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  1. Article ; Online: Posterior Wall Isolation in Persistent AF With Rapid Posterior Wall Activity: The Quest for Evidence.

    Saglietto, Andrea / Falasconi, Giulio / Berruezo, Antonio / De Ferrari, Gaetano Maria / Anselmino, Matteo

    JACC. Clinical electrophysiology

    2024  Volume 10, Issue 1, Page(s) 139–140

    MeSH term(s) Humans ; Atrial Fibrillation/surgery ; Heart Atria
    Language English
    Publishing date 2024-01-25
    Publishing country United States
    Document type Letter
    ZDB-ID 2846739-5
    ISSN 2405-5018 ; 2405-500X ; 2405-500X
    ISSN (online) 2405-5018 ; 2405-500X
    ISSN 2405-500X
    DOI 10.1016/j.jacep.2023.10.036
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Commentary: Differential Risk of Dementia Between Patients With Atrial Flutter and Atrial Fibrillation: A National Cohort Study.

    Saglietto, Andrea / De Ferrari, Gaetano Maria / Anselmino, Matteo

    Frontiers in cardiovascular medicine

    2022  Volume 9, Page(s) 850968

    Language English
    Publishing date 2022-02-17
    Publishing country Switzerland
    Document type Journal Article ; Comment
    ZDB-ID 2781496-8
    ISSN 2297-055X
    ISSN 2297-055X
    DOI 10.3389/fcvm.2022.850968
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: A Quantitative Assessment of Cerebral Hemodynamic Perturbations Associated with Long R-R Intervals in Atrial Fibrillation: A Pilot-Case-Based Experience.

    Canova, Daniela / Roatta, Silvestro / Saglietto, Andrea / Scarsoglio, Stefania / Gianotto, Nefer Roberta / Piccotti, Alessandro / De Ferrari, Gaetano Maria / Ridolfi, Luca / Anselmino, Matteo

    Medicina (Kaunas, Lithuania)

    2024  Volume 60, Issue 4

    Abstract: Background and Objectives: ...

    Abstract Background and Objectives:
    MeSH term(s) Humans ; Atrial Fibrillation/physiopathology ; Male ; Female ; Pilot Projects ; Aged ; Middle Aged ; Cerebrovascular Circulation/physiology ; Spectroscopy, Near-Infrared/methods ; Hemodynamics/physiology ; Electrocardiography/methods ; Electric Countershock/methods ; Blood Pressure/physiology
    Language English
    Publishing date 2024-03-25
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2188113-3
    ISSN 1648-9144 ; 1010-660X
    ISSN (online) 1648-9144
    ISSN 1010-660X
    DOI 10.3390/medicina60040531
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6270: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Atrial Fibrillation and Dementia: Epidemiological Insights on an Undervalued Association.

    Saglietto, Andrea / Ballatore, Andrea / Xhakupi, Henri / De Ferrari, Gaetano Maria / Anselmino, Matteo

    Medicina (Kaunas, Lithuania)

    2022  Volume 58, Issue 3

    Abstract: Background and ... ...

    Abstract Background and objectives
    MeSH term(s) Aged ; Atrial Fibrillation/epidemiology ; Dementia/epidemiology ; Global Health ; Humans ; Incidence ; Prevalence
    Language English
    Publishing date 2022-03-01
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2188113-3
    ISSN 1648-9144 ; 1010-660X
    ISSN (online) 1648-9144
    ISSN 1010-660X
    DOI 10.3390/medicina58030361
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6270: Show issues Location:
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  5. Article ; Online: Pulmonary vein isolation through trans-jugular approach in a patient with inferior vena cava interruption.

    Saglietto, Andrea / De Ferrari, Gaetano Maria / Ferraris, Federico / Anselmino, Matteo

    Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing

    2022  Volume 64, Issue 2, Page(s) 267–268

    MeSH term(s) Atrial Fibrillation/diagnostic imaging ; Atrial Fibrillation/surgery ; Humans ; Pulmonary Embolism ; Pulmonary Veins/diagnostic imaging ; Pulmonary Veins/surgery ; Vena Cava, Inferior/diagnostic imaging ; Vena Cava, Inferior/surgery
    Language English
    Publishing date 2022-01-10
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1329179-8
    ISSN 1572-8595 ; 1383-875X
    ISSN (online) 1572-8595
    ISSN 1383-875X
    DOI 10.1007/s10840-021-01114-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5214: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article: MRI pattern characterization of cerebral cardioembolic lesions following atrial fibrillation ablation.

    Saglietto, Andrea / Bertello, Eleonora / Barra, Marina / Ferraro, Ilenia / Rovera, Chiara / Orzan, Fulvio / De Ferrari, Gaetano Maria / Anselmino, Matteo

    Frontiers in cardiovascular medicine

    2024  Volume 11, Page(s) 1327567

    Abstract: Background: Recognizing etiology is essential for treatment and secondary prevention of cerebral ischemic events. A magnetic resonance imaging (MRI) pattern suggestive of an embolic etiology has been described but, to date, there are no uniformly ... ...

    Abstract Background: Recognizing etiology is essential for treatment and secondary prevention of cerebral ischemic events. A magnetic resonance imaging (MRI) pattern suggestive of an embolic etiology has been described but, to date, there are no uniformly accepted criteria.
    Aim: The purpose of the study is to describe MRI features of ischemic cerebral lesions occurring after transcatheter ablation of atrial fibrillation (AF).
    Methods: A systematic review and meta-analysis of studies performing brain imaging investigations before and after AF transcatheter ablation was performed. The incidence of cerebral ischemic lesions after AF transcatheter ablation was the primary endpoint. The co-primary endpoints were the prevalence of the different neuroimaging features regarding the embolic cerebral ischemic lesions.
    Results: A total of 25 studies, encompassing 3,304 patients, were included in the final analysis. The incidence of ischemic cerebral lesions following AF transcatheter ablation was 17.2% [95% confidence interval (CI) 12.2%-23.8%], of which a minimal fraction was symptomatic [0.60% (95% CI 0.09%-3.9%)]. Only 1.6% of the lesions (95% CI 0.9%-3.0%) had a diameter >10 mm, and in 20.5% of the cases the lesions were multiple (95% CI 17.1%-24.4%). Brain lesions were equally distributed across the two hemispheres and the different lobes; cortical location was more frequent [64.0% (95% CI 42.9%-80.8%)] while the middle cerebral artery territory was the most involved 37.0% (95% CI 27.3-48.0).
    Conclusions: The prevailing MRI pattern comprises a predominance of small (<10 mm) cortical lesions, more prevalent in the territory of the middle cerebral artery.
    Language English
    Publishing date 2024-01-24
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2781496-8
    ISSN 2297-055X
    ISSN 2297-055X
    DOI 10.3389/fcvm.2024.1327567
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Convolutional neural network (CNN)-enabled electrocardiogram (ECG) analysis: a comparison between standard twelve-lead and single-lead setups.

    Saglietto, Andrea / Baccega, Daniele / Esposito, Roberto / Anselmino, Matteo / Dusi, Veronica / Fiandrotti, Attilio / De Ferrari, Gaetano Maria

    Frontiers in cardiovascular medicine

    2024  Volume 11, Page(s) 1327179

    Abstract: Background: Artificial intelligence (AI) has shown promise in the early detection of various cardiac conditions from a standard 12-lead electrocardiogram (ECG). However, the ability of AI to identify abnormalities from single-lead recordings across a ... ...

    Abstract Background: Artificial intelligence (AI) has shown promise in the early detection of various cardiac conditions from a standard 12-lead electrocardiogram (ECG). However, the ability of AI to identify abnormalities from single-lead recordings across a range of pathological conditions remains to be systematically investigated. This study aims to assess the performance of a convolutional neural network (CNN) using a single-lead (D1) rather than a standard 12-lead setup for accurate identification of ECG abnormalities.
    Methods: We designed and trained a lightweight CNN to identify 20 different cardiac abnormalities on ECGs, using data from the PTB-XL dataset. With a relatively simple architecture, the network was designed to accommodate different combinations of leads as input (<100,000 learnable parameters). We compared various lead setups such as the standard 12-lead, D1 alone, and D1 paired with an additional lead.
    Results: This has been corrected to “The CNN based on single-lead ECG (D1) achieved satisfactory performance compared to the standard 12-lead framework (average percentage AUC difference: −8.7%). Notably, for certain diagnostic classes, there was no difference in the diagnostic AUC between the single-lead and the standard 12-lead setups. When a second lead was detected in the CNN in addition to D1, the AUC gap was further reduced to an average percentage difference of -2.8% compared with that of the standard 12-lead setup.
    Conclusions: A relatively lightweight CNN can predict different classes of cardiac abnormalities from D1 alone and the standard 12-lead ECG. Considering the growing availability of wearable devices capable of recording a D1-like single-lead ECG, we discuss how our findings contribute to the foundation of a large-scale screening of cardiac abnormalities.
    Language English
    Publishing date 2024-02-15
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2781496-8
    ISSN 2297-055X
    ISSN 2297-055X
    DOI 10.3389/fcvm.2024.1327179
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: The Brugada syndrome: risk stratification.

    Gaita, Fiorenzo / Cerrato, Natascia / Saglietto, Andrea / Caponi, Domenico / Calò, Leonardo / Giustetto, Carla

    European heart journal supplements : journal of the European Society of Cardiology

    2023  Volume 25, Issue Suppl C, Page(s) C27–C31

    Abstract: Thirty years after its first description, the knowledge regarding Brugada syndrome has greatly increased. Spontaneous type 1 ECG pattern (BrECG) is a well-defined prognostic marker in asymptomatic patients and is associated with a double risk of ... ...

    Abstract Thirty years after its first description, the knowledge regarding Brugada syndrome has greatly increased. Spontaneous type 1 ECG pattern (BrECG) is a well-defined prognostic marker in asymptomatic patients and is associated with a double risk of arrhythmic events during follow-up as compared to drug-induced ECG pattern. Due to the extreme variability of the ECG pattern over time, the spontaneous type 1 BrECG must be carefully sought, not only through periodic ECGs but especially with repeated 12-lead 24-h Holter monitoring, with V1 and V2 electrodes placed also on the second and third intercostal space, in order to explore the right ventricular outflow tract. 12-lead 24-h Holter should also be performed in all the patients with a dubious BrECG pattern even before the drug challenge with sodium channel blockers, which carries a low but definite risk of complications. In addition to spontaneous type 1, other electrocardiographic markers of increased arrhythmic risk have been described, such as first-degree AV block, QRS fragmentation, S wave in lead I and II, and increased QRS duration. The electrophysiological study in asymptomatic patients with a spontaneous ECG Brugada pattern is still under jury and further studies need to clarify its precise role.
    Language English
    Publishing date 2023-04-26
    Publishing country England
    Document type Journal Article
    ZDB-ID 1463769-8
    ISSN 1554-2815 ; 1520-765X
    ISSN (online) 1554-2815
    ISSN 1520-765X
    DOI 10.1093/eurheartjsupp/suad035
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1563 -Suppl.-: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  9. Article ; Online: Beat-to-beat finger photoplethysmography in atrial fibrillation patients undergoing electrical cardioversion.

    Saglietto, Andrea / Scarsoglio, Stefania / Canova, Daniela / De Ferrari, Gaetano Maria / Ridolfi, Luca / Anselmino, Matteo

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 6751

    Abstract: Atrial fibrillation (AF)-induced peripheral microcirculatory alterations have poorly been investigated. The present study aims to expand current knowledge through a beat-to-beat analysis of non-invasive finger photoplethysmography (PPG) in AF patients ... ...

    Abstract Atrial fibrillation (AF)-induced peripheral microcirculatory alterations have poorly been investigated. The present study aims to expand current knowledge through a beat-to-beat analysis of non-invasive finger photoplethysmography (PPG) in AF patients restoring sinus rhythm by electrical cardioversion (ECV). Continuous non-invasive arterial blood pressure and left middle finger PPG pulse oximetry waveform (POW) signals were continuously recorded before and after elective ECV of consecutive AF or atrial flutter (AFL) patients. The main metrics (mean, standard deviation, coefficient of variation), as well as a beat-to-beat analysis of the pulse pressure (PP) and POW beat-averaged value (aPOW), were computed to compare pre- and post-ECV phases. 53 patients (mean age 69 ± 8 years, 79% males) were enrolled; cardioversion was successful in restoring SR in 51 (96%) and signal post-processing was feasible in 46 (87%) patients. In front of a non-significant difference in mean PP (pre-ECV: 51.96 ± 13.25, post-ECV: 49.58 ± 10.41 mmHg; p = 0.45), mean aPOW significantly increased after SR restoration (pre-ECV: 0.39 ± 0.09, post-ECV: 0.44 ± 0.06 a.u.; p < 0.001). Moreover, at beat-to-beat analysis linear regression yielded significantly different slope (m) for the PP (RR) relationship compared to aPOW(RR) [PP(RR): 0.43 ± 0.18; aPOW(RR): 1.06 ± 0.17; p < 0.001]. Long (> 95th percentile) and short (< 5th percentile) RR intervals were significantly more irregular in the pre-ECV phases for both PP and aPOW; however, aPOW signal suffered more fluctuations compared to PP (p < 0.001 in both phases). Present findings suggest that AF-related hemodynamic alterations are more manifest at the peripheral (aPOW) rather than at the upstream macrocirculatory level (PP). Restoring sinus rhythm increases mean peripheral microvascular perfusion and decreases variability of the microvascular hemodynamic signals. Future dedicated studies are required to determine if AF-induced peripheral microvascular alterations might relate to long-term prognostic effects.
    MeSH term(s) Male ; Humans ; Middle Aged ; Aged ; Female ; Atrial Fibrillation/therapy ; Electric Countershock ; Photoplethysmography ; Microcirculation ; Atrial Flutter
    Language English
    Publishing date 2023-04-25
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-33952-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Association of Catheter Ablation and Reduced Incidence of Dementia among Patients with Atrial Fibrillation during Long-Term Follow-Up: A Systematic Review and Meta-Analysis of Observational Studies.

    Saglietto, Andrea / Ballatore, Andrea / Xhakupi, Henri / De Ferrari, Gaetano Maria / Anselmino, Matteo

    Journal of cardiovascular development and disease

    2022  Volume 9, Issue 5

    Abstract: Background: Atrial fibrillation (AF) is independently associated with the onset of cognitive decline/dementia. AF catheter ablation (AFCA) is the most effective treatment strategy in terms of sinus rhythm maintenance, but its effects on dementia ... ...

    Abstract Background: Atrial fibrillation (AF) is independently associated with the onset of cognitive decline/dementia. AF catheter ablation (AFCA) is the most effective treatment strategy in terms of sinus rhythm maintenance, but its effects on dementia prevention remain under investigation. The aim of the present study was to perform a systematic review and meta-analysis of the presently available studies exploring the effect of AFCA on dementia occurrence.
    Methods: PubMed/MEDLINE databases were screened for articles through 14 March 2022 reporting adjusted time-to-event outcome data comparing AFCA and non-AFCA cohorts in terms of de novo dementia occurrence. A random effect meta-analysis was performed to estimate the meta-analytic hazard ratio (HR) of dementia occurrence in AFCA vs. non-AFCA cohorts, as well as the meta-analytic incidence rate of dementia in the non-AFCA cohort. Based on the aforementioned estimates, the number needed to treat (NNT), projected at median follow-up, was derived.
    Results: Four observational studies were included in the analysis, encompassing 40,146 patients (11,312 in the AFCA cohort; 28,834 in the non-AFCA cohort). AFCA conferred a significant protection to the development of dementia with an overall HR of 0.52 (95% CI 0.35-0.76). The incidence rate of dementia in the non-AFCA group was 1.12 events per 100 person-year (95% CI 0.47-2.67). The derived NNT projected to the median follow-up (4.5 years) was 41.
    Conclusion: AFCA is associated with a nearly 50% reduction in dementia occurrence during a median 4.5-year follow-up. Future randomized clinical trials are needed to reinforce these findings.
    Language English
    Publishing date 2022-04-30
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2777082-5
    ISSN 2308-3425 ; 2308-3425
    ISSN (online) 2308-3425
    ISSN 2308-3425
    DOI 10.3390/jcdd9050140
    Database MEDical Literature Analysis and Retrieval System OnLINE

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