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  1. Book: Fighting for our health

    Kirsch, Richard

    the epic battle to make health care a right in the United States

    2011  

    Author's details Richard Kirsch
    Keywords Insurance, Health / legislation & jurisprudence ; Legislation as Topic / history ; Health Care Reform / history ; Health Care Reform / legislation & jurisprudence ; Politics ; History, 21st Century ; United States
    Language English
    Size XX, 396 S.
    Publisher Rockefeller Inst. Press
    Publishing place Albany, NY
    Publishing country United States
    Document type Book
    Note Includes bibliographical references and index
    HBZ-ID HT017029635
    ISBN 978-1-930912-24-3 ; 1-930912-24-2
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2012 A 454 order for loan Magazin

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  2. Article ; Online: Proteins Can Withstand More Extensive Labeling while Providing Accurate Structural Information in Covalent Labeling-Mass Spectrometry.

    Kirsch, Zachary J / Vachet, Richard W

    Journal of the American Society for Mass Spectrometry

    2024  Volume 35, Issue 5, Page(s) 1030–1039

    Abstract: Diethylpyrocarbonate (DEPC) covalent labeling-mass spectrometry (CL-MS) has been extensively utilized to study protein structure and interactions owing to its ease of use, commercial availability, and broad labeling of nucleophilic residues. During ... ...

    Abstract Diethylpyrocarbonate (DEPC) covalent labeling-mass spectrometry (CL-MS) has been extensively utilized to study protein structure and interactions owing to its ease of use, commercial availability, and broad labeling of nucleophilic residues. During typical CL-MS experiments with DEPC, the extent of labeling is kept low to avoid any structural perturbations resulting from covalent modification of the protein. In this study, we demonstrate that proteins can be labeled more extensively via DEPC and still provide accurate structural information. To show this, we modeled labeling kinetics over a range of DEPC concentrations and used molecular dynamics simulations to investigate the molecular-level effects of extensive labeling on the protein structure. Our results indicate that higher extents of DEPC labeling do not significantly perturb the protein structure and can lead to improved precision, detectability of labeled peptides, and protein structural resolution. Furthermore, higher extents of labeling enable better identification of protein-ligand binding sites where lower extents of modification provide ambiguous results.
    MeSH term(s) Diethyl Pyrocarbonate/chemistry ; Molecular Dynamics Simulation ; Proteins/chemistry ; Mass Spectrometry/methods ; Protein Conformation ; Binding Sites ; Kinetics
    Chemical Substances Diethyl Pyrocarbonate (LMR3LZG146) ; Proteins
    Language English
    Publishing date 2024-04-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1073671-2
    ISSN 1879-1123 ; 1044-0305
    ISSN (online) 1879-1123
    ISSN 1044-0305
    DOI 10.1021/jasms.4c00043
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: An American Path to Universal Coverage.

    Kirsch, Richard

    The Journal of ambulatory care management

    2019  Volume 42, Issue 3, Page(s) 211–217

    Abstract: The politics of health care policy create opportunities driven by public demands for lowering costs and providing health security, constrained by fear of loss of what people have now, fears that will be inflamed by opponents. The best course toward ... ...

    Abstract The politics of health care policy create opportunities driven by public demands for lowering costs and providing health security, constrained by fear of loss of what people have now, fears that will be inflamed by opponents. The best course toward reform will provide people a choice of improved public coverage and the ability to keep improved employer coverage. There are a variety of ways to design these proposals, some of which can be characterized as Medicare for All. Inclusion of a Medicare/public plan in the Affordable Care Act marketplaces is a policy option but one of relatively low significance.
    MeSH term(s) Health Care Costs ; Health Care Reform ; Health Policy ; Insurance Coverage ; Patient Protection and Affordable Care Act ; Policy Making ; Politics ; United States ; Universal Health Insurance
    Language English
    Publishing date 2019-05-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 198845-1
    ISSN 1550-3267 ; 0148-9917
    ISSN (online) 1550-3267
    ISSN 0148-9917
    DOI 10.1097/JAC.0000000000000291
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: [Besprechung von:] Die öffentlichen Finanzen in Theorie und Praxis. [Von] Richard A. Musgrave [u.a.]. Bd 1. 2. Tübingen 1975

    Kirsch, Guy / Musgrave, Richard A

    Finanz-Archiv : public finance analysis Vol. 36, No. 1 , p. 187-188

    1977  Volume 36, Issue 1, Page(s) 187–188

    Author's details Guy Kirsch
    Publisher Mohr Siebeck
    Publishing place Tübingen
    Document type Article
    ZDB-ID 2020-5
    Database ECONomics Information System

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  5. Article ; Online: The Role of Mycotoxins in Interactions between

    Sherif, Mohammed / Kirsch, Nadine / Splivallo, Richard / Pfohl, Katharina / Karlovsky, Petr

    Toxins

    2023  Volume 15, Issue 9

    Abstract: ... Fusarium ... ...

    Abstract Fusarium graminearum
    MeSH term(s) Mycotoxins ; Fumonisins ; Zea mays
    Chemical Substances Mycotoxins ; Fumonisins ; nivalenol (5WOP02RM1U)
    Language English
    Publishing date 2023-09-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2518395-3
    ISSN 2072-6651 ; 2072-6651
    ISSN (online) 2072-6651
    ISSN 2072-6651
    DOI 10.3390/toxins15090575
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Mast cell evaluation in gastrointestinal biopsies: should we be counting? A critical review and practical guide for the surgical pathologist.

    Shivji, Sameer / Conner, James Ryan / Kirsch, Richard

    Histopathology

    2023  Volume 82, Issue 7, Page(s) 960–973

    Abstract: Mast cells are residents of the tubular gastrointestinal (GI) tract, where they play an important role in host defence and other vital functions. Dysregulation of mast cells has been implicated in the pathogenesis of several neoplastic, inflammatory, and ...

    Abstract Mast cells are residents of the tubular gastrointestinal (GI) tract, where they play an important role in host defence and other vital functions. Dysregulation of mast cells has been implicated in the pathogenesis of several neoplastic, inflammatory, and functional disorders, some of which may manifest with GI symptoms. Surgical pathologists must therefore confront when and how to evaluate GI biopsies for mast cells, and whether such decisions should be based on morphologic criteria, clinical context, or direct request from clinical colleagues. The pathologist's role in evaluation of mast cell infiltrates is best defined in the diagnosis of systemic mastocytosis, where the utility of morphologic assessment coupled with ancillary studies is well established. In contrast, in nonneoplastic mast cell disorders such as mast cell activation syndrome, irritable bowel syndrome, or so-called 'mastocytic enterocolitis', a role for histopathology, if any, is controversial. Despite this, pathologists have seen a sharp increase in requests for mast cell quantification in the latter setting, despite these requests not being supported by published evidence. Moreover, what constitutes a 'normal' number of mast cells in a luminal GI biopsy is not well established. As a result, there is considerable variation in how these requests are handled in practice. This review evaluates and summarizes the published evidence relating to mast cell evaluation in endoscopic GI biopsies in various clinical scenarios, with a goal of providing practical, evidence-based guidance for the surgical pathologist when approached with requests for mast cell quantification in GI biopsies.
    MeSH term(s) Humans ; Mast Cells/pathology ; Pathologists ; Gastrointestinal Tract ; Mastocytosis/diagnosis ; Mastocytosis/pathology ; Biopsy
    Language English
    Publishing date 2023-03-15
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 131914-0
    ISSN 1365-2559 ; 0309-0167
    ISSN (online) 1365-2559
    ISSN 0309-0167
    DOI 10.1111/his.14897
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1328: Show issues Location:
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  7. Book: Taschenlehrbuch Anatomie

    Kirsch, Joachim / May, Christian Albrecht / Lorke, Dietrich / Winkelmann, Andreas / Schwab, Wolfgang / Herrmann, Gudrun / Funk, Richard

    2017  

    Title variant Anatomie
    Author's details Joachim Kirsch, Christian Albrecht May, Dietrich Lorke, Andreas Winkelmann, Wolfgang Schwab †, Gudrun Herrmann, Richard Funk
    Keywords Anatomie
    Subject Mensch ; Tiere ; Tieranatomie ; Kunst der Zergliederung ; Zergliederungskunst
    Language German
    Size 753 Seiten, Illustrationen
    Edition 2., überarbeitete Auflage
    Publisher Georg Thieme Verlag
    Publishing place Stuttgart ; New York
    Publishing country Germany
    Document type Book
    HBZ-ID HT019441688
    ISBN 978-3-13-144992-4 ; 9783131625120 ; 9783132403505 ; 3-13-144992-6 ; 3131625120 ; 3132403504
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2018 A 390 available for loan (reading room) Lesesaal EG
    Zugang zu zusätzlichem Internetmaterial über Code aus lizenzrechtlichen Gründen nicht verfügbar

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  8. Article ; Online: Commentary on: Multi-institutional Validation Study of Cyst Fluid Protein Biomarkers in Patients With Cystic Lesions of the Pancreas.

    Del Chiaro, Marco / Kirsch, Michael J / Schulick, Richard

    Annals of surgery

    2022  Volume 276, Issue 2, Page(s) e133

    MeSH term(s) Biomarkers ; Biomarkers, Tumor/analysis ; Cyst Fluid ; Diagnosis, Differential ; Humans ; Pancreas/pathology ; Pancreatic Cyst/diagnosis ; Pancreatic Cyst/pathology ; Pancreatic Neoplasms/diagnosis ; Pancreatic Neoplasms/pathology
    Chemical Substances Biomarkers ; Biomarkers, Tumor
    Language English
    Publishing date 2022-07-06
    Publishing country United States
    Document type Journal Article ; Multicenter Study ; Comment
    ZDB-ID 340-2
    ISSN 1528-1140 ; 0003-4932
    ISSN (online) 1528-1140
    ISSN 0003-4932
    DOI 10.1097/SLA.0000000000005505
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Knowledge and technology transfer in and beyond mineral exploration

    Michaela Kesselring / Moritz Kirsch / Frank Wagner / Richard Gloaguen

    Journal of Innovation and Entrepreneurship, Vol 12, Iss 1, Pp 1-

    2023  Volume 19

    Abstract: Abstract In natural sciences, mineral exploration has a high network centrality. For industries with high technological- and knowledge proximity, transfer effects are an important function for innovation. Despite the high level of proximity between ... ...

    Abstract Abstract In natural sciences, mineral exploration has a high network centrality. For industries with high technological- and knowledge proximity, transfer effects are an important function for innovation. Despite the high level of proximity between mineral exploration and other natural sciences, scholars hardly examine transfers from and to mineral exploration. This paper analyzes obstacles and mechanisms of transfer effects in and from mineral exploration and finds answers on how to institutionalize knowledge and technology transfer (KTT). The study employs a qualitative research design. The underlying database consists of 16 expert interviews, from the fields of natural science. The results show that KTT between areas as diverse as mineral exploration, healthcare, and arts are possible. A lack of interdisciplinary exchange and rigid scientific structures is the main inhibitor of KTT. Before this study, evidence for KTT from and to smaller industries is mostly anecdotal. The study is among the few, which investigates KTT concerning functional transfer opportunities.
    Keywords Knowledge transfer ; Technology transfer ; Mineral exploration ; Natural sciences ; Business ; HF5001-6182 ; Commercial geography. Economic geography ; HF1021-1027
    Subject code 910
    Language English
    Publishing date 2023-10-01T00:00:00Z
    Publisher SpringerOpen
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Imaging Features of Gastrointestinal Neoplasms Complicating Inflammatory Bowel Diseases.

    Saleh, Lilyane / Jaffer, Hussein / Kajal, Dilkash / Kirsch, Richard / Jaffer, Nasir

    Current problems in diagnostic radiology

    2023  Volume 52, Issue 6, Page(s) 570–575

    Abstract: Inflammatory bowel diseases (IBD) are chronic inflammatory diseases affecting the gastrointestinal (GI) tract. Patients with IBD, besides other non-neoplastic complications, are also at increased risk of GI malignancies such as colorectal cancer, small ... ...

    Abstract Inflammatory bowel diseases (IBD) are chronic inflammatory diseases affecting the gastrointestinal (GI) tract. Patients with IBD, besides other non-neoplastic complications, are also at increased risk of GI malignancies such as colorectal cancer, small bowel adenocarcinoma and lymphoma. The principal purpose of imaging in patients with IBD to assess complications and to stage a clinically known cancer. In addition, the goal of imaging has expanded to include the diagnosis of GI malignancies in clinical situations where colonoscopy cannot be performed or is incomplete. In addition, imaging allows the detection of cancers in patients where the development of either disease-related or treatment-related neoplasia is clinically suspected. The purpose of this review is to present the different imaging techniques used to detect GI malignancies in IBD patients and describe the radiological appearances of GI malignancies in IBD patients.
    Language English
    Publishing date 2023-07-05
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 198954-6
    ISSN 1535-6302 ; 0363-0188
    ISSN (online) 1535-6302
    ISSN 0363-0188
    DOI 10.1067/j.cpradiol.2023.06.011
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