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Article ; Online: Successful Treatment of Systemic Light Chain Amyloidosis with Liver Involvement using Low-Frequency Daratumumab: A Case Report.

Meng, Xinyi / He, Jingsong / Cheng, Fei / Yan, Hui / Zhu, Chunting / Guo, Xing / Li, Yi / Cai, Zhen / He, Donghua

2024 Volume 25, Page(s) e942534

Abstract: BACKGROUND Systemic light chain (AL) amyloidosis is a disease characterized by the deposition of amyloid fibrils throughout tissues due to the production of misfolded immunoglobulin light chains by clonally expanded populations of CD38+ plasma cells. ... ...

Abstract	BACKGROUND Systemic light chain (AL) amyloidosis is a disease characterized by the deposition of amyloid fibrils throughout tissues due to the production of misfolded immunoglobulin light chains by clonally expanded populations of CD38+ plasma cells. Some patients can have liver involvement, which typically presents with nonspecific symptoms. Daratumumab, a human CD38-targeting antibody, has shown efficacy in improving hematological parameters and organ function in patients with AL amyloidosis. Low-frequency daratumumab can reduce financial burden, but whether it is effective for patients with liver involvement has not been reported. CASE REPORT We present the case of a 64-year-old man admitted to our hospital with fatigue and recurrent fever. Histological analysis of a liver biopsy demonstrated AL amyloidosis. Bone marrow biopsy demonstrated the presence of abnormal plasma cells. Laboratory test results demonstrated increased levels of circulating free kappa (kappa) light chains, which were also seen on blood and urine immunofixation electrophoresis. Based on these findings, AL amyloidosis of the kappa light chain type with liver, cardiac, and renal involvement was diagnosed. The patient ultimately achieved hematological stringent complete response, liver remission, renal complete response, and cardiac very good partial response after 2 cycles of the low-frequency daratumumab, bortezomib, and dexamethasone regimen and 4 cycles of daratumumab and dexamethasone regimen chemotherapy. CONCLUSIONS The case indicates that low-frequency daratumumab treatment can have efficacy in AL amyloidosis with liver involvement.
MeSH term(s)	Male ; Humans ; Middle Aged ; Immunoglobulin Light-chain Amyloidosis/drug therapy ; Immunoglobulin Light-chain Amyloidosis/diagnosis ; Amyloidosis/diagnosis ; Amyloidosis/drug therapy ; Antibodies, Monoclonal/therapeutic use ; Dexamethasone/therapeutic use
Chemical Substances	daratumumab (4Z63YK6E0E) ; Antibodies, Monoclonal ; Dexamethasone (7S5I7G3JQL)
Language	English
Publishing date	2024-01-17
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	2517183-5
ISSN	1941-5923 ; 1941-5923
ISSN (online)	1941-5923
ISSN	1941-5923
DOI	10.12659/AJCR.942534
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Transdermally delivered tolerogenic nanoparticles induced effective immune tolerance for asthma treatment.

Zhao, Jiaxuan / He, Penghui / Jiang, Min / He, Chunting / Zhao, Yuanhao / Zhang, Zhihua / Zhang, Zhibing / Du, Guangsheng / Sun, Xun

Journal of controlled release : official journal of the Controlled Release Society

2024 Volume 366, Page(s) 637–649

Abstract: Induction of antigen-specific immune tolerance for the treatment of allergic or autoimmune diseases is an attractive strategy. Herein, we investigated the protective effect of a transdermal microneedle patch against allergic asthma by stimulating ... ...

Abstract	Induction of antigen-specific immune tolerance for the treatment of allergic or autoimmune diseases is an attractive strategy. Herein, we investigated the protective effect of a transdermal microneedle patch against allergic asthma by stimulating allergen-specific immune tolerance. We fabricated biodegradable tolerogenic nanoparticles (tNPs) that are loaded with a model allergen ovalbumin (OVA) and an immunomodulator rapamycin, and filled the tNPs into microneedle tips by centrifugation to form sustained-release microneedles. After intradermal immunization, the microneedles successfully delivered the cargos into the skin and sustainedly released them for over 96 h. Importantly, the microneedles induced allergen-specific regulatory T cells (Treg), decreased the levels of pro-inflammatory cytokines and antibodies while increased anti-inflammation cytokines, finally leading to restored immune homeostasis. The lung tissue analysis illustrated that the sustained-release microneedles significantly reduced the infiltration of eosinophils, decreased the accumulation of mucus and collagen, and significantly relived asthma symptoms. Our results suggested that the sustained-release microneedle-based transdermal delivery system can induce antigen-specific immune tolerance with improved compliance and efficacy, providing a new therapeutic strategy for the treatment of allergic and autoimmune diseases.
MeSH term(s)	Humans ; Delayed-Action Preparations ; Asthma/drug therapy ; Immune Tolerance ; Allergens ; Hypersensitivity ; Nanoparticles ; Cytokines ; Autoimmune Diseases
Chemical Substances	Delayed-Action Preparations ; Allergens ; Cytokines
Language	English
Publishing date	2024-01-17
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	632533-6
ISSN	1873-4995 ; 0168-3659
ISSN (online)	1873-4995
ISSN	0168-3659
DOI	10.1016/j.jconrel.2024.01.018
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Zs.A 2055: Show issues

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Article ; Online: Melatonin regulates cancer migration and stemness and enhances the anti-tumour effect of cisplatin.

Cheng, Linglin / Li, Shubo / He, Kailun / Kang, Ye / Li, Tianye / Li, Chunting / Zhang, Yi / Zhang, Wanlu / Huang, Yongye

Journal of cellular and molecular medicine

2023 Volume 27, Issue 15, Page(s) 2215–2227

Abstract: Melatonin, a lipophilic hormone released from the pineal gland, has oncostatic effects on various types of cancers. However, its cancer treatment potential needs to be improved by deciphering its corresponding mechanisms of action and optimising ... ...

Abstract	Melatonin, a lipophilic hormone released from the pineal gland, has oncostatic effects on various types of cancers. However, its cancer treatment potential needs to be improved by deciphering its corresponding mechanisms of action and optimising therapeutic strategy. In the present study, melatonin inhibited gastric cancer cell migration and soft agar colony formation. Magnetic-activated cell sorting was applied to isolate CD133
MeSH term(s)	Humans ; Cisplatin/pharmacology ; Cisplatin/therapeutic use ; Melatonin/pharmacology ; Melatonin/therapeutic use ; Stomach Neoplasms/pathology ; Cell Line, Tumor ; Signal Transduction ; Apoptosis ; Cell Proliferation
Chemical Substances	Cisplatin (Q20Q21Q62J) ; Melatonin (JL5DK93RCL)
Language	English
Publishing date	2023-06-12
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2074559-X
ISSN	1582-4934 ; 1582-4934 ; 1582-1838
ISSN (online)	1582-4934
ISSN	1582-4934 ; 1582-1838
DOI	10.1111/jcmm.17809
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Zs.A 5752: Show issues

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Article ; Online: Triple functional mild photothermal improves gene editing of PD-L1 for enhanced antitumor immunity.

Lu, Yi / Wu, Fuhua / Xu, Yanhua / He, Chunting / Luo, Shuang / Sun, Xun

Journal of controlled release : official journal of the Controlled Release Society

2023 Volume 354, Page(s) 57–68

Abstract: Traditional photothermal therapy ablates tumor cells by a high temperature (> 50 °C). Although it has shown good anti-tumor effect in animal models, the potential damages to healthy tissues and the unnecessary inflammatory reactions caused by the high ... ...

Abstract	Traditional photothermal therapy ablates tumor cells by a high temperature (> 50 °C). Although it has shown good anti-tumor effect in animal models, the potential damages to healthy tissues and the unnecessary inflammatory reactions caused by the high temperature have hindered the clinical transitions of traditional photothermal therapy. In this study, we used polydopamine (PDA) as a mild photothermal material and control the maximum temperature below 45 °C, which not only avoided the side effects caused by a high temperature, but also ablated a fraction of tumor cells and produced tumor antigens. Meanwhile, the near-infrared (NIR) light also served as a "switch" to trigger the release of CRISPR/Cas9 RNP from Fe
MeSH term(s)	Mice ; Animals ; Gene Editing ; B7-H1 Antigen ; Hyperthermia, Induced ; Immunosuppression Therapy ; Melanoma ; Phototherapy ; Nanoparticles ; Cell Line, Tumor ; Tumor Microenvironment
Chemical Substances	B7-H1 Antigen
Language	English
Publishing date	2023-01-04
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	632533-6
ISSN	1873-4995 ; 0168-3659
ISSN (online)	1873-4995
ISSN	0168-3659
DOI	10.1016/j.jconrel.2022.12.052
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Zs.A 2055: Show issues

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ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Self-adjuvanting polymeric nanovaccines enhance IFN production and cytotoxic T cell response.

Zhao, Ming / He, Chunting / Zheng, Xueyun / Jiang, Min / Xie, Zhiqiang / Wei, Hongjiao / Zhang, Shujun / Lin, Ying / Zhang, Jiaheng / Sun, Xun

Journal of controlled release : official journal of the Controlled Release Society

2024 Volume 369, Page(s) 556–572

Abstract: Vaccines represent one of the most powerful and cost-effective innovations for controlling a wide range of infectious diseases caused by various viruses and bacteria. Unlike mRNA and DNA-based vaccines, subunit vaccines carry no risk of insertional ... ...

Abstract	Vaccines represent one of the most powerful and cost-effective innovations for controlling a wide range of infectious diseases caused by various viruses and bacteria. Unlike mRNA and DNA-based vaccines, subunit vaccines carry no risk of insertional mutagenesis and can be lyophilized for convenient transportation and long-term storage. However, existing adjuvants are often associated with toxic effect and reactogenicity, necessitating expanding the repertoire of adjuvants with better biocompatibility, for instance, designing self-adjuvating polymeric carriers. We herein report a novel subunit vaccine delivery platform constructed via in situ free radical polymerization of C7A (2-(Hexamethyleneimino) ethyl methacrylate) and acrylamide around the surface of individual protein antigens. Using ovalbumin (OVA) as a model antigen, we observed substantial increases in both diameter (∼70 nm) and surface potential (-1.18 mV) following encapsulation, referred to as n(OVA)C7A. C7A's ultra pH sensitivity with a transition pH around 6.9 allows for rapid protonation in acidic environments. This property facilitates crucial processes such as endosomal escape and major histocompatibility complex (MHC)-I-mediated antigen presentation, culminating in the substantial CD8
Language	English
Publishing date	2024-04-10
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	632533-6
ISSN	1873-4995 ; 0168-3659
ISSN (online)	1873-4995
ISSN	0168-3659
DOI	10.1016/j.jconrel.2024.04.005
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Zs.A 2055: Show issues

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Article ; Online: High purity of human secreted phospholipase A2 group IIE in

Hou, Shulin / Chen, Chunting / He, Huili / Yang, Haishan / Li, Ruining / Bai, Junping / Li, Sijin / Xie, Jun

Preparative biochemistry & biotechnology

2023 Volume 54, Issue 2, Page(s) 239–246

Abstract: Secreted phospholipase A2s (sPLA2s) are a group of enzymes with 6-8 disulfide bonds that participate in numerous physiological processes by catalyzing the hydrolysis of phospholipids at the sn-2 position. Due to their high content of disulfide bonds and ... ...

Abstract	Secreted phospholipase A2s (sPLA2s) are a group of enzymes with 6-8 disulfide bonds that participate in numerous physiological processes by catalyzing the hydrolysis of phospholipids at the sn-2 position. Due to their high content of disulfide bonds and hydrolytic activity toward cell membranes, obtaining the protein of sPLA2s in the soluble and active form is challenging, which hampers their functional study. In this study, one member of recombinant human sPLA2s, tag-free group IIE (GIIE), was expressed in
MeSH term(s)	Humans ; Recombinant Proteins/chemistry ; Salts ; Pichia/genetics ; Pichia/metabolism ; Phospholipases A2, Secretory/genetics ; Phospholipases A2, Secretory/metabolism ; Disulfides/metabolism ; Saccharomycetales
Chemical Substances	Recombinant Proteins ; Salts ; Phospholipases A2, Secretory (EC 3.1.1.4) ; Disulfides
Language	English
Publishing date	2023-08-14
Publishing country	England
Document type	Journal Article
ZDB-ID	1322522-4
ISSN	1532-2297 ; 1082-6068
ISSN (online)	1532-2297
ISSN	1082-6068
DOI	10.1080/10826068.2023.2220043
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Zs.A 821: Show issues

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Article ; Online: Cloaking Mesoporous Polydopamine with Bacterial Membrane Vesicles to Amplify Local and Systemic Antitumor Immunity.

Chen, Wenfei / Song, Yuanshuai / Bai, Shuting / He, Chunting / Guo, Zhaofei / Zhu, Yining / Zhang, Zhirong / Sun, Xun

ACS nano

2023 Volume 17, Issue 8, Page(s) 7733–7749

Abstract: As adjuvants or antigens, bacterial membranes have been widely used in recent antibacterial and antitumor research, but they are often injected multiple times to achieve therapeutic outcomes, with limitations in biosafety and clinical application. Herein, ...

Abstract	As adjuvants or antigens, bacterial membranes have been widely used in recent antibacterial and antitumor research, but they are often injected multiple times to achieve therapeutic outcomes, with limitations in biosafety and clinical application. Herein, we leverage the biocompatibility and immune activation capacity of
MeSH term(s)	Mice ; Animals ; Melanoma ; Cytokines/metabolism ; Indoles ; Polymers ; Immunotherapy ; Nanoparticles
Chemical Substances	polydopamine ; Cytokines ; Indoles ; Polymers
Language	English
Publishing date	2023-04-10
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1936-086X
ISSN (online)	1936-086X
DOI	10.1021/acsnano.3c00363
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Article ; Online: Discovery and optimization of dihydropteridone derivatives as novel PLK1 and BRD4 dual inhibitor for the treatment of cancer.

Liu, Jiuyu / Huang, Jingxuan / Wang, Kang / Li, Yuan / Li, Chunting / Zhu, Yanli / He, Xinzi / Zhang, Yating / Zhao, Yanfang / Hu, Changliang / Xi, Zhiguo / Tong, Minghui / Li, Zhiwei / Gong, Ping / Hou, Yunlei

Bioorganic & medicinal chemistry

2024 Volume 101, Page(s) 117609

Abstract: In this study, we have designed, synthesized and tested three series of novel dihydropteridone derivatives possessing isoindolin-1-one or isoindoline moieties as potent inhibitors of PLK1/BRD4. Remarkably, most of the compounds showed preferable ... ...

Abstract	In this study, we have designed, synthesized and tested three series of novel dihydropteridone derivatives possessing isoindolin-1-one or isoindoline moieties as potent inhibitors of PLK1/BRD4. Remarkably, most of the compounds showed preferable inhibitory activity against PLK1 and BRD4. Compound SC10 exhibited excellent inhibitory activity with IC
MeSH term(s)	Animals ; Rats ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/metabolism ; Cell Cycle Proteins ; Cell Line, Tumor ; Cell Proliferation ; Drug Design ; Drug Screening Assays, Antitumor ; Neoplasms/drug therapy ; Nuclear Proteins/metabolism ; Rats, Sprague-Dawley ; Structure-Activity Relationship ; Transcription Factors ; Bromodomain Containing Proteins/antagonists & inhibitors ; Indoles/chemistry ; Indoles/pharmacology ; Polo-Like Kinase 1/antagonists & inhibitors ; Protein Kinase Inhibitors/chemistry ; Protein Kinase Inhibitors/pharmacology
Chemical Substances	Antineoplastic Agents ; Cell Cycle Proteins ; Nuclear Proteins ; Transcription Factors ; Bromodomain Containing Proteins ; Indoles ; Polo-Like Kinase 1 ; Brd4 protein, rat ; Plk1 protein, rat ; Protein Kinase Inhibitors
Language	English
Publishing date	2024-01-18
Publishing country	England
Document type	Journal Article
ZDB-ID	1161284-8
ISSN	1464-3391 ; 0968-0896
ISSN (online)	1464-3391
ISSN	0968-0896
DOI	10.1016/j.bmc.2024.117609
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Zs.A 3815: Show issues

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Article: Design and Synthesis of 1,3,5-Triazines or Pyrimidines Containing Dithiocarbamate Moiety as PI3Kα Selective Inhibitors.

Tang, Jiechun / Liu, Jiuyu / He, Xinzi / Fu, Siyu / Wang, Kang / Li, Chunting / Li, Yuan / Zhu, Yanli / Gong, Ping / Zhao, Yanfang / Liu, Yajing / Hou, Yunlei

ACS medicinal chemistry letters

2023 Volume 14, Issue 9, Page(s) 1266–1274

Abstract: Recent studies have shown that phosphoinositide 3-kinase (PI3K) plays a vital role in cell division, and it has become a therapeutic target for many cancers. In this paper, some new 1,3,5-triazine or pyrimidine skeleton derivatives containing ... ...

Abstract	Recent studies have shown that phosphoinositide 3-kinase (PI3K) plays a vital role in cell division, and it has become a therapeutic target for many cancers. In this paper, some new 1,3,5-triazine or pyrimidine skeleton derivatives containing dithiocarbamate were designed and synthesized based on the reasonable drug design strategy from the previously effective compound 2-(difluoromethyl)-1-[4,6-di(4-morpholinyl)-1,3,5-triazin-2-yl]-1
Language	English
Publishing date	2023-08-09
Publishing country	United States
Document type	Journal Article
ISSN	1948-5875
ISSN	1948-5875
DOI	10.1021/acsmedchemlett.3c00287
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Article ; Online: Facile Synthesis of Clickable Unnatural Sugars in the Unprotected and 1,6-Di-O-Acylated Forms for Metabolic Glycan Labeling.

Cheng, Bo / Wang, Chunting / Hao, Yi / Wang, Jiankun / Xia, Xiaoqian / Zhang, Hao / He, Rundong / Zhang, Shaoran / Dai, Peng / Chen, Xing

Chemistry (Weinheim an der Bergstrasse, Germany)

2023 Volume 29, Issue 11, Page(s) e202203054

Abstract: Clickable unnatural sugars have been widely used in studying glycosylation in living systems via the metabolic glycan labelling (MGL) strategy. Partial protection of unnatural sugars by 1,6-di-O-acylation increases the labelling efficiency while avoiding ...

Abstract	Clickable unnatural sugars have been widely used in studying glycosylation in living systems via the metabolic glycan labelling (MGL) strategy. Partial protection of unnatural sugars by 1,6-di-O-acylation increases the labelling efficiency while avoiding the non-specific S-glyco-modification. Herein, we report the facile synthesis of a series of clickable unnatural sugars in both the unprotected and 1,6-di-O-acylated forms at the ten-gram scale. By evaluation of the labelling specificity, efficiency, and biocompatibility of various 1,6-di-O-acylated sugars for MGL in cell lines and living mice, we demonstrate that 1,6-di-O-propionylated unnatural sugars are optimal chemical reporters for glycan labelling. The synthetic routes developed in this work should facilitate the widespread use of MGL with no artificial S-glyco-modification for investigating the functional roles of glycans.
MeSH term(s)	Animals ; Mice ; Sugars ; Glycosylation ; Cell Line ; Monosaccharides ; Polysaccharides/metabolism
Chemical Substances	Sugars ; Monosaccharides ; Polysaccharides
Language	English
Publishing date	2023-01-12
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1478547-X
ISSN	1521-3765 ; 0947-6539
ISSN (online)	1521-3765
ISSN	0947-6539
DOI	10.1002/chem.202203054
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