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  1. Article ; Online: Digital work platform: Understanding platforms, workers, clients in a service relation.

    Cruz, Sofia Alexandra / Gameiro, Ana

    Frontiers in sociology

    2023  Volume 7, Page(s) 1075808

    Abstract: The rapid growth of digital economic activity had led to considerable scholarly interest in the phenomenon of platforms. Evidence shows how digital work platforms constitute one of the most relevant changes that have occurred in recent years and assume ... ...

    Abstract The rapid growth of digital economic activity had led to considerable scholarly interest in the phenomenon of platforms. Evidence shows how digital work platforms constitute one of the most relevant changes that have occurred in recent years and assume the condition of actors with an important presence in national and global work markets. However, these changes cannot be understood by focusing only on the work sphere, as the sphere of consumption is also central to this debate. In fact, the new ways of organizing, dividing and coordinating work on digital platforms are interconnected with specific modalities of consumption of the services made available by them. This article argues that a service relation approach allows an understanding of what is happening on digital work platforms, both in terms of the structural and conjunctural configurations of the interrelationships between platforms, workers and clients, as well as their social and economic consequences. This approach allows the analysis of the web of interdependencies between distinctive types of platforms, workers and clients, and to discuss how changes longitudinally within it are conditioned by the very transformations inherent to the platforms market. Thus, future research needs to explore the network of the voices of platforms, workers and clients in order to produce a robust analysis of these triangular relations as well as of the challenges regarding the differences and interconnections between algorithmic and human management.
    Language English
    Publishing date 2023-01-04
    Publishing country Switzerland
    Document type Journal Article ; Review
    ISSN 2297-7775
    ISSN (online) 2297-7775
    DOI 10.3389/fsoc.2022.1075808
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Portugal's farmland bird crisis requires action.

    Silva, João P / Gameiro, João / Valerio, Francesco / Marques, Ana T

    Science (New York, N.Y.)

    2024  Volume 383, Issue 6679, Page(s) 157

    MeSH term(s) Animals ; Birds ; Farms ; Portugal ; Conservation of Natural Resources
    Language English
    Publishing date 2024-01-11
    Publishing country United States
    Document type Letter
    ZDB-ID 128410-1
    ISSN 1095-9203 ; 0036-8075
    ISSN (online) 1095-9203
    ISSN 0036-8075
    DOI 10.1126/science.adn1390
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Morganella morganii: A Rare Cause of Early-Onset Neonatal Sepsis.

    Gameiro, Inês / Botelho, Teresa / Martins, Ana Isabel / Henriques, Raquel / Lapa, Patrícia

    Cureus

    2023  Volume 15, Issue 9, Page(s) e45600

    Abstract: Morganella ... ...

    Abstract Morganella morganii
    Language English
    Publishing date 2023-09-20
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.45600
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Epigenetic reprogramming as a key to reverse ageing and increase longevity.

    Pereira, Beatriz / Correia, Francisca P / Alves, Inês A / Costa, Margarida / Gameiro, Mariana / Martins, Ana P / Saraiva, Jorge A

    Ageing research reviews

    2024  Volume 95, Page(s) 102204

    Abstract: The pursuit for the fountain of youth has long been a fascination amongst scientists and humanity. Ageing is broadly characterized by a cellular decline with increased susceptibility to age-related diseases, being intimately associated with epigenetic ... ...

    Abstract The pursuit for the fountain of youth has long been a fascination amongst scientists and humanity. Ageing is broadly characterized by a cellular decline with increased susceptibility to age-related diseases, being intimately associated with epigenetic modifications. Recently, reprogramming-induced rejuvenation strategies have begun to greatly alter longevity research not only to tackle age-related defects but also to possibly reverse the cellular ageing process. Hence, in this review, we highlight the major epigenetic changes during ageing and the state-of-art of the current emerging epigenetic reprogramming strategies leveraging on transcription factors. Notably, partial reprogramming enables the resetting of the ageing clock without erasing cellular identity. Promising chemical-based rejuvenation strategies harnessing small molecules, including DNA methyltransferase and histone deacetylase inhibitors are also discussed. Moreover, in parallel to longevity interventions, the foundations of epigenetic clocks for accurate ageing assessment and evaluation of reprogramming approaches are briefly presented. Going further, with such scientific breakthroughs, we are witnessing a rise in the longevity biotech industry aiming to extend the health span and ideally achieve human rejuvenation one day. In this context, we overview the main scenarios proposed for the future of the socio-economic and ethical challenges associated with such an emerging field. Ultimately, this review aims to inspire future research on interventions that promote healthy ageing for all.
    MeSH term(s) Humans ; Adolescent ; Longevity/genetics ; DNA Methylation ; Aging/genetics ; Cellular Senescence/genetics ; Epigenesis, Genetic ; Cellular Reprogramming/genetics
    Language English
    Publishing date 2024-01-23
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2075672-0
    ISSN 1872-9649 ; 1568-1637
    ISSN (online) 1872-9649
    ISSN 1568-1637
    DOI 10.1016/j.arr.2024.102204
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Emerging Biomarkers and Targeted Therapies in Feline Mammary Carcinoma.

    Gameiro, Andreia / Urbano, Ana Catarina / Ferreira, Fernando

    Veterinary sciences

    2021  Volume 8, Issue 8

    Abstract: Feline mammary carcinoma (FMC) is a common aggressive malignancy with a low survival rate that lacks viable therapeutic options beyond mastectomy. Recently, increasing efforts have been made to understand the molecular mechanisms underlying FMC ... ...

    Abstract Feline mammary carcinoma (FMC) is a common aggressive malignancy with a low survival rate that lacks viable therapeutic options beyond mastectomy. Recently, increasing efforts have been made to understand the molecular mechanisms underlying FMC development, using the knowledge gained from studies on human breast cancer to discover new diagnostic and prognostic biomarkers, thus reinforcing the utility of the cat as a cancer model. In this article, we review the current knowledge on FMC pathogenesis, biomarkers, and prognosis factors and offer new insights into novel therapeutic options for HER2-positive and triple-negative FMC subtypes.
    Language English
    Publishing date 2021-08-11
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2768971-2
    ISSN 2306-7381 ; 2306-7381
    ISSN (online) 2306-7381
    ISSN 2306-7381
    DOI 10.3390/vetsci8080164
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Preparation of 3D Decellularized Matrices from Fetal Mouse Skeletal Muscle for Cell Culture.

    Gameiro Dos Santos, Pedro / Soares, Ana Rita / Thorsteinsdóttir, Sólveig / Rodrigues, Gabriela

    Journal of visualized experiments : JoVE

    2023  , Issue 193

    Abstract: The extracellular matrix (ECM) plays a crucial role in providing structural support for cells and conveying signals that are important for various cellular processes. Two-dimensional (2D) cell culture models oversimplify the complex interactions between ... ...

    Abstract The extracellular matrix (ECM) plays a crucial role in providing structural support for cells and conveying signals that are important for various cellular processes. Two-dimensional (2D) cell culture models oversimplify the complex interactions between cells and the ECM, as the lack of a complete three-dimensional (3D) support can alter cell behavior, making them inadequate for understanding in vivo processes. Deficiencies in ECM composition and cell-ECM interactions are important contributors to a variety of different diseases. One example is LAMA2-congenital muscular dystrophy (LAMA2-CMD), where the absence or reduction of functional laminin 211 and 221 can lead to severe hypotony, detectable at or soon after birth. Previous work using a mouse model of the disease suggests that its onset occurs during fetal myogenesis. The present study aimed to develop a 3D in vitro model permitting the study of the interactions between muscle cells and the fetal muscle ECM, mimicking the native microenvironment. This protocol uses deep back muscles dissected from E18.5 mouse fetuses, treated with a hypotonic buffer, an anionic detergent, and DNase. The resultant decellularized matrices (dECMs) retained all ECM proteins tested (laminin α2, total laminins, fibronectin, collagen I, and collagen IV) compared to the native tissue. When C2C12 myoblasts were seeded on top of these dECMs, they penetrated and colonized the dECMs, which supported their proliferation and differentiation. Furthermore, the C2C12 cells produced ECM proteins, contributing to the remodeling of their niche within the dECMs. The establishment of this in vitro platform provides a new promising approach to unravel the processes involved in the onset of LAMA2-CMD, and has the potential to be adapted to other skeletal muscle diseases where deficiencies in communication between the ECM and skeletal muscle cells contribute to disease progression.
    MeSH term(s) Humans ; Laminin/metabolism ; Extracellular Matrix/metabolism ; Extracellular Matrix Proteins/metabolism ; Muscle Fibers, Skeletal/metabolism ; Cell Culture Techniques ; Muscular Dystrophies/metabolism ; Fetus ; Collagen Type IV ; Muscle, Skeletal
    Chemical Substances Laminin ; Extracellular Matrix Proteins ; Collagen Type IV
    Language English
    Publishing date 2023-03-03
    Publishing country United States
    Document type Journal Article ; Video-Audio Media ; Research Support, Non-U.S. Gov't
    ZDB-ID 2259946-0
    ISSN 1940-087X ; 1940-087X
    ISSN (online) 1940-087X
    ISSN 1940-087X
    DOI 10.3791/65069
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Emerging Biomarkers and Targeted Therapies in Feline Mammary Carcinoma

    Gameiro, Andreia / Urbano, Ana Catarina / Ferreira, Fernando

    Veterinary sciences. 2021 Aug. 11, v. 8, no. 8

    2021  

    Abstract: Feline mammary carcinoma (FMC) is a common aggressive malignancy with a low survival rate that lacks viable therapeutic options beyond mastectomy. Recently, increasing efforts have been made to understand the molecular mechanisms underlying FMC ... ...

    Abstract Feline mammary carcinoma (FMC) is a common aggressive malignancy with a low survival rate that lacks viable therapeutic options beyond mastectomy. Recently, increasing efforts have been made to understand the molecular mechanisms underlying FMC development, using the knowledge gained from studies on human breast cancer to discover new diagnostic and prognostic biomarkers, thus reinforcing the utility of the cat as a cancer model. In this article, we review the current knowledge on FMC pathogenesis, biomarkers, and prognosis factors and offer new insights into novel therapeutic options for HER2-positive and triple-negative FMC subtypes.
    Keywords biomarkers ; breast neoplasms ; cats ; humans ; models ; pathogenesis ; prognosis ; survival rate ; therapeutics
    Language English
    Dates of publication 2021-0811
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2768971-2
    ISSN 2306-7381
    ISSN 2306-7381
    DOI 10.3390/vetsci8080164
    Database NAL-Catalogue (AGRICOLA)

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  8. Article ; Online: Mosaic epidermolytic ichthyosis.

    Mendes, Sónia Raquel / Gameiro, Ana Rita / Cardoso, José Carlos / Reis, José Pedro

    BMJ case reports

    2021  Volume 14, Issue 2

    MeSH term(s) Humans ; Hyperkeratosis, Epidermolytic/diagnosis ; Hyperkeratosis, Epidermolytic/genetics ; Skin
    Language English
    Publishing date 2021-02-18
    Publishing country England
    Document type Journal Article ; Case Reports
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2020-240424
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Eccrine angiomatous hamartoma in an adult.

    Mendes, Sónia Raquel / Gameiro, Ana Rita / Cardoso, José Carlos / Tellechea, Óscar

    BMJ case reports

    2021  Volume 14, Issue 2

    MeSH term(s) Adult ; Eccrine Glands ; Hamartoma/diagnostic imaging ; Hemangioma ; Humans
    Language English
    Publishing date 2021-02-22
    Publishing country England
    Document type Journal Article ; Case Reports
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2020-240422
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: A nationwide collapse of a priority grassland bird related to livestock conversion and intensification.

    Silva, João Paulo / Marques, Ana Teresa / Carrapato, Carlos / Machado, Rui / Alcazar, Rita / Delgado, Ana / Godinho, Carlos / Elias, Gonçalo / Gameiro, João

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 10005

    Abstract: Grassland birds are among the most threatened and fastest declining terrestrial vertebrate species in Europe, principally due to agricultural intensification and transformation. The little bustard is a priority grassland bird under the European Directive ...

    Abstract Grassland birds are among the most threatened and fastest declining terrestrial vertebrate species in Europe, principally due to agricultural intensification and transformation. The little bustard is a priority grassland bird under the European Directive (2009/147/CE) that led to the classification of a network of Special Protected Areas (SPAs) in Portugal. A third national survey carried out in 2022 reveals a worsening of an ongoing population collapse at a national scale. The population declined by 77% and 56% compared to the previous surveys in 2006 and 2016, respectively. We found that the little bustard has greatly disappeared outside SPAs, while the remaining breeding population concentrated within the protected area network is showing a steep decline at a rate of 9% a year. This decline is now twice as fast when compared to the period 2006-2016. Analysis of the variation of the breeding densities between 2006 and 2022 at 49 survey sites revealed that those that initially had higher bustard densities and shifted toward a higher proportion of cattle among the total stocking rate experienced steeper declines. Areas where the density of roads increased also experienced declines over the course of the study period. Agricultural areas converted to or dominated by beef production likely relate to low breeding success and mortality of nesting females in fodder crops. Still, major habitat conversion outside SPAs to permanent crops led to overall habitat destruction, which contributed to the species decline and range contraction. Other threats are likely acting synergistically such as fragmentation, climate change and anthropogenic mortality. The extinction of the little bustard in Portugal is expected in the short term if no conservation actions are put in place.
    MeSH term(s) Female ; Animals ; Cattle ; Grassland ; Livestock ; Plant Breeding ; Birds ; Acceptance and Commitment Therapy ; Crops, Agricultural ; Shock
    Language English
    Publishing date 2023-06-29
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-36751-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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