LIVIVO - Search results -

Search results

Result 1 - 10 of total 16

Search options

Article ; Online: Histone acetylation: where to go and how to get there.

MacDonald, Vicki E / Howe, LeAnn J

Epigenetics

2009 Volume 4, Issue 3, Page(s) 139–143

Abstract: Transcriptionally active DNA is packaged with histones that are post-translationally acetylated on multiple lysines within their amino termini. While the majority of this acetylation is limited to the promoters of genes, acetylated histones are also ... ...

Abstract	Transcriptionally active DNA is packaged with histones that are post-translationally acetylated on multiple lysines within their amino termini. While the majority of this acetylation is limited to the promoters of genes, acetylated histones are also found throughout transcribed units. Over the last decade we have uncovered many of the pathways involved in directing histone acetylation to active genes. This review will summarize much of this groundbreaking research as well as discuss some of the outcomes of this important protein post-translational modification.
MeSH term(s)	Acetylation ; Animals ; Epigenesis, Genetic ; Histones/metabolism ; Humans ; Promoter Regions, Genetic ; Transcription, Genetic
Chemical Substances	Histones
Language	English
Publishing date	2009-04-18
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ISSN	1559-2308
ISSN (online)	1559-2308
DOI	10.4161/epi.4.3.8484
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Critical determinants for chromatin binding by Saccharomyces cerevisiae Yng1 exist outside of the plant homeodomain finger.

Chruscicki, Adam / Macdonald, Vicki E / Young, Barry P / Loewen, Christopher J R / Howe, Leann J

Genetics

2010 Volume 185, Issue 2, Page(s) 469–477

Abstract: The temporal and spatial regulation of histone post-translational modifications is essential for proper chromatin structure and function. The Saccharomyces cerevisiae NuA3 histone acetyltransferase complex modifies the amino-terminal tail of histone H3, ... ...

Abstract	The temporal and spatial regulation of histone post-translational modifications is essential for proper chromatin structure and function. The Saccharomyces cerevisiae NuA3 histone acetyltransferase complex modifies the amino-terminal tail of histone H3, but how NuA3 is targeted to specific regions of the genome is not fully understood. Yng1, a subunit of NuA3 and a member of the Inhibitor of Growth (ING) protein family, is required for the interaction of NuA3 with chromatin. This protein contains a C-terminal plant homeodomain (PHD) finger that specifically interacts with lysine 4-trimethylated histone H3 (H3K4me3) in vitro. This initially suggested that NuA3 is targeted to regions bearing the H3K4me3 mark; however, deletion of the Yng1 PHD finger does not disrupt the interaction of NuA3 with chromatin or result in a phenotype consistent with loss of NuA3 function in vivo. In this study, we uncovered the molecular basis for the discrepancies in these data. We present both genetic and biochemical evidence that full-length Yng1 has two independent histone-binding motifs: an amino-terminal motif that binds unmodified H3 tails and a carboxyl-terminal PHD finger that specifically recognizes H3K4me3. Although these motifs can bind histones independently, together they increase the apparent association of Yng1 for the H3 tail.
MeSH term(s)	Amino Acid Motifs/genetics ; Chromatin ; DNA-Binding Proteins/chemistry ; DNA-Binding Proteins/genetics ; DNA-Binding Proteins/metabolism ; Histones/chemistry ; Histones/genetics ; Histones/metabolism ; Lysine/chemistry ; Lysine/genetics ; Lysine/metabolism ; Plants/genetics ; Plants/metabolism ; Protein Binding/genetics ; Protein Processing, Post-Translational ; Protein Structure, Tertiary/genetics ; Saccharomyces cerevisiae/genetics ; Saccharomyces cerevisiae/metabolism
Chemical Substances	Chromatin ; DNA-Binding Proteins ; Histones ; Lysine (K3Z4F929H6)
Language	English
Publishing date	2010-03-29
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2167-2
ISSN	1943-2631 ; 0016-6731
ISSN (online)	1943-2631
ISSN	0016-6731
DOI	10.1534/genetics.110.116285
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.B 767: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Tyrosine kinase inhibitor toxicities: A society of gynecologic oncology review and recommendations.

Rimel, Bobbie J / Crane, Erin K / Hou, June / Nakayama, John / MacDonald, Jennifer / Lutz, Kathleen / Makker, Vicky / O'Cearbhaill, Roisin E

Gynecologic oncology

2023 Volume 174, Page(s) 148–156

Abstract: Objective: Oral tyrosine kinase inhibitors (TKIs) have new indications for treatment in gynecologic malignancies. These targeted drugs have both unique and overlapping toxicities, which require careful attention and management. New combination therapies ...

Abstract	Objective: Oral tyrosine kinase inhibitors (TKIs) have new indications for treatment in gynecologic malignancies. These targeted drugs have both unique and overlapping toxicities, which require careful attention and management. New combination therapies with immune-oncology agents have demonstrated promise in endometrial cancer. This review examines common adverse events associated with TKIs and provides readers with an evidence-based review on current uses and strategies for the management of these medications. Methods: A comprehensive review of the medical literature on TKI use in gynecologic cancer was undertaken by a committee approach. Details of each drug, its molecular target, and relevant data on both clinical efficacy and side effects were compiled and organized for clinical use. Information on drug-related secondary effects and management strategies for specific toxicities, including dose reduction and concomitant medications, were gathered. Results: TKIs can potentially offer improved response rates and durable responses for a group of patients who were previously without an effective standard second-line therapy. The combination of lenvatinib and pembrolizumab represents a more targeted approach to the drivers of endometrial cancer; however, there remains significant drug-related toxicity, and thus dose reduction and dose delay are frequently required. Toxicity management requires frequent check-ins and management strategies to help patients find the highest tolerable dose. TKIs are expensive and patient financial toxicity is as critical a measure of a drug's utility as any drug side effect. Many of these drugs have patient assistance programs, which should be fully utilized to minimize cost. Conclusions: Future studies are needed to expand the role of TKIs into new molecularly driven groups. Attention to cost, durability of response, and long-term toxicity management is needed to ensure all eligible patients have access to treatment.
MeSH term(s)	Female ; Humans ; Antineoplastic Agents/adverse effects ; Endometrial Neoplasms/drug therapy ; Treatment Outcome ; Tyrosine Kinase Inhibitors/adverse effects
Chemical Substances	Antineoplastic Agents ; Tyrosine Kinase Inhibitors
Language	English
Publishing date	2023-05-17
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Review
ZDB-ID	801461-9
ISSN	1095-6859 ; 0090-8258
ISSN (online)	1095-6859
ISSN	0090-8258
DOI	10.1016/j.ygyno.2023.05.007
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 885: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Use of standardised assessment forms in referrals to hepatology outpatient services: implications for accurate triaging of patients with chronic hepatitis C.

Horsfall, Leigh / Macdonald, Graeme / Scott, Ian / Skoien, Richard / Khatun, Mohsina / Moss, Cathy / Seligman, Clare / Kardash, Christine / Poxon, Vicki / Powell, Elizabeth E

Australian health review : a publication of the Australian Hospital Association

2013 Volume 37, Issue 2, Page(s) 218–222

Abstract: Objectives: To determine the spectrum of disease among non-urgent referrals to a tertiary hospital hepatology outpatient clinic, assess the adequacy of referral information in terms of risk stratification and determine whether a specifically designed ... ...

Abstract	Objectives: To determine the spectrum of disease among non-urgent referrals to a tertiary hospital hepatology outpatient clinic, assess the adequacy of referral information in terms of risk stratification and determine whether a specifically designed referral template altered urgency for specialist assessment. Methods: A snapshot of the waiting list of a hepatology clinic at a tertiary hospital was taken from the scheduling database. Information was retrieved from referrals and attached investigations. Updated information was requested from subjects and their current general practitioner. Results: Hepatitis C virus accounted for 68.7% of the 1223 reviewed referrals. Clinical information provided by referring clinicians was often incomplete. Provision of updated information identified the presence of comorbidities (obesity, 'heavy' alcohol consumption, mental health issues) and altered the need or urgency for specialist assessment in 22% of cases. Conclusions: Hepatitis C virus accounts for the majority of non-urgent referrals waiting to access hepatology outpatient consultations. Using a standardised assessment form as part of the referral process provides more information on comorbidities and risk factors and facilitates more accurate triaging of clinical urgency. Wider adoption of this strategy may increase appropriate access to hepatology services and reduce the future burden of cirrhosis and hepatocellular cancer. WHAT IS KNOWN ABOUT THE TOPIC? Little published data are available that describe the content and standard of hepatology referrals, or the urgency with which these patients need to be reviewed. Inadequate clinical information impairs the ability to accurately triage referrals and may lead to delays in access. WHAT DOES THE PAPER ADD? Almost 70% of reviewed referrals were for management of patients with hepatitis C virus infection, confirming this condition remains a major priority area in liver disease. Clinical information provided by referring clinicians was often incomplete, impairing the ability to accurately triage referrals. Only a minority of referrals provided information about relevant comorbidities (alcohol intake, injecting drug use, mental health issues and obesity) that negatively impact on the progression of liver disease or the response to antiviral treatment. WHAT ARE THE IMPLICATIONS FOR PRACTITIONERS? Hepatitis C virus remains a major health priority area in liver disease, increasing the future burden of cirrhosis and hepatocellular cancer. Many referred patients have comorbidities that increase their risk of progressive liver disease and related complications. Strategies to increase recognition and management of liver disease and its comorbidities in the community are required. The use of a standardised assessment form in referrals to hepatology outpatient services may assist with triaging of patients and improve access to appropriate care.
MeSH term(s)	Adult ; Ambulatory Care ; Databases, Factual ; Documentation/standards ; Female ; Gastroenterology ; Hepatitis C, Chronic ; Humans ; Male ; Referral and Consultation/standards ; Triage/standards
Language	English
Publishing date	2013-05
Publishing country	Australia
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	639155-2
ISSN	0156-5788 ; 0159-5709
ISSN	0156-5788 ; 0159-5709
DOI	10.1071/AH12162
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.B 3099: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Genomic architecture of autism from comprehensive whole-genome sequence annotation.

Trost, Brett / Thiruvahindrapuram, Bhooma / Chan, Ada J S / Engchuan, Worrawat / Higginbotham, Edward J / Howe, Jennifer L / Loureiro, Livia O / Reuter, Miriam S / Roshandel, Delnaz / Whitney, Joe / Zarrei, Mehdi / Bookman, Matthew / Somerville, Cherith / Shaath, Rulan / Abdi, Mona / Aliyev, Elbay / Patel, Rohan V / Nalpathamkalam, Thomas / Pellecchia, Giovanna /

Hamdan, Omar / Kaur, Gaganjot / Wang, Zhuozhi / MacDonald, Jeffrey R / Wei, John / Sung, Wilson W L / Lamoureux, Sylvia / Hoang, Ny / Selvanayagam, Thanuja / Deflaux, Nicole / Geng, Melissa / Ghaffari, Siavash / Bates, John / Young, Edwin J / Ding, Qiliang / Shum, Carole / D'Abate, Lia / Bradley, Clarrisa A / Rutherford, Annabel / Aguda, Vernie / Apresto, Beverly / Chen, Nan / Desai, Sachin / Du, Xiaoyan / Fong, Matthew L Y / Pullenayegum, Sanjeev / Samler, Kozue / Wang, Ting / Ho, Karen / Paton, Tara / Pereira, Sergio L / Herbrick, Jo-Anne / Wintle, Richard F / Fuerth, Jonathan / Noppornpitak, Juti / Ward, Heather / Magee, Patrick / Al Baz, Ayman / Kajendirarajah, Usanthan / Kapadia, Sharvari / Vlasblom, Jim / Valluri, Monica / Green, Joseph / Seifer, Vicki / Quirbach, Morgan / Rennie, Olivia / Kelley, Elizabeth / Masjedi, Nina / Lord, Catherine / Szego, Michael J / Zawati, Ma'n H / Lang, Michael / Strug, Lisa J / Marshall, Christian R / Costain, Gregory / Calli, Kristina / Iaboni, Alana / Yusuf, Afiqah / Ambrozewicz, Patricia / Gallagher, Louise / Amaral, David G / Brian, Jessica / Elsabbagh, Mayada / Georgiades, Stelios / Messinger, Daniel S / Ozonoff, Sally / Sebat, Jonathan / Sjaarda, Calvin / Smith, Isabel M / Szatmari, Peter / Zwaigenbaum, Lonnie / Kushki, Azadeh / Frazier, Thomas W / Vorstman, Jacob A S / Fakhro, Khalid A / Fernandez, Bridget A / Lewis, M E Suzanne / Weksberg, Rosanna / Fiume, Marc / Yuen, Ryan K C / Anagnostou, Evdokia / Sondheimer, Neal / Glazer, David / Hartley, Dean M / Scherer, Stephen W

Cell

2022 Volume 185, Issue 23, Page(s) 4409–4427.e18

Abstract: Fully understanding autism spectrum disorder (ASD) genetics requires whole-genome sequencing (WGS). We present the latest release of the Autism Speaks MSSNG resource, which includes WGS data from 5,100 individuals with ASD and 6,212 non-ASD parents and ... ...

Abstract	Fully understanding autism spectrum disorder (ASD) genetics requires whole-genome sequencing (WGS). We present the latest release of the Autism Speaks MSSNG resource, which includes WGS data from 5,100 individuals with ASD and 6,212 non-ASD parents and siblings (total n = 11,312). Examining a wide variety of genetic variants in MSSNG and the Simons Simplex Collection (SSC; n = 9,205), we identified ASD-associated rare variants in 718/5,100 individuals with ASD from MSSNG (14.1%) and 350/2,419 from SSC (14.5%). Considering genomic architecture, 52% were nuclear sequence-level variants, 46% were nuclear structural variants (including copy-number variants, inversions, large insertions, uniparental isodisomies, and tandem repeat expansions), and 2% were mitochondrial variants. Our study provides a guidebook for exploring genotype-phenotype correlations in families who carry ASD-associated rare variants and serves as an entry point to the expanded studies required to dissect the etiology in the ∼85% of the ASD population that remain idiopathic.
MeSH term(s)	Humans ; Autism Spectrum Disorder/genetics ; Autistic Disorder ; Genetic Predisposition to Disease ; DNA Copy Number Variations/genetics ; Genomics
Language	English
Publishing date	2022-10-20
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	187009-9
ISSN	1097-4172 ; 0092-8674
ISSN (online)	1097-4172
ISSN	0092-8674
DOI	10.1016/j.cell.2022.10.009
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1167: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 58: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Heritable defects in telomere and mitotic function selectively predispose to sarcomas.

Ballinger, Mandy L / Pattnaik, Swetansu / Mundra, Piyushkumar A / Zaheed, Milita / Rath, Emma / Priestley, Peter / Baber, Jonathan / Ray-Coquard, Isabelle / Isambert, Nicholas / Causeret, Sylvain / van der Graaf, Winette T A / Puri, Ajay / Duffaud, Florence / Le Cesne, Axel / Seddon, Beatrice / Chandrasekar, Coonoor / Schiffman, Joshua D / Brohl, Andrew S / James, Paul A /

Kurtz, Jean-Emmanuel / Penel, Nicolas / Myklebost, Ola / Meza-Zepeda, Leonardo A / Pickett, Hilda / Kansara, Maya / Waddell, Nicola / Kondrashova, Olga / Pearson, John V / Barbour, Andrew P / Li, Shuai / Nguyen, Tuong L / Fatkin, Diane / Graham, Robert M / Giannoulatou, Eleni / Green, Melissa J / Kaplan, Warren / Ravishankar, Shyamsundar / Copty, Joseph / Powell, Joseph E / Cuppen, Edwin / van Eijk, Kristel / Veldink, Jan / Ahn, Jin-Hee / Kim, Jeong Eun / Randall, R Lor / Tucker, Kathy / Judson, Ian / Sarin, Rajiv / Ludwig, Thomas / Genin, Emmanuelle / Deleuze, Jean-Francois / Haber, Michelle / Marshall, Glenn / Cairns, Murray J / Blay, Jean-Yves / Thomas, David M / Tattersall, Martin / Neuhaus, Susan / Lewis, Craig / Carey-Smith, Richard / Wood, David / Porceddu, Sandro / Dickinson, Ian / Thorne, Heather / James, Paul / Cassier, Philippe / Isambert, Nicolas / Ward, Iain / van der Graaf, Winette / Rickar, Rory / Hennig, Ivo / Schiffman, Joshua / Silvestri, Audrey / Zaratzian, Anaiis / Tayao, Michael / Walwyn, Kelly / Niedermayr, Eveline / Mang, Denia / Clark, Richard / Thorpe, Tina / MacDonald, Jessica / Riddell, Kim / Mar, Jasmine / Fennelly, Vicki / Wicht, Allison / Zielony, Belinda / Galligan, Emma / Glavich, Genna / Stoeckert, Johanna / Williams, Lynda / Djandjgava, Lana / Buettner, Iwona / Osinki, Carla / Stephens, Sonya / Rogasik, Muriel / Bouclier, Laure / Girodet, Magali / Charreton, Amandine / Fayet, Yohan / Crasto, Saniya / Sandupatla, Bhanupriya / Yoon, Yeon / Je, Noda / Thompson, Liz / Fowler, Trent / Johnson, Bella / Petrikova, Galina / Hambridge, Thomas / Hutchins, Angela / Bottero, Diego / Scanlon, Deborah / Stokes-Denson, Jo / Génin, Emmanuelle / Campion, Dominique / Dartigues, Jean-François / Deleuze, Jean-François / Lambert, Jean-Charles / Redon, Richard / Grenier-Boley, Benjamin / Letort, Sébastien / Lindenbaum, Pierre / Meyer, Vincent / Quenez, Olivier / Dina, Christian / Bellenguez, Céline / Le Clézio, Camille Charbonnier / Giemza, Joanna / Chatel, Stéphanie / Férec, Claude / Le Marec, Hervé / Letenneur, Luc / Nicolas, Gaël / Rouault, Karen

Science (New York, N.Y.)

2023 Volume 379, Issue 6629, Page(s) 253–260

Abstract: Cancer genetics has to date focused on epithelial malignancies, identifying multiple histotype-specific pathways underlying cancer susceptibility. Sarcomas are rare malignancies predominantly derived from embryonic mesoderm. To identify pathways specific ...

Abstract	Cancer genetics has to date focused on epithelial malignancies, identifying multiple histotype-specific pathways underlying cancer susceptibility. Sarcomas are rare malignancies predominantly derived from embryonic mesoderm. To identify pathways specific to mesenchymal cancers, we performed whole-genome germline sequencing on 1644 sporadic cases and 3205 matched healthy elderly controls. Using an extreme phenotype design, a combined rare-variant burden and ontologic analysis identified two sarcoma-specific pathways involved in mitotic and telomere functions. Variants in centrosome genes are linked to malignant peripheral nerve sheath and gastrointestinal stromal tumors, whereas heritable defects in the shelterin complex link susceptibility to sarcoma, melanoma, and thyroid cancers. These studies indicate a specific role for heritable defects in mitotic and telomere biology in risk of sarcomas.
MeSH term(s)	Humans ; Genetic Predisposition to Disease ; Genetic Variation ; Germ Cells ; Melanoma/genetics ; Mitosis/genetics ; Sarcoma/genetics ; Shelterin Complex/genetics ; Telomere/genetics ; Germ-Line Mutation
Chemical Substances	Shelterin Complex
Language	English
Publishing date	2023-01-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	128410-1
ISSN	1095-9203 ; 0036-8075
ISSN (online)	1095-9203
ISSN	0036-8075
DOI	10.1126/science.abj4784
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 27: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 77: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Genomic architecture of autism from comprehensive whole-genome sequence annotation

Trost, Brett / Thiruvahindrapuram, Bhooma / Chan, Ada J.S. / Engchuan, Worrawat / Higginbotham, Edward J. / Howe, Jennifer L. / Loureiro, Livia O. / Reuter, Miriam S. / Roshandel, Delnaz / Whitney, Joe / Zarrei, Mehdi / Bookman, Matthew / Somerville, Cherith / Shaath, Rulan / Abdi, Mona / Aliyev, Elbay / Patel, Rohan V. / Nalpathamkalam, Thomas / Pellecchia, Giovanna /

Hamdan, Omar / Kaur, Gaganjot / Wang, Zhuozhi / MacDonald, Jeffrey R. / Wei, John / Sung, Wilson W.L. / Lamoureux, Sylvia / Hoang, Ny / Selvanayagam, Thanuja / Deflaux, Nicole / Geng, Melissa / Ghaffari, Siavash / Bates, John / Young, Edwin J. / Ding, Qiliang / Shum, Carole / D'Abate, Lia / Bradley, Clarrisa A. / Rutherford, Annabel / Aguda, Vernie / Apresto, Beverly / Chen, Nan / Desai, Sachin / Du, Xiaoyan / Fong, Matthew L.Y. / Pullenayegum, Sanjeev / Samler, Kozue / Wang, Ting / Ho, Karen / Paton, Tara / Pereira, Sergio L. / Herbrick, Jo-Anne / Wintle, Richard F. / Fuerth, Jonathan / Noppornpitak, Juti / Ward, Heather / Magee, Patrick / Al Baz, Ayman / Kajendirarajah, Usanthan / Kapadia, Sharvari / Vlasblom, Jim / Valluri, Monica / Green, Joseph / Seifer, Vicki / Quirbach, Morgan / Rennie, Olivia / Kelley, Elizabeth / Masjedi, Nina / Lord, Catherine / Szego, Michael J. / Zawati, Ma'n H. / Lang, Michael / Strug, Lisa J. / Marshall, Christian R. / Costain, Gregory / Calli, Kristina / Iaboni, Alana / Yusuf, Afiqah / Ambrozewicz, Patricia / Gallagher, Louise / Amaral, David G. / Brian, Jessica / Elsabbagh, Mayada / Geōrgiadēs, Stelios / Messinger, Daniel S. / Ozonoff, Sally / Sebat, Jonathan / Sjaarda, Calvin / Smith, Isabel M. / Szatmari, Peter / Zwaigenbaum, Lonnie / Kushki, Azadeh / Frazier, Thomas W. / Vorstman, Jacob A.S. / Fakhro, Khalid A. / Fernandez, Bridget A. / Lewis, M.E. Suzanne / Weksberg, Rosanna / Fiume, Marc / Yuen, Ryan K.C. / Anagnostou, Evdokia / Sondheimer, Neal / Glazer, David / Hartley, Dean M. / Scherer, Stephen W.

Cell. 2022 Nov., v. 185, no. 23 p.4409-4427.e18

2022

Abstract	Fully understanding autism spectrum disorder (ASD) genetics requires whole-genome sequencing (WGS). We present the latest release of the Autism Speaks MSSNG resource, which includes WGS data from 5,100 individuals with ASD and 6,212 non-ASD parents and siblings (total n = 11,312). Examining a wide variety of genetic variants in MSSNG and the Simons Simplex Collection (SSC; n = 9,205), we identified ASD-associated rare variants in 718/5,100 individuals with ASD from MSSNG (14.1%) and 350/2,419 from SSC (14.5%). Considering genomic architecture, 52% were nuclear sequence-level variants, 46% were nuclear structural variants (including copy-number variants, inversions, large insertions, uniparental isodisomies, and tandem repeat expansions), and 2% were mitochondrial variants. Our study provides a guidebook for exploring genotype-phenotype correlations in families who carry ASD-associated rare variants and serves as an entry point to the expanded studies required to dissect the etiology in the ∼85% of the ASD population that remain idiopathic.
Keywords	autism ; etiology ; genomics ; genotype-phenotype correlation ; mitochondria ; autism spectrum disorder ; neurodevelopmental disorders ; whole-genome sequencing ; copy-number variation ; structural variation ; rare variants ; polygenic risk scores ; phenotype measures
Language	English
Dates of publication	2022-11
Size	p. 4409-4427.e18.
Publishing place	Elsevier Inc.
Document type	Article ; Online
ZDB-ID	187009-9
ISSN	1097-4172 ; 0092-8674
ISSN (online)	1097-4172
ISSN	0092-8674
DOI	10.1016/j.cell.2022.10.009
Database	NAL-Catalogue (AGRICOLA)

In stock of ZB MED Bonn / Germany

Z 75/702: Show issues
Z 93: Show issues

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾
- See ZB MED holdings
- Order with fees

Article: The Yng1p plant homeodomain finger is a methyl-histone binding module that recognizes lysine 4-methylated histone H3.

Martin, David G E / Baetz, Kristin / Shi, Xiaobing / Walter, Kay L / MacDonald, Vicki E / Wlodarski, Martin J / Gozani, Or / Hieter, Philip / Howe, LeAnn

Molecular and cellular biology

2006 Volume 26, Issue 21, Page(s) 7871–7879

Abstract: The ING (inhibitor of growth) protein family includes a group of homologous nuclear proteins that share a highly conserved plant homeodomain (PHD) finger domain at their carboxyl termini. Members of this family are found in multiprotein complexes that ... ...

Abstract	The ING (inhibitor of growth) protein family includes a group of homologous nuclear proteins that share a highly conserved plant homeodomain (PHD) finger domain at their carboxyl termini. Members of this family are found in multiprotein complexes that posttranslationally modify histones, suggesting that these proteins serve a general role in permitting various enzymatic activities to interact with nucleosomes. There are three members of the ING family in Saccharomyces cerevisiae: Yng1p, Yng2p, and Pho23p. Yng1p is a component of the NuA3 histone acetyltransferase complex and is required for the interaction of NuA3 with chromatin. To gain insight into the function of the ING proteins, we made use of a genetic strategy to identify genes required for the binding of Yng1p to histones. Using the toxicity of YNG1 overexpression as a tool, we showed that Yng1p interacts with the amino-terminal tail of histone H3 and that this interaction can be disrupted by loss of lysine 4 methylation within this tail. Additionally, we mapped the region of Yng1p required for overexpression of toxicity to the PHD finger, showed that this region capable of binding lysine 4-methylated histone H3 in vitro, and demonstrated that mutations of the PHD finger that abolish binding in vitro are no longer toxic in vivo. These results identify a novel function for the Yng1p PHD finger in promoting stabilization of the NuA3 complex at chromatin through recognition of histone H3 lysine 4 methylation.
MeSH term(s)	Animals ; Chromatin/metabolism ; Histone Acetyltransferases ; Histones/genetics ; Histones/metabolism ; Lysine/metabolism ; Methylation ; Protein Binding ; Protein Structure, Tertiary ; Recombinant Fusion Proteins/genetics ; Recombinant Fusion Proteins/metabolism ; Saccharomyces cerevisiae/genetics ; Saccharomyces cerevisiae/metabolism ; Saccharomyces cerevisiae Proteins/genetics ; Saccharomyces cerevisiae Proteins/metabolism
Chemical Substances	Chromatin ; Histones ; Recombinant Fusion Proteins ; Saccharomyces cerevisiae Proteins ; Histone Acetyltransferases (EC 2.3.1.48) ; Yng1 protein, S cerevisiae (EC 2.3.1.48) ; Lysine (K3Z4F929H6)
Language	English
Publishing date	2006-11
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	779397-2
ISSN	1098-5549 ; 0270-7306
ISSN (online)	1098-5549
ISSN	0270-7306
DOI	10.1128/MCB.00573-06
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Full text

In stock of ZB MED Cologne/Königswinter

Zs.A 1666: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: 2023 Canadian Surgery Forum: Sept. 20-23, 2023.

Brière, Raphaëlle / Émond, Marce / Benhamed, Axel / Blanchard, Pierre-Gilles / Drolet, Sébastien / Habashi, Rogeh / Golbon, Bahar / Shellenberger, Jonas / Pasternak, Jesse / Merchant, Shaila / La, Julie / Sawhney, Monakshi / Brogly, Susan / Cadili, Lina / Horkoff, Michael / Ainslie, Scott / Demetrick, Jeffrey / Chai, Brian / Wiseman, Kevin /

Hwang, Hamish / Alhumoud, Zainab / Salem, Amro / Lau, Rebecca / Aw, Katherine / Nessim, Carolyn / Gawad, Nada / Alibhai, Kameela / Towaij, Chelsea / Doan, Danielle / Raîche, Isabelle / Valji, Rahim / Turner, Simon / Balmes, Patricia Nicole / Hameed, S Morad / Tan, Jun Guang Kendric / Wijesuriya, Ruwan / Hew, Nicole Lee Chui / Lund, Matthew / Hawel, Jeffrey / Gregor, Jamie / Leslie, Ken / Lenet, Tori / McIsaac, Daniel / Hallet, Julie / Jerath, Angela / Lalu, Manoj / Nicholls, Stuart / Presseau, Justin / Tinmouth, Alan / Verret, Michael / Wherrett, Christopher / Fergusson, Dean / Martel, Guillaume / Sharma, Sahil / McKechnie, Tyler / Talwar, Gaurav / Patel, Janhavi / Heimann, Luke / Doumouras, Aristithes / Hong, Dennis / Eskicioglu, Cagla / Wang, Christine / Guo, Michael / Huang, Longlong / Sun, Shaun / Davis, Noelle / Wang, Julian / Skulsky, Samuel / Sikora, Lindsey / Son, Hyo Jin / Gee, Denise / Gomez, David / Jung, James / Selvam, Rajajee / Seguin, Nieve / Zhang, Lisa / Lacaille-Ranger, Ariane / Moloo, Husein / Follett, Alicia / Holly / Organ, Michael / Pace, David / Balvardi, Saba / Kaneva, Pepa / Semsar-Kazerooni, Koorosh / Mueller, Carmen / Vassiliou, Melina / Al Mahroos, Mohammed / Fiore, Julio F / Schwartzman, Kevin / Feldman, Liane / Karimuddin, Ahmer / Liu, Gui Ping / Crump, Trafford / Sutherland, Jason / Hickey, Kala / Bonisteel, Erin M / Umali, Jurgienne / Dogar, Ibrahim / Warden, Geoffrey / Boone, Darrell / Mathieson, Alexander / Hogan, Michael / Li, Yiran / Best, Gordon / Leong, Rachel / Wiseman, Sam / Alaoui, Ahmed Amine / Hajjar, Roy / Wassef, Evelyne / Metellus, Danny Sebastien / Dagbert, François / Loungnarath, Rasmy / Ratelle, Richard / Schwenter, Frank / Debroux, Éric / Wassef, Ramses / Gagnon-Konamna, Marianne / Pomp, Alfons / Richard, Carole S / Sebajang, Herawaty / Santos, Manuela M / Shi, Ge / Leung, Regina / Lim, Christina / Knowles, Sarah / Parmar, Simran / Debru, Estifanos / Mohamed, Fardowsa / Anakin, Megan / Lee, Yung / Samarasinghe, Yasith / Khamar, Jigish / Petrisor, Bradley / Yang, Ilun / Mughal, Hanaa N / Bhugio, Mumtaz / Gok, Muhammed A / Khan, Usman A / Fernandes, Alisha R / Spence, Richard / Porter, Geoffrey / Hoogerboord, C Marius / Neumann, Katerina / Pillar, Michal / Manhas, Neraj / Melck, Adrienne / Kazi, Tania / Jessani, Ghazal / Tessier, Léa / Archer, Vicki / Park, Lily / Cohen, Dan / Parpia, Sameer / Bhandari, Mohit / Dionne, Joanna / Bolin, Sara / Afford, Rebecca / Armstrong, Madeleine / Grant, Aaron / Van Koughnett, Julie Ann / Clement, Elizabeth / Lange, Claire / Roshan, Aishwi / Scott, Tracy / Nadeau, Kara / Macmillan, Jennifer / Wilson, Jaime / Deschenes, Madeleine / Nurullah, Aruba / Cahill, Caitlin / Chen, Victoria H / Patterson, Keiko M / Wiseman, Sam M / Wen, Betty / Bhudial, Joshua / Barton, Anise / Lie, Jessica / Park, Chan Mi / Yang, Laiji / Gouskova, Natalia / Kim, Dae Hyun / Morris-Janzen, Dunavan / McLellan, Alastair / Archer, Victoria / Cloutier, Zacharie / Berg, Annie / Wiercioch, Wojtek / Labonté, Joëlle / Bisson, Pascale / Bégin, André / Cheng-Oviedo, Sonia Gabriela / Collin, Yves / Hossain, Intekhab / Ellsmere, James / El-Kefraoui, Charbel / Do, Uyen / Miller, Andrew / Kouyoumdjian, Araz / Cui, David / Khorasani, Elahe / Landry, Tara / Amar-Zifkin, Alexandre / Lee, Lawrence / Fiore, Julio / Au, Tran Michelle / Oppenheimer, Mark / Logsetty, Sarvesh / AlShammari, Raghad / AlAbri, Mohammad / Brown, Carl / Raval, Manoj J / Phang, Paul Terry / Bird, Samantha / Baig, Zarrukh / Abu-Omar, Nawaf / Gill, Dilip / Suresh, Soumiya / Ginther, Nathan / Karpinski, Marta / Ghuman, Amandeep / Malik, Peter R A / Zabolotniuk, Taryn / Mashal, Sarah / Boulanger, Nathalie / Watt, Larry / Razek, Tarek / Fata, Paola / Grushka, Jeremy / Wong, Evan G / Landry, Maxim / Mackey, Sarah / Fairbridge, Nicholas / Greene, Alison / Borgoankar, Mark / Kim, Cullen / DeCarvalho, Diana / Wigen, Robin / Walser, Emily / Davidson, Jacob / Dorward, Michael / Muszynski, Leanne / Dann, Celia / Seemann, Natashia / Lam, Jennifer / Harding, Kaitlyn / Lowik, A J / Guinard, Caroline / Ma, Odelle / Mocanu, Valentin / Lin, Andrea / Karmali, Shahzeer / Bigam, David / Greaves, Grant / Parker, Brent / Nguyen, Vu / Ahmed, Azim / Yee, Belinda / Perren, Joël / Norman, Mathew / Grey, Morgan / Perini, Rafael / Jowhari, Fahd / Bak, Adrian / Drung, Jeremy / Allen, Laura / Wiseman, Daniele / Moffat, Bradley / Lee, Jeremy K H / McGuire, Catherine / Tudorache, Mihaela / Park, Lily J / Borges, Flavia K / Nenshi, Rahima / Jacka, Michael / Heels-Ansdell, Diane / Simunovic, Marko / Bogach, Jessica / Serrano, Pablo E / Thabane, Lehana / Devereaux, P J / Farooq, Sauleha / Lester, Erica / Kung, Janice / Bradley, Nori / Ahn, San / Prince, Nicole / Cheng-Boivin, Olivia / Wang, Harry / Quartermain, Liam / Tan, Sherry / Shamess, Jennifer / Simard, Mathilde / Vigil, Humberto / Hanna, Mary / Azam, Riordan / Ko, Gary / Zhu, Mayanne / Raveendran, Yanuga / Lam, Christine / Tang, Janet / Bajwa, Amrit / Englesakis, Marina / Reel, Emma / Cleland, Jordan / Snell, Laura / Lorello, Gianni / Cil, Tulin / Ahn, Hilalion San / Dube, Catherine / Smith, David / Leclerc, Alexie / Rostom, Alaa / Calo, Natalia / Thavorn, Kednapa / Laplante, Simon / Liu, Louis / Khan, Nadia / Okrainec, Allan / Bruyninx, Gladys / Georgescu, Ilinca / Khokhotva, Vladislav / Yang, Shuling / Spoyalo, Karina / Rebello, Thais Ayres / Chhipi-Shrestha, Gyan / Mayson, Kelly / Sadiq, Rehan / Hewage, Kasun / MacNeill, Andrea / Muncner, Susan / Li, Mo Yu / Mihajlovic, Igor / Dykstra, Mark / Snelgrove, Ryan / Wang, Haili / Schweitzer, Christina / Garcha, Ivneet / Jogiat, Uzair / Baracos, Vickie / Turner, Simon R / Eurich, Dean / Filafilo, Heather / Rouhi, Armin / Bédard, Alexandre / Bédard, Eric L R / Patel, Yogita S / Alaichi, Jacob A / Agzarian, John / Hanna, Wael C / Provost, Esther / Shayegan, Bobby / Adili, Anthony / Mistry, Nikkita / Gatti, Anthony A / Farrokhyar, Forough / Xie, Feng / Sullivan, Kerrie A / Liberman, Moishe / Gonzalez, Anne V / Nayak, Rahul / Yasufuku, Kazuhiro / Cross, Sam / Haché, Pier-Luc / Galvaing, Geraud / Simard, Serge / Grégoire, Jocelyn / Bussières, Jean / Lacasse, Yves / Sassi, Sami / Champagne, Catherine / Laliberté, Anne-Sophie / Jeong, Jin Yong / Wilson, Hillary / Blakely, Pam / Dang, Jerry / Sun, Warren / Wong, Clarence / Hakim, Suhail Yaqoob / Azizi, Samim / El-Menyar, Ayman / Rizoli, Sandro / Al-Thani, Hassan / French, Daniel / Li, Chao / Gossen, Shiloh / Bailey, Jon / Tibbo, Phil / Crocker, Candice / Bondzi-Simpson, Adom / Ribeiro, Tiago / Kidane, Biniam / Ko, Michael / Coburn, Natalie / Kulkarni, Girish / Ramzee, Ahmed Faidh / Afifi, Ibrahim / Alani, Mushrek / Chughtai, Talat / Huo, Bright / Manos, Daria / Xu, Zhaolin / Kontouli, Katerina-Maria / Chun, Samuel / Fris, John / Wallace, Allison M R / French, Daniel G / Giffin, Catherine / Dayan, Gabriel / Farivar, Alexander / Weessies, Cara / Robinson, Madeline / Bednarek, Leeann / Buduhan, Gordon / Liu, Richard / Tan, Lawrence / Srinathan, Sadeesh K / Nasralla, Awrad / Safieddine, Najib / Gazala, Sayf / Simone, Carmine / Ahmadi, Negar / Hilzenrat, Roy / Blitz, Maurice / Deen, Shaun / Humer, Michael / Jugnauth, Anand / Kerr, Laura / Sun, Simon / Browne, Ikennah / Patel, Yogita / Hanna, Wael / Loshusan, Brandon / Shamsil, Arefin / Naish, Michael D / Qiabi, Mehdi / Patel, Rajni / Malthaner, Richard / Pooja, Patel / Roberto, Ribeiro / Greg, Hirsch / Daniel, French / Huynh, Caroline / Sharma, Sohat / Vieira, Arthur / Jain, Fagun / Lee, Yejun / Mousa-Doust, Dorsa / Costa, Jonice / Mezei, Michelle / Chapman, Kristine / Briemberg, Hannah / Jack, Kristin / Grant, Kyle / Choi, James / Yee, John / McGuire, Anna L / Abdul, Sami Aftab / Khazoom, Francois / Gilbert, Sebastien / Sundaresan, Sudhir / Jones, Daniel / Seely, Andrew J E / Villeneuve, Patrick J / Maziak, Donna E / Pigeon, Claudie-Anne / Frigault, Jonathan / Roy, Ève-Marie / Bujold-Pitre, Kristopher / Courval, Valérie / Tessier, Lea / Gangam, Nirupa / Lee, Jay / Patel, Ashaka / Ichhpuniani, Simarpreet / Elder, Geoffrey / Chen, Andrew / Logie, Kathleen / Benko, Randy / Castelo, Matthew / Paszat, Lawrence / Hansen, Bettina / Scheer, Adena / Faught, Neil / Nguyen, Lena / Baxter, Nancy / Wu, Kathy / Passos, Edward / Sachdeva, Anjali / Fei, Linda Y N / Caycedo, Antonio / Patel, Sunil / Popa, Teodora / Boudreau, Lee / Grin, Andrea / Wang, Tao / Phang, Terry / Raval, Manoj / Candy, Sydney / Nanda, Kareena / Li, Christine / Kroeker, Karen / Roy, Haven / Helewa, Ramzi M / Johnson, Garrett / Singh, Harminder / Hyun, Eric / Moffatt, Dana / Vergis, Ashley / Balmes, Patricia / Liu, Jerry / Webber, Sandra / Shariff, Farhana / Hochman, Dave / Park, Jason / Robitaille, Stephan / Wang, Anna / Maalouf, Michael / Alali, Naser / Elhaj, Hiba / Liberman, Sender / Charlebois, Patrick / Stein, Barry / Hu, Richard / Williams, Lara / Musselman, Reilly / Lemke, Maddy / Samarasinghe, Nadeesha / Vogt, Kelly / Brackstone, Muriel / Zwiep, Terry / Alam, Armaghan / Ghuman, Anu / James, Nicholas / Laczko, Dora / Lee, Stephanie / Sritharan, Praveen / Hershorn, Olivia / Phang, P Terry / Chen, Alex / Boutros, Marylise / Caminsky, Natasha / Dumitra, Teodora / Faris-Sabboobeh, Sarah / Demian, Marie / Rigas, Georgia / Monton, Olivia / Smith, Allister / Moon, Jeongyoon / Garfinkle, Richard / Vasilevsky, Carol-Ann / Rajabiyazdi, Fateme / Courage, Emily / LeBlanc, Danielle / Benesch, Matthew / Hartwig, Katia / Armstrong, Casey / Engelbrecht, Reniel / Fagan, Mitchell / Borgaonkar, Mark / Shanahan, Jessica / Salama, Ebram / Arsenault, Mylène / Leon, Nathalie / Loiselle, Carmen / Rajabiyazdi, Fatemeh / Brennan, Kelly / Rai, Mandip / Farooq, Ameer / McClintock, Chad / Kong, Weidong / Boukhili, Neyla / Paradis, Tiffany / Liberman, A Sender / Feldman, Liane S / Abner, Deborah / Alam, Tarik / Beyer, Elaine / Evans, Michele / Hill, Mary / Johnston, Debra / Lohnes, Karla / Menard, Svea / Pitcher, Nicole / Sair, Kelly / Smith, Bev / Yarjau, Bonita / LeBlanc, Kimberly / Karimuddin, Ahmer A / Brown, Carl J / MacDonell, Karen / Harvey, Alexandra / Mckechnie, Tyler / Matta, Mirna / Baker, Laura / Hopkins, Jessica / Rochon, Ryan / Buie, Donald / MacLean, Anthony / Macdonald, Hugh / Wiseman, Vanessa / Booth, Chris / Hann, Tim / Ricci, Alessandro / Kakkar, Rohan / Gonzalez, Emmanuel / Fragoso, Gabriela / Oliero, Manon / Rendos, Hervé Vennin / Djediai, Souad / Cuisiniere, Thibault / Laplante, Patrick / Gerkins, Claire / Ajayi, Ayodeji Samuel / Diop, Khoudia / Taleb, Nassima / Thérien, Sophie / Schampaert, Frédéricke / Alratrout, Hefzi / Cailhier, Jean-François / Routy, Bertrand / Annabi, Borhane / Brereton, Nicholas J B / Richard, Carole / Gimon, Tamara / MacRae, Helen / de Buck van Overstraeten, Anthony / Brar, Mantaj / Chadi, Sami / Kennedy, Erin / Rashanov, Pavel / Alsayari, Rehab / Calvé, Annie / Cuisinière, Thibault / Debroux, Eric / Schmocker, Selina / Stotland, Peter / Jhaveri, Kartik / Kirsch, Richard / Alnajem, Hafssah / Alibrahim, Huseen / Giundi, Christian / Munir, Haroon / Safar, Ali / Sabboobeh, Sarah / Holland, Jessica / Abtahi, Sean / Chhor, Allison / Caminsky, Natasha Grace / Moon, Jenny Jeongyoon / Marinescu, Daniel / Pang, Allison / Al-Abri, Mohammed / Gee, Elliott / Morena, Nina / Ben-Zvi, Libby / Hayman, Victoria / Hou, Mary / Nguyen, Diana / Rentschler, Carrie A / Meguerditchian, Ari N / Mir, Zuhaib / Fei, Linda / McKeown, Sandra / Dinchong, Rachelle / Cofie, Nicholas / Dalgarno, Nancy / Cheifetz, Rona / Jaffer, Alisha / Cullinane, Carolyn / Feeney, Gerard / Jalali, Amirhossein / Merrigan, Anne / Baban, Chwanrow / Buckley, Juliette / Tormey, Shona / Wu, Rongrong / Takabe, Kazuaki / O'Brien, Shalana / Kazazian, Karineh / Abdalaty, Ali Hosni / Brezden, Christine / Burkes, Ron / Chen, Eric / Govindarajan, Anand / Jang, Raymond / Lukovic, Jelena / Mesci, Aruz / Quereshy, Fayez / Swallow, Carol / Marini, Wanda / Zheng, Weiyue / Murakami, Kiichi / Ohashi, Pamela / Reedijk, Michael / Ivankovic, Victoria / Han, Lewis / Gresham, Louise / Mallick, Ranjeeta / Auer, Rebecca / Fontebasso, Adam / Lee, Alex / Bernard-Bedard, Ericka / Wong, Boaz / Li, Heidi / Grose, Elysia / Brandts-Longtin, Olivier / Aw, Katie / Abed, Ahmad / Stevenson, James / Sheikh, Rahat / Chen, Richard / Johnson-Obaseki, Stephanie / Hennessey, Rachel Liu / Meneghetti, Adam T / Bildersheim, Michael / Bouchard-Fortier, Antoine / Nelson, Gregg / Mack, Lloyd / Ghasemi, Farhad / Naeini, Mahtab Malekian / Parsyan, Armen / Kaur, Yuvreet / Covelli, Andrea / Elimova, Elena / Panov, Elan / Brierley, James / Burnett, Bev / Eom, Ashley / Kirkwood, David / Hodgson, Nicole / Whelan, Timothy / Levine, Mark / Parvez, Elena / Ng, Deanna / Lee, Kiera / Lu, Yi Qing / Kim, Dae Kyum / Magalhaes, Marco / Grigor, Emma / Arnaout, Angel / Zhang, Jing / Yee, Elliott K / Look Hong, Nicole J / Wright, Frances C / Gandhi, Sonal / Jerzak, Katarzyna J / Eisen, Andrea / Roberts, Amanda / Ben Lustig, Daniel / Quan, May Lynn / Phan, Tien / Cao, Jeff / Bayley, Conrad / Watanabe, Akie / Yao, Susan / Prisman, Eitan / Groot, Gary / Mitmaker, Elliot / Walker, Ross / Wu, Jonn / Lai, Chi Kien / Eskander, Antoine / Wasserman, Jonathan / Mercier, Frederic / Roth, Kathryn / Gill, Sabrina / Villamil, Carlos / Goldstein, David / Munro, Vicki / Pathak, Alok / Lee, Debon / Nguyen, Anne / Rajendran, Luckshi / Claasen, Marco / Ivanics, Tommy / Selzner, Nazia / McGilvray, Ian / Cattral, Mark / Ghanekar, Anand / Moulton, Carol-Anne / Reichman, Trevor / Shwaartz, Chaya / Metser, Ur / Winter, Erin / Gallinger, Steven / Sapisochin, Gonzalo / Glinka, Juan / Waugh, Evelyn / Skaro, Anton / Tang, Epharaim / Charbonneau, Janyssa / Brind'Amour, Alexandre / Turgeon, Alexis F / O'Connor, Sarah / Couture, Thomas / Wang, Yifan / Yoshino, Osamu / Driedger, Michael / Beckman, Michael / Vrochides, Dionisios / Martinie, John / Alabduljabbar, Abdulrahman / Aali, Maral / Lightfoot, Christopher / Gala-Lopez, Boris / Labelle, Maud / D'Aragon, Frédérick / Hirpara, Dhruvin / Irish, Jonathan / Rashid, Mohammed / Martin, Tharsiya / Zhu, Alice / McKnight, Leah / Hunter, Amber / Jayaraman, Shiva / Wei, Alice / Wright, Frances / Mallette, Katlin / Elnahas, Ahmad / Alkhamesi, Nawar / Schlachta, Christopher / Tang, Ephraim / Punnen, Subin / Zhong, Jade / Yang, Yuwei / Streith, Lucas / Yu, Jordan / Chung, Stephen / Kim, Peter / Chartier-Plante, Stephanie / Segedi, Maja / Bleszynski, Michael / White, Molly / Tsang, Melanie E / Lam-Tin-Cheung, Kimberley / Tsang, Melanie / Greene, Brittany / Pouramin, Panthea / Allen, Susan / Evan Nelson, David / Walsh, Mark / Côté, Julien / Rebolledo, Rolando / Borie, Mélanie / Menaouar, Ahmed / Landry, Carolyne / Plasse, Marylène / Létourneau, Richard / Dagenais, Michel / Rong, Zhixia / Roy, André / Beaudry-Simoneau, Eve / Vandenbroucke-Menu, Franck / Lapointe, Réal / Ferraro, Pasquale / Sarkissian, Shant Der / Noiseux, Nicolas / Turcotte, Simon / Haddad, Yara / Bernard, Antoine / Lafortune, Clara / Brassard, Nathalie / Roy, Annie / Perreault, Claude / Mayer, Gaétan / Marcinkiewicz, Mieczyslaw / Mbikay, Majambu / Chrétien, Michel / Sinclair, Lynne / Shin, Elizabeth / Engelage, Crystal / Muaddi, Hala / Flemming, Jennifer / Dawson, Laura / O'Kane, Grainne / Feld, Jordan / Cleary, Sean / Hamel, Anthonie / Marcoux, Camille / Ngo, Thanh-Quan Philips / Deshaies, Isabelle / Mansouri, Sarah / Amhis, Nawal / Léveillé, Maxime / Lawson, Christine / Achard, Carol / Ilkow, Carolina / Tai, Lee-Hwa / Griffiths, Christopher / D'Souza, Daniel / Rodriguez, Felipe / Panton, O Neely M / Chiu, Chieh Jack / Henao, Oscar / Netto, Fernando Spencer / Mainprize, Marguerite / Jatana, Sukhdeep / Verhoeff, Kevin / Birch, Daniel / Switzer, Noah / Hetherington, Alexandra / Al-Ghaithi, Najla / Vourtzoumis, Phil / Demyttenaere, Sebastian / Court, Olivier / Andalib, Amin / Madsen, Karen / Wu, Ted / He, Wenjing / Hardy, Krista / Zmudzinski, Marta / Daenick, Felica / Linton, Janice / Fowler-Woods, Melinda / Fowler-Woods, Amanda / Shingoose, Geraldine / Molnar, Amber / Nguyen, Francis / Schneider, Romano / Fecso, Andras B / Sharma, Priya / Maeda, Azusa / Jackson, Timothy / McLean, Cheynne / MacVicar, Sarah / McLennan, Steffane / Purich, Kieran / Birch, Daniel W / Switzer, Noah J / Jeffery, Lisa / Ryley, Alexis / Schellenberg, Morgan / Owattanapanich, Natthida / Emigh, Brent / Nichols, Chance / Dilday, Joshua / Ugarte, Chaiss / Onogawa, Atsushi / Matsushima, Kazuhide / Martin, Matthew J / Inaba, Kenji / Shapiro, Doug / Im, Daniel / Lam, Lydia / Rezende-Neto, Joao / Lemke, Madeline / Leeper, William / Walser, Eric / Bateni, Sarah / Barabash, Victoria / Barr, Austin / Chan, Wing / Warraich, Ahmed / Gillman, Lawrence / Ziesmann, Markus / Momic, Jovana / Yassin, Nouf / Kim, Mella / Makish, Amy / Smith, Shane / Ball, Ian / Moffat, Brad / Parry, Neil / Kroeker, Jenna / Evans, David / Fansia, Nahal / Notik, Chana / Coyle, Guire / Seben, David / Smith, Jaiden / Tanenbaum, Brandy / Freedman, Corey / Nathens, Avery / Fowler, Robert / Patel, Prachikumari / Elrick, Tim / Ewing, Meghan / Di Marco, Steven / Engels, Paul / Di Sante, Emily / Vincent, Jessica / Tsiplova, Kate / El-Sayes, Abdullah / Connell, Matthew / Klooster, Amanda / Beck, Jenna / Strickland, Matt / Anantha, Ram / Groszman, Lilly / Caminsky, Natasha G / Livergant, Rachel / McDonald, Brooke / Binda, Catherine / Luthra, Shreya / Ebert, Nicole / Falk, Ryan / Joos, Emilie

Canadian journal of surgery. Journal canadien de chirurgie

2023 Volume 66, Issue 6 Suppl 1, Page(s) S54–S136

Language	English
Publishing date	2023-12-13
Publishing country	Canada
Document type	Journal Article
ZDB-ID	410651-9
ISSN	1488-2310 ; 0008-428X
ISSN (online)	1488-2310
ISSN	0008-428X
DOI	10.1503/cjs.014223
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 221: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: US immigration order strikes against biotech.

Levin, Jeremy M / Holtzman, Steven H / Maraganore, John / Hastings, Paul J / Cohen, Ron / Dahiyat, Bassil / Adams, Julian / Adams, Chris / Ahrens, Brett / Albers, Jeff / Aspinall, Mara G / Audia, James E / Babler, Martin / Barrett, Peter / Barry, Zoe / Bermingham, Nessan / Bloch, Stephen / Blum, Robert I / Bolno, Paul B /

Bonney, Michael W / Booth, Bruce / Bradbury, Daniel M / Brauer, Steven K / Byers, Brook / Cagnoni, Pablo J / Cali, Brian M / Ciechanover, Isaac / Clark, Chip / Clayman, Michael D / Cleland, Jeff L / Cobb, Paula / Cooper, Ron / Currie, Mark G / Diekman, John / Dobmeier, Eric L / Doerfler, Doug / Donley, Elizabeth Lr / Dunsire, Deborah / During, Matthew / Eckstein, Jens W / Elenko, Eric / Exter, Neil A / Fleming, Jonathan J / Flesher, Gregory J / Formela, Jean-Francois / Forrester, Robert / Francois, Cedric / Franklin, Heather / Freeman, Mason W / Furst, Howard / Gage, Leonard Patrick / Galakatos, Nicholas / Gallagher, Brian M / Geraghty, James A / Gill, Simba / Goeddel, David V / Goldsmith, Mark A / Gowen, Maxine / Goyal, Vikas / Graney, Tom / Grayzel, David / Greene, Barry / Grint, Paul / Gutierrez-Ramos, J C / Haney, Bill / Ha-Ngoc, Tuan / Harris, Tim / Hasnain, Faheem / Hata, Yujiro Steve / Hecht, Peter / Henshaw, Leslie / Heyman, Rich / Hoppenot, Herve / Horvitz, H Robert / Hughes, Thomas E / Hutton, Wende S / Isaacs, Stephen T / Jenkins, Annalisa / Jonker, Jeff / Kaplan, Jeff / Karsen, Perry / Keiper, Jeb / Kim, Jean / Kindler, Jeff / King, Rachel / King, Vanessa / Kjellson, Nina / Koenig, Scott / Koenig, Gerhard / Kolchinsky, Peter / Laikind, Paul / Langer, Robert Bob / Lee, John J / Leff, Jonathan S / Leicher, Bruce A / Leschly, Nick / Levin, Andrew / Levin, Mark / Levine, Arnold J / Levy, Alan / Liu, David R / Lodish, Harvey F / Lopatin, Uri / Love, Ted W / Macdonald, Guy / Maderis, Gail J / Mahadevia, Ankit / Mahanthappa, Nagesh K / Martin, Joel F / Martin, Alex / Martucci, W Eddie / McArthur, James G / McCann, Corey M / McCarthy, Sean A / McDonough, C Geoffrey / Mendlein, John / Miller, Larry / Miralles, Diego / Moch, Kenneth I / More, Bob / Myers, Andrew G / Narachi, Michael A / Nashat, Amir / Nelson, Wendy / Newell, William J / Olle, Bernat / Osborn, John E / Owens, Julia C / Pande, Atul / Papadopoulos, Stelios / Parker, H Stewart / Parmar, Kush M / Patterson, Matthew R / Paul, Steve M / Perez, Rob / Perry, Matthew / Pfeffer, Cary G / Powell, Mike / Pruzanski, Mark / Purcell, Dennis J / Rakhit, Amit / Ramamoorthi, Kartik / Rastetter, William / Rawcliffe, Adrian Ad / Reid, Laurence E / Renaud, Ron C / Rhodes, Jason P / Rieflin, William J / Robins, Chad / Rocklage, Scott M / Rosenblatt, Michael / Rosin, Jonathan G / Rutter, William J / Saha, Saurabh / Samuels, Camille / Sato, Vicki L / Scangos, George / Scarlett, John A / Schenkein, David / Schreiber, Stuart L / Schwab, Andrew / Sekhri, Paul / Shah, Rajeev / Shenk, Thomas / Siegall, Clay B / Simon, Nick J / Simonian, Nancy / Stein, Jeff / Su, Michael / Szela, Mary T / Taglietti, Marco / Tandon, Nina / Termeer, Henri / Thornberry, Nancy A / Tolar, Martin / Ulevitch, Richard / Vaishnaw, Akshay K / VanLent, Anne / Varsavsky, Martin / Vlasuk, George P / Vounatsos, Michel / Waksal, Samuel G / Warma, Neil / Watts, Ryan J / Werber, Yaron / Westphal, Christoph / Wierenga, Wendell / Williams, Doug E / Williams, Lewis Rusty / Xanthopoulos, Kleanthis G / Zohar, Daphne / Zweifach, Sandford Sandy

Nature biotechnology

2017 Volume 35, Issue 3, Page(s) 204–206

Language	English
Publishing date	2017-03-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	1311932-1
ISSN	1546-1696 ; 1087-0156
ISSN (online)	1546-1696
ISSN	1087-0156
DOI	10.1038/nbt.3824
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 2167: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 137: Show issues
Zs.MG 43: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

To top

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Bonn / Germany

Order via subito

Inter-library loan at ZB MED

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito