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Article ; Online: The Land of Shu

Liu Huo*

Contemporary Social Sciences (2022)

Where Tang Poetry Rose and Fell

2022

Abstract: During the Tang Dynasty, the land of Shu was composed of the Ba and Shu areas, which were adjacent ... Zhuang of the late Tang. The land of Shu is, therefore, the witness of the rise and fall of Tang poetry. ...

Abstract	During the Tang Dynasty, the land of Shu was composed of the Ba and Shu areas, which were adjacent to present-day Hanzhong city of Shaanxi province to the north, northern Yunnan province to the south, Wushan county of Chongqing to the east, and Xichang city of Sichuan province to the west. In the nearly 300 years of rule under the dynasty, a number of poets, whether they were born or just worked and lived there for a short period of time, wrote many immortal poems, which constitute an integral part of Tang poetry. They range from Chen Zi’ang and Wang Bo of the early Tang to Li Shangyin, Wen Tingyun, and Wei Zhuang of the late Tang. The land of Shu is, therefore, the witness of the rise and fall of Tang poetry.
Keywords	the land of shu ; tang poetry ; rise and fall ; Social Sciences ; H
Language	English
Publishing date	2022-03-01T00:00:00Z
Publisher	Editorial Department of Contemporary Social Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Sung Shu Chien: the founder of modern Chinese botany.

Liu, Huan / Huang, Kaijing / Yuan, Xuefan / Cheng, Hao

Protein & cell

2022 Volume 14, Issue 2, Page(s) 79–83

MeSH term(s)	Humans ; Botany/history ; History, 20th Century ; China
Language	English
Publishing date	2022-10-27
Publishing country	Germany
Document type	Biography ; Journal Article
ZDB-ID	2543451-2
ISSN	1674-8018 ; 1674-8018
ISSN (online)	1674-8018
ISSN	1674-8018
DOI	10.1093/procel/pwac047
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Efficacy of Shu-yi-ning-chang decoction on IBS-D: Modulating Nr4a3 pathway to reduce visceral hypersensitivity.

Guo, Yajing / Lu, Qiongqiong / Yang, Xiao-Jun / He, Yuxi / Wu, Yue / Qin, Baijun / Li, Ting / Duan, Min / Liu, Nvping / Wu, Xin / He, Yuanjun

PloS one

2024 Volume 19, Issue 4, Page(s) e0299376

Abstract: Aim of the study: To evaluate the therapeutic effect of SYNC in diarrhea irritable bowel syndrome (IBS-D) and explore its underlying mechanism through transcriptomic sequencing (RNA-Seq).: Materials and methods: A rat model of IBS-D was constructed ... ...

Abstract	Aim of the study: To evaluate the therapeutic effect of SYNC in diarrhea irritable bowel syndrome (IBS-D) and explore its underlying mechanism through transcriptomic sequencing (RNA-Seq). Materials and methods: A rat model of IBS-D was constructed to elucidate the effects of SYNC. Abdominal withdrawal reflex (AWR), fecal water content (FWC), and recording body weight were calculated to assess visceral sensitivity in rats. Histopathological changes in the colon and alterations in mast cell (MC) count were determined. Immunohistochemistry was employed to assess mast cell tryptase (MCT) expression in rat colons. Serum levels of corticotropin-releasing Hormone (CRH), interleukin-6 (IL-6), calcitonin gene-related peptide (CGRP), and 5-hydroxytryptamine (5-HT) were quantified using ELISA. RNA-Seq of colon tissue was performed, followed by Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses. Western blot analysis was conducted to quantify the expression levels of key proteins in the Nr4a3 pathway in the colon and hypothalamus tissues of rats. Results: SYNC alleviated visceral hypersensitivity and mood disorders in rats with IBS-D. Moreover, it was positively correlated with its dosage and the observed effects, such as the enhancement of the colon's mucosal lining condition and reduction in the number and activation of MCs within the model group. SYNC reduced the expression levels of factors related to the brain-gut axis and inflammatory markers in the bloodstream. RNA-Seq analysis indicated that SYNC down-regulated the expression of Nr4a3 and PI3K. These SYNC-targeted genes primarily played roles in immune regulation and inflammatory responses, correlating with the modulation of Nr4a3 and the PI3K/AKT pathway. Western blot analysis further confirmed SYNC's influence on inflammation-related MC activation by downregulating key proteins in the Nr4a3/PI3K pathway. Conclusions: SYNC inhibited mast cell activation and attenuated visceral hypersensitivity in the colon tissues of IBS-D rats. These effects were mediated by the Nr4a3/PI3K signaling pathway.
MeSH term(s)	Rats ; Animals ; Irritable Bowel Syndrome/pathology ; Rats, Sprague-Dawley ; Phosphatidylinositol 3-Kinases ; Diarrhea ; Corticotropin-Releasing Hormone/metabolism ; DNA-Binding Proteins ; Nerve Tissue Proteins
Chemical Substances	Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; Corticotropin-Releasing Hormone (9015-71-8) ; Nr4a3 protein, rat ; DNA-Binding Proteins ; Nerve Tissue Proteins
Language	English
Publishing date	2024-04-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0299376
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Article: [Effect of application at Shu-Mu acupoint on serum uric acid in hyperuricemic rats].

Liu, Jia-Nan / Tang, Xue-Qing / He, Xiao-Qian / Wu, Xue-Mei / Sui, Ming-He

Zhen ci yan jiu = Acupuncture research

2021 Volume 46, Issue 5, Page(s) 411–415

Abstract: Objective: To observe the effect of application at Back-Shu with Front-Mu acupoints on serum ... the mechanism of Shu-Mu acupoint application on treatment of hyperuricemia.: Methods: SD rats were randomly ... the SUA content in the model group increased (: Conclusion: Medication application at Shu-Mu points ...

Abstract	Objective: To observe the effect of application at Back-Shu with Front-Mu acupoints on serum uric acid (SUA) and kidney uric acid transport related proteins in hyperuricemia rats, so as to explore the mechanism of Shu-Mu acupoint application on treatment of hyperuricemia. Methods: SD rats were randomly divided into blank control, model, vaseline application and medication application groups, with 8 rats in each group. The hyperuricemia rat model was established by gavage of potassium oxonate. Rats in the vaseline application group received application of vaseline at bilateral "Ganshu"(BL18) and "Qimen"(LI14), "Pishu"(BL20) and "Zhangmen"(LR13), "Shenshu" (BL23) and "Jingmen"(GB25). Rats in the medication application group received application of traditional Chinese medicine at the same acupoints. The contents of SUA and creatinine (SCr) were detected by automatic biochemical analyzer. H.E. staining was used to observe the pathological changes of kidney. And the protein expression levels of organic anion transporter 1(OAT1) and adenosine triphosphate binding cassette transporter G2(ABCG2) were detected by immunohistochemistry. Results: Rats in the model group showed symptoms such as polydipsia, polyuria, loose stools, fatigue, weakness, etc. The renal tubules atrophied, and urate crystals can be seen in the lumen. Compared with the control group. the SUA content in the model group increased ( Conclusion: Medication application at Shu-Mu points can effectively reduce the SUA level of hyperuricemia rats, which may be related to its effects in up-regulating the protein expressions of OAT1 and ABCG2 in the kidney and reducing the damage to the kidneys.
MeSH term(s)	Acupuncture Points ; Animals ; Hyperuricemia/drug therapy ; Hyperuricemia/genetics ; Kidney ; Rats ; Rats, Sprague-Dawley ; Uric Acid
Chemical Substances	Uric Acid (268B43MJ25)
Language	Chinese
Publishing date	2021-06-04
Publishing country	China
Document type	Journal Article
ZDB-ID	1283179-7
ISSN	1000-0607
ISSN	1000-0607
DOI	10.13702/j.1000-0607.200708
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Article ; Online: The Herbal Combination Shu Gan Jie Yu Regulates the SNCG/ER-a/AKT-ERK Pathway in DMBA-Induced Breast Cancer and Breast Cancer Cell Lines Based on RNA-Seq and IPA Analysis.

Zhao, Yi / Zhao, Linan / Wang, Tao / Liu, Zhenghao / Tang, Suyuan / Huang, Hongxia / Wu, Li / Sun, Youzhi

Integrative cancer therapies

2024 Volume 23, Page(s) 15347354241233258

Abstract: Background: Soothing the liver (called : The aim of the study: To investigate the inhibiting effect of SGJY on breast cancer in vivo and vitro, and to explore the potential mechanisms.: Materials and methods: SGJY herbal combination was extracted ... ...

Abstract	Background: Soothing the liver (called The aim of the study: To investigate the inhibiting effect of SGJY on breast cancer in vivo and vitro, and to explore the potential mechanisms. Materials and methods: SGJY herbal combination was extracted using water. A breast cancer rat model was developed by chemical DMBA by gavage, then treated with SGJY for 11 weeks. The tumor tissue was preserved for RNA sequencing and analyzed by IPA software. The inhibition effects of SGJY on MCF-7 and T47D breast cancer cells were investigated by SRB assay and cell apoptosis analysis, and the protein expression levels of SNCG, ER-α, Results: SGJY significantly reduced the tumor weight and volume, and the level of estradiol in serum. The results of IPA analysis reveal SGJY upregulated 7 canonical pathways and downregulated 16 canonical pathways. Estrogen receptor signaling was the key canonical pathway with 9 genes downregulated. The results of upstream regulator analysis reveal beta-estradiol was the central target; the upstream regulator network scheme showed that 86 genes could affect the expression of the beta-estradiol, including SNCG, CCL21 and MB. Additionally, SGJY was verified to significantly alter the expression of SNCG mRNA, CCL21 mRNA and MB mRNA which was consistent with the data of RNA-Seq. The inhibition effects of SGJY exhibited a dose-dependent response. The apoptosis rates of MCF7 and T47D cells were upregulated. The protein expression of SNCG, ER-α, Conclusion: The results demonstrate that SGJY may inhibit the growth of breast cancer. The mechanism might involve downregulating the level of serum estradiol, and suppressing the protein expression in the SNCG/ER-α/AKT-ERK pathway.
MeSH term(s)	Animals ; Female ; Humans ; Rats ; Breast Neoplasms/metabolism ; Cell Line, Tumor ; Cell Proliferation ; Estradiol ; gamma-Synuclein/genetics ; gamma-Synuclein/metabolism ; MAP Kinase Signaling System ; MCF-7 Cells ; Neoplasm Proteins/genetics ; Neoplasm Proteins/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; Receptors, Estrogen/metabolism ; RNA, Messenger/metabolism ; RNA-Seq
Chemical Substances	Estradiol (4TI98Z838E) ; gamma-Synuclein ; Neoplasm Proteins ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; Receptors, Estrogen ; RNA, Messenger ; SNCG protein, human
Language	English
Publishing date	2024-02-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	2182320-0
ISSN	1552-695X ; 1534-7354
ISSN (online)	1552-695X
ISSN	1534-7354
DOI	10.1177/15347354241233258
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Article: Shu-Xie decoction alleviates oxidative stress and colon injury in acute sleep-deprived mice by suppressing p62/KEAP1/NRF2/HO1/NQO1 signaling.

Wang, Mengyuan / Li, Bo / Liu, Yijiang / Zhang, Mengting / Huang, Caoxin / Cai, Teng / Jia, Yibing / Huang, Xiaoqing / Ke, Hongfei / Liu, Suhuan / Yang, Shuyu

Frontiers in pharmacology

2023 Volume 14, Page(s) 1107507

Abstract: Introduction: ...

Abstract	Introduction:
Language	English
Publishing date	2023-02-06
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2023.1107507
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Article: Post-marketing safety surveillance and re-evaluaiton of Shu-Xue-Ning injection: a real-world study based on 30,122 cases.

Xinyao, Jin / Yifan, Zhang / Keyi, Wang / Wentai, Pang / Chunyang, Wang / Hui, Wang / Chunxiang, Liu / Yunhua, Xue / Wenke, Zheng

Frontiers in pharmacology

2023 Volume 14, Page(s) 1194367

Abstract: Objective: ...

Abstract	Objective:
Language	English
Publishing date	2023-11-29
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2023.1194367
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Article ; Online: Research on the mechanisms of Shu Yu wan in the treatment of cervical cancer based on network pharmacology analyses and molecular docking technology.

Liu, Shouze / Zhang, Qianqian / Liu, Wenhua / Huang, Xianghua

Natural product research

2022 Volume 37, Issue 4, Page(s) 646–650

Abstract: ... mechanisms of Shu Yu Wan (SYW) for treating cervical cancer (CC). The targets associated with CC and active ...

Abstract	Combining network pharmacology with molecular docking, our study revealed the candidate targets and mechanisms of Shu Yu Wan (SYW) for treating cervical cancer (CC). The targets associated with CC and active compounds in SYW were identified through TCGA, GeneCards and TCMSP databases. Consequently, a total of 16 active compounds in SYW and 38 common targets related to CC were predicted. Genes TP53 and CDK2 are among the hub genes in the PPI network. The results of GO and KEGG enrichment analyses suggested that SYW exerted pharmacological effects on CC by regulating cellular senescence, p53 signaling pathway, cell cycle, apoptosis, viral carcinogenesis and human papillomavirus infection (HPV) signaling pathway. Finally, molecular docking confirmed a strong binding affinity between the main active compounds of SYW with the core target proteins.
MeSH term(s)	Humans ; Female ; Uterine Cervical Neoplasms/drug therapy ; Molecular Docking Simulation ; Network Pharmacology ; Cell Cycle ; Technology ; Drugs, Chinese Herbal/pharmacology ; Drugs, Chinese Herbal/therapeutic use
Chemical Substances	Drugs, Chinese Herbal
Language	English
Publishing date	2022-05-03
Publishing country	England
Document type	Journal Article
ZDB-ID	2185747-7
ISSN	1478-6427 ; 1478-6419
ISSN (online)	1478-6427
ISSN	1478-6419
DOI	10.1080/14786419.2022.2071884
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Article ; Online: Yang-Xin-Shu-Mai granule alleviates atherosclerosis by regulating macrophage polarization via the TLR9/MyD88/NF-κB signaling pathway.

Huang, Hong / Sun, Zeqi / Xu, Junyao / Wang, Linjie / Zhao, Jing / Li, Jie / Zhang, Siqi / Yuan, Fang / Liu, Ming / Fang, Zhuyuan

Journal of ethnopharmacology

2023 Volume 318, Issue Pt A, Page(s) 116868

Abstract: Ethnopharmacological relevance: Previous studies have found that Yang-Xin-Shu-Mai granule (YXSMG ...

Abstract	Ethnopharmacological relevance: Previous studies have found that Yang-Xin-Shu-Mai granule (YXSMG) has certain advantages in the treatment of stable coronary heart disease. However, YXSMG can inhibit the progression of atherosclerotic plaque and stabilize vulnerable plaque needs to be further explored and studied. This research, mass spectrometry analysis, network pharmacology, in vivo and in vitro experimental studies were conducted to explore the mechanism of YXSMG on atherosclerosis. Aim of the study: To decipher the mechanism of atherosclerotic plaque, stabilization for YXSMG by analysis of its active ingredients and biological network and activity in whole animal and at cellular and molecular levels. Methods: The active components of YXSMG were determined using high performance liquid chromatography-mass spectrometry/mass spectrometry (HPLC-MS/MS) analysis. The 'Disease-Compound-Target-Pathway' network diagram was constructed using network pharmacology, and the stability of binding between core targets and core compounds was analyzed with molecular docking. After intervention with YXSMG, the pathology of aortic plaque, inflammation in the surrounding tissue, expression of TLR9/MyD88/NF-κB pathway protein in plaque and M1/M2 polarization of plaque macrophages were evaluated in vivo in apolipoprotein E-deficient (ApoE Results: Five active compounds were identified in YXSMG: catechin, formononetin, tanshinone IIA, cryptotanshinone and glycitein. Network pharmacology studies revealed TLR9 as one of the core targets of YXSMG intervention in atherosclerosis. Computer simulation of molecular docking showed that TLR9 could interact with the core compound to form a stable complex. In vivo experiments confirmed that YXSMG could significantly inhibit atherosclerotic plaque, reduce levels of blood lipids and inflammatory factors, downregulate TLR9/MyD88/NF-κB pathway protein and inhibit aortic sinus macrophages polarization to M1, but promote their polarization to M2 to inhibit inflammation. In vitro experiments revealed that YXSMG could downregulate expression of TLR9 gene and protein in ODN1826-activated RAW264.7 macrophages. ODN2088 had a synergistic effect with YXSMG on the TLR9/MyD88/NF-κB signaling pathway, and reprogrammed macrophages polarization from M1 to M2 by inhibiting TLR9, thus reducing immuno-inflammatory response. Conclusion: YXSMG can reduce the level of blood lipid and improve the size of atherosclerotic plaque and inflammatory infiltration in ApoE
MeSH term(s)	Mice ; Animals ; Plaque, Atherosclerotic/pathology ; NF-kappa B/metabolism ; Myeloid Differentiation Factor 88/metabolism ; Toll-Like Receptor 9/metabolism ; Computer Simulation ; Molecular Docking Simulation ; Tandem Mass Spectrometry ; Atherosclerosis/genetics ; Signal Transduction ; Macrophages ; Adaptor Proteins, Signal Transducing/metabolism ; Inflammation/pathology ; Lipids/pharmacology ; Apolipoproteins E/genetics ; Mice, Inbred C57BL
Chemical Substances	NF-kappa B ; Myeloid Differentiation Factor 88 ; Toll-Like Receptor 9 ; Adaptor Proteins, Signal Transducing ; Lipids ; Apolipoproteins E
Language	English
Publishing date	2023-07-16
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2023.116868
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Article: Effect Western Medicines Combined With Nao-Xue-Shu in Patients With Hypertensive Intracerebral Hemorrhage: A Network Meta-Analysis.

Mei, Li / Fengqun, Mu / Xiaozhuo, Liu / Qing, Wang / Mingming, Fan / Zhengyao, Zuo / Dongpo, Su / Qian, Han / Tong, Chen

Frontiers in pharmacology

2022 Volume 13, Page(s) 892904

Abstract: Purpose: ...

Abstract	Purpose:
Language	English
Publishing date	2022-06-15
Publishing country	Switzerland
Document type	Systematic Review
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2022.892904
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