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  1. Article ; Online: Corrigendum to "EGCG inhibited bladder cancer SW780 cell proliferation and migration both in vitro and in vivo via down-regulation of NF-κB and MMP-9" [Journal of Nutritional Biochemistry 41 (2017) 56-64].

    Luo, Ke-Wang / Chen, Wei / Lung, Wing-Yin / Wei, Xia-Yun / Cheng, Bao-Hui / Cai, Zhi-Ming / Huang, Wei-Ren

    The Journal of nutritional biochemistry

    2023  Volume 123, Page(s) 109530

    Language English
    Publishing date 2023-11-29
    Publishing country United States
    Document type Published Erratum
    ZDB-ID 1014929-6
    ISSN 1873-4847 ; 0955-2863
    ISSN (online) 1873-4847
    ISSN 0955-2863
    DOI 10.1016/j.jnutbio.2023.109530
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    Zs.A 2838: Show issues Location:
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  2. Article ; Online: Unraveling the mystery of antibiotic resistance genes in green and red Antarctic snow.

    Ren, Ze / Li, Huirong / Luo, Wei

    The Science of the total environment

    2024  Volume 915, Page(s) 170148

    Abstract: Antarctic snow is a thriving habitat for a diverse array of complex microorganisms, and can present in different colors due to algae blooms. However, the potential role of Antarctic snow as reservoirs for antibiotic resistance genes (ARGs) has not been ... ...

    Abstract Antarctic snow is a thriving habitat for a diverse array of complex microorganisms, and can present in different colors due to algae blooms. However, the potential role of Antarctic snow as reservoirs for antibiotic resistance genes (ARGs) has not been studied. Using metagenomic sequencing, we studied ARGs in green-snow and red-snow on the Fildes Peninsula, Antarctica. Alpha and beta diversities of ARGs, as well as co-occurrence between ARGs and bacteria were assessed. The results showed that a total of 525 ARGs conferring resistance to 30 antibiotic classes were detected across the samples, with half of the ARGs presented in all samples. Green-snow exhibited a higher number of ARGs compared to red-snow. The most abundant ARGs conferring resistance to commonly used antibiotics, including disinfecting agents and antiseptics, peptide, isoniazid, MLS, fluoroquinolone, aminocoumarin, etc. Multidrug resistance genes stood out as the most diverse and abundant, with antibiotic efflux emerging as the dominant resistance mechanism. Interestingly, the composition of ARGs in green-snow markedly differed from that in red-snow, highlighting distinct ARG profiles. Beta-diversity partitioning showed a higher contribution of nestedness for ARG's variation in green-snow, while higher contribution of turnover in red-snow. Furthermore, the co-occurrence analysis between ARGs and bacteria unveiled intricate relationships, indicating that certain ARGs may have multiple potential hosts. The observed differences in co-occurrence networks between green-snow and red-snow suggested distinct host relationships between ARGs and bacteria in these colored snows. Given the increasing appearance of the colored snow around the world due to the climate change, the results shed light on the mystery and potential implication of ARGs in green and red Antarctic snow.
    MeSH term(s) Anti-Bacterial Agents/pharmacology ; Antarctic Regions ; Snow ; Genes, Bacterial ; Bacteria/genetics ; Drug Resistance, Microbial/genetics
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2024-01-19
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 121506-1
    ISSN 1879-1026 ; 0048-9697
    ISSN (online) 1879-1026
    ISSN 0048-9697
    DOI 10.1016/j.scitotenv.2024.170148
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  3. Article ; Online: Thermokarst lakes are hotspots of antibiotic resistance genes in permafrost regions on the Qinghai-Tibet Plateau.

    Ren, Ze / Zhang, Cheng / Li, Xia / Luo, Wei

    Environmental pollution (Barking, Essex : 1987)

    2024  Volume 344, Page(s) 123334

    Abstract: Antibiotic resistance genes (ARGs) are natural products and emerging pollutants in remote environments, including permafrost regions that are rapidly thawing due to climate warming. We investigated the role of thermokarst lakes (including sediment and ... ...

    Abstract Antibiotic resistance genes (ARGs) are natural products and emerging pollutants in remote environments, including permafrost regions that are rapidly thawing due to climate warming. We investigated the role of thermokarst lakes (including sediment and water) in reserving ARGs compared to permafrost soils across the permafrost regions on the Qinghai-Tibet Plateau. As intrinsically connected distinct environments, permafrost soil, lake sediment, and lake water harbored 1239 ARGs in total, while a considerable number of same ARGs (683 out of 1239) concurrently presented in all these environments. Soil and sediment had a higher number of ARGs than water. Multidrug resistance genes were the most diverse and abundant in all three environments, where cls, ropB, mdfA, fabI, and macB were the top five most abundant ARGs while with different orders. Soil and sediment had similar ARG profiles, and the alpha and beta diversity of ARGs in sediment were positively correlated with that in soil. The beta diversity of ARG profiles between sediment and soil was highly contributed by turnover component (89%). However, turnover and nestedness components were almost equality contributed (46%-54%) to the beta diversity of ARG profiles between soil and water as well as between sediment and water. The results suggested that thermokarst lake sediments might inherit the ARGs in permafrost soils. Water ARGs are the subset of soil ARGs and sediment ARGs to a certain degree with species turnover playing a significant role. When accounting the ARGs in sediment and water together, thermokarst lakes had a significantly higher number of ARGs than permafrost soils, suggesting that thermokarst lakes act as the hotspots of ARGs in permafrost regions. These findings are disturbing especially due to the fact that tremendous number of thermokarst lakes are forming under accelerating climate change.
    MeSH term(s) Permafrost ; Tibet ; Anti-Bacterial Agents ; Lakes ; Soil ; Drug Resistance, Microbial/genetics ; Water
    Chemical Substances Anti-Bacterial Agents ; Soil ; Water (059QF0KO0R)
    Language English
    Publishing date 2024-01-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 280652-6
    ISSN 1873-6424 ; 0013-9327 ; 0269-7491
    ISSN (online) 1873-6424
    ISSN 0013-9327 ; 0269-7491
    DOI 10.1016/j.envpol.2024.123334
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    Zs.A 2599: Show issues Location:
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  4. Article ; Online: Metagenomic analysis reveals the diversity and distribution of antibiotic resistance genes in thermokarst lakes of the Yellow River Source Area.

    Ren, Ze / Luo, Wei

    Environmental pollution (Barking, Essex : 1987)

    2022  Volume 313, Page(s) 120102

    Abstract: Thermokarst lakes form as the results of ice-rich permafrost thawing and act as important water resources in cold regions. However, the distributions of antibiotic resistance genes (ARGs) in thermokarst lakes are far less studied. Using metagenomic ... ...

    Abstract Thermokarst lakes form as the results of ice-rich permafrost thawing and act as important water resources in cold regions. However, the distributions of antibiotic resistance genes (ARGs) in thermokarst lakes are far less studied. Using metagenomic sequencing approach, we provided the first study to document ARGs in thermokarst lakes of the Yellow River Source Area on the Qinghai-Tibet Plateau (QTP). The results revealed that both sediment and water of the thermokarst lakes harbor diverse ARGs. Multidrug resistance genes were the most diverse, while rifamycin resistance genes were the most abundant with rpoB2 and rpoB genes having the highest proportion. Sediment samples contained more ARGs than water samples, but their composition differed between the two types of samples. However, the composition variations of sediment and water ARGs were closely correlated. The Sorensen dissimilarities of ARGs were controlled by strong turnover processes in sediment samples, and by turnover and nestedness in water samples. High contributions of nestedness were found between sediment and water samples. Moreover, ARGs in water had more significant relationships with environmental variables than that in sediment. Given the role of thermokarst lakes as important water resources in permafrost landscape, as well as intensifying influences of climate change and anthropogenetic activities, thermokarst lakes could bring potential ARG risks, warranting further investigation and evaluation.
    MeSH term(s) Anti-Bacterial Agents/pharmacology ; Drug Resistance, Microbial/genetics ; Genes, Bacterial ; Ice ; Lakes ; Rifamycins ; Rivers
    Chemical Substances Anti-Bacterial Agents ; Ice ; Rifamycins
    Language English
    Publishing date 2022-09-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 280652-6
    ISSN 1873-6424 ; 0013-9327 ; 0269-7491
    ISSN (online) 1873-6424
    ISSN 0013-9327 ; 0269-7491
    DOI 10.1016/j.envpol.2022.120102
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  5. Article ; Online: BuresNet: Conditional Bures Metric for Transferable Representation Learning.

    Ren, Chuan-Xian / Luo, You-Wei / Dai, Dao-Qing

    IEEE transactions on pattern analysis and machine intelligence

    2023  Volume 45, Issue 4, Page(s) 4198–4213

    Abstract: As a fundamental manner for learning and cognition, transfer learning has attracted widespread attention in recent years. Typical transfer learning tasks include unsupervised domain adaptation (UDA) and few-shot learning (FSL), which both attempt to ... ...

    Abstract As a fundamental manner for learning and cognition, transfer learning has attracted widespread attention in recent years. Typical transfer learning tasks include unsupervised domain adaptation (UDA) and few-shot learning (FSL), which both attempt to sufficiently transfer discriminative knowledge from the training environment to the test environment to improve the model's generalization performance. Previous transfer learning methods usually ignore the potential conditional distribution shift between environments. This leads to the discriminability degradation in the test environments. Therefore, how to construct a learnable and interpretable metric to measure and then reduce the gap between conditional distributions is very important in the literature. In this article, we design the Conditional Kernel Bures (CKB) metric for characterizing conditional distribution discrepancy, and derive an empirical estimation with convergence guarantee. CKB provides a statistical and interpretable approach, under the optimal transportation framework, to understand the knowledge transfer mechanism. It is essentially an extension of optimal transportation from the marginal distributions to the conditional distributions. CKB can be used as a plug-and-play module and placed onto the loss layer in deep networks, thus, it plays the bottleneck role in representation learning. From this perspective, the new method with network architecture is abbreviated as BuresNet, and it can be used extract conditional invariant features for both UDA and FSL tasks. BuresNet can be trained in an end-to-end manner. Extensive experiment results on several benchmark datasets validate the effectiveness of BuresNet.
    Language English
    Publishing date 2023-03-07
    Publishing country United States
    Document type Journal Article
    ISSN 1939-3539
    ISSN (online) 1939-3539
    DOI 10.1109/TPAMI.2022.3190645
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  6. Article ; Online: Functionally responsive hydrogels with salt-alkali sensitivity effectively target soil amelioration.

    Qi, Le / Xiao, Xiao / Liu, Ting / Ren, Zhong / Ren, Wei / Gao, Qifeng / Liu, Mengting / Wei, Pangzhi / Lai, Yongkang / Yao, Weipeng / An, Huanhuan / Zhang, Lan / Li, Chuncheng / Luo, Shenglian / Luo, Xubiao

    The Science of the total environment

    2024  Volume 918, Page(s) 170350

    Abstract: The long-standing crisis of soil salinization and alkalization poses a significant challenge to global agricultural development. High soil salinity-alkalinity, water dispersion, and nutrient loss present major hurdles to soil improvement. Novel ... ...

    Abstract The long-standing crisis of soil salinization and alkalization poses a significant challenge to global agricultural development. High soil salinity-alkalinity, water dispersion, and nutrient loss present major hurdles to soil improvement. Novel environmentally friendly gels have demonstrated excellent water retention and slow-release capabilities in agricultural enhancement. However, their application for improving saline-alkali soil is both scarce and competitive. This study proposes a new strategy for regulating saline-alkali soil using gel-coated controlled-release soil modifiers (CWR-SRMs), where radical-polymerized gels are embedded on the surface of composite gel beads through spray coating. Characterization and performance analysis reveal that the three-dimensional spatial network structure rich in hydrophilic groups exhibits good thermal stability (first-stage weight loss temperature of 257.7 °C in thermogravimetric analysis) and encapsulation efficiency for fulvic acid‑potassium (FA-K), which can enhance soil quality in saline-alkali environments. The molecular chain relaxation under saline-alkali conditions promotes a synergistic effect of swelling and slow release, endowing it with qualifications as a water reservoir, Ca
    Language English
    Publishing date 2024-02-01
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 121506-1
    ISSN 1879-1026 ; 0048-9697
    ISSN (online) 1879-1026
    ISSN 0048-9697
    DOI 10.1016/j.scitotenv.2024.170350
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  7. Article ; Online: Vibronic coupling of Rhodamine 6G molecules studied by doubly resonant sum frequency generation spectroscopy with narrowband infrared and broadband visible.

    Zeng, Wei-Wang / Luo, Ting / Xu, Peng / Zhou, Chuanyao / Yang, Xueming / Ren, Zefeng

    The Journal of chemical physics

    2024  Volume 160, Issue 2

    Abstract: Doubly resonant sum frequency generation (DR-SFG) serves as a potent characteristic technique for probing the electronic spectra and vibronic coupling of molecules on surfaces. In this study, we successfully developed a novel infrared (IR)-white light ( ... ...

    Abstract Doubly resonant sum frequency generation (DR-SFG) serves as a potent characteristic technique for probing the electronic spectra and vibronic coupling of molecules on surfaces. In this study, we successfully developed a novel infrared (IR)-white light (WL) DR-SFG spectroscopy based on narrowband IR and tunable broadband WL. This novel method was employed to explore the excitation spectrum and vibronic couplings of sub-monolayer Rhodamine 6G molecules. Our findings elucidate that the xanthene skeleton vibrational modes exhibit strong coupling with the S0-S1 electronic transition. Notably, we observed not only the 0-0 transition of the S0-S1 electronic continuum but also the 0-1 transition, a first time observation in the realm of DR-SFG spectroscopy. This advanced DR-SFG spectroscopy methodology facilitates a more sensitive examination of electronic spectra and the coupling between electronic transitions and vibrational modes, heralding a significant advancement in the understanding of molecular interactions on surfaces.
    Language English
    Publishing date 2024-01-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3113-6
    ISSN 1089-7690 ; 0021-9606
    ISSN (online) 1089-7690
    ISSN 0021-9606
    DOI 10.1063/5.0179871
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  8. Article: [Diagnostic Value of American Thyroid Association Guidelines,American College of Radiology Thyroid Imaging Reporting and Data System,and Chinese Thyroid Imaging Reporting and Data System Alone and Combined With BRAF

    Lin, Yu / Luo, Yu-Kun / Li, Jie / Ren, Xiu-Yun / Wang, Hong-Wei

    Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae

    2024  Volume 45, Issue 6, Page(s) 921–928

    Abstract: Objective To explore the diagnostic efficacy of American Thyroid Association(ATA)guidelines,American College of Radiology Thyroid Imaging Report and Data System(ACR-TIRADS),and Chinese Thyroid Imaging Reporting and Data System(C-TIRADS)alone and combined ...

    Abstract Objective To explore the diagnostic efficacy of American Thyroid Association(ATA)guidelines,American College of Radiology Thyroid Imaging Report and Data System(ACR-TIRADS),and Chinese Thyroid Imaging Reporting and Data System(C-TIRADS)alone and combined with BRAF
    MeSH term(s) Humans ; United States ; Infant ; Thyroid Neoplasms/diagnostic imaging ; Thyroid Neoplasms/genetics ; Proto-Oncogene Proteins B-raf/genetics ; Adenocarcinoma, Follicular/genetics ; Adenocarcinoma, Follicular/pathology ; Retrospective Studies ; Data Systems ; Thyroid Nodule/diagnostic imaging ; Thyroid Nodule/genetics ; Ultrasonography/methods ; Mutation ; China ; Radiology
    Chemical Substances Proto-Oncogene Proteins B-raf (EC 2.7.11.1) ; BRAF protein, human (EC 2.7.11.1)
    Language Chinese
    Publishing date 2024-01-03
    Publishing country China
    Document type English Abstract ; Journal Article
    ZDB-ID 604853-5
    ISSN 1000-503X
    ISSN 1000-503X
    DOI 10.3881/j.issn.1000-503X.15754
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  9. Article ; Online: Effects of indirect actions and oxygen on relative biological effectiveness: estimate of DSB inductions and conversions induced by therapeutic proton beams.

    Luo, Wei-Ren / Chen, Fang-Hsin / Huang, Ren-Jing / Chen, Yu-Pin / Hsiao, Ya-Yun

    International journal of radiation biology

    2019  Volume 96, Issue 2, Page(s) 187–196

    Abstract: Purpose: ...

    Abstract Purpose:
    MeSH term(s) Cell Line, Tumor ; Cell Survival/drug effects ; Cobalt Radioisotopes ; DNA/radiation effects ; DNA Breaks, Double-Stranded ; DNA Repair/radiation effects ; Dimethyl Sulfoxide ; Gamma Rays ; Humans ; Hypoxia ; Monte Carlo Method ; Mutation ; Oxygen/metabolism ; Proton Therapy/methods ; Protons ; Reactive Oxygen Species/metabolism ; Relative Biological Effectiveness
    Chemical Substances Cobalt Radioisotopes ; Protons ; Reactive Oxygen Species ; DNA (9007-49-2) ; Oxygen (S88TT14065) ; Dimethyl Sulfoxide (YOW8V9698H)
    Language English
    Publishing date 2019-11-13
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 3065-x
    ISSN 1362-3095 ; 0020-7616 ; 0955-3002
    ISSN (online) 1362-3095
    ISSN 0020-7616 ; 0955-3002
    DOI 10.1080/09553002.2020.1688883
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  10. Article ; Online: Down-regulation of β-lactam antibiotics resistance and biofilm formation by

    Ren, Qiang / Luo, Wanhe / Chi, Haoming / Zhang, Lili / Chen, Wei

    Frontiers in cellular and infection microbiology

    2023  Volume 13, Page(s) 1139796

    Abstract: Introduction: Biofilm formation is the major pathogenicity of : Method: The inhibiting mechanisms of isookanin against biofilm formation through surface hydrophobicity assay, exopolysaccharides, eDNA, gene expression analysis, microscopic ... ...

    Abstract Introduction: Biofilm formation is the major pathogenicity of
    Method: The inhibiting mechanisms of isookanin against biofilm formation through surface hydrophobicity assay, exopolysaccharides, eDNA, gene expression analysis, microscopic visualization, and molecular docking were explored. Additionally, the combination of isookanin and β-lactam antibiotics were evaluated by the broth micro-checkerboard assay.
    Results: The results showed that isookanin could decrease the biofilm formation of
    Discussion: This study improved the antibiotic susceptibility of
    MeSH term(s) Staphylococcus epidermidis/genetics ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/metabolism ; Down-Regulation ; Molecular Docking Simulation ; Biofilms ; Monobactams/metabolism ; Microbial Sensitivity Tests
    Chemical Substances Anti-Bacterial Agents ; isookanin ; Monobactams
    Language English
    Publishing date 2023-05-10
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2619676-1
    ISSN 2235-2988 ; 2235-2988
    ISSN (online) 2235-2988
    ISSN 2235-2988
    DOI 10.3389/fcimb.2023.1139796
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