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  1. Book ; Online ; E-Book: Laparoscopic colon surgery

    Kouraklis, Gregory / Matsiota, Eugenia

    milestones, education, & best practice

    2021  

    Abstract: This book is the structured, comprehensive work of experienced surgeons and constitutes the condensed and succinct epitome of knowledge and guidance for those interested in Laparoscopic Colon Surgery (LCS), focusing only on colon laparoscopy. The ... ...

    Author's details Gregory Kouraklis, Eugenia (Jenny) Matsiota, editors
    Abstract This book is the structured, comprehensive work of experienced surgeons and constitutes the condensed and succinct epitome of knowledge and guidance for those interested in Laparoscopic Colon Surgery (LCS), focusing only on colon laparoscopy. The milestones in LCS are presented offering valuable background information about the evolution of LCS throughout the years and presenting how it still has a limited application, no matter the need for minimal invasive, fast-track, surgical procedures that can offer better quality to patients and less cost for any healthcare system. The book aims to highlight the preferred diagnostic procedures, the right methods for the efficient and rational selection of patients, the choice of the best surgical techniques and treatments, and the best management of post-operative complications for an early discharge. It provides adequate information to the surgeons or the surgical residents interested in LCS about how to select, what to avoid, what instruments to use, what techniques to follow, how the evaluation of patient’s anatomy can lead to better surgical planning, and the add-on of robotic colon surgery in the quality of patients’ life. Moreover, the book provides information about the most efficient anaesthesia adequate for LCS; information that most books of its kind do not include. Finally, the book provides excellent information about the best education and practices to be followed in LCS; something of special importance after considering the level of difficulty associated with LCS and the high conversion rate compared to other laparoscopic procedures. Although the primary focus of this book are surgeons (LCS, GI, General) and surgical residents, the content still can offer valuable information to these healthcare leaders who are interested in understanding the milestones and benefits of the right model of education, and the best practices related to LCS. .
    Keywords Colon (Anatomy)/Endoscopic surgery ; Laparoscopic surgery
    Subject code 617.5547
    Language English
    Size 1 online resource (XV, 165 p. 72 illus., 68 illus. in color.)
    Edition 1st ed. 2021.
    Publisher Springer
    Publishing place Cham, Switzerland
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 3-030-56728-1 ; 3-030-56727-3 ; 978-3-030-56728-6 ; 978-3-030-56727-9
    DOI 10.1007/978-3-030-56728-6
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: The Prognostic Value of G1 Cyclins, p21 and Rb Protein in Patients With Colon Cancer.

    Palaiologos, Pantelis / Chrysikos, Dimosthenis / Theocharis, Stamatios / Kouraklis, Gregory

    Anticancer research

    2019  Volume 39, Issue 11, Page(s) 6291–6297

    Abstract: Background/aim: Cyclins D1 and E play different roles in the cell cycle. Cyclin E promotes chromosome instability, whereas cyclin D1 regulates apoptosis of cells. This study evaluated the prognostic significance of G1 cyclins, p21 and pRb in tumor ... ...

    Abstract Background/aim: Cyclins D1 and E play different roles in the cell cycle. Cyclin E promotes chromosome instability, whereas cyclin D1 regulates apoptosis of cells. This study evaluated the prognostic significance of G1 cyclins, p21 and pRb in tumor proliferation.
    Patients and methods: A total of 102 patients with colon cancer were operated on and staged according to TNM. Follow-up was 2 to 68 months (mean 38.3±16.7 months). Expression of cyclin E and D1 were evaluated using immunohistochemistry.
    Results: Levels of cyclin E expression were correlated with cyclin D1 expression (p=0.038), p21 expression (p=0.047), and pRb expression (p=0.004). The 5-year survival rate along with prognosis of patients with advanced stage (III, IV) colon cancer and cyclin D1 positive tumors, were significantly worse (p=0.009). Statistically significant association was observed between tumor proliferative capacity Ki-67, cyclin D1 (p=0.009), pRb (p=0.031) and p21 (p=0.050).
    Conclusion: Cyclin D1 is highly expressed in advanced stage colon cancer patients, implying a potential prognostic value.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Colonic Neoplasms/chemistry ; Colonic Neoplasms/metabolism ; Colonic Neoplasms/mortality ; Colonic Neoplasms/pathology ; Cyclin D1/analysis ; Cyclin D1/metabolism ; Cyclin E/analysis ; Cyclin E/metabolism ; Cyclin-Dependent Kinase Inhibitor p21/analysis ; Cyclin-Dependent Kinase Inhibitor p21/metabolism ; Female ; Follow-Up Studies ; G1 Phase ; Humans ; Ki-67 Antigen/analysis ; Ki-67 Antigen/metabolism ; Male ; Middle Aged ; Neoplasm Proteins/metabolism ; Oncogene Proteins/analysis ; Oncogene Proteins/metabolism ; Prognosis ; Retinoblastoma Protein/analysis ; Retinoblastoma Protein/metabolism ; Survival Rate
    Chemical Substances CCND1 protein, human ; CCNE1 protein, human ; CDKN1A protein, human ; Cyclin E ; Cyclin-Dependent Kinase Inhibitor p21 ; Ki-67 Antigen ; Neoplasm Proteins ; Oncogene Proteins ; Retinoblastoma Protein ; Cyclin D1 (136601-57-5)
    Language English
    Publishing date 2019-11-08
    Publishing country Greece
    Document type Journal Article
    ZDB-ID 604549-2
    ISSN 1791-7530 ; 0250-7005
    ISSN (online) 1791-7530
    ISSN 0250-7005
    DOI 10.21873/anticanres.13839
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: HDAC inhibitors in leukemia: current status and perspectives.

    Kouraklis, Gregory

    Leukemia research

    2009  Volume 33, Issue 2, Page(s) 207–208

    MeSH term(s) Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Cell Proliferation/drug effects ; DNA (Cytosine-5-)-Methyltransferase 1 ; DNA (Cytosine-5-)-Methyltransferases/antagonists & inhibitors ; Enzyme Inhibitors/therapeutic use ; Epigenesis, Genetic/drug effects ; Histone Deacetylase Inhibitors ; Humans ; Leukemia/drug therapy ; Leukemia/pathology
    Chemical Substances Enzyme Inhibitors ; Histone Deacetylase Inhibitors ; DNA (Cytosine-5-)-Methyltransferase 1 (EC 2.1.1.37) ; DNA (Cytosine-5-)-Methyltransferases (EC 2.1.1.37)
    Language English
    Publishing date 2009-02
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 752396-8
    ISSN 1873-5835 ; 0145-2126
    ISSN (online) 1873-5835
    ISSN 0145-2126
    DOI 10.1016/j.leukres.2008.07.022
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Insulin-like growth factor-I and wound healing, a potential answer to non-healing wounds: A systematic review of the literature and future perspectives.

    Garoufalia, Zoe / Papadopetraki, Argyro / Karatza, Elli / Vardakostas, Dimitrios / Philippou, Anastassios / Kouraklis, Gregory / Mantas, Dimitrios

    Biomedical reports

    2021  Volume 15, Issue 2, Page(s) 66

    Abstract: The induction of wound healing by insulin-like growth factor-I (IGF-I) has been demonstrated in several animal studies; however, there are disproportionately fewer studies assessing its value in humans. The aim of the present review is to provide a ... ...

    Abstract The induction of wound healing by insulin-like growth factor-I (IGF-I) has been demonstrated in several animal studies; however, there are disproportionately fewer studies assessing its value in humans. The aim of the present review is to provide a comprehensive summary of all the available evidence pertaining to the effects of IGF-I administration on the process of wound anaplasias, both in human tissues
    Language English
    Publishing date 2021-06-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 2763624-0
    ISSN 2049-9442 ; 2049-9434
    ISSN (online) 2049-9442
    ISSN 2049-9434
    DOI 10.3892/br.2021.1442
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Surgical dilemmas in the management of colorectal liver metastases: The role of timing.

    Dimitroulis, Dimitrios / Kouraklis, Gregory

    World journal of gastroenterology

    2016  Volume 22, Issue 21, Page(s) 4963–4965

    Abstract: Colorectal cancer (CRC) is an emerging health problem in the Western World both for its raising tendency as well as for its metastatic potential. Almost half of the patients with CRC will develop liver metastases during the course of their disease. The ... ...

    Abstract Colorectal cancer (CRC) is an emerging health problem in the Western World both for its raising tendency as well as for its metastatic potential. Almost half of the patients with CRC will develop liver metastases during the course of their disease. The liver surgeon dealing with colorectal liver metastases faces several surgical dilemmas especially in the setting of the timing of operation. Synchronous resectable metastases should be treated prior or after induction chemotherapy? Furthermore in the case of synchronous colorectal liver metastases which organ should we first deal with, the liver or the colon? All these questions are set in the editorial and impulse for further investigation is put focusing on multidisciplinary approach and individualization of treatment modalities.
    MeSH term(s) Chemotherapy, Adjuvant ; Colectomy/adverse effects ; Colorectal Neoplasms/pathology ; Colorectal Neoplasms/surgery ; Hepatectomy/adverse effects ; Humans ; Liver Neoplasms/secondary ; Liver Neoplasms/surgery ; Neoadjuvant Therapy ; Patient Selection ; Postoperative Complications/etiology ; Risk Factors ; Time-to-Treatment ; Treatment Outcome ; Tumor Burden
    Language English
    Publishing date 2016-06-07
    Publishing country United States
    Document type Editorial
    ZDB-ID 2185929-2
    ISSN 2219-2840 ; 1007-9327
    ISSN (online) 2219-2840
    ISSN 1007-9327
    DOI 10.3748/wjg.v22.i21.4963
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Operating on Jehovah's Witnesses: A Challenging Surgical Issue.

    Garoufalia, Zoe / Aggelis, Apostolos / Antoniou, Efstathios A / Kouraklis, Gregory / Vagianos, Costantine

    Journal of religion and health

    2021  Volume 61, Issue 3, Page(s) 2447–2457

    Abstract: Blood transfusion is often utilized in surgery. Greece is the second-highest consumer of blood components in Europe. It has been shown that at least half of all transfusions are unnecessary and could be avoided. Jehovah's Witnesses (JWs) are a Christian ... ...

    Abstract Blood transfusion is often utilized in surgery. Greece is the second-highest consumer of blood components in Europe. It has been shown that at least half of all transfusions are unnecessary and could be avoided. Jehovah's Witnesses (JWs) are a Christian religion that do not accept transfusion of whole blood or the four primary components of blood-namely, red blood cells, white blood cells, platelets, and plasma. This a retrospective study from September of 2015 to January of 2018, analyzing all JWs who underwent an elective operation at the Second Department of Propaedeutic Surgery in Laiko University Hospital. Twenty-nine (Rogers et al. in NCCN Guidelines Version 2.2014 Cancer- and Chemotherapy-Induced Anemia. NCCN Clinical Practice Guidelines in Oncology. National Comprehensive Cancer Network, Fort Washington, 2013) JW patients, 23 females (74.1%) and eight males, were operated on during the aforementioned period. The median ASA score was 1 (range 1-3), and only two of the patients needed postoperative monitoring in the ICU. Almost half of the patients (45.1%) needed iron infusion and EPO injection preoperatively. Two patients presented with postoperative complications, with no postoperative deaths. In conclusion, we found that surgery, in our small group of JW patients, was safe and successful despite the lack of blood transfusion. Techniques developed to treat JW patients should be more widely used to improve clinical outcomes and reduce costs to the healthcare system.
    MeSH term(s) Blood Transfusion ; Christianity ; Europe ; Female ; Humans ; Jehovah's Witnesses ; Male ; Retrospective Studies
    Language English
    Publishing date 2021-01-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2017250-3
    ISSN 1573-6571 ; 0022-4197
    ISSN (online) 1573-6571
    ISSN 0022-4197
    DOI 10.1007/s10943-020-01175-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Liver Transplantation and Budd-Chiari Syndrome: When the Cause Becomes the Solution.

    Garmpis, Nikolaos / Damaskos, Christos / Prevezanos, Dionysios / Garmpi, Anna / Georgakopoulou, Vasiliki E / Antoniou, Efstathios A / Kouraklis, Gregory / Dimitroulis, Dimitrios

    Maedica

    2022  Volume 17, Issue 2, Page(s) 415–419

    Abstract: Budd-Chiari syndrome consists a rare medical entity which has an estimated incidence of 0.1 to 10 people per million every year. It is defined by the obstruction of the flow in the inferior vena cava or the hepatic veins. Various classifications have ... ...

    Abstract Budd-Chiari syndrome consists a rare medical entity which has an estimated incidence of 0.1 to 10 people per million every year. It is defined by the obstruction of the flow in the inferior vena cava or the hepatic veins. Various classifications have been proposed. So, it can be acute or chronic and primary or secondary. Iatrogenic, a subtype of secondary Budd-Chiari syndrome, is caused by various medical interventions, including liver transplantation. On the other hand, liver transplantation is the ultimate therapeutic management of Budd-Chiari syndrome. Finally, a medical paradox and a vicious circle has been created. Liver transplantation can potentially be both the cause and treatment of Budd-Chiari syndrome. Budd-Chiari syndrome is simultaneously the cause and complication of liver transplantation. Our aim is to describe this double role of liver transplantation in Budd-Chiari syndrome and to acknowledge that a high degree of clinical suspicion is necessary for the proper recognition and management of this life-threatening condition.
    Language English
    Publishing date 2022-07-11
    Publishing country Romania
    Document type Editorial
    ZDB-ID 2399972-X
    ISSN 2069-6116 ; 1841-9038
    ISSN (online) 2069-6116
    ISSN 1841-9038
    DOI 10.26574/maedica.2022.17.2.415
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Evaluation of the Histone Deacetylase 2 (HDAC-2) Expression in Human Breast Cancer.

    Damaskos, Christos / Psilopatis, Iason / Garmpi, Anna / Dimitroulis, Dimitrios / Nikolettos, Konstantinos / Vrettou, Kleio / Sarantis, Panagiotis / Koustas, Evangelos / Kouraklis, Gregory / Antoniou, Efstathios A / Karamouzis, Michail V / Nikolettos, Nikolaos / Tsikouras, Panagiotis / Marinos, Georgios / Kontomanolis, Emmanouil / Kontzoglou, Konstantinos / Garmpis, Nikolaos

    Cancers

    2024  Volume 16, Issue 1

    Abstract: Background/aim: Triple negative breast cancer belongs to the most aggressive breast cancer forms. Histone deacetylases (HDACs) constitute a class of enzymes that exhibit a significant role in breast cancer genesis and progression. In this study, we ... ...

    Abstract Background/aim: Triple negative breast cancer belongs to the most aggressive breast cancer forms. Histone deacetylases (HDACs) constitute a class of enzymes that exhibit a significant role in breast cancer genesis and progression. In this study, we aimed at assessing the clinical importance of HDAC-2 in triple negative breast cancer.
    Materials and methods: A total of 138 breast cancer specimens were examined on an immunohistochemical basis. A statistical analysis was performed in order to examine the association between HDAC-2 and the survival and clinicopathological features of the patients.
    Results: Increased HDAC-2 expression was observed in every fourth case of triple negative breast cancer with positive HDAC-2 staining, whereas only 12 out of 98 non-triple negative breast cancer samples showed high HDAC-2 expression. HDAC-2 overexpression correlated with prolonged overall survival (OS) and disease-free survival (DFS) in triple negative breast cancer.
    Conclusions: High HDAC-2 levels in triple negative breast cancer seem to positively influence patient survival, disease stage and recurrence.
    Language English
    Publishing date 2024-01-01
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers16010209
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: FDA-Approved Monoclonal Antibodies for Unresectable Hepatocellular Carcinoma: What Do We Know So Far?

    Psilopatis, Iason / Damaskos, Christos / Garmpi, Anna / Sarantis, Panagiotis / Koustas, Evangelos / Antoniou, Efstathios A / Dimitroulis, Dimitrios / Kouraklis, Gregory / Karamouzis, Michail V / Vrettou, Kleio / Marinos, Georgios / Kontzoglou, Konstantinos / Garmpis, Nikolaos

    International journal of molecular sciences

    2023  Volume 24, Issue 3

    Abstract: Unresectable hepatocellular carcinoma (HCC) is an advanced primary liver malignancy with a poor prognosis. The Food and Drug Administration (FDA) has, to date, approved nivolumab, pembrolizumab, ramucirumab, nivolumab/ipilimumab, atezolizumab/bevacizumab, ...

    Abstract Unresectable hepatocellular carcinoma (HCC) is an advanced primary liver malignancy with a poor prognosis. The Food and Drug Administration (FDA) has, to date, approved nivolumab, pembrolizumab, ramucirumab, nivolumab/ipilimumab, atezolizumab/bevacizumab, as well as tremelimumab/durvalumab, as first- or second-line monoclonal antibodies (mAbs) for unresectable HCC. The present review examines the current state of knowledge, and provides a useful update on the safety and efficacy of these therapeutic agents, thus attempting to define the suitability of each mAb for different patient subgroups.
    MeSH term(s) United States ; Humans ; Carcinoma, Hepatocellular/pathology ; Nivolumab/therapeutic use ; Liver Neoplasms/pathology ; United States Food and Drug Administration ; Antibodies, Monoclonal/therapeutic use
    Chemical Substances Nivolumab (31YO63LBSN) ; Antibodies, Monoclonal
    Language English
    Publishing date 2023-01-31
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24032685
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Synchronous Insulinoma and Glucagonoma: A Review of the Literature.

    Damaskos, Christos / Dimitroulis, Dimitrios / Garmpi, Anna / Antoniou, Efstathios A / Kouraklis, Gregory / Psilopatis, Iason / Mavri, Maria / Diamantis, Evangelos / Marinos, Georgios / Kyriakos, Georgios / Farmaki, Paraskevi / Patsouras, Alexandros / Kontzoglou, Konstantinos / Garmpis, Nikolaos

    In vivo (Athens, Greece)

    2023  Volume 37, Issue 6, Page(s) 2402–2408

    Abstract: Background/aim: Pancreatic neuroendocrine tumors (PNETs) are pancreatic neoplasms with neuroendocrine features, divided into functioning and non-functioning. The non-functioning PNETs are the largest group, and their morbidity is the result of their ... ...

    Abstract Background/aim: Pancreatic neuroendocrine tumors (PNETs) are pancreatic neoplasms with neuroendocrine features, divided into functioning and non-functioning. The non-functioning PNETs are the largest group, and their morbidity is the result of their potential to invade surrounding tissues and metastasize. The functioning PNETs produce hormonal symptoms due to over-secretion of specific hormones. They constitute 1% to 2% of all pancreatic tumors. The use of novel imaging methods has rendered their detection more frequent. Insulinoma, the most common functioning PNET, comprises 35-40% of all functioning PNETs. Its clinical presentation is due to hyperinsulinemia and the subsequent hypoglycemia. Glucagonoma accounts for 5% of all PNETs and is the fourth most frequent functioning PNET, following insulinoma, gastrinoma, and vipoma. Its symptoms are due to the massive secretion of glucagon and ensuing hyperglycemia. The co-existence of two PNETs is a very rare entity. This report aimed to describe cases of concomitant insulinomas and glucagonomas.
    Materials and methods: A review of the literature was performed using the PubMed database and Cochrane library aiming to identify reported cases of concomitant pancreatic insulinoma and glucagonoma. Specifically, the research was conducted using the keywords, separately and in various combination, including insulinoma, glucagonoma, cystic, pancreatic neuroendocrine tumors and hypoglycemia. Only publications in English were included in the present study.
    Results: A total of 8 cases of concomitant pancreatic insulinoma and glucagonoma were identified, corresponding to the period 1992-2021.
    Conclusion: Concomitant insulinoma and glucagonoma are rare and challenging. A multidisciplinary approach is necessary for diagnosis, prognosis, and therapy.
    MeSH term(s) Humans ; Insulinoma/diagnosis ; Insulinoma/therapy ; Glucagonoma/diagnosis ; Glucagonoma/therapy ; Neuroendocrine Tumors/therapy ; Pancreatic Neoplasms/pathology ; Hypoglycemia/diagnosis ; Hypoglycemia/etiology ; Neuroectodermal Tumors, Primitive
    Language English
    Publishing date 2023-10-30
    Publishing country Greece
    Document type Journal Article ; Review
    ZDB-ID 807031-3
    ISSN 1791-7549 ; 0258-851X
    ISSN (online) 1791-7549
    ISSN 0258-851X
    DOI 10.21873/invivo.13345
    Database MEDical Literature Analysis and Retrieval System OnLINE

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