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  1. Article ; Online: Conceptualizing an Integrative Multiple Myeloma Care: The Role of Nutrition, Supplements, and Complementary Modalities.

    Andreazzoli, Francesca / Levy Yurkovski, Ilana / Ben-Arye, Eran / Bonucci, Massimo

    Nutrients

    2024  Volume 16, Issue 2

    Abstract: Multiple Myeloma (MM) is the second most prevalent hematologic malignancy, and its incidence has been increasing enormously in recent years. The prognosis of MM has changed radically with the introduction of new drugs that have improved life expectancy; ... ...

    Abstract Multiple Myeloma (MM) is the second most prevalent hematologic malignancy, and its incidence has been increasing enormously in recent years. The prognosis of MM has changed radically with the introduction of new drugs that have improved life expectancy; recurrences are a common occurrence during the course of the disease and are characterized by an increase in refractory to treatment. Moreover, MM patients are challenged by quality of life-related concerns while limited conventional therapy may be offered. This includes bone pain and dialysis due to the complications of acute renal failure. We, therefore, believe that it is very important to add new treatment modalities, including supplements, nutritional modifications, acupuncture, and mind-body therapies, with the goal of improving treatment tolerance, effectiveness, and patients' quality of life. Moreover, many patients use some of these supplements on their own, in the hope of reducing the side effects, so it is even more important to know their action and potential. The purpose of this review is to illustrate all these strategies potentially available to enrich our approach to this, to date, incurable disease.
    MeSH term(s) Humans ; Multiple Myeloma/complications ; Multiple Myeloma/therapy ; Quality of Life ; Renal Dialysis ; Nutritional Status ; Hematologic Neoplasms
    Language English
    Publishing date 2024-01-11
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu16020237
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Structural Flexibility of Tau in Its Interaction with Microtubules as Viewed by Site-Directed Spin Labeling EPR Spectroscopy.

    Martinho, Marlène / Allegro, Diane / Etienne, Emilien / Lohberger, Cynthia / Bonucci, Alessio / Belle, Valérie / Barbier, Pascale

    Methods in molecular biology (Clifton, N.J.)

    2024  Volume 2754, Page(s) 55–75

    Abstract: Tau is a microtubule-associated protein that belongs to the Intrinsically Disordered Proteins (IDPs) family. IDPs or Intrinsically Disordered Regions (IDRs) play key roles in protein interaction networks and their dysfunctions are often related to severe ...

    Abstract Tau is a microtubule-associated protein that belongs to the Intrinsically Disordered Proteins (IDPs) family. IDPs or Intrinsically Disordered Regions (IDRs) play key roles in protein interaction networks and their dysfunctions are often related to severe diseases. Defined by their lack of stable secondary and tertiary structures in physiological conditions while being functional, these proteins use their inherent structural flexibility to adapt to and interact with various binding partners. Knowledges on the structural dynamics of IDPs and their different conformers are crucial to finely decipher fundamental biological processes controlled by mechanisms such as conformational adaptations or switches, induced fit, or conformational selection events. Different mechanisms of binding have been proposed: among them, the so-called folding-upon-binding in which the IDP adopts a certain conformation upon interacting with a partner protein, or the formation of a "fuzzy" complex in which the IDP partly keeps its dynamical character at the surface of its partner. The dynamical nature and physicochemical properties of unbound as well as bound IDPs make this class of proteins particularly difficult to characterize by classical bio-structural techniques and require specific approaches for the fine description of their inherent dynamics.Among other techniques, Site-Directed Spin Labeling combined with Electron Paramagnetic Resonance (SDSL-EPR) spectroscopy has gained much interest in this last decade for the study of IDPs. SDSL-EPR consists in grafting a paramagnetic label (mainly a nitroxide radical) at selected site(s) of the macromolecule under interest followed by its observation using and/or combining different EPR strategies. These nitroxide spin labels detected by continuous wave (cw) EPR spectroscopy are used as perfect reporters or "spy spins" of their local environment, being able to reveal structural transitions, folding/unfolding events, etc. Another approach is based on the measurement of inter-label distance distributions in the 1.5-8.0 nm range using pulsed dipolar EPR experiments, such as Double Electron-Electron Resonance (DEER) spectroscopy. The technique is then particularly well suited to study the behavior of Tau in its interaction with its physiological partner: microtubules (MTs). In this chapter we provide a detailed experimental protocol for the labeling of Tau protein and its EPR study while interacting with preformed (Paclitaxel-stabilized) MTs, or using Tau as MT inducer. We show how the choice of nitroxide label can be crucial to obtain functional information on Tau/tubulin complexes.
    MeSH term(s) Electron Spin Resonance Spectroscopy/methods ; Spin Labels ; tau Proteins ; Microtubules ; Intrinsically Disordered Proteins ; Nitrogen Oxides
    Chemical Substances Spin Labels ; nitroxyl (GFQ4MMS07W) ; tau Proteins ; Intrinsically Disordered Proteins ; Nitrogen Oxides
    Language English
    Publishing date 2024-03-21
    Publishing country United States
    Document type Journal Article
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-3629-9_3
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  3. Article ; Online: Understanding nanocalcification: a role suggested for crystal ghosts.

    Bonucci, Ermanno

    Marine drugs

    2014  Volume 12, Issue 7, Page(s) 4231–4246

    Abstract: The present survey deals with the initial stage of the calcification process in bone and other hard tissues, with special reference to the organic-inorganic relationship and the transformation that the early inorganic particles undergo as the process ... ...

    Abstract The present survey deals with the initial stage of the calcification process in bone and other hard tissues, with special reference to the organic-inorganic relationship and the transformation that the early inorganic particles undergo as the process moves towards completion. Electron microscope studies clearly exclude the possibility that these particles might be crystalline structures, as often believed, by showing that they are, instead, organic-inorganic hybrids, each comprising a filamentous organic component (the crystal ghost) made up of acidic proteins. The hypothesis is suggested that the crystal ghosts bind and stabilize amorphous calcium phosphate and that their subsequent degradation allows the calcium phosphate, once released, to acquire a hydroxyapatite, crystal-like organization. A conclusive view of the mechanism of biological calcification cannot yet be proposed; even so, however, the role of crystal ghosts as a template of the structures usually called "crystallites" is a concept that has gathered increasing support and can no longer be disregarded.
    MeSH term(s) Calcification, Physiologic ; Crystallization ; Humans
    Language English
    Publishing date 2014-07-23
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2175190-0
    ISSN 1660-3397 ; 1660-3397
    ISSN (online) 1660-3397
    ISSN 1660-3397
    DOI 10.3390/md12074231
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  4. Article: La colecistite cronica calcolosa: lesioni elementari e displastiche, correlazioni ecografiche e approccio immunoistochimico.

    Pingitore, R / Bonucci, M / Bigini, D / Ciancia, E M / Vignati, S

    Pathologica

    1992  Volume 84, Issue 1090, Page(s) 171–185

    Abstract: ... are in direct relation; (e) echographic preoperative assessment of wall's thickness has predictive ...

    Title translation Chronic calculous cholecystitis: elementary and dysplastic lesions, echographic correlations and immunohistochemical approach.
    Abstract The morphological analysis of 223 cases of chronic calculous cholecystitis has drawn attention to the following outstanding facts: (a) elementary lesions are numerous (above all ulceration, mucosal erosion, antral and intestinal metaplasia) and put together a complex sight; (b) mild, moderate and severe dysplasias have a surprising high incidence (67%), even in the age-group under 40; (c) dysplasia is more common in the gallbladders bearing parallel hyperplastic and metaplastic mucosal changes, if compared with gallbladders where these changes are lacking; (d) thickness of gallbladder's wall and incidence of dysplasia are in direct relation; (e) echographic preoperative assessment of wall's thickness has predictive value for presence of dysplasia; (f) CEA and CA 19-9 have a progressively increasing expression in the various degrees of dysplasia.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Antigens, Tumor-Associated, Carbohydrate/analysis ; Biomarkers ; Carcinoembryonic Antigen/analysis ; Cholecystitis/etiology ; Cholecystitis/pathology ; Cholelithiasis/complications ; Cholelithiasis/pathology ; Chronic Disease ; Female ; Gallbladder/pathology ; Gallbladder Neoplasms/pathology ; Humans ; Incidence ; Male ; Middle Aged ; Mucous Membrane/pathology ; Precancerous Conditions/epidemiology ; Precancerous Conditions/pathology ; Preoperative Care
    Chemical Substances Antigens, Tumor-Associated, Carbohydrate ; Biomarkers ; Carcinoembryonic Antigen
    Language Italian
    Publishing date 1992-03
    Publishing country Italy
    Document type English Abstract ; Journal Article
    ZDB-ID 418229-7
    ISSN 1591-951X ; 0031-2983
    ISSN (online) 1591-951X
    ISSN 0031-2983
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  5. Article ; Online: Nitroxide spin labels and EPR spectroscopy: A powerful association for protein dynamics studies.

    Torricella, F / Pierro, A / Mileo, E / Belle, V / Bonucci, A

    Biochimica et biophysica acta. Proteins and proteomics

    2021  Volume 1869, Issue 7, Page(s) 140653

    Abstract: Site-Directed Spin Labelling (SDSL) technique is based on the attachment of a paramagnetic label onto a specific position of a protein (or other bio-molecules) and the subsequent study by Electron Paramagnetic Resonance (EPR) spectroscopy. In particular, ...

    Abstract Site-Directed Spin Labelling (SDSL) technique is based on the attachment of a paramagnetic label onto a specific position of a protein (or other bio-molecules) and the subsequent study by Electron Paramagnetic Resonance (EPR) spectroscopy. In particular, continuous-wave EPR (cw-EPR) spectra can detect the local conformational dynamics for proteins under various conditions. Moreover, pulse-EPR experiments on doubly spin-labelled proteins allow measuring distances between spin centres in the 1.5-8 nm range, providing information about structures and functions. This review focuses on SDSL-EPR spectroscopy as a structural biology tool to investigate proteins using nitroxide labels. The versatility of this spectroscopic approach for protein structural characterization has been demonstrated through the choice of recent studies. The main aim is to provide a general overview of the technique, particularly for non-experts, to spread the applicability of this technique in various fields of structural biology.
    Language English
    Publishing date 2021-03-20
    Publishing country Netherlands
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2918798-9
    ISSN 1878-1454 ; 1570-9639
    ISSN (online) 1878-1454
    ISSN 1570-9639
    DOI 10.1016/j.bbapap.2021.140653
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  6. Article ; Online: Bone mineralization.

    Bonucci, Ermanno

    Frontiers in bioscience (Landmark edition)

    2012  Volume 17, Issue 1, Page(s) 100–128

    Abstract: This review attempts to summarize the findings made available by the literature on the mineralization of bone. The types of bone, their structures and compositions, the nature and organization of organic and inorganic matter, the organic-inorganic ... ...

    Abstract This review attempts to summarize the findings made available by the literature on the mineralization of bone. The types of bone, their structures and compositions, the nature and organization of organic and inorganic matter, the organic-inorganic relationships, and the mineralization mechanism itself, are the main topics of the present review. As in other hard tissues, bone mineralization occurs in, and is conditioned by, the components of the organic matrix. Collagen fibrils have long been considered the factor that is able to induce the deposition of apatite crystallites through a process of heterogeneous nucleation. Interfibrillar non-collagenous proteins are now considered to be co-factors that permit crystallite deposition. The main components of these proteins are reviewed. It is hypothesized that two independent types of mineral are present in bone, one contained in the collagen fibrils and corresponding to the granular, electron-dense bands, and the other contained in the interfibrillar spaces and corresponding to needle- and filament-like crystals. The deposition mechanism of these mineral structures remains elusive. The formation of the crystallites through an epitaxial mechanism is discussed.
    MeSH term(s) Animals ; Bone Density ; Bone and Bones/metabolism ; Calcification, Physiologic/physiology ; Collagen/metabolism ; Glycoproteins/metabolism ; Humans ; Lipid Metabolism ; Models, Biological ; Osteocalcin/metabolism ; Proteoglycans/metabolism
    Chemical Substances Glycoproteins ; Proteoglycans ; Osteocalcin (104982-03-8) ; Collagen (9007-34-5)
    Language English
    Publishing date 2012-01-01
    Publishing country Singapore
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2704569-9
    ISSN 2768-6698 ; 1093-9946
    ISSN (online) 2768-6698
    ISSN 1093-9946
    DOI 10.2741/3918
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  7. Book ; Online: D'Italie et d'ailleurs : Mélanges en l'honneur de Pierre Milza

    Blanc-Chaléard, Marie-Claude / Dulphy, Anne / Douki, Caroline / Matard-Bonucci, Marie-Anne

    2014  

    Abstract: ... En rassemblant des textes inédits, dont les auteur(e)s ont pour la plupart mené leur doctorat sous sa direction ...

    Abstract Depuis le début de sa carrière, Pierre Milza est un passeur de frontières dans toutes les acceptions du mot, géographique et linguistique, académique et thématique. Il a ainsi construit une œuvre historique originale, féconde, en perpétuelle évolution, dans des domaines aussi divers que lhistoire de lItalie, lhistoire de limmigration et des relations internationales, lhistoire politique et culturelle, en particulier celle des fascismes et des extrêmes droites. En tant quenseignant et auteur de manuels du secondaire et du supérieur, il a aussi marqué des générations de lycéens et détudiants, particulièrement à Sciences Po. En rassemblant des textes inédits, dont les auteur(e)s ont pour la plupart mené leur doctorat sous sa direction, ce volume se propose de donner un aperçu du rayonnement de Pierre Milza sur lhistoriographie contemporaine et de rendre hommage au caractère foisonnant, inventif et multiforme de ses travaux
    Keywords History (General)
    Size 1 electronic resource ( pages)
    Publisher Presses universitaires de Rennes
    Document type Book ; Online
    Note French ; Open Access
    HBZ-ID HT020323071
    ISBN 9782753559950 ; 2753559953
    DOI 10.4000/books.pur.49139
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  8. Article: Modalità di localizzazione e di accrescimento delle metastasi nel tessuto osseo.

    Bonucci, E

    La Radiologia medica

    1981  Volume 67, Issue 4, Page(s) 243–247

    Title translation Mechanisms of localization and increase of metastases in bone tissue.
    MeSH term(s) Bone Neoplasms/secondary ; Humans ; Neoplasm Invasiveness ; Neoplasm Metastasis
    Language Italian
    Publishing date 1981-04
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 205751-7
    ISSN 1826-6983 ; 0033-8362
    ISSN (online) 1826-6983
    ISSN 0033-8362
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  9. Article ; Online: Mediterranean Diet and Neurodegenerative Diseases: The Neglected Role of Nutrition in the Modulation of the Endocannabinoid System.

    Armeli, Federica / Bonucci, Alessio / Maggi, Elisa / Pinto, Alessandro / Businaro, Rita

    Biomolecules

    2021  Volume 11, Issue 6

    Abstract: Neurodegenerative disorders are a widespread cause of morbidity and mortality worldwide, characterized by neuroinflammation, oxidative stress and neuronal depletion. The broad-spectrum neuroprotective activity of the Mediterranean diet is widely ... ...

    Abstract Neurodegenerative disorders are a widespread cause of morbidity and mortality worldwide, characterized by neuroinflammation, oxidative stress and neuronal depletion. The broad-spectrum neuroprotective activity of the Mediterranean diet is widely documented, but it is not yet known whether its nutritional and caloric balance can induce a modulation of the endocannabinoid system. In recent decades, many studies have shown how endocannabinoid tone enhancement may be a promising new therapeutic strategy to counteract the main hallmarks of neurodegeneration. From a phylogenetic point of view, the human co-evolution between the endocannabinoid system and dietary habits could play a key role in the pro-homeostatic activity of the Mediterranean lifestyle: this adaptive balance among our ancestors has been compromised by the modern Western diet, resulting in a "clinical endocannabinoid deficiency syndrome". This review aims to evaluate the evidence accumulated in the literature on the neuroprotective, immunomodulatory and antioxidant properties of the Mediterranean diet related to the modulation of the endocannabinoid system, suggesting new prospects for research and clinical interventions against neurodegenerative diseases in light of a nutraceutical paradigm.
    MeSH term(s) Diet, Mediterranean ; Endocannabinoids/metabolism ; Humans ; Neurodegenerative Diseases/diet therapy ; Neurodegenerative Diseases/metabolism ; Neuroprotection
    Chemical Substances Endocannabinoids
    Language English
    Publishing date 2021-05-24
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2701262-1
    ISSN 2218-273X ; 2218-273X
    ISSN (online) 2218-273X
    ISSN 2218-273X
    DOI 10.3390/biom11060790
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  10. Article ; Online: Assessment of Enamel Color Stability of Resins Infiltration Treatment in Human Teeth: A Systematic Review.

    Saccucci, Matteo / Corridore, Denise / Di Carlo, Gabriele / Bonucci, Elisa / Cicciù, Marco / Vozza, Iole

    International journal of environmental research and public health

    2022  Volume 19, Issue 18

    Abstract: 1) The evolution of techniques and materials used in dentistry has led to the introduction of a technique known as micro-infiltration, using ICON infiltrating resin. The purpose of this study was to evaluate whether the resin infiltrant can remain ... ...

    Abstract (1) The evolution of techniques and materials used in dentistry has led to the introduction of a technique known as micro-infiltration, using ICON infiltrating resin. The purpose of this study was to evaluate whether the resin infiltrant can remain stable in the enamel color of human teeth over time or if it causes discoloration and review current knowledge on color stability based on the literature selected solely on studies performed on human teeth and to provide a perspective on the methods proposed by clinicians in the infiltration procedure; (2) Methods: This systematic review was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement; (3) Results: Twelve studies were selected for this review. The study results suggest that the device content is sufficiently comprehensive. The reviewers expressed strong support for the device's content for assessing the quality of reviews. The paper summarizes current reports regarding the color stability assessment of enamel treated by in- filtration resin confirmed in in vitro and in vivo studies; (4) Conclusions: Based on these considerations, the resin infiltration method can be recommended to improve the appearance of enamel lesions. The infiltrated lesions remained chromatically stable, showing no significant color changes in the long term.
    MeSH term(s) Color ; Dental Caries ; Dental Enamel ; Humans ; Resins, Synthetic/therapeutic use ; Tooth
    Chemical Substances Resins, Synthetic
    Language English
    Publishing date 2022-09-07
    Publishing country Switzerland
    Document type Journal Article ; Review ; Systematic Review
    ZDB-ID 2175195-X
    ISSN 1660-4601 ; 1661-7827
    ISSN (online) 1660-4601
    ISSN 1661-7827
    DOI 10.3390/ijerph191811269
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