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Article ; Online: Biocomputational characterisation of MBO_200107 protein of

Talukder, Asma / Rahman, Md Mijanur / Masum, Md Habib Ullah

Journal of biomolecular structure & dynamics

2022 Volume 41, Issue 15, Page(s) 7204–7223

Abstract: The principal objective of this study was to delineate the potentiality of the MBO_200107 protein from ... ...

Abstract	The principal objective of this study was to delineate the potentiality of the MBO_200107 protein from the
Language	English
Publishing date	2022-08-30
Publishing country	England
Document type	Journal Article
ZDB-ID	49157-3
ISSN	1538-0254 ; 0739-1102
ISSN (online)	1538-0254
ISSN	0739-1102
DOI	10.1080/07391102.2022.2118167
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Article ; Online: Comorbidities and their association with COVID-19 mortality in Mexico between January 2020 and August 2021.

Lowhorn, Ryan J / Chowdhury, Mohammed / Kimitei, Symon / Haskin, Sammie / Masum, Mohammad / Rahman, A K M Fazlur

PloS one

2024 Volume 19, Issue 4, Page(s) e0296895

Abstract: By August 17, 2021, 4.3 million people had died globally as a result of SARS-CoV-2 infection. While data collection is ongoing, it is abundantly obvious that this is one of the most significant public health crises in modern history. Consequently, global ...

Abstract	By August 17, 2021, 4.3 million people had died globally as a result of SARS-CoV-2 infection. While data collection is ongoing, it is abundantly obvious that this is one of the most significant public health crises in modern history. Consequently, global efforts are being made to attain a greater understanding of this disease and to identify risk factors associated with more severe outcomes. The goal of this study is to identify clinical characteristics and risk factors associated with COVID-19 mortality in Mexico. The dataset used in this study was released by Sistema Nacional de Vigilancia Epidemiologica de Enfermedades Respiratorias (SISVER) de la Secretaría de Salud and contains 2.9 million COVID-19 cases. The effects of risk factors on COVID-19 mortality were estimated using multivariable logistic regression models with generalized estimation equation and Kaplan-Meier curves. Case fatality rates, case hospitalization rates are also reported using the Centers for Disease Control and Prevention (CDC) USA death-to-case ratio method. In general, older males with pre-existing conditions had higher odds of death. Age greater than 40, male sex, hypertension, diabetes, and obesity are associated with higher COVID-19 mortality. End-stage renal disease, chronic obstructive pulmonary disease, and immunosuppression are all linked with COVID-19 patient fatalities. Smoking and Asthma are associated with lower COVID-19 mortality which is consistent with findings from the article published in Nature based on National Health Service (NHS) of UK dataset (17 million cases). Intensive care unit (ICU), patient intubation, and pneumonia diagnosis are shown to substantially increase mortality risk for COVID-19 patients.
MeSH term(s)	Humans ; Male ; COVID-19 ; Mexico ; State Medicine ; SARS-CoV-2 ; Comorbidity ; Risk Factors ; Hospitalization
Language	English
Publishing date	2024-04-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0296895
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Article: A comprehensive review on COVID-19 vaccines: development, effectiveness, adverse effects, distribution and challenges.

Rahman, Md Mijanur / Masum, Md Habib Ullah / Wajed, Shah / Talukder, Asma

Virusdisease

2022 Volume 33, Issue 1, Page(s) 1–22

Abstract: The present SARS-CoV-2 induced COVID-19 pandemic is responsible for millions of deaths, illnesses, and economic loss worldwide. There are 21 COVID-19 vaccines from different platforms approved worldwide for emergency use until 13 August 2021. Later, ... ...

Abstract	The present SARS-CoV-2 induced COVID-19 pandemic is responsible for millions of deaths, illnesses, and economic loss worldwide. There are 21 COVID-19 vaccines from different platforms approved worldwide for emergency use until 13 August 2021. Later, BNT162b2 obtained full approval from the FDA. The efficacy of the leading vaccines such as BNT162b2, mRNA-1273, Gam-Covid-Vac, Ad26.COV2.S, ChAdOx1 nCoV-19, and BBIBP-CorV, against SARS-CoV-2 documented as 95%, 94.1%, 91.6%, 67%, 70.4%, and 78.1%, respectively. Moreover, against the Delta variant of SARS-CoV-2, BNT162b2, ChAdOx1 nCoV-19, and BBV152 showed 88%, 70%, and 65.2% efficacy, respectively. Apart from the common adverse effects such as fever, fatigue, headache, and pain in the injection site, Bell's palsy with BNT162b2, myocarditis and pericarditis with mRNA-1273, and thrombosis with ChAdOx1 nCoV-19 have been reported though seemed not alarming. Furthermore, global production and distribution of vaccines should be ensured in an equal and justifiable way that the immunity and protection against the virus would be optimum and persistent.
Language	English
Publishing date	2022-02-01
Publishing country	India
Document type	Journal Article ; Review
ZDB-ID	2846993-8
ISSN	2347-3517 ; 2347-3584
ISSN (online)	2347-3517
ISSN	2347-3584
DOI	10.1007/s13337-022-00755-1
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Article: The impact of deontological and teleological variables on the intention to visit green hotel: The moderating role of trust.

Haq, Md Mahbubul / Miah, Masum / Biswas, Subarna / Rahman, S M Mahbubur

Heliyon

2023 Volume 9, Issue 4, Page(s) e14720

Abstract: Green hotels have grown in popularity due to customers' increased awareness of environmental issues. This study aims to construct and evaluate a model that combines the theory of Planned Behavior (TPB) and the theory of ethics to explain green hotel ... ...

Abstract	Green hotels have grown in popularity due to customers' increased awareness of environmental issues. This study aims to construct and evaluate a model that combines the theory of Planned Behavior (TPB) and the theory of ethics to explain green hotel visitors' intentions and behavior. The study also considers the role of trust & subjective norms as a moderator. The framework of the study was evaluated using a quantitative method. Most of the respondents to the study, which was carried out in Noakhali, Bangladesh, were students at Noakhali Science and Technology University and their family members. The data was collected from 414 respondents and analyzed using the structural equation modeling (SEM) technique. The data collection took around two weeks, starting from December 3, 2021. According to the study's findings, the deontological (Moral obligation and justice) and teleological variables (perceived benefit and perceived risk) significantly influence green hotel visitors' intentions and actual behavior. Moreover, trust noticeably influences the relationship between subjective norm (SN) and Intention, and subjective norm affects the connection between attitude and intention. Therefore, hotel management can utilize this research to examine and understand visitors' intention and actual behavior to visit green hotels, which will assist them in attracting guests by portraying their services as eco-friendly. Furthermore, the findings may help hotel management formulate competitive marketing strategies, design effective promotional tools, and help generate an eco-conscious customer base.
Language	English
Publishing date	2023-03-29
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2023.e14720
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Article ; Online: Coinfection of fungi with SARS-CoV-2 is a detrimental health risk for COVID-19 patients.

Baten, Nahida / Wajed, Shah / Talukder, Asma / Masum, Md Habib Ullah / Rahman, Md Mijanur

Beni-Suef University journal of basic and applied sciences

2022 Volume 11, Issue 1, Page(s) 64

Abstract: Background: Notable fungal coinfections with SARS-CoV-2 in COVID-19 patients have been reported worldwide in an alarming way. : Main body: Impaired CD4 + T cell response due to SARS-CoV-2 infection creates an opportunity for fungi to take over the ... ...

Abstract	Background: Notable fungal coinfections with SARS-CoV-2 in COVID-19 patients have been reported worldwide in an alarming way. Main body: Impaired CD4 + T cell response due to SARS-CoV-2 infection creates an opportunity for fungi to take over the host cells and, consequently, cause severe fungal coinfections, including candidiasis and candidemia, mucormycosis, invasive pulmonary aspergillosis (IPA), and COVID-19-associated pulmonary aspergillosis (CAPA). Among them, mucormycosis and CAPA have been reported with a mortality rate of 66% in India and 60% in Colombia. Moreover, IPA has been reported in Belgium, Netherlands, France, and Germany with a morbidity rate of 20.6%, 19.6%, 33.3%, and 26%, respectively. Several antifungal drugs have been applied to combat fungal coinfection in COVID-19 patients, including Voriconazole, Isavuconazole, and Echinocandins. Conclusion: SARS-CoV-2 deteriorates the immune system so that several fungi could take that opportunity and cause life-threatening health situations. To reduce the mortality and morbidity of fungal coinfections, it needs immunity boosting, proper hygiene and sanitation, and appropriate medication based on the diagnosis.
Language	English
Publishing date	2022-05-04
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2768279-1
ISSN	2314-8543 ; 2314-8535 ; 2314-8543
ISSN (online)	2314-8543
ISSN	2314-8535 ; 2314-8543
DOI	10.1186/s43088-022-00245-9
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Article ; Online: Nexus between heat wave, food security and human health (HFH)

Md Ashikur Rahman / Said Afridi / Md Belal Hossain / Masud Rana / Abdullah Al Masum / Md Mostafizur Rahman / Abdullah Al-Maruf

Environmental Challenges, Vol 14, Iss , Pp 100802- (2024)

Developing a framework for livelihood resilience in Bangladesh

1481

Abstract: Bangladesh has been severely affected by the extreme heatwave that is affecting most of Asia. Extreme climate events, particularly heatwave impacts on the food system, pose risks to human health in Bangladesh, explicitly in the north-west part of the ... ...

Abstract	Bangladesh has been severely affected by the extreme heatwave that is affecting most of Asia. Extreme climate events, particularly heatwave impacts on the food system, pose risks to human health in Bangladesh, explicitly in the north-west part of the country. The association between the heatwave, food security and health are narrowly described in the existing literature, resulting in a research lacuna related diverse component of food system that are particularly vulnerable to the heatwave. The current study therefore aims to develop a framework for understanding the nexus between heatwave, food security, and human health, which will ultimately help to improve livelihood resilience in Bangladesh. A comprehensive literature review was conducted to examine the link between heat waves, food security including human health (HFH) to explore the vulnerabilities in the food system in Rajshahi, Bangladesh. Additionally, the current study conducted a case study on the tribal community (e.g., Santals) of Rajshahi to understand heatwave, food security and health nexus. There is evidence that critical activities in the food system are prone to risk to heat waves. It is complex how heatwaves propagate along the food system and impact elucidative dimensions of food security to impact human health impacts. Different types of disruption related to heatwave can indirectly affect human health by compromising food security, a critical factor of health. The case study of the current investigation reveals that human health can also be affected by the physical impact of the heat wave on the food system, particularly with regard to diet-related impacts and food-borne diseases within the tribal community. In the study, we propose to offer a novel analytical framework to examine and respond to the relationship between heat waves, food security and human health. The investigation provide a benchmark to policymakers, academia, and relevant stakeholders to examine and understand current and future heatwave risks and to develop adaptation ...
Keywords	Food system ; Human health resilience ; Climate change ; Santals ; Vulnerabilities ; Food-borne diseases ; Environmental sciences ; GE1-350
Subject code	360
Language	English
Publishing date	2024-01-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
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Article: P21 Overexpression Promotes Cell Death and Induces Senescence in Human Glioblastoma.

Mansour, Moustafa A / Rahman, Masum / Ayad, Ahmad A / Warrington, Arthur E / Burns, Terry C

Cancers

2023 Volume 15, Issue 4

Abstract: High-grade gliomas are the most common and aggressive adult primary brain tumors with a median survival of only 12-15 months. Current standard therapy consists of maximal safe surgical resection followed by DNA-damaging agents, such as irradiation and ... ...

Abstract	High-grade gliomas are the most common and aggressive adult primary brain tumors with a median survival of only 12-15 months. Current standard therapy consists of maximal safe surgical resection followed by DNA-damaging agents, such as irradiation and chemotherapy that can delay but not prevent inevitable recurrence. Some have interpreted glioma recurrence as evidence of glioma stem cells which persist in a relatively quiescent state after irradiation and chemotherapy, before the ultimate cell cycle re-entry and glioma recurrence. Conversely, latent cancer cells with a therapy-induced senescent phenotype have been shown to escape senescence, giving rise to more aggressive stem-like tumor cells than those present in the original tumor. Therefore, approaches are needed to either eliminate or keep these glioma initiating cells in a senescent state for a longer time to prolong survival. In our current study, we demonstrate that the radiation-induced cell cycle inhibitor P21 can provide a powerful route to induce cell death in short-term explants of PDXs derived from three molecularly diverse human gliomas. Additionally, cells not killed by P21 overexpression were maintained in a stable senescent state for longer than control cells. Collectively, these data suggest that P21 activation may provide an attractive therapeutic target to improve therapeutic outcomes.
Language	English
Publishing date	2023-02-17
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers15041279
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Article ; Online: An in silico reverse vaccinology approach to design a novel multiepitope peptide vaccine for non-small cell lung cancers

Md Mijanur Rahman / Md Habib Ullah Masum / Asma Talukder / Rekha Akter

Informatics in Medicine Unlocked, Vol 37, Iss , Pp 101169- (2023)

2023

Abstract: Non-small cell lung cancer (NSCLC) is the most prevalent and fatal lung cancer. The multiepitope vaccine is one of the immunotherapies successfully applied to treat NSCLC. We designed a multiepitope vaccine with MHC-I, MHC-II, CTL, and linear B cell ... ...

Abstract	Non-small cell lung cancer (NSCLC) is the most prevalent and fatal lung cancer. The multiepitope vaccine is one of the immunotherapies successfully applied to treat NSCLC. We designed a multiepitope vaccine with MHC-I, MHC-II, CTL, and linear B cell epitopes of MAGE-A3, EGF, and MUC-1 oncoproteins employing in silico immunoinformatics approach. The structural assessment of the vaccine showed it as a well-stable protein (Z score of −7.53). The molecular docking between the vaccine and human receptors (TLR-2, TLR-4, MHC-I and MHC-II alleles) implied a high affinity of the vaccine to the receptors. The codon optimization and in silico cloning of the vaccine into the pET-28a (+) plasmid of the E. coli K12 strain revealed its potentiality upon expression (CAI value of 0.9607). Furthermore, immune simulation of the vaccine depicted its ability to stimulate immune responses (B cell, T cell, antibody, and cytokines) against NSCLC. Almost all developed NSCLC vaccines cannot treat or prevent NSCLC satisfactorily, and there is still no multiepitope vaccine available that contains all three significant oncoproteins; therefore, our designed vaccine could be a significant weapon against NSCLC. This novel multiepitope vaccine could be developed upon considering its safety, efficacy, and adverse effects on humans through further studies.
Keywords	Non-small cell lung cancer ; Reverse vaccinology ; Multiepitope vaccine ; MAGE-A3 ; EGF ; MUC-1 ; Computer applications to medicine. Medical informatics ; R858-859.7
Subject code	570
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
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Article ; Online: The impact of deontological and teleological variables on the intention to visit green hotel

Md Mahbubul Haq / Masum Miah / Subarna Biswas / S.M. Mahbubur Rahman

Heliyon, Vol 9, Iss 4, Pp e14720- (2023)

The moderating role of trust

2023

Abstract	Green hotels have grown in popularity due to customers' increased awareness of environmental issues. This study aims to construct and evaluate a model that combines the theory of Planned Behavior (TPB) and the theory of ethics to explain green hotel visitors' intentions and behavior. The study also considers the role of trust & subjective norms as a moderator. The framework of the study was evaluated using a quantitative method. Most of the respondents to the study, which was carried out in Noakhali, Bangladesh, were students at Noakhali Science and Technology University and their family members. The data was collected from 414 respondents and analyzed using the structural equation modeling (SEM) technique. The data collection took around two weeks, starting from December 3, 2021. According to the study's findings, the deontological (Moral obligation and justice) and teleological variables (perceived benefit and perceived risk) significantly influence green hotel visitors' intentions and actual behavior. Moreover, trust noticeably influences the relationship between subjective norm (SN) and Intention, and subjective norm affects the connection between attitude and intention. Therefore, hotel management can utilize this research to examine and understand visitors' intention and actual behavior to visit green hotels, which will assist them in attracting guests by portraying their services as eco-friendly. Furthermore, the findings may help hotel management formulate competitive marketing strategies, design effective promotional tools, and help generate an eco-conscious customer base.
Keywords	Green hotel ; Structural equation modeling ; Theory of planned behavior ; Ethical theory ; Smartpls ; Science (General) ; Q1-390 ; Social sciences (General) ; H1-99
Subject code	910
Language	English
Publishing date	2023-04-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Natural disasters, livelihood, and healthcare challenges of the people of a riverine island in Bangladesh: A mixed-method exploration.

Hossain, Ahmed / Chowdhury, Anika Tasneem / Mahbub, Masum / Khan, Mahmuda / Rahman, Taifur / Sharif, Azaz Bin / Hijazi, Heba / Alameddine, Mohamad

PloS one

2024 Volume 19, Issue 3, Page(s) e0298854

Abstract: Background: Bangladesh's islands, because of their geographical location, frequently encounter crises like floods and river erosion, which pose significant threats to the residents' well-being and livelihoods. To delve into the effects of these ... ...

Abstract	Background: Bangladesh's islands, because of their geographical location, frequently encounter crises like floods and river erosion, which pose significant threats to the residents' well-being and livelihoods. To delve into the effects of these disasters on livelihood and healthcare challenges, a mixed-method study was undertaken in a riverine-island near a major river of Bangladesh. Methodology: Between February 15th and February 28th, 2023, a cross-sectional study was conducted on an island in Bangladesh. The quantitative method involved conducting a survey of 442 households, with a total of 2921 participants. Additionally, 10 in-depth interviews and 10 key-informant interviews were conducted using semi-structured guidelines. Qualitative interviews were audio-recorded, transcribed verbatim, and analyzed using a thematic analysis. Triangulation was employed in this study through the integration of qualitative and quantitative analysis, resulting in the presentation of findings that offer an in-depth comprehension of the phenomenon being investigated. Results: River erosions and floods are common and recurring natural disasters that significantly impact the lives of the riverine island inhabitants. These disasters often disrupted their livelihoods, forced many residents to endure substandard living conditions or relocated during flood events. The island faced a low diagnostic prevalence of chronic diseases (e.g., 5.1% of adults were hypertension and 2.5% are diabetes) because of the absence of diagnostic facilities and a shortage of certified doctors. A significant number of chronic illness people in the community turned to alternative medicine sources (39.3%) such as homeopathy, Kabiraj, and Ayurvedic medicine, especially it gets increased during periods of natural disasters. Moreover, reproductive aged women revealed that 79.4% of them gave birth at home, with 6.0% of these home deliveries resulting in miscarriage or infant death. The destruction of crops, unstable job opportunities, an inadequate educational system, and a deficient healthcare delivery system exacerbated the hardships faced by the population affected by these disasters. Conclusion: The failure to seek treatment for chronic diseases and undiagnosed diseases is a significant health issue among the aging adults on the island. Island residents face the challenge of establishing effective prevention strategies for the well-being of older adults especially at the period of natural disasters. It is crucial for the government and non-governmental organizations (NGOs) to collaborate to prevent the negative effects of floods and river erosions. This should include efforts to enhance the quality of education, healthcare services, job opportunities, and financial assistance for rebuilding homes.
MeSH term(s)	Humans ; Female ; Adult ; Aged ; Bangladesh/epidemiology ; Cross-Sectional Studies ; Floods ; Natural Disasters ; Delivery of Health Care ; Chronic Disease
Language	English
Publishing date	2024-03-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0298854
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