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Article: The Prevalence and Clinical Impact of Adenomyosis in Pregnancy-Related Hysterectomy.

Orsi, Michele / Somigliana, Edgardo / Cribiù, Fulvia Milena / Lopez, Gianluca / Buggio, Laura / Ossola, Manuela Wally / Ferrazzi, Enrico

Journal of clinical medicine

2022 Volume 11, Issue 16

Abstract: Background: The epidemiology of adenomyosis has been traditionally based on patients undergoing hysterectomy for gynecological indications, while its prevalence among hysterectomies performed for obstetric complications is unknown. The aim of this study ...

Abstract	Background: The epidemiology of adenomyosis has been traditionally based on patients undergoing hysterectomy for gynecological indications, while its prevalence among hysterectomies performed for obstetric complications is unknown. The aim of this study was to assess the prevalence and clinical impact of adenomyosis diagnosed through histology among women undergoing pregnancy-related hysterectomy (PH). Methods: This was a retrospective cohort study. Women who delivered at a tertiary care regional obstetric hub in Milan between 2009 and 2020 were reviewed to identify cases of PH. Histopathological reports of surgical specimens were examined. Cases with adenomyosis were compared to those without adenomyosis for baseline characteristics, obstetric history and outcomes. Results: During the study period there were 71,061 births and a total of 130 PH, giving a PH incidence of 1.83 per 1000 deliveries. Adenomyosis cases were 18, giving a prevalence of 13.8%. Adenomyosis was associated with placenta previa (77.8 vs. 45.5%, Conclusion: Adenomyosis entails a relevant impact on obstetric and perinatal outcomes related to PH. More evidence is needed on the clinical relevance of an ultrasonographic diagnosis of adenomyosis before conception.
Language	English
Publishing date	2022-08-17
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm11164814
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Article: Adjuvant and neoadjuvant chemotherapy for MSI early gastric cancer: a systematic review and meta-analysis.

Petrelli, Fausto / Antista, Maria / Marra, Francesca / Cribiu', Fulvia Milena / Rampulla, Valentina / Pietrantonio, Filippo / Dottorini, Lorenzo / Ghidini, Michele / Luciani, Andrea / Zaniboni, Alberto / Tomasello, Gianluca

Therapeutic advances in medical oncology

2024 Volume 16, Page(s) 17588359241231259

Abstract: Background: Perioperative chemotherapy (CT) is an established therapeutic approach for patients diagnosed with stage IB-III gastric cancer (GC).: Objectives: This study aimed to investigate the efficacy of this approach in individuals with GC ... ...

Abstract	Background: Perioperative chemotherapy (CT) is an established therapeutic approach for patients diagnosed with stage IB-III gastric cancer (GC). Objectives: This study aimed to investigate the efficacy of this approach in individuals with GC exhibiting high microsatellite instability (MSI-H). Design: A systematic review was conducted, including studies that provided data on (neo)adjuvant CT outcomes in patients with MSI-H GC. Methods: Systematic searches were conducted in PubMed, Cochrane Central of Controlled Trials, and Embase databases. Data were aggregated using hazard ratios (HRs) to compare overall survival between CT and surgery. Results: Data analysis from 23 studies, including 22,011 patients, revealed that the prevalence of MSI-H is 9.8%. Administration of adjuvant or perioperative CT did not significantly reduce the risk of death or relapse in patients with MSI-H GC (HR = 0.8, 95% CI 0.54-1.16; Conclusion: Chemotherapy did not benefit patients diagnosed with MSI-H nonmetastatic GC but rather will be integrated with immune checkpoint inhibitors in the near future.
Language	English
Publishing date	2024-02-29
Publishing country	England
Document type	Journal Article
ZDB-ID	2503443-1
ISSN	1758-8359 ; 1758-8340
ISSN (online)	1758-8359
ISSN	1758-8340
DOI	10.1177/17588359241231259
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Article ; Online: BRAF mutations and survival with surgery for colorectal liver metastases: A systematic review and meta-analysis.

Petrelli, Fausto / Arru, Marcella / Colombo, Silvia / Cavallone, Matteo / Cribiu', Fulvia Milena / Villardita, Viola / Floris, Paola / Digiesi, Luciano / Severgnini, Gabriele / Moraes, Mariana Teixeira / Conti, Barbara / Celotti, Andrea / Viti, Matteo / Sozzi, Andrea

European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology

2024 Volume 50, Issue 6, Page(s) 108306

Abstract: Introduction: Mutations in the BRAF gene (BRAFmut) are associated with an unfavorable prognosis in patients with metastatic colorectal cancer (CRC). The aim of this meta-analysis was to evaluate the prognosis of colorectal cancer (CRC) patients with ... ...

Abstract	Introduction: Mutations in the BRAF gene (BRAFmut) are associated with an unfavorable prognosis in patients with metastatic colorectal cancer (CRC). The aim of this meta-analysis was to evaluate the prognosis of colorectal cancer (CRC) patients with liver metastases and the potential benefits of liver resection in patients with BRAFmut CRC. Material and methods: A systematic search of PubMed, Cochrane Central Controlled Trials, and Embase databases was conducted on May 31, 2023. The inclusion criteria were as follows:1) reporting of outcomes in patients with BRAFmut CRC who underwent surgery for liver metastases and/or comparison of outcomes between those who underwent and those who did not undergo resection; 2) reporting of survival information as hazard ratios (HR); and 3) publication in English. Results: 34 studies were included. Median follow up was 48 months for prognostic BRAF status meta-analysis. BRAFmut status showed a significantly increased risk of mortality (hazard ratio [HR] = 2.56, 95% confidence interval [CI] 2.04-3.22; P < 0.01) and relapse (HR = 1.97, 95% CI 1.44-2.71; P < 0.01). Resection of liver metastases was associated with a survival benefit (median follow up 46 months). The HR for survival was 0.44 (95% confidence interval [CI] 0.33-0.59; P < 0.01) in favor of surgery. Conclusions: and Relevance: Our analysis indeed confirms that BRAF mutation is associated with poor survival outcomes after liver resection of CRC metastases. However, upon quantitatively assessing the survival benefit of surgical intervention in patients with BRAF-mutated CRC liver metastases, we identified a significant 56% reduction in the risk of death.
Language	English
Publishing date	2024-03-29
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	632519-1
ISSN	1532-2157 ; 0748-7983
ISSN (online)	1532-2157
ISSN	0748-7983
DOI	10.1016/j.ejso.2024.108306
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Zs.A 1149: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Intratumor Microbiome in Neuroendocrine Neoplasms: A New Partner of Tumor Microenvironment? A Pilot Study.

Massironi, Sara / Facciotti, Federica / Cavalcoli, Federica / Amoroso, Chiara / Rausa, Emanuele / Centonze, Giovanni / Cribiù, Fulvia Milena / Invernizzi, Pietro / Milione, Massimo

Cells

2022 Volume 11, Issue 4

Abstract: Neuroendocrine neoplasms (NENs) are rare neoplasms with heterogeneous clinical behavior. Alteration in human microbiota was reported in association with carcinogenesis in different solid tumors. However, few studies addressed the role of microbiota in ... ...

Abstract	Neuroendocrine neoplasms (NENs) are rare neoplasms with heterogeneous clinical behavior. Alteration in human microbiota was reported in association with carcinogenesis in different solid tumors. However, few studies addressed the role of microbiota in NEN. We here aimed at evaluating the presence of bacterial infiltration in neuroendocrine tumoral tissue. To assess the presence of bacteria, 20 specimens from pancreatic NEN (pan-NEN) and 20 from intestinal NEN (I-NEN) were evaluated through Fluorescent In situ Hybridization and confocal microscopy. Demographic data, pre-operative investigations, operative findings, pathological diagnosis, follow-up, and survival data were evaluated. Among I-NEN, bacteria were detected in 15/20 (75%) specimens, with high variability in microbial distribution. In eight patients, a high infiltration of microorganisms was observed. Among pan-NEN, 18/20 (90%) showed microorganisms' infiltration, with a homogeneous microbial distribution. Bacterial localization in pan-NEN was observed in the proximity of blood vessels. A higher bacterial infiltration in the tumoral specimen as compared with non-tumoral tissue was reported in 10/20 pan-NEN (50%). No significant differences were observed in mean bacterial count according to age, sex, ki67%, site, tumor stage. Mean bacterial count did not result to be a predictor of disease-specific survival. This preliminary study demonstrates the presence of a significant microbiota in the NEN microenvironment. Further research is needed to investigate the potential etiological or clinical role of microbiota in NEN.
MeSH term(s)	Humans ; In Situ Hybridization, Fluorescence ; Microbiota ; Neuroendocrine Tumors/pathology ; Pilot Projects ; Tumor Microenvironment
Language	English
Publishing date	2022-02-16
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2661518-6
ISSN	2073-4409 ; 2073-4409
ISSN (online)	2073-4409
ISSN	2073-4409
DOI	10.3390/cells11040692
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Article ; Online: SCARB1 downregulation in adrenal insufficiency with Allgrove syndrome.

Bitetto, Giacomo / Lopez, Gianluca / Ronchi, Dario / Pittaro, Alessandra / Melzi, Valentina / Peverelli, Erika / Cribiù, Fulvia Milena / Comi, Giacomo P / Mantovani, Giovanna / Di Fonzo, Alessio

Orphanet journal of rare diseases

2023 Volume 18, Issue 1, Page(s) 152

Abstract: Background: Allgrove disease is a rare genetic syndrome characterized by adrenal insufficiency, alacrimia, achalasia and complex neurological involvement. Allgrove disease is due to recessive mutations in the AAAS gene, which encodes for the nucleoporin ...

Abstract	Background: Allgrove disease is a rare genetic syndrome characterized by adrenal insufficiency, alacrimia, achalasia and complex neurological involvement. Allgrove disease is due to recessive mutations in the AAAS gene, which encodes for the nucleoporin Aladin, implicated in the nucleocytoplasmic transport. The adrenal insufficiency has been suggested to rely on adrenal gland-ACTH resistance. However, the link between the molecular pathology affecting the nucleoporin Aladin and the glucocorticoid deficiency is still unknown. Results: By analyzing postmortem patient's adrenal gland, we identified a downregulation of Aladin transcript and protein. We found a downregulation of Scavenger receptor class B-1 (SCARB1), a key component of the steroidogenic pathway, and SCARB1 regulatory miRNAs (mir125a, mir455) in patient's tissues. With the hypothesis of an impairment in the nucleocytoplasmic transport of the SCARB1 transcription enhancer cyclic AMP-dependent protein kinase (PKA), we detected a reduction of nuclear Phospho-PKA and a cytoplasmic mislocalization in patient's samples. Conclusions: These results shed a light on the possible mechanisms linking ACTH resistance, SCARB1 impairment, and defective nucleocytoplasmic transport.
MeSH term(s)	Humans ; Esophageal Achalasia/genetics ; Esophageal Achalasia/metabolism ; Esophageal Achalasia/pathology ; Nuclear Pore Complex Proteins/genetics ; Nuclear Pore Complex Proteins/metabolism ; Down-Regulation/genetics ; Nerve Tissue Proteins/genetics ; Adrenal Insufficiency/genetics ; Adrenal Insufficiency/metabolism ; Adrenal Insufficiency/pathology ; Nuclear Proteins/genetics ; Scavenger Receptors, Class B/genetics ; Scavenger Receptors, Class B/metabolism ; MicroRNAs
Chemical Substances	Nuclear Pore Complex Proteins ; Nerve Tissue Proteins ; Nuclear Proteins ; SCARB1 protein, human ; Scavenger Receptors, Class B ; MIRN455 microRNA, human ; MicroRNAs
Language	English
Publishing date	2023-06-19
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2225857-7
ISSN	1750-1172 ; 1750-1172
ISSN (online)	1750-1172
ISSN	1750-1172
DOI	10.1186/s13023-023-02763-w
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Article ; Online: Intratumor Microbiome in Neuroendocrine Neoplasms

Sara Massironi / Federica Facciotti / Federica Cavalcoli / Chiara Amoroso / Emanuele Rausa / Giovanni Centonze / Fulvia Milena Cribiù / Pietro Invernizzi / Massimo Milione

Cells, Vol 11, Iss 692, p

A New Partner of Tumor Microenvironment? A Pilot Study

2022 Volume 692

Abstract	Neuroendocrine neoplasms (NENs) are rare neoplasms with heterogeneous clinical behavior. Alteration in human microbiota was reported in association with carcinogenesis in different solid tumors. However, few studies addressed the role of microbiota in NEN. We here aimed at evaluating the presence of bacterial infiltration in neuroendocrine tumoral tissue. To assess the presence of bacteria, 20 specimens from pancreatic NEN (pan-NEN) and 20 from intestinal NEN (I-NEN) were evaluated through Fluorescent In situ Hybridization and confocal microscopy. Demographic data, pre-operative investigations, operative findings, pathological diagnosis, follow-up, and survival data were evaluated. Among I-NEN, bacteria were detected in 15/20 (75%) specimens, with high variability in microbial distribution. In eight patients, a high infiltration of microorganisms was observed. Among pan-NEN, 18/20 (90%) showed microorganisms’ infiltration, with a homogeneous microbial distribution. Bacterial localization in pan-NEN was observed in the proximity of blood vessels. A higher bacterial infiltration in the tumoral specimen as compared with non-tumoral tissue was reported in 10/20 pan-NEN (50%). No significant differences were observed in mean bacterial count according to age, sex, ki67%, site, tumor stage. Mean bacterial count did not result to be a predictor of disease-specific survival. This preliminary study demonstrates the presence of a significant microbiota in the NEN microenvironment. Further research is needed to investigate the potential etiological or clinical role of microbiota in NEN.
Keywords	neuroendocrine tumors ; pancreatic neuroendocrine neoplasms ; gut microbiota ; bacterial infiltration ; bacterial invasion ; confocal fluorescent microscopy ; Biology (General) ; QH301-705.5
Subject code	610
Language	English
Publishing date	2022-02-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
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Article ; Online: SCARB1 downregulation in adrenal insufficiency with Allgrove syndrome

Giacomo Bitetto / Gianluca Lopez / Dario Ronchi / Alessandra Pittaro / Valentina Melzi / Erika Peverelli / Fulvia Milena Cribiù / Giacomo P. Comi / Giovanna Mantovani / Alessio Di Fonzo

Orphanet Journal of Rare Diseases, Vol 18, Iss 1, Pp 1-

2023 Volume 8

Abstract: Abstract Background Allgrove disease is a rare genetic syndrome characterized by adrenal insufficiency, alacrimia, achalasia and complex neurological involvement. Allgrove disease is due to recessive mutations in the AAAS gene, which encodes for the ... ...

Abstract	Abstract Background Allgrove disease is a rare genetic syndrome characterized by adrenal insufficiency, alacrimia, achalasia and complex neurological involvement. Allgrove disease is due to recessive mutations in the AAAS gene, which encodes for the nucleoporin Aladin, implicated in the nucleocytoplasmic transport. The adrenal insufficiency has been suggested to rely on adrenal gland-ACTH resistance. However, the link between the molecular pathology affecting the nucleoporin Aladin and the glucocorticoid deficiency is still unknown. Results By analyzing postmortem patient’s adrenal gland, we identified a downregulation of Aladin transcript and protein. We found a downregulation of Scavenger receptor class B-1 (SCARB1), a key component of the steroidogenic pathway, and SCARB1 regulatory miRNAs (mir125a, mir455) in patient’s tissues. With the hypothesis of an impairment in the nucleocytoplasmic transport of the SCARB1 transcription enhancer cyclic AMP-dependent protein kinase (PKA), we detected a reduction of nuclear Phospho-PKA and a cytoplasmic mislocalization in patient’s samples. Conclusions These results shed a light on the possible mechanisms linking ACTH resistance, SCARB1 impairment, and defective nucleocytoplasmic transport.
Keywords	Allgrove syndrome ; Adrenal cortex ; Adrenal insufficiency ; PKA ; SCARB1 ; Medicine ; R
Subject code	630
Language	English
Publishing date	2023-06-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Tracheal extramedullary plasmacytoma: a rare cause of chronic cough.

Carrinola, Rosaria / Basile, FiorPaolo / Aliprandi, Marta / Bellone, Stefano / Cribiù, Fulvia Milena / Vismara, Alessandro / Aliprandi, Pierluigi

Monaldi archives for chest disease = Archivio Monaldi per le malattie del torace

2020 Volume 90, Issue 4

Abstract: Operative Rigid Bronchoscopy treatment. ...

Abstract	Operative Rigid Bronchoscopy treatment.
MeSH term(s)	Bronchoscopy ; Cough/etiology ; Humans ; Plasmacytoma/complications ; Plasmacytoma/diagnostic imaging
Language	English
Publishing date	2020-12-07
Publishing country	Italy
Document type	Journal Article
ZDB-ID	1160940-0
ISSN	1122-0643 ; 1120-0391
ISSN	1122-0643 ; 1120-0391
DOI	10.4081/monaldi.2020.1531
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Zs.B 65: Show issues

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Article ; Online: Histological characterization of placenta in COVID19 pregnant women.

Cribiù, Fulvia Milena / Croci, Giorgio Alberto / Del Gobbo, Alessandro / Rizzuti, Tommaso / Iurlaro, Enrico / Tondo, Marta / Viscardi, Anna / Bosari, Silvano / Ferrero, Stefano

European journal of obstetrics, gynecology, and reproductive biology

2020 Volume 252, Page(s) 619–621

MeSH term(s)	COVID-19 ; Female ; Humans ; Placenta ; Pregnancy ; Pregnant Women ; SARS-CoV-2
Keywords	covid19
Language	English
Publishing date	2020-06-23
Publishing country	Ireland
Document type	Letter
ZDB-ID	190605-7
ISSN	1872-7654 ; 0301-2115 ; 0028-2243
ISSN (online)	1872-7654
ISSN	0301-2115 ; 0028-2243
DOI	10.1016/j.ejogrb.2020.06.041
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Zs.A 837: Show issues

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Article ; Online: Histological evaluation of ischemic alterations in donors after cardiac death: A useful tool to predict post-transplant renal function.

Zagni, Moreno / Croci, Giorgio Alberto / Cannavò, Antonino / Passamonti, Serena Maria / De Feo, Tullia / Boggio, Francesca Laura / Cribiù, Fulvia Milena / Maggioni, Marco / Ferrero, Stefano / Del Gobbo, Alessandro / Gianelli, Umberto

Clinical transplantation

2022 Volume 36, Issue 5, Page(s) e14622

Abstract: Kidneys retrieved from donors after cardiac death (DCD) pose significant challenges from a clinical and technical point of view, undergoing a variable degree of ischemia-reperfusion injury. At present, the utilization of kidneys is assessed according to ... ...

Abstract	Kidneys retrieved from donors after cardiac death (DCD) pose significant challenges from a clinical and technical point of view, undergoing a variable degree of ischemia-reperfusion injury. At present, the utilization of kidneys is assessed according to the Karpinski score, which does not take into account the ischemic insult and does not predict the functional recovery of the organ once transplanted. Therefore, the correlation between biopsy results and post-transplant graft function is still debated. In this study we examined kidney biopsies from DCD donors; we calculated the Karpinski score and subsequently identified and quantified the ischemic lesions in the glomerular, interstitial, and tubular compartments. These same lesions were quantified in kidney biopsies from donors after brain death (DBD) in a case-control analysis. The collected data were correlated with the clinical data of the donors and the post-transplant follow-up. Proximal tubule alterations are crucial in ischemia-reperfusion damage, showing precise histological alterations, which are more frequent in DCD than in DBD donors and are statistically correlated with functional recovery of the organ. Quantification of ischemic tubular lesions in biopsies of kidneys from DCD donors is a useful tool for predicting post-transplant renal function and a valid parameter for assessing the quality of the graft.
MeSH term(s)	Brain Death ; Death ; Delayed Graft Function/etiology ; Delayed Graft Function/pathology ; Graft Survival ; Humans ; Ischemia ; Kidney/pathology ; Kidney/physiology ; Kidney Transplantation/adverse effects ; Kidney Transplantation/methods ; Retrospective Studies ; Tissue Donors ; Tissue and Organ Procurement
Language	English
Publishing date	2022-02-24
Publishing country	Denmark
Document type	Journal Article
ZDB-ID	639001-8
ISSN	1399-0012 ; 0902-0063
ISSN (online)	1399-0012
ISSN	0902-0063
DOI	10.1111/ctr.14622
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