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Article ; Online: Vaccine effectiveness against influenza hospitalisation in adults during the 2022/2023 mixed season of influenza A(H1N1)pdm09, A(H3N2) and B circulation, Europe: VEBIS SARI VE hospital network.

Rose, Angela M C / Pozo, Francisco / Martínez-Baz, Iván / Mazagatos, Clara / Bossuyt, Nathalie / Cauchi, John Paul / Petrović, Goranka / Loghin, Isabela I / Vaikutyte, Roberta / Buda, Silke / Machado, Ausenda / Duffy, Róisín / Oroszi, Beatrix / Howard, Jennifer / Echeverria, Aitziber / Andreu, Cristina / Barbezange, Cyril / Džiugytė, Aušra / Nonković, Diana /

Influenza and other respiratory viruses

2024 Volume 18, Issue 2, Page(s) e13255

Abstract: ... 20% (95% CI: -4-39) against A(H3N2) and 56% (95% CI: 22-75) against B. During the 2022/2023 season ... while VE against hospitalisation with influenza B was >55%, it was ≤20% for influenza A subtypes ...

Abstract	We conducted a multicentre hospital-based test-negative case-control study to measure vaccine effectiveness (VE) against PCR-confirmed influenza in adult patients with severe acute respiratory infection (SARI) during the 2022/2023 influenza season in Europe. Among 5547 SARI patients ≥18 years, 2963 (53%) were vaccinated against influenza. Overall VE against influenza A(H1N1)pdm09 was 11% (95% CI: -23-36); 20% (95% CI: -4-39) against A(H3N2) and 56% (95% CI: 22-75) against B. During the 2022/2023 season, while VE against hospitalisation with influenza B was >55%, it was ≤20% for influenza A subtypes. While influenza vaccination should be a priority for future seasons, improved vaccines against influenza are needed.
MeSH term(s)	Adult ; Humans ; Influenza, Human/epidemiology ; Influenza, Human/prevention & control ; Seasons ; Influenza A Virus, H1N1 Subtype/genetics ; Influenza A Virus, H3N2 Subtype/genetics ; Case-Control Studies ; Vaccine Efficacy ; Influenza Vaccines ; Europe/epidemiology ; Hospitalization ; Hospitals ; Pneumonia ; Vaccination
Chemical Substances	Influenza Vaccines
Language	English
Publishing date	2024-02-23
Publishing country	England
Document type	Journal Article
ZDB-ID	2274538-5
ISSN	1750-2659 ; 1750-2640
ISSN (online)	1750-2659
ISSN	1750-2640
DOI	10.1111/irv.13255
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Article ; Online: Exploring the Physiological Multiplicity of Native Microalgae from the Ecuadorian Highland, Italian Lowland and Indoor Locations in Response to UV-B.

Huarancca Reyes, Thais / Chiellini, Carolina / Barozzi, Emilio / Sandoval, Carla / Echeverría, Cristina / Guglielminetti, Lorenzo

International journal of molecular sciences

2023 Volume 24, Issue 2

Abstract: The differential effects of UV-B on the inhibition or activation of protective mechanisms ...

Abstract	The differential effects of UV-B on the inhibition or activation of protective mechanisms to maintain cells photosynthetically active were investigated in native microalgae. Four strains were used, including two
MeSH term(s)	Chlorophyll/metabolism ; Chlorophyll A ; Microalgae/metabolism ; Chlorella/metabolism ; Ecuador ; Photosynthesis ; Antioxidants/metabolism ; Ultraviolet Rays
Chemical Substances	Chlorophyll (1406-65-1) ; Chlorophyll A (YF5Q9EJC8Y) ; Antioxidants
Language	English
Publishing date	2023-01-10
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms24021346
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Article ; Online: Efficacy of omecamtiv mecarbil in heart failure with reduced ejection fraction according to N-terminal pro-B-type natriuretic peptide level: insights from the GALACTIC-HF trial.

Docherty, Kieran F / McMurray, John J V / Claggett, Brian L / Miao, Zi Michael / Adams, Kirkwood F / Arias-Mendoza, Alexandra / Cleland, John G F / Diaz, Rafael / Echeverria Correa, Luis E / Felker, G Michael / Fonseca, Candida / Li, Jing / Metra, Marco / Sliwa-Hahnle, Karen / Solomon, Scott D / Vandekerckhove, Hans J / Vinereanu, Dragos / Voors, Adriaan A / Heitner, Stephen B /

Kupfer, Stuart / Malik, Fady I / Meng, Lisa / Teerlink, John R

European journal of heart failure

2023 Volume 25, Issue 2, Page(s) 248–259

Abstract: Aim: N-terminal pro-B-type natriuretic peptide (NT-proBNP) is predictive of both outcomes and ...

Abstract	Aim: N-terminal pro-B-type natriuretic peptide (NT-proBNP) is predictive of both outcomes and response to treatment in patients with heart failure with reduced ejection fraction (HFrEF). The aim of this study was to examine the effect of the cardiac myosin activator omecamtiv mecarbil according to baseline NT-proBNP level in the Global Approach to Lowering Adverse Cardiac outcomes Through Improving Contractility in Heart Failure trial (GALACTIC-HF). Methods and results: The primary outcome was the composite of a worsening heart failure event (urgent clinic visit, emergency department visit, or hospitalization) or cardiovascular death. We prespecified analysis of the effect of treatment according to baseline NT-proBNP (≤ median, > median), excluding individuals with atrial fibrillation/flutter (AF/AFL). Of the 8232 patients analysed, 8206 had an available baseline NT-proBNP measurement. Among the 5971 patients not in AF/AFL, the median (Q1-Q3) NT-proBNP level was 1675 (812-3579) pg/ml. Hazard ratios (HR) for the effect of omecamtiv mecarbil, compared with placebo, for the primary endpoint in patients without AF/AFL were: ≤ median 0.94 (95% confidence interval [CI] 0.80-1.09), > median 0.81 (0.73-0.90) (p-interaction = 0.095); for the overall population (including patients with AF/AFL) the HRs were ≤ median 1.01 (0.90-1.15) and > median 0.88 (0.80-0.96) (p-interaction = 0.035). There was an interaction between treatment and NT-proBNP, examined as a continuous variable, with greater effect of omecamtiv mecarbil on the primary outcome in patients with a higher baseline NT-proBNP (p-interaction = 0.086). Conclusions: In GALACTIC-HF, the benefit of omecamtiv mecarbil appeared to be larger in patients with higher baseline NT-proBNP levels, especially in patients without AF/AFL. Clinical trial registration: ClinicalTrials.gov Identifier NCT02929329; EudraCT number, 2016-002299-28.
MeSH term(s)	Humans ; Atrial Fibrillation ; Biomarkers ; Heart Failure ; Natriuretic Peptide, Brain/therapeutic use ; Peptide Fragments/therapeutic use ; Prognosis ; Stroke Volume/physiology
Chemical Substances	Biomarkers ; Natriuretic Peptide, Brain (114471-18-0) ; omecamtiv mecarbil (2M19539ERK) ; Peptide Fragments ; pro-brain natriuretic peptide (1-76)
Language	English
Publishing date	2023-01-16
Publishing country	England
Document type	Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ZDB-ID	1483672-5
ISSN	1879-0844 ; 1388-9842
ISSN (online)	1879-0844
ISSN	1388-9842
DOI	10.1002/ejhf.2763
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Article: Plan B water assessment: Efficiency and circularity for agricultural and municipal adaptation to water scarcity

Asprilla Echeverría, John M

Groundwater for sustainable development. 2021 Aug., v. 14

2021

Abstract: ... as essential criteria for seeking solutions in designing long-term supply management. A Plan B water assessment ...

Abstract	Municipal supply of water under climate variations, growing population, uncertainty, and scarcity, requires water planners to devise feasible and sustainable water sourcing plans; especially for territories relying on groundwater. The conventional ways to cope with water scarcity will no longer guarantee reaping the maximum benefits of declining available water resources. Efficiency and circularity of water are claimed as essential criteria for seeking solutions in designing long-term supply management. A Plan B water assessment applied to a group of municipalities in dry areas of Colombia, is proposed as a hydro-economic model aimed at providing inputs for water resources planning, in which the depletable and common-pool character of aquifers are incorporated. A declination speed index is introduced in two ways: the surface → water table distance and water table → saturated thickness distance. This issue should not be overlooked if spatial differentiation in water tables is incorporated in groundwater extraction permits analysis for multiple and convergent water users. Research results are promising for sustainability of water management in dry areas around the world. Respect to status quo situation a 22% of efficiency gain might be achieved in the next 20 years in Sucre – Colombia, under an efficient model of water consumption. If an efficient and circular water management model is endeavored, multiple gains would be harvested for the benefit of water users and ecosystems relying on aquifers. Increased efficiency is mostly driven by 30 million m³ sewage water recirculated in agriculture, which in turn would prevent aquifer extraction for this activity. In business-as-usual scheme, water efficiency gap will be wider; extraction costs will rise to prohibitive levels for low income municipalities; the declining water tables will oblige to make new punches by simultaneous water users and water declination index calculated would reflect a precipitous decay. Research results provide empirical evidence to the discussion on possible solutions for sustainable and efficient water management as stated in Sustainable Development Goals; specifically target goal 6.4 determines that water efficiency and sustainability in water withdrawals should be accomplished. Local setting on water resources availability, competition on resources, types of users, sewage water treatment technology, energy costs, and institutions in time and place, would determine the replicability of research results.
Keywords	aquifers ; energy ; groundwater ; groundwater extraction ; income ; models ; municipal wastewater ; spatial variation ; sustainable development ; uncertainty ; water management ; water shortages ; water table ; water treatment ; Colombia
Language	English
Dates of publication	2021-08
Publishing place	Elsevier B.V.
Document type	Article
Note	NAL-AP-2-clean
ISSN	2352-801X
DOI	10.1016/j.gsd.2021.100602
Database	NAL-Catalogue (AGRICOLA)

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Article: Seroprevalence of hepatitis B and C viruses in moderate and severe COVID-19 inpatients: A cross-sectional study at a referral center in Mexico.

Jiménez-Mendoza, J C / Rivera-López, F E / González-Lara, M F / Valdez-Echeverría, R D / Castro-Narro, G E / Tore, A / Uscanga-Domínguez, L F / Moctezuma-Velázquez, C

Annals of hepatology

2022 Volume 27, Issue 3, Page(s) 100684

Abstract: ... COVID-19) has caused a great impact on healthcare systems worldwide, including hepatitis B and C viruses ... opportunity to screen patients for hepatitis B virus (HBV) and hepatitis C virus (HCV), which was the aim ...

Abstract	Introduction and objectives: The emergence of SARS-CoV-2, which causes the coronavirus disease (COVID-19) has caused a great impact on healthcare systems worldwide, including hepatitis B and C viruses screening and elimination programs. The high number of COVID-19 hospitalizations represent a great opportunity to screen patients for hepatitis B virus (HBV) and hepatitis C virus (HCV), which was the aim of this study. Material and methods: Cross-sectional, retrospective study performed between April 2020 and 20201 at a referral center in Mexico dedicated to the care of adults with severe/critical COVID-19. We retrieved clinical, demographic, and laboratory results from each patient´s medical records, including antibodies against HCV (anti-HCV), HBV surface antigen (HBsAg), antibodies against the HBV core antigen (anti-HBcAg), and antibodies against HBsAg (anti-HBsAg). Results: Out of 3620 patients that were admitted to the hospital, 24 (0.66%), 4 (0.11%), and 72 (1.99%) tested positive for anti-HCV, HBsAg, and anti-HBcAg, respectively. Of all seronegative patients, 954 (27%) had undetectable anti-HBsAg and 401 (12%) had anti-HBsAg at protective levels. Blood transfusion was the most relevant risk factor. Only 9.7% of the anti-HBc positive, 25% of the HBsAg positive, and 52% of the anti-HCV positive were aware of their serological status. Conclusions: In this study we found a prevalence of anti-HCV of 0.66%, HBsAg in 0.11%, and isolated anti-HBcAg in 1.99%. We also found that HBV vaccination coverage has been suboptimal and needs to be reinforced. This study gave us a trustworthy insight of the actual seroprevalence in Mexico, which can help provide feedback to the Hepatitis National Elimination Plan.
MeSH term(s)	Adult ; COVID-19/diagnosis ; COVID-19/epidemiology ; Cross-Sectional Studies ; Hepacivirus ; Hepatitis B/diagnosis ; Hepatitis B/epidemiology ; Hepatitis B Antibodies ; Hepatitis B Core Antigens ; Hepatitis B Surface Antigens ; Hepatitis B virus ; Hepatitis C/diagnosis ; Hepatitis C/epidemiology ; Hepatitis C Antibodies ; Humans ; Inpatients ; Mexico/epidemiology ; Referral and Consultation ; Retrospective Studies ; SARS-CoV-2 ; Seroepidemiologic Studies
Chemical Substances	Hepatitis B Antibodies ; Hepatitis B Core Antigens ; Hepatitis B Surface Antigens ; Hepatitis C Antibodies
Language	English
Publishing date	2022-02-12
Publishing country	Mexico
Document type	Journal Article
ZDB-ID	2188733-0
ISSN	1665-2681
ISSN	1665-2681
DOI	10.1016/j.aohep.2022.100684
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Article: Vitamins E, A and B

Elsen, C / Rivas-Echeverría, C / Sahland, K / Sánchez, R / Molma, L / Pahl, L / Wallinger, R / Volz, J / Wacker, J / Frühauf, J

Geburtshilfe und Frauenheilkunde

2014 Volume 72, Issue 9, Page(s) 846–852

Abstract: ... B ...

Abstract	In the course of the prospective, randomized, double-blind trial the influence of a high-dose riboflavin substitution on the risk for preeclampsia was studied in a high-risk collective 1. The present contribution evaluates supplementary data from the already published PROPER trial. The patients were from the two study centers Mérida, Venezuela, and Moshi, Tanzania, they were randomized from the 20th week of pregnancy and received either 15 mg riboflavin daily or placebo. Clinical and laboratory checks were carried out at four-week intervals up to childbirth. Concerning the question of whether there is a relationship between the serum levels of antioxidative vitamins and the risk of developing preeclampsia, it was found that no relationship could be detected between the measured laboratory values of vitamins E, A and B
Language	English
Publishing date	2014-10-14
Publishing country	Germany
Document type	Journal Article
ZDB-ID	80111-2
ISSN	1438-8804 ; 0016-5751 ; 1615-3359
ISSN (online)	1438-8804
ISSN	0016-5751 ; 1615-3359
DOI	10.1055/s-0032-1315365
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Article: Osteoarticular Cryptococcosis Successfully Treated with High-Dose Liposomal Amphotericin B Followed by Oral Fluconazole.

Deus, Guillem / Gómez-Zorrilla, Silvia / Echeverria-Esnal, Daniel / Siverio, Ana / Güerri-Fernandez, Robert / Ares, Jesús / Campillo, Nuria / Letang, Emili / Knobel, Hernando / Grau, Santiago / Horcajada, Juan Pablo

Infection and drug resistance

2021 Volume 14, Page(s) 719–722

Abstract: Background: Skeletal involvement of : Case presentation: We herein report a case of bone and soft tissue cryptococcal infection in a 42-year-old male from Pakistan with well-controlled diabetes without other associated immunodeficiencies treated with ...

Abstract	Background: Skeletal involvement of Case presentation: We herein report a case of bone and soft tissue cryptococcal infection in a 42-year-old male from Pakistan with well-controlled diabetes without other associated immunodeficiencies treated with antifungal therapy without surgical debridement. Furthermore, the patient developed toxidermia due to fluconazole use, so a fluconazole desensitization was performed. Therapeutic management also included the performance of therapeutic drug monitoring of fluconazole plasma concentrations. Conclusion: To our knowledge, this is the first case of osteoarticular cryptococcosis treated with this treatment regimen. This strategy may be of interest to try to reduce hospital stay and associated complications.
Language	English
Publishing date	2021-02-24
Publishing country	New Zealand
Document type	Case Reports
ZDB-ID	2494856-1
ISSN	1178-6973
ISSN	1178-6973
DOI	10.2147/IDR.S294299
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Article ; Online: Seroprevalence of hepatitis B and C viruses in moderate and severe COVID-19 inpatients

JC Jiménez-Mendoza / FE Rivera-López / MF González-Lara / RD Valdez-Echeverría / GE Castro-Narro / A Tore / LF Uscanga-Domínguez / C Moctezuma-Velázquez

Annals of Hepatology, Vol 27, Iss 3, Pp 100684- (2022)

A cross-sectional study at a referral center in Mexico

2022

Abstract	Introduction and Objectives: The emergence of SARS-CoV-2, which causes the coronavirus disease (COVID-19) has caused a great impact on healthcare systems worldwide, including hepatitis B and C viruses screening and elimination programs. The high number of COVID-19 hospitalizations represent a great opportunity to screen patients for hepatitis B virus (HBV) and hepatitis C virus (HCV), which was the aim of this study. Material and Methods: Cross-sectional, retrospective study performed between April 2020 and 20201 at a referral center in Mexico dedicated to the care of adults with severe/critical COVID-19. We retrieved clinical, demographic, and laboratory results from each patient´s medical records, including antibodies against HCV (anti-HCV), HBV surface antigen (HBsAg), antibodies against the HBV core antigen (anti-HBcAg), and antibodies against HBsAg (anti-HBsAg). Results: Out of 3620 patients that were admitted to the hospital, 24 (0.66%), 4 (0.11%), and 72 (1.99%) tested positive for anti-HCV, HBsAg, and anti-HBcAg, respectively. Of all seronegative patients, 954 (27%) had undetectable anti-HBsAg and 401 (12%) had anti-HBsAg at protective levels. Blood transfusion was the most relevant risk factor. Only 9.7% of the anti-HBc positive, 25% of the HBsAg positive, and 52% of the anti-HCV positive were aware of their serological status. Conclusions: In this study we found a prevalence of anti-HCV of 0.66%, HBsAg in 0.11%, and isolated anti-HBcAg in 1.99%. We also found that HBV vaccination coverage has been suboptimal and needs to be reinforced. This study gave us a trustworthy insight of the actual seroprevalence in Mexico, which can help provide feedback to the Hepatitis National Elimination Plan.
Keywords	Screening ; Hepatitis B ; Hepatitis C ; Seroprevalence ; COVID-19 ; SARS-CoV-2 ; Specialties of internal medicine ; RC581-951
Subject code	360
Language	English
Publishing date	2022-05-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Dihydrogen intermolecular contacts in group 13 compounds: HH or EH (E = B, Al, Ga) interactions?

Echeverría, Jorge / Aullón, Gabriel / Alvarez, Santiago

Dalton transactions (Cambridge, England : 2003)

2017 Volume 46, Issue 9, Page(s) 2844–2854

Abstract: ... involving B-HH-B contacts are comparable in strength to the previously studied C-HH-C ones, yet attractive ... skeleton enhances the B-HH-B interaction strength with respect to non-polyhedral compounds, and it has also ... been proven that Al-HH-Al and Ga-HH-Ga interactions can be attractive in some cases. If HE (B, Al and ...

Abstract	A systematic theoretical analysis of homopolar dihydrogen interactions in group 13 compounds is presented here. Ab initio calculations and structural analysis allow us to demonstrate that interactions involving B-HH-B contacts are comparable in strength to the previously studied C-HH-C ones, yet attractive and important for the stabilization of dimers of large molecules. We have also shown that a polyhedral skeleton enhances the B-HH-B interaction strength with respect to non-polyhedral compounds, and it has also been proven that Al-HH-Al and Ga-HH-Ga interactions can be attractive in some cases. If HE (B, Al and Ga) short contacts are present, the interaction is significantly strengthened, especially for Al and Ga. In general, HH interactions combined with associated HE (B, Al and Ga) short contacts are responsible for the stability of a large number of dimers of group 13 compounds and may play an important role in the packing of their crystal structures.
Language	English
Publishing date	2017-02-28
Publishing country	England
Document type	Journal Article
ZDB-ID	1472887-4
ISSN	1477-9234 ; 1364-5447 ; 0300-9246 ; 1477-9226
ISSN (online)	1477-9234 ; 1364-5447
ISSN	0300-9246 ; 1477-9226
DOI	10.1039/c6dt02854c
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Book ; Article ; Online: Costo-beneficio de la vacunación contra la hepatitis B en trabajadores de hospitales de Venezuela

Fernández Barboza, Raúl / Rivero, Dalia / Echeverria, Beatriz / Machado, Irma V

2015

Abstract: ... de hospitales en Venezuela contra la hepatitis B. Para ello, se utilizó un modelo de árbol de toma de decisiones ... de la hepatitis B en Venezuela ...

Abstract	Se realizó un análisis del beneficio en función del costo de la vacunación de trabajadores de hospitales en Venezuela contra la hepatitis B. Para ello, se utilizó un modelo de árbol de toma de decisiones mediante el cual se calcularon las probabilidades de la posible evolución de la infección. El costo medio actual estimado de la enfermedad para el Gobierno de Venezuela fué de $US 1 759 por paciente. Los resultados indican que la vacunación selectiva o las campañas de vacunación en masa de los trabajadores de hospitales reducirán el costo total de esa infección a 51 o a 28 por ciento, lo que representa un ahorro de $US 17 a 26 millones. Este tipo de análisis puede influir en la distribución de recursos que se pretender asignar al control de la hepatitis B en Venezuela
Keywords	Análise Custo-Benefício ; Hepatite B ; Vacinação em Massa ; Recursos Humanos em Hospital ; Gastos em Saúde ; Venezuela
Publishing date	2015-12-08T03:07:10Z
Document type	Book ; Article ; Online
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