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  1. Article ; Online: Pathology: the narrative continues.

    Scolyer, Richard A

    Pathology

    2024  Volume 56, Issue 3, Page(s) 297

    MeSH term(s) Humans ; Narration
    Language English
    Publishing date 2024-02-01
    Publishing country England
    Document type Editorial
    ZDB-ID 7085-3
    ISSN 1465-3931 ; 0031-3025
    ISSN (online) 1465-3931
    ISSN 0031-3025
    DOI 10.1016/j.pathol.2024.01.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 723: Show issues Location:
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  2. Book: Pathology of melanocytic tumors

    Busam, Klaus J. / Gerami, Pedram / Scolyer, Richard A.

    2019  

    Author's details editors Klaus J. Busam, Pedram Gerami, Richard A. Scolyer
    Keywords Melatonin/Pathophysiology
    Subject code 616.99477
    Language English
    Size xiv, 414 Seiten, Illustrationen, 29 cm
    Publisher Elsevier
    Publishing place Philadelphia, PA
    Publishing country United States
    Document type Book
    Note Zugang zur Online-Ausgabe über Code
    HBZ-ID HT019842247
    ISBN 978-0-323-37457-6 ; 9780323508681 ; 0-323-37457-3 ; 0323508685
    Database Catalogue ZB MED Medicine, Health

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    2018 A 1751 on loan 0 Vormerkungen
    Zugang zur Online-Ausgabe über Code aus lizenzrechtlichen Gründen nicht verfügbar

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  3. Article ; Online: Pathology: the next chapter.

    Scolyer, Richard A

    Pathology

    2022  Volume 54, Issue 1, Page(s) 4–5

    MeSH term(s) Pathology ; Periodicals as Topic
    Language English
    Publishing date 2022-01-10
    Publishing country England
    Document type Editorial ; Portrait
    ZDB-ID 7085-3
    ISSN 1465-3931 ; 0031-3025
    ISSN (online) 1465-3931
    ISSN 0031-3025
    DOI 10.1016/j.pathol.2021.12.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Melanoma In Situ-Getting the Diagnosis and Prognosis Right.

    Cust, Anne E / Scolyer, Richard A

    JAMA dermatology

    2023  Volume 159, Issue 7, Page(s) 699–701

    MeSH term(s) Humans ; Melanoma/diagnosis ; Skin Neoplasms/diagnosis ; Prognosis ; Melanoma, Cutaneous Malignant
    Language English
    Publishing date 2023-06-07
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 2701761-8
    ISSN 2168-6084 ; 2168-6068
    ISSN (online) 2168-6084
    ISSN 2168-6068
    DOI 10.1001/jamadermatol.2023.1485
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  5. Article ; Online: Perspectives and Strategies to Minimize Harm From Melanoma Diagnosis.

    Busam, Klaus J / Gerami, Pedram / Scolyer, Richard A

    JAMA dermatology

    2023  Volume 159, Issue 12, Page(s) 1307–1309

    MeSH term(s) Humans ; Melanoma/diagnosis
    Language English
    Publishing date 2023-11-08
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2701761-8
    ISSN 2168-6084 ; 2168-6068
    ISSN (online) 2168-6084
    ISSN 2168-6068
    DOI 10.1001/jamadermatol.2023.4324
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  6. Book: WHO classification of skin tumours

    Elder, David E. / Massi, Daniela / Scolyer, Richard A. / Willemzen, Rein

    (World Health Organization classification of tumours. 4th edition ; 11)

    2018  

    Title variant Skin tumors
    Institution Weltgesundheitsorganisation
    International Agency for Research on Cancer
    Author's details edited by David E. Elder ; Daniela Massi ; Richard A. Scolyer ; Rein Willemze
    Series title World Health Organization classification of tumours. 4th edition ; 11
    World Health Organization classification of tumours
    World Health Organization classification of tumours. 4th edition
    Collection World Health Organization classification of tumours
    World Health Organization classification of tumours. 4th edition
    Keywords Skin Neoplasms / pathology ; Melanoma / pathology ; Skin neoplasms
    Language English
    Size 470 Seiten, Illustrationen
    Edition 4th edition
    Publisher International Agency for Research on Cancer
    Publishing place Lyon
    Publishing country France
    Document type Book
    Note "The WHO Classification of Skin Tumors presented in this book reflects the views of a Working Group that convened for a Consensus and Editorial Meeting at the International Agency for Research on Cancer, Lyon, 24-26 September 2017"
    HBZ-ID HT019947573
    ISBN 978-92-832-2440-2 ; 92-832-2440-X
    Database Catalogue ZB MED Medicine, Health

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  7. Article ; Online: Neoadjuvant Checkpoint Immunotherapy and Melanoma: The Time Is Now.

    Long, Georgina V / Menzies, Alexander M / Scolyer, Richard A

    Journal of clinical oncology : official journal of the American Society of Clinical Oncology

    2023  Volume 41, Issue 17, Page(s) 3236–3248

    Abstract: The role of neoadjuvant therapy is undergoing an historic shift in oncology. The emergence of potent immunostimulatory anticancer agents has transformed neoadjuvant therapy from a useful tool in minimizing surgical morbidity to a life-saving treatment ... ...

    Abstract The role of neoadjuvant therapy is undergoing an historic shift in oncology. The emergence of potent immunostimulatory anticancer agents has transformed neoadjuvant therapy from a useful tool in minimizing surgical morbidity to a life-saving treatment with curative promise, led by research in the field of melanoma. Health practitioners have witnessed remarkable improvements in melanoma survival outcomes over the past decade, beginning with checkpoint immunotherapies and BRAF-targeted therapies in the advanced setting that were successfully adopted into the postsurgical adjuvant setting for high-risk resectable disease. Despite substantial reductions in postsurgical recurrence, high-risk resectable melanoma has remained a life-altering and potentially fatal disease. In recent years, data from preclinical models and early-phase clinical trials have pointed to the potential for greater clinical efficacy when checkpoint inhibitors are administered in the neoadjuvant rather than adjuvant setting. Early feasibility studies showed impressive pathologic response rates to neoadjuvant immunotherapy, which were associated with recurrence-free survival rates of over 90%. Recently, the randomized phase II SWOG S1801 trial (ClinicalTrials.gov identifier: NCT03698019) reported a 42% reduction in 2-year event-free survival risk with neoadjuvant versus adjuvant pembrolizumab in resectable stage IIIB-D/IV melanoma (72%
    MeSH term(s) Humans ; Neoadjuvant Therapy ; Melanoma/drug therapy ; Melanoma/pathology ; Antineoplastic Agents/therapeutic use ; Treatment Outcome ; Immunotherapy ; Clinical Trials, Phase III as Topic ; Randomized Controlled Trials as Topic ; Clinical Trials, Phase II as Topic
    Chemical Substances Antineoplastic Agents
    Language English
    Publishing date 2023-04-27
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 604914-x
    ISSN 1527-7755 ; 0732-183X
    ISSN (online) 1527-7755
    ISSN 0732-183X
    DOI 10.1200/JCO.22.02575
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 650: Show issues

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  8. Article ; Online: Lentigo maligna and lentigo maligna melanoma in young patients in Australian tertiary centres.

    Huang, Cheng / Burke, Hazel / Scolyer, Richard A / Guitera, Pascale

    Clinical and experimental dermatology

    2023  Volume 48, Issue 7, Page(s) 799–800

    MeSH term(s) Humans ; Hutchinson's Melanotic Freckle ; Australia/epidemiology ; Melanoma/epidemiology ; Skin Neoplasms/epidemiology ; Lentigo
    Language English
    Publishing date 2023-03-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 195504-4
    ISSN 1365-2230 ; 0307-6938
    ISSN (online) 1365-2230
    ISSN 0307-6938
    DOI 10.1093/ced/llad089
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1278: Show issues Location:
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  9. Article ; Online: Affecting change as a clinical academic.

    Long, Georgina V / Durante, Jennifer / Browne, Matthew / Scolyer, Richard A

    Trends in cancer

    2023  Volume 10, Issue 2, Page(s) 93–96

    Abstract: Clinical academics can effectively advocate for cultural and policy transformations to improve health outcomes; but where do you begin? We present a case study of academics from Melanoma Institute Australia (MIA) who are engaging with the public, media, ... ...

    Abstract Clinical academics can effectively advocate for cultural and policy transformations to improve health outcomes; but where do you begin? We present a case study of academics from Melanoma Institute Australia (MIA) who are engaging with the public, media, and policymakers to affect meaningful change in melanoma skin cancer.
    MeSH term(s) Humans ; Melanoma/therapy ; Academia ; Health Policy ; Australia
    Language English
    Publishing date 2023-11-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2852626-0
    ISSN 2405-8025 ; 2405-8033 ; 2405-8033
    ISSN (online) 2405-8025 ; 2405-8033
    ISSN 2405-8033
    DOI 10.1016/j.trecan.2023.10.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Prognostic and predictive biomarkers in melanoma.

    Maher, Nigel G / Vergara, Ismael A / Long, Georgina V / Scolyer, Richard A

    Pathology

    2023  Volume 56, Issue 2, Page(s) 259–273

    Abstract: Biomarkers help to inform the clinical management of patients with melanoma. For patients with clinically localised primary melanoma, biomarkers can help to predict post-surgical outcome (including via the use of risk prediction tools), better select ... ...

    Abstract Biomarkers help to inform the clinical management of patients with melanoma. For patients with clinically localised primary melanoma, biomarkers can help to predict post-surgical outcome (including via the use of risk prediction tools), better select patients for sentinel lymph node biopsy, and tailor catch-all follow-up protocols to the individual. Systemic drug treatments, including immune checkpoint inhibitor (ICI) therapies and BRAF-targeted therapies, have radically improved the prognosis of metastatic (stage III and IV) cutaneous melanoma patients, and also shown benefit in the earlier setting of stage IIB/C primary melanoma. Unfortunately, a response is far from guaranteed. Here, we review clinically relevant, established, and emerging, prognostic, and predictive pathological biomarkers that refine clinical decision-making in primary and metastatic melanoma patients. Gene expression profile assays and nomograms are emerging tools for prognostication and sentinel lymph node risk prediction in primary melanoma patients. Biomarkers incorporated into clinical practice guidelines include BRAF V600 mutations for the use of targeted therapies in metastatic cutaneous melanoma, and the HLA-A∗02:01 allele for the use of a bispecific fusion protein in metastatic uveal melanoma. Several predictive biomarkers have been proposed for ICI therapies but have not been incorporated into Australian clinical practice guidelines. Further research, validation, and assessment of clinical utility is required before more prognostic and predictive biomarkers are fluidly integrated into routine care.
    MeSH term(s) Humans ; Melanoma/diagnosis ; Melanoma/genetics ; Melanoma/drug therapy ; Skin Neoplasms/diagnosis ; Skin Neoplasms/genetics ; Skin Neoplasms/pathology ; Prognosis ; Proto-Oncogene Proteins B-raf/genetics ; Australia ; Biomarkers, Tumor/genetics ; Sentinel Lymph Node Biopsy
    Chemical Substances Proto-Oncogene Proteins B-raf (EC 2.7.11.1) ; Biomarkers, Tumor
    Language English
    Publishing date 2023-12-20
    Publishing country England
    Document type Review ; Journal Article
    ZDB-ID 7085-3
    ISSN 1465-3931 ; 0031-3025
    ISSN (online) 1465-3931
    ISSN 0031-3025
    DOI 10.1016/j.pathol.2023.11.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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