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Book ; Online: Myelodysplastic syndromes

Hofmann, Wolf-Karsten / Germing, Ulrich / Mahlknecht, Ulrich Rudolph / Passweg, Jakob R. / Platzbecker, Uwe / Stauder, Reinhard

guideline : recommendations from the society for diagnosis and therapy of haematological and oncological diseases

(Onkopedia guidelines)

2011

Title translation	Myelodysplastische Syndrome (MDS)
Institution	Deutsche Gesellschaft für Hämatologie und Medizinische Onkologie Österreichische Gesellschaft für Hämatologie & Medizinische Onkologie Schweizerische Gesellschaft für Hämatologie
Author's details	Deutsche Gesellschaft für Hämatologie und Medizinische Onkologie, Österreichische Gesellschaft für Hämatologie & Medizinische Onkologie, SGH/SSH ; authors: Wolf-Karsten Hofmann, Ulrich Germing, Ulrich Mahlknecht, Jakob Passweg, Uwe Platzbecker, Reinhard Stauder
Series title	Onkopedia guidelines
Subject code	610
Language	English
Size	1 Online-Ressource (16 Seiten)
Edition	Status: March 2011
Publisher	DGHO Deutsche Gesellschaft für Hämatologie und Medizinische Onkologie e.V
Publishing place	Berlin
Publishing country	Germany
Document type	Book ; Online
HBZ-ID	HT019120595
DOI	10.4126/FRL01-006401023
Database	Repository for Life Sciences

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Book ; Online: Myelodysplastische Syndrome (MDS)

Hofmann, Wolf-Karsten / Platzbecker, Uwe / Mahlknecht, Ulrich Rudolph / Stauder, Reinhard / Passweg, Jakob R. / Germing, Ulrich

Leitlinie : Empfehlungen der Fachgesellschaft zur Diagnostik und Therapie hämatologischer und onkologischer Erkrankungen

(Onkopedia Leitlinien)

2011

Institution	Deutsche Gesellschaft für Hämatologie und Medizinische Onkologie Österreichische Gesellschaft für Hämatologie & Medizinische Onkologie Schweizerische Gesellschaft für Hämatologie
Author's details	Deutsche Gesellschaft für Hämatologie und Medizinische Onkologie, Österreichische Gesellschaft für Hämatologie & Medizinische Onkologie, SGH/SSH ; Autoren: Wolf-K. Hofmann, Uwe Platzbecker, Ulrich Mahlknecht, Reinhard Stauder, Jacob Passweg, Ulrich Germing
Series title	Onkopedia Leitlinien
Subject code	610
Language	German
Size	1 Online-Ressource (19 Seiten)
Edition	Stand: März 2011
Publisher	DGHO Deutsche Gesellschaft für Hämatologie und Medizinische Onkologie e.V
Publishing place	Berlin
Publishing country	Germany
Document type	Book ; Online
HBZ-ID	HT019102646
DOI	10.4126/FRL01-006400859
Database	Repository for Life Sciences

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Article: Den Krebs im Visier

Mahlknecht, U.

Aktuelle Ernährungsmedizin

2013 Volume 38, Issue S 01, Page(s) S37–S41

Abstract: Schätzungen der Weltgesundheitsorganisation (WHO) zufolge wären über 30 % aller Krebserkrankungen durch eine gesunde Ernährung vermeidbar. Ernährungsfaktoren beeinflussen nahezu jeden Schritt der Kanzerogenese über epigenetische Modifikationen. Diese ... ...

Abstract	Schätzungen der Weltgesundheitsorganisation (WHO) zufolge wären über 30 % aller Krebserkrankungen durch eine gesunde Ernährung vermeidbar. Ernährungsfaktoren beeinflussen nahezu jeden Schritt der Kanzerogenese über epigenetische Modifikationen. Diese regulieren die Genaktivität, indem sie die Lesbarkeit von Genabschnitten ermöglichen oder verhindern. Solche Zielstrukturen sind Ansatzpunkte für epigenetische Therapieverfahren, die mittlerweile z. B. bei akuten Leukämien zum Einsatz kommen. Die Ernährung spielt in der Onkologie eine große Rolle, sowohl für die Prävention als auch für die Therapie der Mangelernährung, die bei einem Drittel der Tumorpatienten zum Tod führt. Lebensmittel wie Alkohol oder rotes Fleisch sind besonders häufig mit bestimmten Tumorerkrankungen assoziiert und können zur Progression einer Krebserkrankung beitragen. Substanzen mit chemopräventivem Potenzial finden sich insbesondere in pflanzlichen Lebensmitteln. Gut untersucht sind Resveratrol aus Rotwein, Curcumin aus Gelbwurz und Epigallocatechingallat aus grünem Tee. Sie sind über epigenetische Modifikationen unter anderem an der Reaktivierung von Tumor-Repressorgenen, an der Induktion von Zelltod infolge Apoptose oder an der Suppression von Onkogenen beteiligt.
Keywords	Todesursachen ; Krebs ; epigenetische Therapie ; Valproinsäure ; oxidativer Stress ; Ernährung ; Resveratrol ; Curcumin ; grüner Tee ; causes of death ; cancer ; epigenetic therapy ; valproic acid ; oxidative stress ; nutrition ; resveratrol ; curcumin ; green tea
Language	German
Publishing date	2013-03-01
Publisher	© Georg Thieme Verlag KG
Publishing place	Stuttgart ; New York
Document type	Article
ZDB-ID	131268-6
ISSN	1438-9916 ; 0341-0501
ISSN (online)	1438-9916
ISSN	0341-0501
DOI	10.1055/s-0032-1332826
Database	Thieme publisher's database

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Article ; Online: Clinical Epigenetics is now a fully open access journal.

Mahlknecht, Ulrich

Clinical epigenetics

2011 Volume 3, Page(s) 1

Language	English
Publishing date	2011-10-26
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2553921-8
ISSN	1868-7083 ; 1868-7075
ISSN (online)	1868-7083
ISSN	1868-7075
DOI	10.1186/1868-7083-3-1
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Article ; Online: Cloning, chromosomal characterization and FISH mapping of the NAD(+)-dependent histone deacetylase gene sirtuin 5 in the mouse.

Voelter-Mahlknecht, Susanne / Mahlknecht, Ulrich

International journal of oncology

2013 Volume 43, Issue 1, Page(s) 237–245

Abstract: Sirtuin 5 (SIRT5) is a nicotinamide adenine dinucleotide (NAD+)-dependent deacetylase, belonging to the silent information regulator 2 (Sir2) family of sirtuin histone deacetylases (sirtuins). The yeast Sir2 protein and its mammalian derivatives are ... ...

Abstract	Sirtuin 5 (SIRT5) is a nicotinamide adenine dinucleotide (NAD+)-dependent deacetylase, belonging to the silent information regulator 2 (Sir2) family of sirtuin histone deacetylases (sirtuins). The yeast Sir2 protein and its mammalian derivatives are important in epigenetic gene silencing, DNA repair and recombination, cell cycle, microtubule organization and in the regulation of aging. In mammals, 7 sirtuin isoforms have been identified to date of which three (SIRT3, SIRT4 and SIRT5) are localized in the mitochondria, which serve as the center of energy management and the initiation of cellular apoptosis. In the study presented herein, we report the genomic organization and chromosomal localization of the murine sirt5 gene. We have isolated and characterized the murine sirt5 genomic sequence, which spans a region of 24,449 bp and which has one single genomic locus. The murine sirt5 gene consists of 8 exons and encodes a 310-aa protein with a predictive mo-lecular weight of 34.1 kDa and an isoelectric point of 8.90. For the murine sirt5 gene only one single genomic locus has been identified. The gene has been localized to mouse chromosome 13A4 and is flanked by STS-marker 164522 (synonymous WI MRC-RH: 506859).
MeSH term(s)	Amino Acid Sequence ; Animals ; Chromosome Mapping ; Cloning, Molecular ; Group III Histone Deacetylases/genetics ; In Situ Hybridization, Fluorescence ; Mice ; NAD/genetics ; NAD/metabolism ; Phylogeny ; Sequence Alignment ; Sirtuins/genetics ; Sirtuins/metabolism
Chemical Substances	NAD (0U46U6E8UK) ; Group III Histone Deacetylases (EC 3.5.1.-) ; Sirtuins (EC 3.5.1.-)
Language	English
Publishing date	2013-07
Publishing country	Greece
Document type	Journal Article
ZDB-ID	1154403-x
ISSN	1791-2423 ; 1019-6439
ISSN (online)	1791-2423
ISSN	1019-6439
DOI	10.3892/ijo.2013.1939
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Article: Pharmakogenomik: Prinzip und Perspektive.

Mahlknecht, U

Deutsche medizinische Wochenschrift (1946)

2006 Volume 131, Issue 7, Page(s) 310–313

Title translation	Pharmacogenomics: principles and perspectives.
MeSH term(s)	DNA Fingerprinting/ethics ; Drug Industry/economics ; Drug Industry/legislation & jurisprudence ; Drug Industry/standards ; Drug Prescriptions/standards ; Drug Therapy/standards ; Drug-Related Side Effects and Adverse Reactions ; Germany ; Humans ; Insurance, Health/economics ; Insurance, Health/ethics ; International Cooperation ; Oligonucleotide Array Sequence Analysis ; Pharmacogenetics/ethics ; Pharmacogenetics/legislation & jurisprudence ; Pharmacogenetics/standards ; Risk Factors
Language	German
Publishing date	2006-02-17
Publishing country	Germany
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	200446-x
ISSN	1439-4413 ; 0012-0472
ISSN (online)	1439-4413
ISSN	0012-0472
DOI	10.1055/s-2006-932516
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Article: Evolution of Youth's Mental Health and Quality of Life during the COVID-19 Pandemic in South Tyrol, Italy: Comparison of Two Representative Surveys.

Barbieri, Verena / Wiedermann, Christian J / Piccoliori, Giuliano / Mahlknecht, Angelika / Plagg, Barbara / Ausserhofer, Dietmar / Ravens-Sieberer, Ulrike / Engl, Adolf

Children (Basel, Switzerland)

2023 Volume 10, Issue 5

Abstract: Background: The coronavirus disease 2019 pandemic has led to an increase in youth mental health problems worldwide. Studies have revealed substantial variation in the incidence of these problems across different regions. Longitudinal studies of children ...

Abstract	Background: The coronavirus disease 2019 pandemic has led to an increase in youth mental health problems worldwide. Studies have revealed substantial variation in the incidence of these problems across different regions. Longitudinal studies of children and adolescents in Italy are lacking. This study aimed to investigate the development of health-related quality of life (HRQoL) and mental health in Northern Italy by comparing surveys conducted in June 2021 and in March 2022. Methods: A representative, large cross-sectional, online survey investigated HRQoL, psychosomatic complaints, and symptoms of anxiety and depression among 5159 and 6675 children and adolescents in 2021 and 2022, respectively, using the KIDSCREEN-10 index, HBSC symptom checklist, SCARED, CES-DC, and PHQ-2 instruments. Statistical analyses included a multivariate linear regression analysis. Results: Baseline characteristics showed significant differences in demographic variables between the two surveys. Girls and their parents reported a significantly lower HRQoL in 2021 than in 2022. Psychosomatic complaints differed significantly between sexes, and the results showed no decrease in psychosomatic complaints, anxiety, or depression between 2021 and 2022. Predictors of HRQoL, anxiety, depressive symptoms, and psychosomatic complaints in 2022 differed from those in 2021. Conclusions: The characteristics of the 2021 pandemic, including lockdowns and home schooling, may have contributed to the differences between the two surveys. As most pandemic restrictions ended in 2022, the results confirm the need for measures to improve the mental and physical health of children and adolescents after the pandemic.
Language	English
Publishing date	2023-05-17
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2732685-8
ISSN	2227-9067
ISSN	2227-9067
DOI	10.3390/children10050895
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Article ; Online: Quality of chronic care in general practices in Salzburg, Austria, and South Tyrol, Italy: a comparative process of care intervention study.

Paier-Abuzahra, Muna E / Mahlknecht, Angelika / Piccoliori, Giuliano / Engl, Adolf / Sönnichsen, Andreas

Zeitschrift fur Evidenz, Fortbildung und Qualitat im Gesundheitswesen

2022 Volume 170, Page(s) 14–20

Abstract: ... quality indicators, a supra-regional quality score was calculated and compared using Mann-Whitney U tests.: Results ...

Abstract	Background: Quality indicators to assess the quality of primary care have only been applied on a national or regional level in European countries, and there have been no comparisons between regions of different countries. In the interventional pre-post-study "Improvement of Quality by Benchmarking - IQuaB" (level of evidence: 3), we aimed to improve and compare quality of process care in 57 participating general practices in Salzburg, Austria, and South Tyrol, Italy. Methods: The intervention consisted of self-audit, benchmarking and quality circles. Quality indicators for eight common chronic diseases (e. g., diabetes) were extracted from the electronic health records in 2012, 2013 and 2014. Based on 19 quality indicators, a supra-regional quality score was calculated and compared using Mann-Whitney U tests. Results: A relatively weak baseline performance was identified in both regions. In all three assessments, the median quality score increased in both regions and was significantly higher in South Tyrol than in Salzburg. During the study period the median supra-regional quality score increased from 20.00 to 38.00 in the Salzburg sample and from 47.00 to 79.50 in the South Tyrolian sample. The differences between the two regions were significant at baseline and after intervention (2012: p=0.015, 2014: p=0.001). Discussion: Despite data extraction challenges in Austria, we are convinced that our data highlight real differences in (processual) quality of care between the two regions. Conclusions: The reasons underlying the persisting differences between the two regions may include: (1) different functions in electronic health records, (2) benchmarking as an integral part of the electronic health record, (3) gate-keeping system and use of registration lists, (4) state-supported quality initiatives.
MeSH term(s)	Austria ; General Practice ; Germany ; Humans ; Italy ; Management Quality Circles
Language	English
Publishing date	2022-04-14
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2412512-X
ISSN	2212-0289 ; 1865-9217
ISSN (online)	2212-0289
ISSN	1865-9217
DOI	10.1016/j.zefq.2022.01.005
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Article ; Online: Genomic organization and localization of the NAD-dependent histone deacetylase gene sirtuin 3 (Sirt3) in the mouse.

Mahlknecht, Ulrich / Voelter-Mahlknecht, Susanne

International journal of oncology

2011 Volume 38, Issue 3, Page(s) 813–822

Abstract: Sirtuin 3 (SIRT3) is a nicotinamide adenine dinucleotide (NAD+)-dependent deacetylase, which belongs to the Silent information regulator 2 (Sir2) family of histone deacetylases (sirtuin HDACs). The yeast Sir2 protein and its mammalian derivatives play a ... ...

Abstract	Sirtuin 3 (SIRT3) is a nicotinamide adenine dinucleotide (NAD+)-dependent deacetylase, which belongs to the Silent information regulator 2 (Sir2) family of histone deacetylases (sirtuin HDACs). The yeast Sir2 protein and its mammalian derivatives play a central role in epigenetic gene silencing, DNA repair and recombination, cell-cycle, microtubule organization, and in the regulation of aging. We have isolated and characterized the murine Sirt3 genomic sequence, which spans a region of 18,646 bp and which has one single genomic locus. Determination of the exon-intron splice junctions identified murine SIRT3 to be encoded by 7 exons ranging in size from 101 (exon 4) to 420 bp (exon 7). Characterization of the 5' flanking genomic region, which precedes the murine Sirt3 open reading frame, revealed a number of STATx, GATA and SP1 transcription factor binding sites. A CpG island was not detected. The 1,473-bp murine Sirt3 transcript has an open reading frame of 774 bp and encodes a 257-aa protein (cytoplasmic SIRT3) with a predictive molecular weight of 28.8 kDa and an isoelectric point of 5.82. Recently, a 1,406-bp murine SIRT3 splice variant that encodes a 334-aa mitochondrial precursor protein with a molecular weight of 36.6 kDa and an isoelectric point of 7.19 has been described. Fluorescence in situ hybridization analysis identified a single genomic locus for murine Sirt3 gene on chromosome 7F4 and which is neighbored by the Ric8 and PSMD13 genes. Our study brings light and a number of corrections and additions to previous reports on the genomic organization and the genomic sequence of murine Sirt3, which may be of importance in view of studies on potential genetic polymorphisms in relation to cellular respiration, metabolism, aging-related disease and cancer.
MeSH term(s)	Amino Acid Sequence ; Animals ; Base Sequence ; Chromosome Mapping ; Chromosomes, Artificial, Bacterial/genetics ; Chromosomes, Mammalian ; Cloning, Molecular ; Genome ; Group III Histone Deacetylases/genetics ; In Situ Hybridization, Fluorescence ; Mice/genetics ; Molecular Sequence Data ; Multigene Family/genetics ; Phylogeny ; Sequence Homology, Nucleic Acid ; Sirtuin 3/genetics
Chemical Substances	Sirt3 protein, mouse ; Group III Histone Deacetylases (EC 3.5.1.-) ; Sirtuin 3 (EC 3.5.1.-)
Language	English
Publishing date	2011-03
Publishing country	Greece
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1154403-x
ISSN	1791-2423 ; 1019-6439
ISSN (online)	1791-2423
ISSN	1019-6439
DOI	10.3892/ijo.2010.872
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Article ; Online: The sirtuins in the pathogenesis of cancer.

Voelter-Mahlknecht, Susanne / Mahlknecht, Ulrich

Clinical epigenetics

2010 Volume 1, Issue 3-4, Page(s) 71–83

Abstract: Aging is the natural trace that time leaves behind on life during blossom and maturation, culminating in senescence and death. This process is accompanied by a decline in the healthy function of multiple organ systems, leading to increased incidence and ... ...

Abstract	Aging is the natural trace that time leaves behind on life during blossom and maturation, culminating in senescence and death. This process is accompanied by a decline in the healthy function of multiple organ systems, leading to increased incidence and mortality from diseases such as diabetes, cancer, cardiovascular disease, and neurodegeneration. Based on the fact that both sirtuin expression and activity appear to be upregulated in some types of cancer while they are being downregulated in others, there is quite some controversy stirring up as to the role of sirtuins, acting as cancer suppressors in some cases while under other circumstances they may promote cellular malignancy. It is therefore currently quite unclear as to what extent and under which particular circumstances sirtuin activators and/or inhibitors will find their place in the treatment of age-related disease and cancer. In this review, we take an effort to bring together the highlights of sirtuin research in order to shed some light on the mechanistic impact that sirtuins have on the pathogenesis of cellular malignancy.
Language	English
Publishing date	2010-08-20
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2553921-8
ISSN	1868-7083 ; 1868-7075
ISSN (online)	1868-7083
ISSN	1868-7075
DOI	10.1007/s13148-010-0008-0
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