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Article ; Online: Molecular characterization of the histiocytoses: Neoplasia of dendritic cells and macrophages.

Durham, Benjamin H

Seminars in cell & developmental biology

2018 Volume 86, Page(s) 62–76

Abstract: The systemic histiocytoses encompass a clinically heterogeneous group of disorders leading to tissue damage secondary to the accumulation and infiltration of pathological cells thought to be derived from the dendritic or monocytic lineages with ... ...

Abstract	The systemic histiocytoses encompass a clinically heterogeneous group of disorders leading to tissue damage secondary to the accumulation and infiltration of pathological cells thought to be derived from the dendritic or monocytic lineages with accompanying inflammation. For decades, whether or not the histiocytoses were inflammatory or neoplastic disorders was unclear, and their cellular origins have long been obscure and heavily debated. However, the rise of the molecular era led to the discovery of recurrent BRAF
MeSH term(s)	Dendritic Cells/metabolism ; Dendritic Cells/pathology ; Histiocytic Disorders, Malignant/genetics ; Histiocytic Disorders, Malignant/metabolism ; Histiocytic Disorders, Malignant/pathology ; Humans ; Macrophages/metabolism ; Macrophages/pathology ; Mitogen-Activated Protein Kinases/genetics ; Mitogen-Activated Protein Kinases/metabolism ; Mutation ; Phosphatidylinositol 3-Kinases/genetics ; Phosphatidylinositol 3-Kinases/metabolism ; Proto-Oncogene Proteins c-akt/genetics ; Proto-Oncogene Proteins c-akt/metabolism ; Signal Transduction/genetics
Chemical Substances	Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; Mitogen-Activated Protein Kinases (EC 2.7.11.24)
Language	English
Publishing date	2018-03-16
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	1312473-0
ISSN	1096-3634 ; 1084-9521
ISSN (online)	1096-3634
ISSN	1084-9521
DOI	10.1016/j.semcdb.2018.03.002
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Zs.A 2918: Show issues

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Article ; Online: MAP-Kinase-Driven Hematopoietic Neoplasms: A Decade of Progress in the Molecular Age.

Chakraborty, Rikhia / Abdel-Wahab, Omar / Durham, Benjamin H

Cold Spring Harbor perspectives in medicine

2021 Volume 11, Issue 5

Abstract: Mutations in members of the mitogen-activated protein kinase (MAPK) pathway are extensively studied in epithelial malignancies, ... ...

Abstract	Mutations in members of the mitogen-activated protein kinase (MAPK) pathway are extensively studied in epithelial malignancies, with
MeSH term(s)	Erdheim-Chester Disease/genetics ; Erdheim-Chester Disease/physiopathology ; Hematologic Neoplasms/genetics ; Humans ; MAP Kinase Kinase 1 ; Mitogen-Activated Protein Kinases/genetics ; Mutation
Chemical Substances	Mitogen-Activated Protein Kinases (EC 2.7.11.24) ; MAP Kinase Kinase 1 (EC 2.7.12.2) ; MAP2K1 protein, human (EC 2.7.12.2)
Language	English
Publishing date	2021-05-03
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Review
ISSN	2157-1422
ISSN (online)	2157-1422
DOI	10.1101/cshperspect.a034892
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Article ; Online: Histiocytic neoplasm subtypes differ in their MAP2K1 mutational type.

Emile, Jean-François / Hélias-Rodzewicz, Zofia / Durham, Benjamin H / Héritier, Sébastien / da Silva, Malik / Younas, Komel / Cohen-Aubart, Fleur / Abdel-Wahab, Omar / Diamond, Eli L / Donadieu, Jean / Haroche, Julien

Blood advances

2024 Volume 7, Issue 23, Page(s) 7254–7257

MeSH term(s)	Humans ; Mutation ; Neoplasms ; MAP Kinase Kinase 1
Chemical Substances	MAP2K1 protein, human (EC 2.7.12.2) ; MAP Kinase Kinase 1 (EC 2.7.12.2)
Language	English
Publishing date	2024-01-10
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2915908-8
ISSN	2473-9537 ; 2473-9529
ISSN (online)	2473-9537
ISSN	2473-9529
DOI	10.1182/bloodadvances.2023011414
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Zs.A 7153: Show issues

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Article ; Online: A model for delivery of extracorporeal life support in a stand-alone veterans affairs medical center.

Seadler, Benjamin D / Melamed, Joshua / Sow, Mami / Rogers, Austin L / Syed, Ali / Linsky, Paul L / Ubert, H Adam / Schena, Stefano / Durham, Lucian A / Almassi, G Hossein

Artificial organs

2024

Abstract: ... Mean time from the initial shock call to arrival at the ECLS center was 2.8 h. There were no ...

Abstract	Introduction: For the Veterans Health Administration (VHA) to continue to perform complex cardiothoracic surgery, there must be an established pathway for providing urgent/emergent extracorporeal life support (ECLS). Partnership with a nearby tertiary care center with such expertise may be the most resource-efficient way to provide ECLS services to patients in post-cardiotomy cardiogenic shock or respiratory failure. The goal of this project was to assess the efficiency, safety, and outcomes of surgical patients who required transfer for perioperative ECLS from a single stand-alone Veterans Affairs Medical Center (VAMC) to a separate ECLS center. Methods: Cohort consisted of all cardiothoracic surgery patients who experienced cardiogenic shock or refractory respiratory failure at the local VAMC requiring urgent or emergent institution of ECLS between 2019 and 2022. The primary outcomes are the safety and timeliness of transport. Results: Mean time from the initial shock call to arrival at the ECLS center was 2.8 h. There were no complications during transfer. Six patients (86%) survived to decannulation. Conclusion: These results suggest that complex cardiothoracic surgery can be performed within the VHA system and when there is an indication for ECLS, those services can be safely and effectively provided at an affiliated, properly equipped center.
Language	English
Publishing date	2024-02-06
Publishing country	United States
Document type	Case Reports
ZDB-ID	441812-8
ISSN	1525-1594 ; 0160-564X
ISSN (online)	1525-1594
ISSN	0160-564X
DOI	10.1111/aor.14722
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Zs.A 1463: Show issues

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Article ; Online: Surgical management of pediatric spinal aneurysmal bone cysts: patient series.

Flyer, Benjamin E / Vanstrum, Erik B / Chapman, Nicholas / Ha, Joseph H / Al-Husseini, Jacob K / Chu, Jason K / McComb, J Gordon / Durham, Susan R / Krieger, Mark D / Chiarelli, Peter A

Journal of neurosurgery. Case lessons

2024 Volume 7, Issue 4

Abstract: Background: Aneurysmal bone cysts (ABCs) are rare, highly vascular osteolytic bone lesions that predominantly affect pediatric populations. This report evaluates the clinicopathological data of pediatric patients with spinal ABCs. The medical records ... ...

Abstract	Background: Aneurysmal bone cysts (ABCs) are rare, highly vascular osteolytic bone lesions that predominantly affect pediatric populations. This report evaluates the clinicopathological data of pediatric patients with spinal ABCs. The medical records for all patients at Children's Hospital Los Angeles with biopsy-proven ABCs of the spine between 1998 and 2018 were evaluated. Observations: Seventeen patients, 6 males and 11 females, were identified. The mean age at surgery was 10.4 years (range, 3.5-20 years). The most common presenting complaint was pain at the lesion site 16/17 (94%), followed by lower-extremity weakness 8/17 (47%). Resection and intralesional curettage were performed in all patients. Three (18%) of 17 patients underwent selective arterial embolization prior to resection. Spinal stability was compromised in 15 of 17 patients (88%), requiring instrumented fusion. Five (29%) of the 17 patients received additional therapy including radiation, calcitonin-methylprednisolone, or phenol. Four (23.5%) of 17 patients experienced a recurrence, and the mean time to recurrence was 15 months. The postoperative follow-up ranged from 6 to 108 months (median, 28 months). Reoperation occurred after an average of 35 months. At the recent follow-up, patients were free of disease. Lessons: Gross-total resection by intralesional curettage with case-dependent instrumented spinal fusion for instability remains an effective strategy for managing pediatric spinal ABCs. Long-term follow-up is necessary to detect tumor recurrence.
Language	English
Publishing date	2024-01-22
Publishing country	United States
Document type	Journal Article
ISSN	2694-1902
ISSN (online)	2694-1902
DOI	10.3171/CASE23637
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Article ; Online: CSF1R inhibition for histiocytic neoplasm with CBL mutations refractory to MEK1/2 inhibition.

Diamond, Eli L / Francis, Jasmine H / Lacouture, Mario E / Rotemberg, Veronica / Yabe, Mariko / Petrova-Drus, Kseniya / Ulaner, Gary A / Reddy, Ryan / Abdel-Wahab, Omar / Durham, Benjamin H

Leukemia

2023 Volume 37, Issue 8, Page(s) 1737–1740

MeSH term(s)	Humans ; Mutation ; Receptor Protein-Tyrosine Kinases/genetics ; Histiocytosis/genetics ; Hematologic Neoplasms
Chemical Substances	Receptor Protein-Tyrosine Kinases (EC 2.7.10.1)
Language	English
Publishing date	2023-06-24
Publishing country	England
Document type	Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural ; Letter
ZDB-ID	807030-1
ISSN	1476-5551 ; 0887-6924
ISSN (online)	1476-5551
ISSN	0887-6924
DOI	10.1038/s41375-023-01947-4
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Zs.A 2295: Show issues

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Article ; Online: First report of bilateral breast-implant associated anaplastic large cell lymphoma caused by identical T-cell clone.

Stuver, Robert / Lewis, Natasha E / Ewalt, Mark D / Dogan, Ahmet / Durham, Benjamin H / Plitas, George / McCarthy, Colleen / Horwitz, Steven M

Leukemia & lymphoma

2022 Volume 63, Issue 11, Page(s) 2747–2750

MeSH term(s)	Humans ; Female ; Lymphoma, Large-Cell, Anaplastic/diagnosis ; Lymphoma, Large-Cell, Anaplastic/etiology ; Lymphoma, Large-Cell, Anaplastic/pathology ; Breast Implants/adverse effects ; T-Lymphocytes/pathology ; Breast Implantation/adverse effects ; Clone Cells/pathology ; Breast Neoplasms/diagnosis ; Breast Neoplasms/etiology
Language	English
Publishing date	2022-06-25
Publishing country	United States
Document type	Letter
ZDB-ID	1042374-6
ISSN	1029-2403 ; 1042-8194
ISSN (online)	1029-2403
ISSN	1042-8194
DOI	10.1080/10428194.2022.2092860
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Zs.A 2997: Show issues

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Article ; Online: Vemurafenib and Obinutuzumab as Frontline Therapy for Hairy Cell Leukemia.

Park, Jae H / Devlin, Sean / Durham, Benjamin H / Winer, Eric S / Huntington, Scott / von Keudell, Gottfried / Vemuri, Shreya / Shukla, Madhulika / Falco, Victoria / Cuello, Bernadette / Gore, Steven / Stone, Richard / Abdel-Wahab, Omar / Tallman, Martin S

NEJM evidence

2023 Volume 2, Issue 10, Page(s) EVIDoa2300074

Abstract: Vemurafenib and Obinutuzumab for Hairy Cell LeukemiaIn this study of vemurafenib plus obinutuzumab of patients with previously untreated hairy cell leukemia, treatment was administered for four cycles, and the primary end point was complete remission ... ...

Abstract	Vemurafenib and Obinutuzumab for Hairy Cell LeukemiaIn this study of vemurafenib plus obinutuzumab of patients with previously untreated hairy cell leukemia, treatment was administered for four cycles, and the primary end point was complete remission rate. Twenty-seven of 30 patients completed all four cycles of treatment and achieved complete remission. No dose-limiting toxicity was observed.
MeSH term(s)	Humans ; Vemurafenib ; Leukemia, Hairy Cell/chemically induced ; Antibodies, Monoclonal, Humanized/adverse effects ; Remission Induction
Chemical Substances	Vemurafenib (207SMY3FQT) ; obinutuzumab (O43472U9X8) ; Antibodies, Monoclonal, Humanized
Language	English
Publishing date	2023-09-21
Publishing country	United States
Document type	Journal Article
ISSN	2766-5526
ISSN (online)	2766-5526
DOI	10.1056/EVIDoa2300074
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Article ; Online: Outcomes after interruption of targeted therapy in patients with histiocytic neoplasms.

Reiner, Anne S / Durham, Benjamin H / Yabe, Mariko / Petrova-Drus, Kseniya / Francis, Jasmine H / Rampal, Raajit K / Lacouture, Mario E / Rotemberg, Veronica / Abdel-Wahab, Omar / Panageas, Katherine S / Diamond, Eli L

British journal of haematology

2023 Volume 203, Issue 3, Page(s) 389–394

Abstract: Little is known about outcomes following interruption of targeted therapy in adult patients with histiocytic neoplasms. This is an IRB-approved study of patients with histiocytic neoplasms whose BRAF and MEK inhibitors were interrupted after achieving ... ...

Abstract	Little is known about outcomes following interruption of targeted therapy in adult patients with histiocytic neoplasms. This is an IRB-approved study of patients with histiocytic neoplasms whose BRAF and MEK inhibitors were interrupted after achieving complete or partial response by 18-fluorodeoxyglucose positron emission tomography (FDG-PET). 17/22 (77%) of patients experienced disease relapse following treatment interruption. Achieving a complete response prior to interruption, having a mutation other than BRAFV600E, and receiving MEK inhibition only were each associated with a statistically significant improvement in relapse-free survival. Relapse is common following treatment interruption however some patients may be suitable for limited-duration treatment.
MeSH term(s)	Adult ; Humans ; Neoplasms ; Positron-Emission Tomography ; Protein Kinase Inhibitors/therapeutic use ; Protein Kinase Inhibitors/pharmacology ; Mitogen-Activated Protein Kinase Kinases ; Recurrence ; Fluorodeoxyglucose F18 ; Proto-Oncogene Proteins B-raf/genetics
Chemical Substances	Protein Kinase Inhibitors ; Mitogen-Activated Protein Kinase Kinases (EC 2.7.12.2) ; Fluorodeoxyglucose F18 (0Z5B2CJX4D) ; Proto-Oncogene Proteins B-raf (EC 2.7.11.1)
Language	English
Publishing date	2023-07-03
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	80077-6
ISSN	1365-2141 ; 0007-1048
ISSN (online)	1365-2141
ISSN	0007-1048
DOI	10.1111/bjh.18964
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Article ; Online: Histiocytosis and the nervous system: from diagnosis to targeted therapies.

Cohen Aubart, Fleur / Idbaih, Ahmed / Emile, Jean-François / Amoura, Zahir / Abdel-Wahab, Omar / Durham, Benjamin H / Haroche, Julien / Diamond, Eli L

Neuro-oncology

2021 Volume 23, Issue 9, Page(s) 1433–1446

Abstract: Histiocytoses are heterogeneous hematopoietic diseases characterized by the accumulation of CD68(+) cells with various admixed inflammatory infiltrates. The identification of the pivotal role of the mitogen-activated protein kinase (MAPK) pathway has ... ...

Abstract	Histiocytoses are heterogeneous hematopoietic diseases characterized by the accumulation of CD68(+) cells with various admixed inflammatory infiltrates. The identification of the pivotal role of the mitogen-activated protein kinase (MAPK) pathway has opened new avenues of research and therapeutic approaches. We review the neurologic manifestations of 3 histiocytic disorders with frequent involvement of the brain and spine: Langerhans cell histiocytosis (LCH), Erdheim-Chester disease (ECD), and Rosai-Dorfman-Destombes disease (RDD). Central nervous system (CNS) manifestations occur in 10%-25% of LCH cases, with both tumorous or neurodegenerative forms. These subtypes differ by clinical and radiological presentation, pathogenesis, and prognosis. Tumorous or degenerative neurologic involvement occurs in 30%-40% of ECD patients and affects the hypothalamic-pituitary axis, meninges, and brain parenchyma. RDD lesions are typically tumorous with meningeal or parenchymal masses with strong contrast enhancement. Unlike LCH and ECD, neurodegenerative lesions or syndromes have not been described with RDD. Familiarity with principles of evaluation and treatment both shared among and distinct to each of these 3 diseases is critical for effective management. Refractory or disabling neurohistiocytic involvement should prompt the consideration for use of targeted kinase inhibitor therapies.
MeSH term(s)	Central Nervous System ; Erdheim-Chester Disease/diagnosis ; Erdheim-Chester Disease/drug therapy ; Histiocytosis, Langerhans-Cell/diagnosis ; Histiocytosis, Langerhans-Cell/drug therapy ; Histiocytosis, Sinus ; Humans ; Prognosis
Language	English
Publishing date	2021-05-14
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2028601-6
ISSN	1523-5866 ; 1522-8517
ISSN (online)	1523-5866
ISSN	1522-8517
DOI	10.1093/neuonc/noab107
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