / Larkin, J / Lasorak, P / Last, D / Laundrie, A / Laurenti, G / Lawrence, A / Lazanu, I / LaZur, R / Lazzaroni, M / Le, T / Leardini, S / Learned, J / LeBrun, P / LeCompte, T / Lee, C / Lee, S Y / Miotto, G Lehmann / Lehnert, R / de Oliveira, M A Leigui / Leitner, M / Lepin, L M / Li, S W / Li, Y / Liao, H / Lin, C S / Lin, Q / Lin, S / Lineros, R A / Ling, J / Lister, A / Littlejohn, B R / Liu, J / Liu, Y / Lockwitz, S / Loew, T / Lokajicek, M / Lomidze, I / Long, K / Lord, T / LoSecco, J M / Louis, W C / Lu, X-G / Luk, K B / Lunday, B / Luo, X / Luppi, E / Lux, T / Luzio, V P / Maalmi, J / MacFarlane, D / Machado, A A / Machado, P / Macias, C T / Macier, J R / Maddalena, A / Madera, A / Madigan, P / Magill, S / Mahn, K / Maio, A / Major, A / Maloney, J A / Mandrioli, G / Mandujano, R C / Maneira, J / Manenti, L / Manly, S / Mann, A / Manolopoulos, K / Plata, M Manrique / Manyam, V N / Manzanillas, L / Marchan, M / Marchionni, A / Marciano, W / Marfatia, D / Mariani, C / Maricic, J / Marie, R / Marinho, F / Marino, A D / Marsden, D / Marshak, M / Marshall, C / Marshall, J / Marteau, J / Martín-Albo, J / Martinez, N / Caicedo, D A Martinez / Miravé, P Martínez / Martynenko, S / Mascagna, V / Mason, K / Mastbaum, A / Matichard, F / Matsuno, S / Matthews, J / Mauger, C / Mauri, N / Mavrokoridis, K / Mawby, I / Mazza, R / Mazzacane, A / Mazzucato, E / McAskill, T / McCluskey, E / McConkey, N / McFarland, K S / McGrew, C / McNab, A / Mefodiev, A / Mehta, P / Melas, P / Mena, O / Mendez, H / Mendez, P / Méndez, D P / Menegolli, A / Meng, G / Messier, M D / Metcalf, W / Mettler, T / Mewes, M / Meyer, H / Miao, T / Michna, G / Miedema, T / Mikola, V / Milincic, R / Miller, G / Miller, W / Mills, J / Mineev, O / Minotti, A / Miranda, O G / Miryala, S / Mishra, C S / Mishra, S R / Mislivec, A / Mitchell, M / Mladenov, D / Mocioiu, I / Moffat, K / Moggi, N / Mohanta, R / Mohayai, T A / Mokhov, N / Molina, J / Bueno, L Molina / Montagna, E / Montanari, A / Montanari, C / Montanari, D / Zetina, L M Montañno / Moon, S H / Mooney, M / Moor, A F / Moreno, D / Moretti, D / Morris, C / Mossey, C / Mote, M / Motuk, E / Moura, C A / Mousseau, J / Mouster, G / Mu, W / Mualem, L / Mueller, J / Muether, M / Mufson, S / Muheim, F / Muir, A / Mulhearn, M / Munford, D / Muramatsu, H / Murphy, S / Musser, J / Nachtman, J / Nagu, S / Nalbandyan, M / Nandakumar, R / Naples, D / Narita, S / Nath, A / Navrer-Agasson, A / Nayak, N / Nebot-Guinot, M / Negishi, K / Nelson, J K / Nesbit, J / Nessi, M / Newbold, D / Newcomer, M / Newton, H / Nichol, R / Nicolas-Arnaldos, F / Nikolica, A / Niner, E / Nishimura, K / Norman, A / Norrick, A / Northrop, R / Novella, P / Nowak, J A / Oberling, M / Ochoa-Ricoux, J / Olivier, A / Olshevskiy, A / Onel, Y / Onishchuk, Y / Ott, J / Pagani, L / Palacio, G / Palamara, O / Palestini, S / Paley, J M / Pallavicini, M / Palomares, C / Vazquez, W Panduro / Pantic, E / Paolone, V / Papadimitriou, V / Papaleo, R / Papanestis, A / Paramesvaran, S / Parke, S / Parozzi, E / Parsa, Z / Parvu, M / Pascoli, S / Pasqualini, L / Pasternak, J / Pater, J / Patrick, C / Patrizii, L / Patterson, R B / Patton, S J / Patzak, T / Paudel, A / Paulos, B / Paulucci, L / Pavlovic, Z / Pawloski, G / Payne, D / Pec, V / Peeters, S J M / Perez, A Pena / Pennacchio, E / Penzo, A / Peres, O L G / Perry, J / Pershey, D / Pessina, G / Petrillo, G / Petta, C / Petti, R / Pia, V / Piastra, F / Pickering, L / Pietropaolo, F / Pimentel, V L / Pinaroli, G / Plows, K / Plunkett, R / Poling, R / Pompa, F / Pons, X / Poonthottathil, N / Poppi, F / Pordes, S / Porter, J / Potekhin, M / Potenza, R / Potukuchi, B V K S / Pozimski, J / Pozzato, M / Prakash, S / Prakash, T / Prest, M / Prince, S / Psihas, F / Pugnere, D / Qian, X / Raaf, J L / Radeka, V / Rademacker, J / Radics, B / Rafique, A / Raguzin, E / Rai, M / Rajaoalisoa, M / Rakhno, I / Rakotonandrasana, A / Rakotondravohitra, L / Rameika, R / Delgado, M A Ramirez / Ramson, B / Rappoldi, A / Raselli, G / Ratoff, P / Raut, S / Razakamiandra, R F / Rea, E M / Real, J S / Rebel, B / Rechenmacher, R / Reggiani-Guzzo, M / Reichenbacher, J / Reitzner, S D / Sfar, H Rejeb / Renshaw, A / Rescia, S / Resnati, F / Ribas, M / Riboldi, S / Riccio, C / Riccobene, G / Rice, L C J / Ricol, J S / Rigamonti, A / Rigaut, Y / Rincón, E V / Ritchie-Yates, H / Rivera, D / Robert, A / Rochester, L / Roda, M / Rodrigues, P / Alonso, M J Rodriguez / Bonilla, E Rodriguez / Rondon, J Rodriguez / Rosauro-Alcaraz, S / Rosenberg, M / Rosier, P / Roskovec, B / Rossella, M / Rossi, M / Rout, J / Roy, P / Rubbia, A / Rubbia, C / Russell, B / Ruterbories, D / Rybnikov, A / Saa-Hernandez, A / Saakyan, R / Sacerdoti, S / Safford, T / Sahu, N / Sakashita, K / Sala, P / Samios, N / Samoylov, O / Sanchez, M C / Sandberg, V / Sanders, D A / Sankey, D / Santana, S / Santos-Maldonado, M / Saoulidou, N / Sapienza, P / Sarasty, C / Sarcevic, I / Savage, G / Savinov, V / Scaramelli, A / Scarff, A / Scarpelli, A / Schefke, T / Schellman, H / Schifano, S / Schlabach, P / Schmitz, D / Schneider, A W / Scholberg, K / Schukraft, A / Segreto, E / Selyunin, A / Senise, C R / Sensenig, J / Sergi, A / Sgalaberna, D / Shaevitz, M H / Shafaq, S / Shaker, F / Shamma, M / Sharankova, R / Sharma, H R / Sharma, R / 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Suter, L / Sutera, C M / Svoboda, R / Szczerbinska, B / Szelc, A M / Tanaka, H / Tang, S / Tapia, A / Oregui, B Tapia / Tapper, A / Tariq, S / Tarpara, E / Tata, N / Tatar, E / Tayloe, R / Teklu, A M / Tennessen, P / Tenti, M / Terao, K / Ternes, C A / Terranova, F / Testera, G / Thakore, T / Thea, A / Thompson, J L / Thorn, C / Timm, S C / Tishchenko, V / Tomassetti, L / Tonazzo, A / Torbunov, D / Torti, M / Tortola, M / Tortorici, F / Tosi, N / Totani, D / Toups, M / Touramanis, C / Travaglini, R / Trevor, J / Trilov, S / Trzaska, W H / Tsai, Y / Tsai, Y-T / Tsamalaidze, Z / Tsang, K V / Tsverava, N / Tufanli, S / Tull, C / Tyley, E / Tzanov, M / Uboldi, L / Uchida, M A / Urheim, J / Usher, T / Uzunyan, S / Vagins, M R / Vahle, P / Valder, S / Valdiviesso, G D A / Valencia, E / Valentim, R / Vallari, Z / Vallazza, E / Valle, J W F / Vallecorsa, S / Berg, R Van / de Water, R G Van / Forero, D Vanegas / Vannerom, D / Varanini, F / Oliva, D Vargas / Varner, G / Vasel, J / Vasina, S / Vasseur, G / Vaughan, N / Vaziri, K / Ventura, S / Verdugo, A / Vergani, S / Vermeulen, M A / Verzocchi, M / Vicenzi, M / de Souza, H Vieira / Vignoli, C / Vilela, C / Viren, B / Vrba, T / Wachala, T / Waldron, A V / Wallbank, M / Wallis, C / Wang, H / Wang, J / Wang, L / Wang, M H L S / Wang, X / Wang, Y / Warburton, K / Warner, D / Wascko, M O / Waters, D / Watson, A / Wawrowska, K / Weatherly, P / Weber, A / Weber, M / Wei, H / Weinstein, A / Wenman, D / Wetstein, M / White, A / Whitehead, L H / Whittington, D / Wilking, M J / Wilkinson, A / Wilkinson, C / Williams, Z / Wilson, F / Wilson, R J / Wisniewski, W / Wolcott, J / Wongjirad, T / Wood, A / Wood, K / Worcester, E / Worcester, M / Wresilo, K / Wret, C / Wu, W / Xiao, Y / Xie, F / Yaeggy, B / Yandel, E / Yang, G / Yang, K / Yang, T / Yankelevich, A / Yershov, N / Yonehara, K / Yoon, Y S / Young, T / Yu, B / Yu, H / Yu, J / Yu, Y / Yuan, W / Zaki, R / Zalesak, J / Zambelli, L / Zamorano, B / Zani, A / Zazueta, L / Zeller, G P / Zennamo, J / Zeug, K / Zhang, C / Zhang, S / Zhang, Y / Zhao, M / Zhivun, E / Zhu, G / Zimmerman, E D / Zucchelli, S / Zuklin, J / Zutshi, V / Zwaska, R

The European physical journal. C, Particles and fields

2022 Volume 82, Issue 7, Page(s) 618

Abstract: DUNE is a dual-site experiment for long-baseline neutrino oscillation studies, neutrino astrophysics and nucleon decay searches. ProtoDUNE Dual Phase (DP) is a ... ...

Abstract	DUNE is a dual-site experiment for long-baseline neutrino oscillation studies, neutrino astrophysics and nucleon decay searches. ProtoDUNE Dual Phase (DP) is a 6
Language	English
Publishing date	2022-07-16
Publishing country	France
Document type	Journal Article
ZDB-ID	1459069-4
ISSN	1434-6052 ; 1434-6044
ISSN (online)	1434-6052
ISSN	1434-6044
DOI	10.1140/epjc/s10052-022-10549-w
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Article ; Online: Inhibitory effects of 190 compounds against SARS-CoV-2 M

Archiv der Pharmazie

2023 Volume 356, Issue 8, Page(s) e2300207

Abstract: ... protease (M ...

Abstract	COVID-19 has caused many deaths since the first outbreak in 2019. The burden on healthcare systems around the world has been reduced by the success of vaccines. However, population adherence and the occurrence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants are still challenging tasks to be affronted. In addition, the newly approved drug presents some limitations in terms of side effects and drug interference, highlighting the importance of searching for new antiviral agents against SARS-CoV-2. The SARS-CoV-2 main protease (M
MeSH term(s)	Humans ; SARS-CoV-2 ; Molecular Docking Simulation ; COVID-19 ; Protease Inhibitors/pharmacology ; Protease Inhibitors/chemistry ; Structure-Activity Relationship ; Antiviral Agents/pharmacology ; Antiviral Agents/chemistry ; Molecular Dynamics Simulation
Chemical Substances	Protease Inhibitors ; Antiviral Agents
Language	English
Publishing date	2023-05-31
Publishing country	Germany
Document type	Journal Article
ZDB-ID	6381-2
ISSN	1521-4184 ; 0365-6233 ; 1437-1014
ISSN (online)	1521-4184
ISSN	0365-6233 ; 1437-1014
DOI	10.1002/ardp.202300207
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Article ; Conference proceedings: Sleep Dentistry Improving School Performance and Child Development

Braga, M. F. C.

Sleep Science

2023 Volume 16, Issue S 01

Event/congress	XIX Congresso Brasileiro do Sono, Goiânia, 2022-11-30
Keywords	sleep dentistry ; cross bite ; development
Language	English
Publishing date	2023-06-01
Publisher	Thieme Revinter Publicações Ltda.
Publishing place	Stuttgart ; New York
Document type	Article ; Conference proceedings
ZDB-ID	2697016-8
ISSN	1984-0063 ; 1984-0659 ; 1984-0063
ISSN (online)	1984-0063
ISSN	1984-0659 ; 1984-0063
DOI	10.1055/s-0043-1770211
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Article ; Online: Inhibitory effects against SARSCoV-2 main protease (M

Moreira Costa, Monalisa A / de Sousa, Natália F / Mansur Pontes, Carime L / Scotti, Marcus T / de Assis, Francisco F / Braga, Antonio L / Sandjo, Louis P

Fitoterapia

2023 Volume 173, Page(s) 105784

Abstract: ... on natural products from an edible fruit with potential inhibitory effects against the SARS-CoV-2 main protease (M ...

Abstract	The SARS-CoV-2 mutation and the limitation of the approved drug against COVID-19 are still a challenge in many country healthcare systems and need to be affronted despite the set of vaccines to prevent this viral infection. To contribute to the identification of new antiviral agents, the present study focused on natural products from an edible fruit with potential inhibitory effects against the SARS-CoV-2 main protease (M
MeSH term(s)	Molecular Docking Simulation ; Fruit ; Antiviral Agents/pharmacology ; Antiviral Agents/chemistry ; Benzophenones ; Biflavonoids/pharmacology ; Molecular Structure ; Peptide Hydrolases
Chemical Substances	Antiviral Agents ; Benzophenones ; Biflavonoids ; Peptide Hydrolases (EC 3.4.-)
Language	English
Publishing date	2023-12-19
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	412385-2
ISSN	1873-6971 ; 0367-326X
ISSN (online)	1873-6971
ISSN	0367-326X
DOI	10.1016/j.fitote.2023.105784
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Article ; Online: Integrated management of residues from tomato production: Recovery of value-added compounds and biogas production in the biorefinery context.

Almeida, P V / Rodrigues, R P / Gaspar, M C / Braga, M E M / Quina, M J

Journal of environmental management

2021 Volume 299, Page(s) 113505

Abstract: The biorefinery approach must be boosted in the management of agro-residues in the future. The present study aims to investigate the valorization of tomato production residues, namely rotten tomato (unfit for consumption - RT), green tomato (GT), and ... ...

Abstract	The biorefinery approach must be boosted in the management of agro-residues in the future. The present study aims to investigate the valorization of tomato production residues, namely rotten tomato (unfit for consumption - RT), green tomato (GT), and tomato branches (TB). The assessment involves the recovery of value-added compounds through the extraction process followed by biogas production through anaerobic digestion. A thorough characterization of the three residues (RT, GT, and TB) was carried out, including the identification of volatile compounds by solid-phase microextraction (SPME) and gas chromatography/mass spectrometry (GC/MS). The volatiles analysis revealed the presence of flavor enhancer compounds and molecules with insecticidal properties. A solid-liquid extraction with ethanol allowed the recovery of value-added compounds in the extracts, in particular phenolic compounds, β-carotene, and lycopene, which contributed to the antioxidant activity. RT and TB extracts were found to be richer in total phenolic compounds (~27 mg GAE/g
MeSH term(s)	Antioxidants ; Biofuels ; Lycopene ; Lycopersicon esculentum ; Methane ; Phenols/analysis
Chemical Substances	Antioxidants ; Biofuels ; Phenols ; Methane (OP0UW79H66) ; Lycopene (SB0N2N0WV6)
Language	English
Publishing date	2021-08-25
Publishing country	England
Document type	Journal Article
ZDB-ID	184882-3
ISSN	1095-8630 ; 0301-4797
ISSN (online)	1095-8630
ISSN	0301-4797
DOI	10.1016/j.jenvman.2021.113505
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Article ; Online: Gestational trophoblastic neoplasia: one size does not fit all - Authors' reply.

Braga, Antonio / Berkowitz, Ross S / Seckl, Michael J

The Lancet. Oncology

2021 Volume 22, Issue 10, Page(s) e421

MeSH term(s)	Female ; Gestational Trophoblastic Disease/diagnosis ; Gestational Trophoblastic Disease/epidemiology ; Humans ; Pregnancy ; Uterine Neoplasms
Language	English
Publishing date	2021-09-27
Publishing country	England
Document type	Letter ; Comment
ZDB-ID	2049730-1
ISSN	1474-5488 ; 1470-2045
ISSN (online)	1474-5488
ISSN	1470-2045
DOI	10.1016/S1470-2045(21)00527-1
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