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  1. Article ; Online: Expected and unexpected effects after systemic inhibition of Hippo transcriptional output in cancer.

    Baroja, Isabel / Kyriakidis, Nikolaos C / Halder, Georg / Moya, Iván M

    Nature communications

    2024  Volume 15, Issue 1, Page(s) 2700

    Abstract: Hyperactivation of YAP/TAZ, the Hippo pathway downstream effectors, is common in human cancer. The requirement of YAP/TAZ for cancer cell survival in preclinical models, prompted the development of pharmacological inhibitors that suppress their ... ...

    Abstract Hyperactivation of YAP/TAZ, the Hippo pathway downstream effectors, is common in human cancer. The requirement of YAP/TAZ for cancer cell survival in preclinical models, prompted the development of pharmacological inhibitors that suppress their transcriptional activity. However, systemic YAP/TAZ inhibition may sometimes have unpredictable patient outcomes, with limited or even adverse effects because YAP/TAZ action is not simply tumor promoting but also tumor suppressive in some cell types. Here, we review the role of the Hippo pathway in distinct tumor cell populations, discuss the impact of inhibiting Hippo output on tumor growth, and examine current developments in YAP/TAZ inhibitors.
    MeSH term(s) Humans ; Signal Transduction ; Adaptor Proteins, Signal Transducing/metabolism ; Transcription Factors/metabolism ; Protein Serine-Threonine Kinases/metabolism ; YAP-Signaling Proteins ; Neoplasms/drug therapy ; Neoplasms/genetics
    Chemical Substances Adaptor Proteins, Signal Transducing ; Transcription Factors ; Protein Serine-Threonine Kinases (EC 2.7.11.1) ; YAP-Signaling Proteins
    Language English
    Publishing date 2024-03-27
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-024-46531-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Book ; Thesis: Pharmakokinetik von Ciprofloxacin und seiner Metabolite M1, M2 und M3 bei Patienten mit chronischer Niereninsuffizienz

    Halder, Georg

    vergleichende Untersuchung von HPLC und Bioassay im Rahmen eines Drugmonitorings

    1994  

    Author's details vorgelegt von Georg Halder
    Language German
    Size 43 Bl. : zahlr. graph. Darst.
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Marburg, Univ., Diss., 1996
    HBZ-ID HT007279580
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    96 D 2875 order for loan Magazin

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  3. Article ; Online: The Enigma of Identity of the Anglo-Indian Women in Shyam Benegal's Junoon (1978).

    Somdatta Halder

    Litinfinite, Vol 3, Iss 2, Pp 51-

    2021  Volume 60

    Abstract: ... the social being requires the look of the ‘other’, Georg Wilhelm Friedrich Hegelremarks that the relation ...

    Abstract Jean-Paul Sartre argues that human beings are consisted of ‘being’ and ‘nothingness’. They do not bear, unlike nonhuman entities, any predecided meaning or purpose of existence. Rather, they play roles to fashion their ‘self’ and thereby obtain an essence of their being. Though, to be recognized as a ‘self’ the social being requires the look of the ‘other’, Georg Wilhelm Friedrich Hegelremarks that the relation of self/other is not simply that of mutual recognition. Rather, it stimulates the primitive urge of dominating the other. This ambiguous relation of self/other is the central theme of the veteran Indian director Shyam Benegal’s feature film Junoon. The paper probes into the enigma of identity of the Anglo-Indian women in the concerned film and subsequently addresses such aspects as the Sartrean notions of role-play and bad faith, the influence of the ‘other’ as the look in the identity crisis of the Anglo-Indian women, representation of different cultures in the film, the contradicting elements of cultural enmity and co-existence, and so on.
    Keywords anglo-indian identity ; identity crisis ; other as the look ; Language and Literature ; P ; Social Sciences ; H
    Subject code 950
    Language Bengali
    Publishing date 2021-12-01T00:00:00Z
    Publisher Supriyo Chakraborty, Penprints Publication
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Cell Junctions in Hippo Signaling.

    Karaman, Ruchan / Halder, Georg

    Cold Spring Harbor perspectives in biology

    2018  Volume 10, Issue 5

    Abstract: The Hippo signal transduction pathway is an important regulator of organ growth and cell differentiation, and its deregulation contributes to the development of cancer. The activity of the Hippo pathway is strongly dependent on cell junctions, cellular ... ...

    Abstract The Hippo signal transduction pathway is an important regulator of organ growth and cell differentiation, and its deregulation contributes to the development of cancer. The activity of the Hippo pathway is strongly dependent on cell junctions, cellular architecture, and the mechanical properties of the microenvironment. In this review, we discuss recent advances in our understanding of how cell junctions transduce signals from the microenvironment and control the activity of the Hippo pathway. We also discuss how these mechanisms may control organ growth during development and regeneration, and how defects in them deregulate Hippo signaling in cancer cells.
    MeSH term(s) Adherens Junctions/metabolism ; Adherens Junctions/physiology ; Animals ; Cell Differentiation ; Cell Proliferation ; Cellular Microenvironment ; Cytoskeleton/metabolism ; Cytoskeleton/ultrastructure ; Intercellular Junctions ; Models, Biological ; Protein-Serine-Threonine Kinases/genetics ; Protein-Serine-Threonine Kinases/metabolism ; Protein-Serine-Threonine Kinases/physiology ; Signal Transduction ; Tight Junctions/metabolism ; Tight Junctions/physiology
    Chemical Substances Hippo protein, human (EC 2.7.11.1) ; Protein-Serine-Threonine Kinases (EC 2.7.11.1)
    Language English
    Publishing date 2018-05-01
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ISSN 1943-0264
    ISSN (online) 1943-0264
    DOI 10.1101/cshperspect.a028753
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Hippo-YAP/TAZ signalling in organ regeneration and regenerative medicine.

    Moya, Iván M / Halder, Georg

    Nature reviews. Molecular cell biology

    2018  Volume 20, Issue 4, Page(s) 211–226

    Abstract: The Hippo pathway and its downstream effectors, the transcriptional co-activators Yes-associated protein (YAP) and transcriptional co-activator with PDZ-binding motif (TAZ), regulate organ growth and cell plasticity during animal development and ... ...

    Abstract The Hippo pathway and its downstream effectors, the transcriptional co-activators Yes-associated protein (YAP) and transcriptional co-activator with PDZ-binding motif (TAZ), regulate organ growth and cell plasticity during animal development and regeneration. Remarkably, experimental activation of YAP/TAZ in the mouse can promote regeneration in organs with poor or compromised regenerative capacity, such as the adult heart and the liver and intestine of old or diseased mice. However, therapeutic YAP/TAZ activation may cause serious side effects. Most notably, YAP/TAZ are hyperactivated in human cancers, and prolonged activation of YAP/TAZ triggers cancer development in mice. Thus, can the power of YAP/TAZ to promote regeneration be harnessed in a safe way? Here, we review the role of Hippo signalling in animal regeneration, examine the promises and risks of YAP/TAZ activation for regenerative medicine and discuss strategies to activate YAP/TAZ for regenerative therapy while minimizing adverse side effects.
    MeSH term(s) Adaptor Proteins, Signal Transducing/metabolism ; Animals ; Humans ; Protein Serine-Threonine Kinases/metabolism ; Regenerative Medicine/methods ; Signal Transduction/physiology ; Transcription Factors/metabolism
    Chemical Substances Adaptor Proteins, Signal Transducing ; Transcription Factors ; Protein Serine-Threonine Kinases (EC 2.7.11.1)
    Language English
    Publishing date 2018-12-13
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2031313-5
    ISSN 1471-0080 ; 1471-0072
    ISSN (online) 1471-0080
    ISSN 1471-0072
    DOI 10.1038/s41580-018-0086-y
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    Zs.A 5446: Show issues Location:
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    Zs.MG 26: Show issues

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  6. Article ; Online: The Hippo pathway in cellular reprogramming and regeneration of different organs.

    Moya, Iván M / Halder, Georg

    Current opinion in cell biology

    2016  Volume 43, Page(s) 62–68

    Abstract: We have a limited ability to stimulate cells in damaged tissues to regenerate properly patterned and functional organs. Excitingly, however, recent work shows that experimental modulation of the Hippo pathway can promote the regeneration of several ... ...

    Abstract We have a limited ability to stimulate cells in damaged tissues to regenerate properly patterned and functional organs. Excitingly, however, recent work shows that experimental modulation of the Hippo pathway can promote the regeneration of several organs in mice. The Hippo pathway plays pivotal and specific roles in organ growth, cellular plasticity, and stem cell biology, which are all important for regeneration. In this review we survey and compare the effects of experimental manipulation of Hippo signaling in mouse on the development, homeostasis, and regeneration of the heart, liver, intestine, and other organs. We also discuss the potential of targeting the Hippo pathway as a therapeutic approach for regenerative medicine.
    MeSH term(s) Animals ; Cellular Reprogramming ; Humans ; Neoplasms/pathology ; Organ Specificity ; Protein-Serine-Threonine Kinases/metabolism ; Regeneration ; Signal Transduction ; Stem Cells/metabolism
    Chemical Substances Protein-Serine-Threonine Kinases (EC 2.7.11.1)
    Language English
    Publishing date 2016-12
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1026381-0
    ISSN 1879-0410 ; 0955-0674
    ISSN (online) 1879-0410
    ISSN 0955-0674
    DOI 10.1016/j.ceb.2016.08.004
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    Zs.A 2963: Show issues Location:
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  7. Article ; Online: Single-cell spatial multi-omics and deep learning dissect enhancer-driven gene regulatory networks in liver zonation.

    Bravo González-Blas, Carmen / Matetovici, Irina / Hillen, Hanne / Taskiran, Ibrahim Ihsan / Vandepoel, Roel / Christiaens, Valerie / Sansores-García, Leticia / Verboven, Elisabeth / Hulselmans, Gert / Poovathingal, Suresh / Demeulemeester, Jonas / Psatha, Nikoleta / Mauduit, David / Halder, Georg / Aerts, Stein

    Nature cell biology

    2024  Volume 26, Issue 1, Page(s) 153–167

    Abstract: In the mammalian liver, hepatocytes exhibit diverse metabolic and functional profiles based on their location within the liver lobule. However, it is unclear whether this spatial variation, called zonation, is governed by a well-defined gene regulatory ... ...

    Abstract In the mammalian liver, hepatocytes exhibit diverse metabolic and functional profiles based on their location within the liver lobule. However, it is unclear whether this spatial variation, called zonation, is governed by a well-defined gene regulatory code. Here, using a combination of single-cell multiomics, spatial omics, massively parallel reporter assays and deep learning, we mapped enhancer-gene regulatory networks across mouse liver cell types. We found that zonation affects gene expression and chromatin accessibility in hepatocytes, among other cell types. These states are driven by the repressors TCF7L1 and TBX3, alongside other core hepatocyte transcription factors, such as HNF4A, CEBPA, FOXA1 and ONECUT1. To examine the architecture of the enhancers driving these cell states, we trained a hierarchical deep learning model called DeepLiver. Our study provides a multimodal understanding of the regulatory code underlying hepatocyte identity and their zonation state that can be used to engineer enhancers with specific activity levels and zonation patterns.
    MeSH term(s) Mice ; Animals ; Multiomics ; Gene Regulatory Networks ; Deep Learning ; Liver/metabolism ; Hepatocytes ; Mammals
    Language English
    Publishing date 2024-01-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 1474722-4
    ISSN 1476-4679 ; 1465-7392
    ISSN (online) 1476-4679
    ISSN 1465-7392
    DOI 10.1038/s41556-023-01316-4
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    Zs.A 5169: Show issues Location:
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    Zs.MG 12: Show issues

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  8. Article ; Online: Walter J Gehring (1939-2014).

    Mlodzik, Marek / Halder, Georg

    The EMBO journal

    2014  Volume 33, Issue 15, Page(s) 1615–1616

    MeSH term(s) Animals ; Antennapedia Homeodomain Protein/genetics ; Developmental Biology/history ; Drosophila/genetics ; Drosophila/growth & development ; History, 20th Century ; History, 21st Century ; Switzerland
    Chemical Substances Antennapedia Homeodomain Protein
    Language English
    Publishing date 2014-07-08
    Publishing country England
    Document type Biography ; Historical Article ; Journal Article ; Portrait
    ZDB-ID 586044-1
    ISSN 1460-2075 ; 0261-4189
    ISSN (online) 1460-2075
    ISSN 0261-4189
    DOI 10.15252/embj.201489291
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  9. Article ; Online: Walter J. Gehring (1939-2014).

    Mlodzik, Marek / Halder, Georg

    Developmental biology

    2014  Volume 395, Issue 1, Page(s) 1–3

    MeSH term(s) Animals ; Antennapedia Homeodomain Protein/genetics ; Developmental Biology/history ; Drosophila/genetics ; Drosophila/growth & development ; Drosophila Proteins/genetics ; History, 20th Century ; History, 21st Century ; Morphogenesis/genetics ; Switzerland
    Chemical Substances Antennapedia Homeodomain Protein ; Antp protein, Drosophila ; Drosophila Proteins
    Language English
    Publishing date 2014-10-08
    Publishing country United States
    Document type Biography ; Historical Article ; Journal Article ; Portrait
    ZDB-ID 1114-9
    ISSN 1095-564X ; 0012-1606
    ISSN (online) 1095-564X
    ISSN 0012-1606
    DOI 10.1016/j.ydbio.2014.09.007
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  10. Article ; Online: Discovering the Hippo pathway protein-protein interactome.

    Moya, Iván M / Halder, Georg

    Cell research

    2014  Volume 24, Issue 2, Page(s) 137–138

    Abstract: The Hippo pathway is a signal transduction pathway that regulates organ growth, stem cell biology, regeneration and cancer. Three recent proteomic studies with Hippo pathway components uncovered extensive networks of interacting proteins revealing novel ... ...

    Abstract The Hippo pathway is a signal transduction pathway that regulates organ growth, stem cell biology, regeneration and cancer. Three recent proteomic studies with Hippo pathway components uncovered extensive networks of interacting proteins revealing novel connections to cell-cell junctions, regulation by vesicle trafficking, and phosphorylation-dependent remodeling of the interactome, and provide a rich landscape of novel interactors ripe for mechanistic studies.
    MeSH term(s) Animals ; Cytoskeleton/metabolism ; Drosophila ; Humans ; Nuclear Proteins/metabolism ; Phosphorylation ; Protein Interaction Maps ; Protein Transport ; Protein-Serine-Threonine Kinases/metabolism ; RNA Interference ; Signal Transduction ; Tight Junction Proteins/metabolism ; Transcription Factors/metabolism
    Chemical Substances Nuclear Proteins ; Tight Junction Proteins ; Transcription Factors ; Hippo protein, human (EC 2.7.11.1) ; Protein-Serine-Threonine Kinases (EC 2.7.11.1)
    Language English
    Publishing date 2014-01-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 1319303-x
    ISSN 1748-7838 ; 1001-0602
    ISSN (online) 1748-7838
    ISSN 1001-0602
    DOI 10.1038/cr.2014.6
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    Zs.A 5283: Show issues Location:
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