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  1. Article ; Online: The Pho23-Rpd3 histone deacetylase complex regulates the yeast metabolic transcription factor Stb5.

    Delorme-Axford, Elizabeth / Tasmi, Tabassum Ahmad / Klionsky, Daniel J

    microPublication biology

    2023  Volume 2023

    Abstract: Macroautophagy/autophagy is an essential catabolic process for maintaining homeostasis and cell survival under stressful conditions. We previously characterized the metabolic transcription factor Stb5 as a negative modulator of autophagy through its ... ...

    Abstract Macroautophagy/autophagy is an essential catabolic process for maintaining homeostasis and cell survival under stressful conditions. We previously characterized the metabolic transcription factor Stb5 as a negative modulator of autophagy through its regulation of genes involved in NADPH production. However, the molecular mechanisms regulating
    Language English
    Publishing date 2023-08-25
    Publishing country United States
    Document type Journal Article
    ISSN 2578-9430
    ISSN (online) 2578-9430
    DOI 10.17912/micropub.biology.000940
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: The yeast transcription factor Stb5 acts as a negative regulator of autophagy by modulating cellular metabolism.

    Delorme-Axford, Elizabeth / Wen, Xin / Klionsky, Daniel J

    Autophagy

    2023  Volume 19, Issue 10, Page(s) 2719–2732

    Abstract: Macroautophagy/autophagy is a highly conserved pathway of cellular degradation and recycling that maintains cell health during homeostatic conditions and facilitates survival during stress. Aberrant cellular autophagy contributes to the pathogenesis of ... ...

    Abstract Macroautophagy/autophagy is a highly conserved pathway of cellular degradation and recycling that maintains cell health during homeostatic conditions and facilitates survival during stress. Aberrant cellular autophagy contributes to the pathogenesis of human diseases such as cancer, neurodegeneration, and cardiovascular, metabolic and lysosomal storage disorders. Despite decades of research, there remain unanswered questions as to how autophagy modulates cellular metabolism, and, conversely, how cellular metabolism affects autophagy activity. Here, we have identified the yeast metabolic transcription factor Stb5 as a negative regulator of autophagy. Chromosomal deletion of
    MeSH term(s) Humans ; Autophagy/genetics ; Gene Expression Regulation, Fungal ; NADP/metabolism ; Saccharomyces cerevisiae/genetics ; Saccharomyces cerevisiae/metabolism ; Transcription Factors/metabolism
    Chemical Substances NADP (53-59-8) ; Transcription Factors ; Stb5 protein, S cerevisiae
    Language English
    Publishing date 2023-07-02
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 2454135-7
    ISSN 1554-8635 ; 1554-8627
    ISSN (online) 1554-8635
    ISSN 1554-8627
    DOI 10.1080/15548627.2023.2228533
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6741: Show issues Location:
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  3. Article ; Online: The LC3-conjugation machinery specifies cargo loading and secretion of extracellular vesicles.

    Delorme-Axford, Elizabeth / Klionsky, Daniel J

    Autophagy

    2020  Volume 16, Issue 7, Page(s) 1169–1171

    Abstract: Classical macroautophagy/autophagy functions to maintain cell health during stressful conditions by targeting cytosolic components for degradation and recycling through the lysosomal pathway. In contrast, nondegradative secretory autophagy functions as ... ...

    Abstract Classical macroautophagy/autophagy functions to maintain cell health during stressful conditions by targeting cytosolic components for degradation and recycling through the lysosomal pathway. In contrast, nondegradative secretory autophagy functions as an alternative autophagy mechanism to mediate extracellular secretion. A recent study published in
    Abbreviations: ATG, autophagy-related; BioID, proximity-dependent biotinylation; CM, conditioned medium; EV, extracellular vesicle; HNRNPK, heterogeneous nuclear ribonuclear protein K; ILVs, intralumenal vesicles; LDELS, LC3-dependent EV loading and secretion; LIR, LC3-interacting region; MAP1LC3/LC3, microtubule associated protein 1 light chain 3; MS, mass spectrometry; MVBs, multivesicular bodies; ncRNA, non-coding RNA; NSMAF/FAN, neutral sphingomyelinase activation associated factor; P-bodies, processing bodies; PE, phosphatidylethanolamine; RB1CC1/FIP200, RB1 inducible coiled-coil 1; RBP, RNA-binding protein; RNA-seq, RNA sequencing; SAFB, scaffold-attachment factor B; SILAC, stable isotope labeling of amino acids in cell culture; SMPD3/nSMase2, sphingomyelin phosphodiesterase 3; TEM, transmission electron microscopy; TMT, tandem mass tagging.
    Language English
    Publishing date 2020-05-13
    Publishing country United States
    Document type Editorial
    ZDB-ID 2454135-7
    ISSN 1554-8635 ; 1554-8627
    ISSN (online) 1554-8635
    ISSN 1554-8627
    DOI 10.1080/15548627.2020.1760057
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  4. Article ; Online: Highlights in the fight against COVID-19: does autophagy play a role in SARS-CoV-2 infection?

    Delorme-Axford, Elizabeth / Klionsky, Daniel J

    Autophagy

    2020  Volume 16, Issue 12, Page(s) 2123–2127

    Abstract: In the preceding months, the novel SARS-CoV-2 pandemic has devastated global communities. The need for safe and effective prophylactic and therapeutic treatments to combat COVID-19 - the human disease resulting from SARS-CoV-2 infection - is clear. Here, ...

    Abstract In the preceding months, the novel SARS-CoV-2 pandemic has devastated global communities. The need for safe and effective prophylactic and therapeutic treatments to combat COVID-19 - the human disease resulting from SARS-CoV-2 infection - is clear. Here, we present recent developments in the effort to combat COVID-19 and consider whether SARS-CoV-2 may potentially interact with the host autophagy pathway.
    MeSH term(s) Adenosine Monophosphate/analogs & derivatives ; Adenosine Monophosphate/therapeutic use ; Alanine/analogs & derivatives ; Alanine/therapeutic use ; Animals ; Antibodies, Monoclonal/therapeutic use ; Antimetabolites/therapeutic use ; Antiviral Agents/therapeutic use ; Autophagy/physiology ; Betacoronavirus/physiology ; COVID-19/epidemiology ; COVID-19/immunology ; COVID-19/pathology ; COVID-19/therapy ; Dexamethasone/therapeutic use ; Disease Outbreaks ; Drug Development/trends ; Humans ; Mice ; Pandemics ; SARS-CoV-2/immunology ; SARS-CoV-2/pathogenicity ; SARS-CoV-2/physiology ; Signal Transduction/physiology ; Virus Internalization
    Chemical Substances Antibodies, Monoclonal ; Antimetabolites ; Antiviral Agents ; remdesivir (3QKI37EEHE) ; Adenosine Monophosphate (415SHH325A) ; Dexamethasone (7S5I7G3JQL) ; Alanine (OF5P57N2ZX)
    Keywords covid19
    Language English
    Publishing date 2020-11-05
    Publishing country United States
    Document type Editorial
    ZDB-ID 2454135-7
    ISSN 1554-8635 ; 1554-8627
    ISSN (online) 1554-8635
    ISSN 1554-8627
    DOI 10.1080/15548627.2020.1844940
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: TEX264 is a major receptor for mammalian reticulophagy.

    Delorme-Axford, Elizabeth / Popelka, Hana / Klionsky, Daniel J

    Autophagy

    2019  Volume 15, Issue 10, Page(s) 1677–1681

    Abstract: The endoplasmic reticulum (ER) is the main site of cellular protein and calcium homeostasis, as well as lipid synthesis in eukaryotic cells. Reticulophagy is the selective clearance and degradation of ER components and membranes by the cellular autophagy ...

    Abstract The endoplasmic reticulum (ER) is the main site of cellular protein and calcium homeostasis, as well as lipid synthesis in eukaryotic cells. Reticulophagy is the selective clearance and degradation of ER components and membranes by the cellular autophagy machinery. Recently, 2 groups (the laboratories of Noboru Mizushima and Wade Harper) independently identified the previously uncharacterized protein TEX264 (testis expressed gene 264) as a major receptor for selective reticulophagy in mammalian cells. Here we highlight and integrate the major findings of their recent work.
    MeSH term(s) Animals ; Autophagy ; Carrier Proteins ; Cell Cycle Proteins ; Endoplasmic Reticulum ; Endoplasmic Reticulum Stress ; Mice ; Nerve Tissue Proteins ; Nutrients
    Chemical Substances Carrier Proteins ; Ccpg1 protein, mouse ; Cell Cycle Proteins ; Nerve Tissue Proteins ; Rtn3 protein, mouse
    Language English
    Publishing date 2019-07-30
    Publishing country United States
    Document type Editorial ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 2454135-7
    ISSN 1554-8635 ; 1554-8627
    ISSN (online) 1554-8635
    ISSN 1554-8627
    DOI 10.1080/15548627.2019.1646540
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Transcriptional and post-transcriptional regulation of autophagy in the yeast

    Delorme-Axford, Elizabeth / Klionsky, Daniel J

    The Journal of biological chemistry

    2018  Volume 293, Issue 15, Page(s) 5396–5403

    Abstract: Autophagy is a highly conserved catabolic pathway that is vital for development, cell survival, and the degradation of dysfunctional organelles and potentially toxic aggregates. Dysregulation of autophagy is associated with cancer, neurodegeneration, and ...

    Abstract Autophagy is a highly conserved catabolic pathway that is vital for development, cell survival, and the degradation of dysfunctional organelles and potentially toxic aggregates. Dysregulation of autophagy is associated with cancer, neurodegeneration, and lysosomal storage diseases. Accordingly, autophagy is precisely regulated at multiple levels (transcriptional, post-transcriptional, translational, and post-translational) to prevent aberrant activity. Various model organisms are used to study autophagy, but the baker's yeast
    MeSH term(s) Autophagy/genetics ; Gene Expression Regulation, Fungal ; Protein Processing, Post-Translational/genetics ; Saccharomyces cerevisiae/genetics ; Saccharomyces cerevisiae/metabolism ; Saccharomyces cerevisiae Proteins/biosynthesis ; Saccharomyces cerevisiae Proteins/genetics ; Transcription, Genetic
    Chemical Substances Saccharomyces cerevisiae Proteins
    Language English
    Publishing date 2018-01-25
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 2997-x
    ISSN 1083-351X ; 0021-9258
    ISSN (online) 1083-351X
    ISSN 0021-9258
    DOI 10.1074/jbc.R117.804641
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  7. Article ; Online: Secretory autophagy holds the key to lysozyme secretion during bacterial infection of the intestine.

    Delorme-Axford, Elizabeth / Klionsky, Daniel J

    Autophagy

    2018  Volume 14, Issue 3, Page(s) 365–367

    Abstract: In 2013, Dr. Lora Hooper and colleagues described the induction of antibacterial macroautophagy/autophagy in intestinal epithelial cells as a cytoprotective host defense mechanism against invading Salmonella enterica serovar Typhimurium (S. Typhimurium). ...

    Abstract In 2013, Dr. Lora Hooper and colleagues described the induction of antibacterial macroautophagy/autophagy in intestinal epithelial cells as a cytoprotective host defense mechanism against invading Salmonella enterica serovar Typhimurium (S. Typhimurium). Canonical autophagy functions in a primarily degradative capacity to safeguard cells and ensure survival during stress conditions, including pathogen infection. In contrast, secretory autophagy has emerged as an alternative nondegradative mechanism for cellular trafficking and unconventional protein secretion. More recently, a study by Bel et al. from Dr. Hooper's lab describes how intestinal Paneth cells exploit the endoplasmic reticulum (ER) stress response to release antibacterial lysozyme through secretory autophagy in response to S. Typhimurium infection.
    MeSH term(s) Animals ; Autophagy/physiology ; Bacterial Infections/microbiology ; Humans ; Intestines/microbiology ; Muramidase/metabolism ; Salmonella Infections/microbiology ; Salmonella typhimurium/pathogenicity
    Chemical Substances Muramidase (EC 3.2.1.17)
    Language English
    Publishing date 2018-01-29
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 2454135-7
    ISSN 1554-8635 ; 1554-8627
    ISSN (online) 1554-8635
    ISSN 1554-8627
    DOI 10.1080/15548627.2017.1401425
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  8. Article ; Online: On the edge of degradation: Autophagy regulation by RNA decay.

    Delorme-Axford, Elizabeth / Klionsky, Daniel J

    Wiley interdisciplinary reviews. RNA

    2018  Volume 10, Issue 3, Page(s) e1522

    Abstract: Cells must dynamically adapt to altered environmental conditions, particularly during times of stress, to ensure their ability to function effectively and survive. The macroautophagy/autophagy pathway is highly conserved across eukaryotic cells and ... ...

    Abstract Cells must dynamically adapt to altered environmental conditions, particularly during times of stress, to ensure their ability to function effectively and survive. The macroautophagy/autophagy pathway is highly conserved across eukaryotic cells and promotes cell survival during stressful conditions. In general, basal autophagy occurs at a low level to sustain cellular homeostasis and metabolism. However, autophagy is robustly upregulated in response to nutrient deprivation, pathogen infection and increased accumulation of potentially toxic protein aggregates and superfluous organelles. Within the cell, RNA decay maintains quality control to remove aberrant transcripts and regulate appropriate levels of gene expression. Recent evidence has identified components of the cellular mRNA decay machinery as novel regulators of autophagy. Here, we review current findings that demonstrate how autophagy is modulated through RNA decay. This article is categorized under: RNA Turnover and Surveillance > Turnover/Surveillance Mechanisms RNA Turnover and Surveillance > Regulation of RNA Stability.
    MeSH term(s) Autophagy ; Eukaryotic Cells/physiology ; Gene Expression Regulation ; RNA Stability ; Stress, Physiological
    Language English
    Publishing date 2018-12-17
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 2634714-3
    ISSN 1757-7012 ; 1757-7004
    ISSN (online) 1757-7012
    ISSN 1757-7004
    DOI 10.1002/wrna.1522
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  9. Article ; Online: Highlights in the fight against COVID-19

    Delorme-Axford, Elizabeth / Klionsky, Daniel J.

    Autophagy

    does autophagy play a role in SARS-CoV-2 infection?

    2020  , Page(s) 1–5

    Keywords Cell Biology ; Molecular Biology ; covid19
    Language English
    Publisher Informa UK Limited
    Publishing country uk
    Document type Article ; Online
    ZDB-ID 2146183-1
    ISSN 1551-4005 ; 1538-4101 ; 1554-8627
    ISSN (online) 1551-4005
    ISSN 1538-4101 ; 1554-8627
    DOI 10.1080/15548627.2020.1844940
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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    Zs.A 5881: Show issues Location:
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  10. Article ; Online: Inflammatory-dependent Sting activation induces antiviral autophagy to limit zika virus in the Drosophila brain.

    Delorme-Axford, Elizabeth / Klionsky, Daniel J

    Autophagy

    2018  Volume 15, Issue 1, Page(s) 1–3

    Abstract: Incidences of congenital syndrome associated with maternal zika virus (ZIKV) infection during pregnancy are well documented; however, the cellular and molecular mechanisms by which ZIKV infection causes these devastating fetal pathologies are still under ...

    Abstract Incidences of congenital syndrome associated with maternal zika virus (ZIKV) infection during pregnancy are well documented; however, the cellular and molecular mechanisms by which ZIKV infection causes these devastating fetal pathologies are still under active investigation. ZIKV is a member of the flavivirus family and is mainly transmitted to human hosts through Aedes mosquito vectors. However, in vivo models for the neurological tropism of the virus and the arthropod vector have been lacking. A recent study published in Cell Host & Microbe from Dr. Sara Cherry's lab investigates both of these key aspects of the ZIKV infectious life cycle. Liu et al. demonstrate how inflammatory activated Sting/dSTING-dependent antiviral macroautophagy/autophagy is sufficient to restrict ZIKV infection in the Drosophila melanogaster brain. Additionally, this study provides further evidence for the ancestral function of autophagy in protecting host cells from viral invaders. Abbreviations: AGO2: Argonaute 2; ATG: autophagy-related; Dcr-2: Dicer-2; DptA/Dipt: Diptericin A; Drs: Drosomycin; DCV: Drosophila C virus; IMD: immune-deficiency; qRT-PCR: quantitative real-time PCR; Rel/NF-κB: Relish; RNAi: RNA interference; ZIKV: zika virus.
    MeSH term(s) Animals ; Antiviral Agents ; Autophagy ; Brain ; Drosophila ; Drosophila melanogaster ; Humans ; Inflammation ; Mosquito Vectors ; Virus Replication/drug effects ; Zika Virus ; Zika Virus Infection
    Chemical Substances Antiviral Agents
    Language English
    Publishing date 2018-11-01
    Publishing country United States
    Document type Editorial ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 2454135-7
    ISSN 1554-8635 ; 1554-8627
    ISSN (online) 1554-8635
    ISSN 1554-8627
    DOI 10.1080/15548627.2018.1539585
    Database MEDical Literature Analysis and Retrieval System OnLINE

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