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  1. Article ; Online: H

    Itai, Shunsuke / Fujii, Yuki / Kaneko, Mika K / Yamada, Shinji / Nakamura, Takuro / Yanaka, Miyuki / Saidoh, Noriko / Chang, Yao-Wen / Handa, Saori / Takahashi, Maki / Suzuki, Hiroyoshi / Harada, Hiroyuki / Kato, Yukinari

    Monoclonal antibodies in immunodiagnosis and immunotherapy

    2017  Volume 36, Issue 4, Page(s) 143–148

    Abstract: ... mAb clones, only three mAbs reacted with HER2 in Western blot, and clone H ...

    Abstract Human epidermal growth factor receptor 2 (HER2) plays a critical role in the progression of breast cancers, and HER2 overexpression is associated with poor clinical outcomes. Trastuzumab is an anti-HER2 humanized antibody that leads to significant survival benefits in patients with HER2-positive metastatic breast cancers. In this study, we developed novel anti-HER2 monoclonal antibodies (mAbs) and characterized their efficacy in flow cytometry, Western blot, and immunohistochemical analyses. Initially, we expressed the full length or ectodomain of HER2 in LN229 glioblastoma cells and then immunized mice with ectodomain of HER2 or LN229/HER2, and performed the first screening by enzyme-linked immunosorbent assays using ectodomain of HER2. Subsequently, we selected mAbs according to their efficacy in flow cytometry (second screening), Western blot (third screening), and immunohistochemical analyses (fourth screening). Among 100 mAb clones, only three mAbs reacted with HER2 in Western blot, and clone H
    MeSH term(s) Animals ; Antibodies, Monoclonal/immunology ; Antibody Specificity ; CHO Cells ; Cell Line, Tumor ; Cricetulus ; Female ; Flow Cytometry ; HEK293 Cells ; Humans ; Hybridomas ; Immunohistochemistry ; Mice, Inbred BALB C ; Protein Binding ; Receptor, ErbB-2/immunology ; Receptor, ErbB-2/metabolism ; Sensitivity and Specificity
    Chemical Substances Antibodies, Monoclonal ; ERBB2 protein, human (EC 2.7.10.1) ; Receptor, ErbB-2 (EC 2.7.10.1)
    Language English
    Publishing date 2017-07-12
    Publishing country United States
    Document type Journal Article
    ISSN 2167-9436
    ISSN (online) 2167-9436
    DOI 10.1089/mab.2017.0026
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  2. Article ; Online: Aerobic H

    Mori, Toshio / Takahashi, Saaya / Soga, Ayumi / Arimoto, Misa / Kishikawa, Rintaro / Yama, Yuhei / Dohra, Hideo / Kawagishi, Hirokazu / Hirai, Hirofumi

    Frontiers in fungal biology

    2023  Volume 4, Page(s) 1201889

    Abstract: ... anaerobic conditions. In higher eukaryotes, it is thought that molecular hydrogen (H ...

    Abstract Biohydrogen is mainly produced by anaerobic bacteria, anaerobic fungi, and algae under anaerobic conditions. In higher eukaryotes, it is thought that molecular hydrogen (H
    Language English
    Publishing date 2023-06-27
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2673-6128
    ISSN (online) 2673-6128
    DOI 10.3389/ffunb.2023.1201889
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Phosphorylation of plasma membrane H

    Hayashi, Yuki / Fukatsu, Kohei / Takahashi, Koji / Kinoshita, Satoru N / Kato, Kyohei / Sakakibara, Taku / Kuwata, Keiko / Kinoshita, Toshinori

    Nature communications

    2024  Volume 15, Issue 1, Page(s) 1194

    Abstract: Plasma membrane (PM) H ...

    Abstract Plasma membrane (PM) H
    MeSH term(s) Arabidopsis/metabolism ; Phosphorylation ; Light ; Plant Stomata/metabolism ; Proton-Translocating ATPases/genetics ; Proton-Translocating ATPases/metabolism ; Arabidopsis Proteins/genetics ; Arabidopsis Proteins/metabolism ; Cell Membrane/metabolism
    Chemical Substances Proton-Translocating ATPases (EC 3.6.3.14) ; Arabidopsis Proteins
    Language English
    Publishing date 2024-02-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-024-45248-5
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  4. Article ; Online: Impact of Modified H

    Shikama, Taku / Otaki, Yoichiro / Watanabe, Tetsu / Takahashi, Hiroki / Kurokawa, Tasuku / Tamura, Harutoshi / Kato, Shigehiko / Nishiyama, Satoshi / Arimoto, Takanori / Watanabe, Masafumi

    Circulation reports

    2022  Volume 4, Issue 8, Page(s) 378–387

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2022-07-15
    Publishing country Japan
    Document type Journal Article
    ISSN 2434-0790
    ISSN (online) 2434-0790
    DOI 10.1253/circrep.CR-22-0063
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Mechanism of H

    Tanahashi, Yuki / Takahashi, Kosuke / Tsubonouchi, Yuta / Nozawa, Shunsuke / Adachi, Shin-Ichi / Hirahara, Masanari / Mohamed, Eman A / Zahran, Zaki N / Saito, Kenji / Yui, Tatsuto / Yagi, Masayuki

    Proceedings of the National Academy of Sciences of the United States of America

    2021  Volume 118, Issue 52

    Abstract: The understanding of O-O bond formation is of great importance for revealing the mechanism of water oxidation in photosynthesis and for developing efficient catalysts for water oxidation in artificial photosynthesis. The chemical oxidation of the ... ...

    Abstract The understanding of O-O bond formation is of great importance for revealing the mechanism of water oxidation in photosynthesis and for developing efficient catalysts for water oxidation in artificial photosynthesis. The chemical oxidation of the Ru
    Language English
    Publishing date 2021-12-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.2113910118
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1148: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article: Histamine H

    Ito, Takehito / Kimura, Yasuyuki / Seki, Chie / Ichise, Masanori / Yokokawa, Keita / Kawamura, Kazunori / Takahashi, Hidehiko / Higuchi, Makoto / Zhang, Ming-Rong / Suhara, Tetsuya / Yamada, Makiko

    EJNMMI research

    2018  Volume 8, Issue 1, Page(s) 48

    Abstract: Background: The histamine H: Findings: Ten healthy volunteers underwent both fMRI and PET scans ... The N-back task was used to assess the neural activities related to working memory. H: Conclusions ... Higher neural activity of working memory was associated with lower H ...

    Abstract Background: The histamine H
    Findings: Ten healthy volunteers underwent both fMRI and PET scans. The N-back task was used to assess the neural activities related to working memory. H
    Conclusions: Higher neural activity of working memory was associated with lower H
    Language English
    Publishing date 2018-06-14
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2619892-7
    ISSN 2191-219X
    ISSN 2191-219X
    DOI 10.1186/s13550-018-0406-4
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  7. Article ; Online: Carbonization and H

    Trinh, Trang K / Tsubota, Toshiki / Takahashi, Shuto / Mai, Nga T / Nguyen, Minh N / Nguyen, Nam H

    Scientific reports

    2020  Volume 10, Issue 1, Page(s) 19974

    Abstract: ... surface area (SSA) and pore volumes of biochars derived from the D. linearis by H ...

    Abstract Today, the world's climate change is a growing problem, plant carbon sequestration is one of the effective ways to mitigate climate change by reducing greenhouse gases, mostly carbon gases. Dicranopteris linearis (D. linearis), a common fern species in the tropic or subtropic ecoregions, has been recently recognized as a potential feedstock to produce highly porous biochar. This study aims to enhance the specific surface area (SSA) and pore volumes of biochars derived from the D. linearis by H
    Language English
    Publishing date 2020-11-17
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-020-77099-7
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  8. Article ; Online: C-H Arylation of Benzene with Aryl Halides using H

    Yatabe, Takeshi / Tome, Tamon / Takahashi, Yukina / Matsumoto, Takahiro / Yoon, Ki-Seok / Nakai, Hidetaka / Ogo, Seiji

    Chemistry (Weinheim an der Bergstrasse, Germany)

    2021  Volume 27, Issue 69, Page(s) 17326–17330

    Abstract: This paper reports the first example of C-H arylation of benzene under mild conditions, using H ...

    Abstract This paper reports the first example of C-H arylation of benzene under mild conditions, using H
    Language English
    Publishing date 2021-10-25
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1478547-X
    ISSN 1521-3765 ; 0947-6539
    ISSN (online) 1521-3765
    ISSN 0947-6539
    DOI 10.1002/chem.202102735
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  9. Article ; Online: Screening the Drug:H

    Santos, Rui / Cavalheiro, Mafalda / Costa, Catarina / Takahashi-Nakaguchi, Azusa / Okamoto, Michiyo / Chibana, Hiroji / Teixeira, Miguel C

    Frontiers in cellular and infection microbiology

    2020  Volume 10, Page(s) 29

    Abstract: Biofilm formation and drug resistance are two key pathogenesis traits exhibited ... ...

    Abstract Biofilm formation and drug resistance are two key pathogenesis traits exhibited by
    MeSH term(s) Antifungal Agents ; Antiporters/genetics ; Biofilms ; Candida glabrata/genetics ; Humans ; Microbial Sensitivity Tests ; Pharmaceutical Preparations
    Chemical Substances Antifungal Agents ; Antiporters ; Pharmaceutical Preparations
    Language English
    Publishing date 2020-02-04
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2619676-1
    ISSN 2235-2988 ; 2235-2988
    ISSN (online) 2235-2988
    ISSN 2235-2988
    DOI 10.3389/fcimb.2020.00029
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Association between the Co-administration of Histamine H

    Yamazaki, Tomoko / Uozumi, Ryuji / Kawazoe, Hitoshi / Kitazume, Yoshiko / Iihara, Hirotoshi / Fujii, Hironori / Takahashi, Masaya / Arai, Takahiro / Murachi, Yasushi / Sato, Yumiko / Mikami, Takahiro / Hashiguchi, Koji / Yoshizawa, Tomoe / Takahashi, Katsuyuki / Fujita, Yukiyoshi / Hosokawa, Yuki / Morozumi, Issei / Tsuchiya, Masami / Yokoyama, Atsushi /
    Hashimoto, Hironobu / Furukawa, Tetsuya

    Journal of Cancer

    2022  Volume 13, Issue 10, Page(s) 3073–3083

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2022-08-08
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 2573318-7
    ISSN 1837-9664
    ISSN 1837-9664
    DOI 10.7150/jca.73385
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