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  1. Book ; Online ; E-Book: Paraproteinemia and related disorders

    Goubran, Hadi / Quartuccio, Luca / Ragab, Gaafar

    2022  

    Author's details editors : Gaafar Ragab, Luca Quartuccio, Hadi Goubran
    Keywords Plasma cell diseases ; Paraproteinemia/Diagnosis ; Paraproteinemia/Treatment
    Subject code 571.64
    Language English
    Size 1 online resource (398 pages)
    Publisher Springer
    Publishing place Cham, Switzerland
    Document type Book ; Online ; E-Book
    Note Includes index.
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 3-031-10131-6 ; 9783031101304 ; 978-3-031-10131-1 ; 3031101308
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: The paradigm shift in ANCA-associated vasculitis: prime time for the complement targeting.

    Quartuccio, Luca / Treppo, Elena / Alberici, Federico

    Rheumatology (Oxford, England)

    2023  Volume 62, Issue 8, Page(s) 2633–2634

    MeSH term(s) Humans ; Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis/drug therapy ; Complement System Proteins ; Antibodies, Antineutrophil Cytoplasmic
    Chemical Substances Complement System Proteins (9007-36-7) ; Antibodies, Antineutrophil Cytoplasmic
    Language English
    Publishing date 2023-04-21
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 1464822-2
    ISSN 1462-0332 ; 1462-0324
    ISSN (online) 1462-0332
    ISSN 1462-0324
    DOI 10.1093/rheumatology/kead188
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Risk of Thrombosis in Sjögren Syndrome: The Open Question of Endothelial Function Immune-mediated Dysregulation.

    Quartuccio, Luca

    The Journal of rheumatology

    2017  Volume 44, Issue 8, Page(s) 1106–1108

    MeSH term(s) Humans ; Risk ; Sjogren's Syndrome ; Thrombosis
    Language English
    Publishing date 2017-07-29
    Publishing country Canada
    Document type Editorial ; Comment
    ZDB-ID 194928-7
    ISSN 1499-2752 ; 0315-162X
    ISSN (online) 1499-2752
    ISSN 0315-162X
    DOI 10.3899/jrheum.170462
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Recent updates in the diagnosis and management of cryoglobulinemic vasculitis.

    Treppo, Elena / Quartuccio, Luca / De Vita, Salvatore

    Expert review of clinical immunology

    2023  Volume 19, Issue 12, Page(s) 1457–1467

    Abstract: Introduction: Cryoglobulinemic vasculitis (CV), also known as mixed cryoglobulinemic syndrome (MCS), is a systemic vasculitis that affects small blood vessels. It exhibits a wide range of clinical manifestations, making its treatment a continuing ... ...

    Abstract Introduction: Cryoglobulinemic vasculitis (CV), also known as mixed cryoglobulinemic syndrome (MCS), is a systemic vasculitis that affects small blood vessels. It exhibits a wide range of clinical manifestations, making its treatment a continuing challenge for physicians.
    Areas covered: We conducted a comprehensive review to evaluate the current status of diagnosis, management, and treatment of mixed cryoglobulinemia (MC). The accurate clinical and serological evaluation plays a vital role in diagnosing MC, identifying potential comorbidities, and monitoring its main manifestations and complications. Treatment strategies should be individualized based on the underlying etiopathogenesis, the severity of organ involvement, and the associated underlying disease. At present, the two mainstays of CV treatment are direct antiviral agents (for HCV-related CV) and B-cell-targeted therapy.
    Expert opinion: MC remains one of the few autoimmune diseases where the etiology is known, at least for the majority of patients. Its pathogenetic mechanism offers a unique opportunity to investigate the interplay between infections and the immune system. Moving forward, the primary challenge will continue to lie in the treatment of resistant or refractory cases of CV, particularly those associated with autoimmune diseases, or cases classified as 'essential' CV.
    MeSH term(s) Humans ; Vasculitis/diagnosis ; Cryoglobulinemia ; Autoimmune Diseases/complications ; Antiviral Agents/therapeutic use ; Syndrome
    Chemical Substances Antiviral Agents
    Language English
    Publishing date 2023-09-12
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2274260-8
    ISSN 1744-8409 ; 1744-666X
    ISSN (online) 1744-8409
    ISSN 1744-666X
    DOI 10.1080/1744666X.2023.2249609
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Rheumatologists at a crossroads: blocking tumour necrosis factor or interleukin 6 in disease-modifying anti-rheumatic drug inadequate responder patients with rheumatoid arthritis.

    Quartuccio, Luca / Choy, Ernest H

    Rheumatology (Oxford, England)

    2021  Volume 60, Issue 11, Page(s) 4953–4955

    MeSH term(s) Antirheumatic Agents/therapeutic use ; Arthritis, Rheumatoid/drug therapy ; Humans ; Interleukin-6 ; Rheumatologists ; Tumor Necrosis Factor-alpha
    Chemical Substances Antirheumatic Agents ; Interleukin-6 ; Tumor Necrosis Factor-alpha
    Language English
    Publishing date 2021-05-11
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 1464822-2
    ISSN 1462-0332 ; 1462-0324
    ISSN (online) 1462-0332
    ISSN 1462-0324
    DOI 10.1093/rheumatology/keab425
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  6. Article ; Online: The pre-clinical phase of giant cell arteritis: new clues in the pathogenesis of giant cell arteritis supporting emerging targets.

    Quartuccio, Luca / Treppo, Elena / Dejaco, Christian

    Rheumatology (Oxford, England)

    2022  Volume 62, Issue 6, Page(s) 2032–2034

    MeSH term(s) Humans ; Giant Cell Arteritis/pathology ; Polymyalgia Rheumatica/complications
    Language English
    Publishing date 2022-12-15
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 1464822-2
    ISSN 1462-0332 ; 1462-0324
    ISSN (online) 1462-0332
    ISSN 1462-0324
    DOI 10.1093/rheumatology/keac697
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  7. Article ; Online: Applications of PET and SPECT in Patients with Autism Spectrum Disorder.

    Martini, Anna Lisa / Quartuccio, Natale / Schiera, Irene Giovanna / Berti, Valentina / Burroni, Luca / Cistaro, Angelina

    Current medical imaging

    2024  Volume 20, Page(s) 1–11

    Abstract: Autism spectrum disorder (ASD) consists of neurological development disorders that manifest before three years of age and affect social interactions, markedly restricting range of interests and activities, often associated with some degree of ... ...

    Abstract Autism spectrum disorder (ASD) consists of neurological development disorders that manifest before three years of age and affect social interactions, markedly restricting range of interests and activities, often associated with some degree of intellectual disability. Single-photon emission computed tomography (SPECT) and positron emission tomography (PET) are non-invasive imaging tools to investigate the function of the brain in vivo. SPECT and PET studies exploring rCBF and brain glucose metabolism in patients with ASD have been performed, providing important insights into the brain regions involved in ASD. Abnormalities in serotonergic, dopaminergic, GABAergic, cholinergic, and glutamatergic systems have been suggested to contribute to the observed distorted brain circuitry associated with ASD. However, the specificity of such abnormalities needs to be fully clarified because schizophrenia and other psychiatric diseases have been shown to present with comparable changes in neurotransmitter systems. Neuroinflammation could also play a role in the development of autism. Therefore, ASD is a complicated process involving a number of factors. It is mandatory to perform more research studies to determine the molecular cornerstone of ASD and to improve our comprehension of the clinical correlates of ASD.
    MeSH term(s) Humans ; Autism Spectrum Disorder/diagnostic imaging ; Tomography, X-Ray Computed ; Positron-Emission Tomography ; Tomography, Emission-Computed, Single-Photon/methods ; Brain/diagnostic imaging ; Brain/metabolism
    Language English
    Publishing date 2024-02-22
    Publishing country United Arab Emirates
    Document type Journal Article
    ISSN 1573-4056
    ISSN (online) 1573-4056
    DOI 10.2174/0115734056232408230927072959
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Ponesimod in the Treatment of Relapsing Forms of Multiple Sclerosis: An Update on the Emerging Clinical Data.

    Ruggieri, Serena / Quartuccio, Maria Esmeralda / Prosperini, Luca

    Degenerative neurological and neuromuscular disease

    2022  Volume 12, Page(s) 61–73

    Abstract: Sphingosine 1-phosphate (S1P) receptors are bioactive lipid metabolites that bind five different types of receptors expressed ubiquitously in human body and mediate a broad range of biological functions. Targeting S1P receptors is nowadays a well- ... ...

    Abstract Sphingosine 1-phosphate (S1P) receptors are bioactive lipid metabolites that bind five different types of receptors expressed ubiquitously in human body and mediate a broad range of biological functions. Targeting S1P receptors is nowadays a well-established pharmacological strategy to treat multiple sclerosis (MS). However, the adverse events associated with the ancestor (fingolimod), especially in terms of heart conduction and slow reversibility of its pharmacodynamics effect on lymphocytes, have stimulated a search for a S1P modulator with greater selectivity for S1P
    Language English
    Publishing date 2022-03-22
    Publishing country New Zealand
    Document type Journal Article ; Review
    ISSN 1179-9900
    ISSN (online) 1179-9900
    DOI 10.2147/DNND.S313825
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Sonographic Appearance of Lacrimal Glands in Sjögren's Syndrome at High Risk for Lymphoma Development.

    Giovannini, Ivan / Pegolo, Enrico / Longhino, Simone / Quartuccio, Luca / Zabotti, Alen

    Cureus

    2023  Volume 15, Issue 12, Page(s) e50047

    Abstract: Primary Sjögren's syndrome (pSS) is an autoimmune systemic disease characterized by the destruction of exocrine glands, mainly salivary and lacrimal glands. The diagnosis is generally made upon objective tests aimed at assessing salivary and lacrimal ... ...

    Abstract Primary Sjögren's syndrome (pSS) is an autoimmune systemic disease characterized by the destruction of exocrine glands, mainly salivary and lacrimal glands. The diagnosis is generally made upon objective tests aimed at assessing salivary and lacrimal glandular function, autoantibody assays, and the results of labial salivary gland biopsies. A major salivary gland biopsy is usually reserved to assess lymphoproliferative complications. Recently, the sonographic evaluation of the major salivary glands has gained a crucial role in assessing the glandular parenchyma and early detecting abnormalities, while the role of ultrasonography in the assessment of lacrimal glands is still secondary. Our case report is about a male patient who presented parotid gland swelling and purpuric lesions, with preserved salivary and lacrimal glandular function. Considering the presence of risk factors associated with lymphoproliferative development and the peculiar characteristics detected by salivary and lacrimal gland ultrasonography, we performed a parotid gland biopsy, confirming Sjögren's syndrome. Our case demonstrates that lacrimal gland ultrasonography could be implemented, along with major salivary gland ultrasonography, as a routine procedure in evaluating patients with suspected or definite diagnoses of pSS.
    Language English
    Publishing date 2023-12-06
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.50047
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Crioglobulinemia.

    Retamozo, Soledad / Quartuccio, Luca / Ramos-Casals, Manuel

    Medicina clinica

    2022  Volume 158, Issue 10, Page(s) 478–487

    Abstract: Cryoglobulins are immunoglobulins that precipitate in vitro at temperatures below 37 ̊C. Cryoglobulin-associated disease is heterogeneous, as not all patients present with it, includes various syndromic presentations (vasculitis is the most common, ... ...

    Title translation Cryoglobulinemia.
    Abstract Cryoglobulins are immunoglobulins that precipitate in vitro at temperatures below 37 ̊C. Cryoglobulin-associated disease is heterogeneous, as not all patients present with it, includes various syndromic presentations (vasculitis is the most common, hyperviscosity syndrome is more exceptional), and can be associated with acute clinical pictures with high mortality. Until the appearance of specific antiviral treatments, the main aetiology has been chronic HCV infection, and currently it is mainly associated with systemic autoimmune diseases, malignant neoplasms and cases with no identified aetiology (essential cryoglobulinemia). Treatment should be modulated according to the predominant etiopathogenesis (vasculitis or hyperviscosity), the severity of internal organ involvement and, especially, the associated underlying disease. Due to the complex aetiological, clinical and pathological scenario of cryoglobulinaemia, early recognition of the most common clinical presentations, a comprehensive clinical assessment of the different organs that may be affected, and multidisciplinary work led by a unit specialised in systemic autoimmune diseases is essential.
    MeSH term(s) Antiviral Agents/therapeutic use ; Autoimmune Diseases/complications ; Autoimmune Diseases/diagnosis ; Autoimmune Diseases/drug therapy ; Cryoglobulinemia/diagnosis ; Cryoglobulinemia/etiology ; Cryoglobulinemia/therapy ; Humans ; Immunoglobulins ; Vasculitis/diagnosis ; Vasculitis/etiology ; Vasculitis/therapy
    Chemical Substances Antiviral Agents ; Immunoglobulins
    Language Spanish
    Publishing date 2022-02-22
    Publishing country Spain
    Document type Journal Article ; Review
    ZDB-ID 411607-0
    ISSN 1578-8989 ; 0025-7753
    ISSN (online) 1578-8989
    ISSN 0025-7753
    DOI 10.1016/j.medcli.2021.11.017
    Database MEDical Literature Analysis and Retrieval System OnLINE

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