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Article: Observation of e(+)e(-) annihilation into the C = +1 hadronic final states rho(0)rho(0) and phirho(0).

Aubert, B / Barate, R / Bona, M / Boutigny, D / Couderc, F / Karyotakis, Y / Lees, J P / Poireau, V / Tisserand, V / Zghiche, A / Grauges, E / Palano, A / Chen, J C / Qi, N D / Rong, G / Wang, P / Zhu, Y S / Eigen, G / Ofte, I /

Stugu, B / Abrams, G S / Battaglia, M / Brown, D N / Button-Shafer, J / Cahn, R N / Charles, E / Gill, M S / Groysman, Y / Jacobsen, R G / Kadyk, J A / Kerth, L T / Kolomensky, Yu G / Kukartsev, G / Lynch, G / Mir, L M / Oddone, P J / Orimoto, T J / Pripstein, M / Roe, N A / Ronan, M T / Wenzel, W A / Del Amo Sanchez, P / Barrett, M / Ford, K E / Harrison, T J / Hart, A J / Hawkes, C M / Morgan, S E / Watson, A T / Goetzen, K / Held, T / Koch, H / Lewandowski, B / Pelizaeus, M / Peters, K / Schroeder, T / Steinke, M / Boyd, J T / Burke, J P / Cottingham, W N / Walker, D / Cuhadar-Donszelmann, T / Fulsom, B G / Hearty, C / Knecht, N S / Mattison, T S / McKenna, J A / Khan, A / Kyberd, P / Saleem, M / Sherwood, D J / Teodorescu, L / Blinov, V E / Bukin, A D / Druzhinin, V P / Golubev, V B / Onuchin, A P / Serednyakov, S I / Skovpen, Yu I / Solodov, E P / Todyshev, K Yu / Best, D S / Bondioli, M / Bruinsma, M / Chao, M / Curry, S / Eschrich, I / Kirkby, D / Lankford, A J / Lund, P / Mandelkern, M / Mommsen, R K / Roethel, W / Stoker, D P / Abachi, S / Buchanan, C / Foulkes, S D / Gary, J W / Long, O / Shen, B C / Wang, K / Zhang, L / Hadavand, H K / Hill, E J / Paar, H P / Rahatlou, S / Sharma, V / Berryhill, J W / Campagnari, C / Cunha, A / Dahmes, B / Hong, T M / Kovalskyi, D / Richman, J D / Beck, T W / Eisner, A M / Flacco, C J / Heusch, C A / Kroseberg, J / Lockman, W S / Nesom, G / Schalk, T / Schumm, B A / Seiden, A / Spradlin, P / Williams, D C / Wilson, M G / Albert, J / Chen, E / Dvoretskii, A / Fang, F / Hitlin, D G / Narsky, I / Piatenko, T / Porter, F C / Ryd, A / Samuel, A / Mancinelli, G / Meadows, B T / Sokoloff, M D / Blanc, F / Bloom, P C / Chen, S / Ford, W T / Hirschauer, J F / Kreisel, A / Nauenberg, U / Olivas, A / Ruddick, W O / Smith, J G / Ulmer, K A / Wagner, S R / Zhang, J / Chen, A / Eckhart, E A / Soffer, A / Toki, W H / Wilson, R J / Winklmeier, F / Zeng, Q / Altenburg, D D / Feltresi, E / Hauke, A / Jasper, H / Petzold, A / Spaan, B / Brandt, T / Klose, V / Lacker, H M / Mader, W F / Nogowski, R / Schubert, J / Schubert, K R / Schwierz, R / Sundermann, J E / Volk, A / Bernard, D / Bonneaud, G R / Grenier, P / Latour, E / Thiebaux, Ch / Verderi, M / Bard, D J / Clark, P J / Gradl, W / Muheim, F / Playfer, S / Robertson, A I / Xie, Y / Andreotti, M / Bettoni, D / Bozzi, C / Calabrese, R / Cibinetto, G / Luppi, E / Negrini, M / Petrella, A / Piemontese, L / Prencipe, E / Anulli, F / Baldini-Ferroli, R / Calcaterra, A / de Sangro, R / Finocchiaro, G / Pacetti, S / Patteri, P / Peruzzi, I M / Piccolo, M / Rama, M / Zallo, A / Buzzo, A / Capra, R / Contri, R / Lo Vetere, M / Macri, M M / Monge, M R / Passaggio, S / Patrignani, C / Robutti, E / Santroni, A / Tosi, S / Brandenburg, G / Chaisanguanthum, K S / Morii, M / Wu, J / Dubitzky, R S / Marks, J / Schenk, S / Uwer, U / Bhimji, W / Bowerman, D A / Dauncey, P D / Egede, U / Flack, R L / Nash, J A / Nikolich, M B / Panduro Vazquez, W / Chai, X / Charles, M J / Mallik, U / Meyer, N T / Ziegler, V / Cochran, J / Crawley, H B / Dong, L / Eyges, V / Meyer, W T / Prell, S / Rosenberg, E I / Rubin, A E / Gritsan, A V / Fritsch, M / Schott, G / Arnaud, N / Davier, M / Grosdidier, G / Höcker, A / Le Diberder, F / Lepeltier, V / Lutz, A M / Oyanguren, A / Pruvot, S / Rodier, S / Roudeau, P / Schune, M H / Stocchi, A / Wang, W F / Wormser, G / Cheng, C H / Lange, D J / Wright, D M / Chavez, C A / Forster, I J / Fry, J R / Gabathuler, E / Gamet, R / George, K A / Hutchcroft, D E / Payne, D J / Schofield, K C / Touramanis, C / Bevan, A J / Di Lodovico, F / Menges, W / Sacco, R / Cowan, G / Flaecher, H U / Hopkins, D A / Jackson, P S / McMahon, T R / Ricciardi, S / Salvatore, F / Wren, A C / Davis, C L / Allison, J / Barlow, N R / Barlow, R J / Chia, Y M / Edgar, C L / Lafferty, G D / Naisbit, M T / Williams, J C / Yi, J I / Chen, C / Hulsbergen, W D / Jawahery, A / Lae, C K / Roberts, D A / Simi, G / Blaylock, G / Dallapiccola, C / Hertzbach, S S / Li, X / Moore, T B / Saremi, S / Staengle, H / Cowan, R / Sciolla, G / Sekula, S J / Spitznagel, M / Taylor, F / Yamamoto, R K / Kim, H / Patel, P M / Robertson, S H / Lazzaro, A / Lombardo, V / Palombo, F / Bauer, J M / Cremaldi, L / Eschenburg, V / Godang, R / Kroeger, R / Sanders, D A / Summers, D J / Zhao, H W / Brunet, S / Côté, D / Taras, P / Viaud, F B / Nicholson, H / Cavallo, N / De Nardo, G / Fabozzi, F / Gatto, C / Lista, L / Monorchio, D / Paolucci, P / Piccolo, D / Sciacca, C / Baak, M / Raven, G / Snoek, H L / Jessop, C P / Losecco, J M / Allmendinger, T / Benelli, G / Gan, K K / Honscheid, K / Hufnagel, D / Jackson, P D / Kagan, H / Kass, R / Rahimi, A M / Ter-Antonyan, R / Wong, Q K / Blount, N L / Brau, J / Frey, R / Igonkina, O / Lu, M / Potter, C T / Rahmat, R / Sinev, N B / Strom, D / Strube, J / Torrence, E / Galeazzi, F / Gaz, A / Margoni, M / Morandin, M / Pompili, A / Posocco, M / Rotondo, M / Simonetto, F / Stroili, R / Voci, C / Benayoun, M / Chauveau, J / David, P / Del Buono, L / de la Vaissière, Ch / Hamon, O / Hartfiel, B L / John, M J J / Malclès, J / Ocariz, J / Roos, L / Therin, G / Behera, P K / Gladney, L / Panetta, J / Biasini, M / Covarelli, R / Angelini, C / Batignani, G / Bettarini, S / Bucci, F / Calderini, G / Carpinelli, M / Cenci, R / Forti, F / Giorgi, M A / Lusiani, A / Marchiori, G / Mazur, M A / Morganti, M / Neri, N / Rizzo, G / Walsh, J J / Haire, M / Judd, D / Wagoner, D E / Biesiada, J / Danielson, N / Elmer, P / Lau, Y P / Lu, C / Olsen, J / Smith, A J S / Telnov, A V / Bellini, F / Cavoto, G / D'Orazio, A / Del Re, D / Di Marco, E / Faccini, R / Ferrarotto, F / Ferroni, F / Gaspero, M / Li Gioi, L / Mazzoni, M A / Morganti, S / Piredda, G / Polci, F / Safai Tehrani, F / Voena, C / Ebert, M / Schröder, H / Waldi, R / Adye, T / De Groot, N / Franek, B / Olaiya, E O / Wilson, F F / Emery, S / Gaidot, A / Ganzhur, S F / Hamel de Monchenault, G / Kozanecki, W / Legendre, M / Vasseur, G / Yèche, Ch / Zito, M / Chen, X R / Liu, H / Park, W / Purohit, M V / Wilson, J R / Allen, M T / Aston, D / Bartoldus, R / Bechtle, P / Berger, N / Claus, R / Coleman, J P / Convery, M R / Cristinziani, M / Dingfelder, J C / Dorfan, J / Dubois-Felsmann, G P / Dujmic, D / Dunwoodie, W / Field, R C / Glanzman, T / Gowdy, S J / Graham, M T / Halyo, V / Hast, C / Hryn'ova, T / Innes, W R / Kelsey, M H / Kim, P / Leith, D W G S / Li, S / Luitz, S / Luth, V / Lynch, H L / Macfarlane, D B / Marsiske, H / Messner, R / Muller, D R / O'grady, C P / Ozcan, V E / Perazzo, A / Perl, M / Pulliam, T / Ratcliff, B N / Roodman, A / Salnikov, A A / Schindler, R H / Schwiening, J / Snyder, A / Stelzer, J / Su, D / Sullivan, M K / Suzuki, K / Swain, S K / Thompson, J M / Va'vra, J / van Bakel, N / Weaver, M / Weinstein, A J R / Wisniewski, W J / Wittgen, M / Wright, D H / Yarritu, A K / Yi, K / Young, C C / Burchat, P R / Edwards, A J / Majewski, S A / Petersen, B A / Roat, C / Wilden, L / Ahmed, S / Alam, M S / Bula, R / Ernst, J A / Jain, V / Pan, B / Saeed, M A / Wappler, F R / Zain, S B / Bugg, W / Krishnamurthy, M / Spanier, S M / Eckmann, R / Ritchie, J L / Satpathy, A / Schilling, C J / Schwitters, R F / Izen, J M / Lou, X C / Ye, S / Bianchi, F / Gallo, F / Gamba, D / Bomben, M / Bosisio, L / Cartaro, C / Cossutti, F / Della Ricca, G / Dittongo, S / Lanceri, L / Vitale, L / Azzolini, V / Martinez-Vidal, F / Banerjee, Sw / Bhuyan, B / Brown, C M / Fortin, D / Hamano, K / Kowalewski, R / Nugent, I M / Roney, J M / Sobie, R J / Back, J J / Harrison, P F / Latham, T E / Mohanty, G B / Pappagallo, M / Band, H R / Chen, X / Cheng, B / Dasu, S / Datta, M / Flood, K T / Hollar, J J / Kutter, P E / Mellado, B / Mihalyi, A / Pan, Y / Pierini, M / Prepost, R / Wu, S L / Yu, Z / Neal, H

Physical review letters

2006 Volume 97, Issue 11, Page(s) 112002

Abstract: We report the first observation of e(+)e(-) annihilation into states of positive C parity, namely ... at the Positron-Electron Project II e(+)e(-) storage rings at energies near sqrt[s]=10.58 GeV. The distributions ... costheta(*)|<0.8 of sigma(e(+)e(-)-->rho(0)rho(0))=20.7+/-0.7(stat)+/-2.7(syst) fb and sigma(e(+)e ...

Abstract	We report the first observation of e(+)e(-) annihilation into states of positive C parity, namely, rho(0)rho(0) and phirho(0). The two states are observed in the pi(+)pi(-)pi(+)pi(-) and K(+)K(-)pi(+)pi(-) final states, respectively, in a data sample of 225 fb(-1) collected by the BABAR experiment at the Positron-Electron Project II e(+)e(-) storage rings at energies near sqrt[s]=10.58 GeV. The distributions of costheta(), where theta() is the center-of-mass polar angle of the phi meson or the forward rho(0) meson, suggest production by two-virtual-photon annihilation. We measure cross sections within the range \|costheta(*)\|<0.8 of sigma(e(+)e(-)-->rho(0)rho(0))=20.7+/-0.7(stat)+/-2.7(syst) fb and sigma(e(+)e(-)-->phirho(0))=5.7+/-0.5(stat)+/-0.8(syst) fb.
Language	English
Publishing date	2006-09-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	208853-8
ISSN	1079-7114 ; 0031-9007
ISSN (online)	1079-7114
ISSN	0031-9007
DOI	10.1103/PhysRevLett.97.112002
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Article ; Online: Interaction of vitamins C and E as better cosmeceuticals.

Burke, Karen E

Dermatologic therapy

2007 Volume 20, Issue 5, Page(s) 314–321

Abstract: Although many cosmeceutical formulations contain vitamin C and/or vitamin E, very few are actually ... isomer of the antioxidant, vitamins C and E do indeed inhibit the acute ultraviolet (UV) damage ... Because vitamin C regenerates oxidized vitamin E, the combination in a cosmeceutical formulation is synergistic ...

Abstract	Although many cosmeceutical formulations contain vitamin C and/or vitamin E, very few are actually effective in topical application. First because there is only a low concentration, second because the stability is compromised as soon as the product is opened and exposed to air and light, and third because the form of the molecule (an ester or a mixture of isomers) is not absorbed or metabolized effectively by the skin. However, when a stable formulation delivers a high concentration of the nonesterified, optimal isomer of the antioxidant, vitamins C and E do indeed inhibit the acute ultraviolet (UV) damage of erythema, sunburn, and tanning as well as chronic UV photoaging and skin cancer. Both are highly effective depigmenting agents. Topical vitamin C also increases collagen synthesis in both young and old fibroblasts. Because vitamin C regenerates oxidized vitamin E, the combination in a cosmeceutical formulation is synergistic - particularly in UV protection.
MeSH term(s)	Administration, Topical ; Antioxidants/administration & dosage ; Ascorbic Acid/administration & dosage ; Cosmetics/pharmacology ; Dermatologic Agents/administration & dosage ; Drug Interactions ; Esthetics ; Female ; Humans ; Male ; Skin Aging/drug effects ; Skin Aging/physiology ; Skin Care/methods ; Vitamin E/administration & dosage
Chemical Substances	Antioxidants ; Cosmetics ; Dermatologic Agents ; Vitamin E (1406-18-4) ; Ascorbic Acid (PQ6CK8PD0R)
Language	English
Publishing date	2007-09
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1354801-3
ISSN	1529-8019 ; 1396-0296
ISSN (online)	1529-8019
ISSN	1396-0296
DOI	10.1111/j.1529-8019.2007.00145.x
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Zs.A 5181: Show issues

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Article ; Online: Trends in observation stays for Medicare beneficiaries with and without Alzheimer's disease and related dementias.

Burke, Laura G / Burke, Ryan C / Duggan, Ciara E / Figueroa, Jose F / Boltz, Marie / Fick, Donna M / Orav, E John / Marcantonio, Edward R

Journal of the American Geriatrics Society

2024

Abstract: Background: There has been a marked rise in the use of observation care for Medicare beneficiaries visiting the emergency department (ED) in recent years. Whether trends in observation use differ for people with Alzheimer's disease and Alzheimer's ... ...

Abstract	Background: There has been a marked rise in the use of observation care for Medicare beneficiaries visiting the emergency department (ED) in recent years. Whether trends in observation use differ for people with Alzheimer's disease and Alzheimer's disease-related dementias (AD/ADRD) is unknown. Methods: Using a national 20% sample of Medicare beneficiaries ages 68+ from 2012 to 2018, we compared trends in ED visits and observation stays by AD/ADRD status for beneficiaries visiting the ED. We then examined the degree to which trends differed by nursing home (NH) residency status, assigning beneficiaries to four groups: AD/ADRD residing in NH (AD/ADRD+ NH+), AD/ADRD not residing in NH (AD/ADRD+ NH-), no AD/ADRD residing in NH (AD/ADRD- NH+), and no AD/ADRD not residing in NH (AD/ADRD- NH-). Results: Of 7,489,780 unique beneficiaries, 18.6% had an AD/ADRD diagnosis. Beneficiaries with AD/ADRD had more than double the number of ED visits per 1000 in all years compared to those without AD/ADRD and saw a faster adjusted increase over time (+26.7 vs. +8.2 visits/year; p < 0.001 for interaction). The annual increase in the adjusted proportion of ED visits ending in observation was also greater among people with AD/ADRD (+0.78%/year, 95% CI 0.77-0.80%) compared to those without AD/ADRD (+0.63%/year, 95% CI 0.59-0.66%; p < 0.001 for interaction). Observation utilization was greatest for the AD/ADRD+ NH+ population and lowest for the AD/ADRD- NH- population, but the AD/ADRD+ NH- group saw the greatest increase in observation stays over time (+15.4 stays per 1000 people per year, 95% CI 15.0-15.7). Conclusions: Medicare beneficiaries with AD/ADRD have seen a disproportionate increase in observation utilization in recent years, driven by both an increase in ED visits and an increase in the proportion of ED visits ending in observation.
Language	English
Publishing date	2024-03-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	80363-7
ISSN	1532-5415 ; 0002-8614
ISSN (online)	1532-5415
ISSN	0002-8614
DOI	10.1111/jgs.18890
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Article: Extreme Value Theory Applications to Space Radiation Damage Assessment in Satellite Microelectronics.

Marshall, P W / Dale, C J / Burke, E A

Journal of research of the National Institute of Standards and Technology

2023 Volume 99, Issue 4, Page(s) 485–494

Abstract: Calculations of the first and second moments of displacement damage energy distributions from clastic collisions and from nuclear reactions, at proton energies ranging from 10 MeV to 300 MeV, are incorporated into a model describing the probability of ... ...

Abstract	Calculations of the first and second moments of displacement damage energy distributions from clastic collisions and from nuclear reactions, at proton energies ranging from 10 MeV to 300 MeV, are incorporated into a model describing the probability of damage as a function of the proton fluence and the size of the sensitive micro-volume in Si. Comparisons between the predicted and measured leakage currents in Si imaging arrays illustrate how the Poisson distribution of higher energy nuclear reaction recoils affects the pixel-to-pixel variance in the damage across the array for proton exposures equivalent to mission duration of a few years within the earth's trapped proton belts. Extreme value statistics (EVS) quantify the largest expected damage extremes following a given proton fluence, and an analysis derived from the first-principle damage calculations shows excellent agreement with the measured extremes. EVS is also used to demonstrate the presence of high dark current pixels, or "spikes," which occur from different mechanisms. Different sources of spikes were seen in two different imager designs.
Language	English
Publishing date	2023-06-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	1473724-3
ISSN	1044-677X ; 0160-1741
ISSN	1044-677X ; 0160-1741
DOI	10.6028/jres.099.046
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Article ; Online: When the individual comes into play: The role of self and the partner in the dyadic play fighting of rats.

Achterberg, E J M / Burke, C J / Pellis, S M

Behavioural processes

2023 Volume 212, Page(s) 104933

Abstract: ... of the other rat (i.e., emotional contagion vs homeostasis). Analyses of individuals' contribution to the play ...

Abstract	Social play in rats is rewarding and important for the development of brain and social skills. There are differences in the amount of play behavior displayed among individuals, with earlier studies suggesting that, despite variation across trials, individual differences tend to be consistent. In the present study, juvenile Lister-hooded rats were paired with a different, unfamiliar same-sex partner on three days and based on the amount of play each individual initiated, it was characterized as a high, medium or low player. Using this categorization, we explored three features related to individual differences. First, we show that by increasing the number of test days from two, as was done in a previous study (Lesscher et al., 2021), to three, characterization was effectively improved. Secondly, while the earlier study only used males, the present study showed that both sexes exhibit a similar pattern of individual differences in the degree of playfulness. Even though low players consistently initiated less play than medium and high players, all rats varied in how much play they initiated from one trial to the next. Thirdly, we assessed two potential mechanisms by which the playfulness of one rat can modify the level of playfulness of the other rat (i.e., emotional contagion vs homeostasis). Analyses of individuals' contribution to the play of dyads suggest that rats consistently adjust their play behavior depending on the behavior displayed by the partner. Since this adjustment can be positive or negative, our data support a homeostatic mechanism, whereby individuals increase or decrease the amount of play they initiate, which results in the experience of an overall stable pattern of play across trials. Future research will investigate the neural bases for individual differences in play and how rats maintain a preferred level of play.
Language	English
Publishing date	2023-08-27
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	196999-7
ISSN	1872-8308 ; 0376-6357
ISSN (online)	1872-8308
ISSN	0376-6357
DOI	10.1016/j.beproc.2023.104933
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Article ; Online: Entropy and temperature in finite isolated quantum systems.

Burke, Phillip C / Haque, Masudul

Physical review. E

2023 Volume 107, Issue 3-1, Page(s) 34125

Abstract: We investigate how the temperature calculated from the microcanonical entropy compares with the canonical temperature for finite isolated quantum systems. We concentrate on systems with sizes that make them accessible to numerical exact diagonalization. ... ...

Abstract	We investigate how the temperature calculated from the microcanonical entropy compares with the canonical temperature for finite isolated quantum systems. We concentrate on systems with sizes that make them accessible to numerical exact diagonalization. We thus characterize the deviations from ensemble equivalence at finite sizes. We describe multiple ways to compute the microcanonical entropy and present numerical results for the entropy and temperature computed in these various ways. We show that using an energy window whose width has a particular energy dependence results in a temperature with minimal deviations from the canonical temperature.
Language	English
Publishing date	2023-04-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	2844562-4
ISSN	2470-0053 ; 2470-0045
ISSN (online)	2470-0053
ISSN	2470-0045
DOI	10.1103/PhysRevE.107.034125
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Article ; Online: An XIC-Centric Strategy for Improved Identification and Quantification in Proteomic Data Analyses.

Wang, Guanghui / Zhang, Zheng / Liu, Yi / Burke, Meghan C / Sheetlin, Sergey L / Stein, Stephen E

Journal of proteome research

2024 Volume 23, Issue 5, Page(s) 1571–1582

Abstract: Reproducibility is a "proteomic dream" yet to be fully realized. A typical data analysis workflow utilizing extracted ion chromatograms (XICs) often treats the information path from identification to quantification as a one-way street. Here, we propose ... ...

Abstract	Reproducibility is a "proteomic dream" yet to be fully realized. A typical data analysis workflow utilizing extracted ion chromatograms (XICs) often treats the information path from identification to quantification as a one-way street. Here, we propose an XIC-centric approach in which the data flow is bidirectional: identifications are used to derive XICs whose information is in turn applied to validate the identifications. In this study, we employed liquid chromatography-mass spectrometry data from glycoprotein and human hair samples to illustrate the XIC-centric concept. At the core of this approach was XIC-based monoisotope repicking. Taking advantage of the intensity information for all detected isotopes across the whole range of an XIC peak significantly improved the accuracy and uncovered misidentifications originating from monoisotope assignment mistakes. It could also rescue non-top-ranked glycopeptide hits. Identification of glycopeptides is particularly susceptible to precursor mass errors for their low abundances, large masses, and glycans differing by 1 or 2 Da easily confused as isotopes. In addition, the XIC-centric strategy significantly reduced the problem of one XIC peak associated with multiple unique identifications, a source of quantitative irreproducibility. Taken together, the proposed approach can lead to improved identification and quantification accuracy and, ultimately, enhanced reproducibility in proteomic data analyses.
MeSH term(s)	Proteomics/methods ; Humans ; Chromatography, Liquid/methods ; Hair/chemistry ; Reproducibility of Results ; Glycoproteins/analysis ; Glycoproteins/chemistry ; Glycopeptides/analysis ; Glycopeptides/chemistry ; Data Analysis ; Mass Spectrometry/methods ; Tandem Mass Spectrometry/methods
Chemical Substances	Glycoproteins ; Glycopeptides
Language	English
Publishing date	2024-04-10
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2078618-9
ISSN	1535-3907 ; 1535-3893
ISSN (online)	1535-3907
ISSN	1535-3893
DOI	10.1021/acs.jproteome.3c00633
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Zs.A 6189: Show issues

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Article ; Online: Preadapted to adapt: underpinnings of adaptive plasticity revealed by the downy brome genome.

Revolinski, Samuel R / Maughan, Peter J / Coleman, Craig E / Burke, Ian C

Communications biology

2023 Volume 6, Issue 1, Page(s) 326

Abstract: Bromus tectorum L. is arguably the most successful invasive weed in the world. It has fundamentally altered arid ecosystems of the western United States, where it now found on an excess of 20 million hectares. Invasion success is related to avoidance of ... ...

Abstract	Bromus tectorum L. is arguably the most successful invasive weed in the world. It has fundamentally altered arid ecosystems of the western United States, where it now found on an excess of 20 million hectares. Invasion success is related to avoidance of abiotic stress and human management. Early flowering is a heritable trait utilized by B. tectorum, enabling the species to temporally monopolize limited resources and outcompete the native plant community. Thus, understanding the genetic underpinning of flowering time is critical for the design of integrated management strategies. To study flowering time traits in B. tectorum, we assembled a chromosome scale reference genome for B. tectorum. To assess the utility of the assembled genome, 121 diverse B. tectorum accessions are phenotyped and subjected to a genome wide association study (GWAS). Candidate genes, representing homologs of genes that have been previously associated with plant height or flowering phenology traits in related species are located near QTLs we identified. This study uses a high-resolution GWAS to identify reproductive phenology genes in a weedy species and represents a considerable step forward in understanding the mechanisms underlying genetic plasticity in one of the most successful invasive weed species.
MeSH term(s)	Humans ; United States ; Bromus/genetics ; Ecosystem ; Genome-Wide Association Study ; Quantitative Trait Loci ; Adaptation, Physiological/genetics
Language	English
Publishing date	2023-03-27
Publishing country	England
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, Non-U.S. Gov't
ISSN	2399-3642
ISSN (online)	2399-3642
DOI	10.1038/s42003-023-04620-9
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Article ; Online: Nontuberculous Mycobacteria in Cystic Fibrosis in the Era of Cystic Fibrosis Transmembrane Regulator Modulators.

Burke, Andrew / Thomson, Rachel M / Wainwright, Claire E / Bell, Scott C

Seminars in respiratory and critical care medicine

2023 Volume 44, Issue 2, Page(s) 287–296

Abstract: Nontuberculous mycobacteria (NTM) are a group of mycobacteria which represent opportunistic pathogens that are of increasing concern in people with cystic fibrosis (pwCF). The acquisition has been traditionally though to be from environmental sources, ... ...

Abstract	Nontuberculous mycobacteria (NTM) are a group of mycobacteria which represent opportunistic pathogens that are of increasing concern in people with cystic fibrosis (pwCF). The acquisition has been traditionally though to be from environmental sources, though recent work has suggested clustered clonal infections do occur and transmission potential demonstrated among pwCF attending CF specialist centers. Guidelines for the screening, diagnosis, and identification of NTM and management of pwCF have been published. The emergence of CF-specific therapies, in particular cystic fibrosis transmembrane regulator (CFTR) modulator drugs, have led to significant improvement in the health and well-being of pwCF and may lead to challenges in sampling the lower respiratory tract including to screen for NTM. This review highlights the epidemiology, modes of acquisition, screening and diagnosis, therapeutic approaches in the context of improved clinical status for pwCF, and the clinical application of CFTR modulator therapies.
MeSH term(s)	Humans ; Cystic Fibrosis/drug therapy ; Nontuberculous Mycobacteria ; Cystic Fibrosis Transmembrane Conductance Regulator/genetics ; Mycobacterium Infections, Nontuberculous/diagnosis ; Mycobacterium Infections, Nontuberculous/drug therapy ; Mycobacterium Infections, Nontuberculous/epidemiology
Chemical Substances	Cystic Fibrosis Transmembrane Conductance Regulator (126880-72-6)
Language	English
Publishing date	2023-01-17
Publishing country	United States
Document type	Review ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1183617-9
ISSN	1098-9048 ; 1069-3424
ISSN (online)	1098-9048
ISSN	1069-3424
DOI	10.1055/s-0042-1759883
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Article: Isolated Upper Extremity Compartment Syndrome: A Case of Rhabdomyolysis-induced Myoglobinuria and Acute Kidney Injury after Opioid Overdose.

Yatsonsky, David / Tranovich, Meaghan / Sawyer, Ethan / Burke, Connor / Ebraheim, Nabil

Journal of orthopaedic case reports

2024 Volume 14, Issue 1, Page(s) 131–136

Abstract: Introduction: The association between rhabdomyolysis secondary to traumatic crush injuries and the resultant acute kidney injury has been well described . The pathway of opioid overdose and acute kidney injury (AKI) has been documented but not fully ... ...

Abstract	Introduction: The association between rhabdomyolysis secondary to traumatic crush injuries and the resultant acute kidney injury has been well described . The pathway of opioid overdose and acute kidney injury (AKI) has been documented but not fully elucidated. This process is believed to be multifactorial in its pathophysiology, but it remains obscure. Acidosis, systemic hypoxia, hypothermia, muscle compression, immunologic, or direct toxic effects have been identified as contributing factors to opioid-induced AKI. Musculoskeletal crush injuries account for one of the most common causes of rhabdomyolysis leading to AKI. However, the vast majority of crush injuries documented involve large regions of the body and most commonly involve the lower extremity. This is hypothesized to be due to the need for a considerable amount of muscle necrosis and sufficient myoglobinuria to cause AKI. There is a paucity of literature describing isolated upper extremity crush injuries severe enough to cause AKI. The case described herein outlines a patient who developed isolated right upper extremity compartment syndrome and resultant rhabdomyolysis leading to AKI in the setting of an opioid overdose. Case report: Rhabdomyolysis may be caused by a variety of metabolic events. The pathophysiology of rhabdomyolysis secondary to acute crush injuries with resultant AKI is well documented. However, the literature describing cases of acute kidney injury caused by upper extremity compartment syndrome-induced rhabdomyolysis is limited. We present the case of a 33-year-old male who developed right upper extremity compartment syndrome after being incapacitated following an opioid overdose. He subsequently underwent emergent fasciotomies and was found to have an AKI secondary to rhabdomyolysis in the acute post-operative period. Conclusion: This case describes a patient who was found to have isolated right upper extremity compartment syndrome and subsequent rhabdomyolysis, which resulted in AKI following an opioid overdose. This case highlights that an isolated incidence of upper extremity rhabdomyolysis is sufficient to cause acute kidney injury. The literature describing this pathology in isolated upper extremity injuries is limited as this phenomenon is typically encountered in the setting of lower extremity compartment syndrome.The pathophysiology and mechanism of this pathology are of particular importance to the fields of orthopedic surgery, nephrology, and internal medicine. This case highlights the need for early and adequate fluid resuscitation in patients with isolated upper extremity injuries to minimize the risk of subsequent AKI.
Language	English
Publishing date	2024-01-23
Publishing country	India
Document type	Case Reports
ZDB-ID	2658169-3
ISSN	2250-0685
ISSN	2250-0685
DOI	10.13107/jocr.2024.v14.i01.4174
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