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  1. Article: Gingival lymphatic malformation. An atypical case report.

    Alberdi-Navarro, Javier / Ruiz-Ochoa, Nerea / De Juan-Galindez, Andoni / Uribarri-Etxebarria, Agurne

    Journal of clinical and experimental dentistry

    2023  Volume 15, Issue 6, Page(s) e514–e517

    Abstract: Lymphatic malformations are a rare pathology that presents a highly variable clinical expression. Intraorally, it mainly affects the dorsum of the tongue. The objective of this work is to present a case of lymphatic malformation in an atypical location. ... ...

    Abstract Lymphatic malformations are a rare pathology that presents a highly variable clinical expression. Intraorally, it mainly affects the dorsum of the tongue. The objective of this work is to present a case of lymphatic malformation in an atypical location. A 20-year-old male who attended the clinic for multiple vesicular lesion in attached gingiva, asymptomatic and of unknown evolution. Removal of the lesion and subsequent histological analysis were performed, which showed a microcystic lymphatic vascular lesion. Immunohistochemistry for D2-40 was performed, which corroborated the lymphatic origin of the lesion. At 6 months, no recurrence of the lesion was recognized. Clinicians should include lymphatic malformations in the differential diagnosis of multiple vesicular lesions. Knowing the oral manifestations of this entity is essential for its proper diagnosis and clinical management.
    Language English
    Publishing date 2023-06-01
    Publishing country Spain
    Document type Case Reports
    ZDB-ID 2586647-3
    ISSN 1989-5488
    ISSN 1989-5488
    DOI 10.4317/jced.60488
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Non-infectious granulomatous disorders of the upper lip: clinicopathological analysis of 11 patients.

    Lafuente-Ibáñez de Mendoza, Irene / Vigarios, Emmanuelle / Herbault-Barres, Béatrice / Alberdi-Navarro, Javier / Sibaud, Vincent / Maret, Delphine / Aguirre-Urizar, José Manuel

    BMC oral health

    2022  Volume 22, Issue 1, Page(s) 173

    Abstract: Background: Non-infectious granulomatous disorders of the upper lip represent a special chapter of oral and maxillofacial pathology. In this work we report a case-series of this process, to analyse its main clinicopathological features and find ... ...

    Abstract Background: Non-infectious granulomatous disorders of the upper lip represent a special chapter of oral and maxillofacial pathology. In this work we report a case-series of this process, to analyse its main clinicopathological features and find differential data that allow us improve its diagnosis and understand its pathogenesis.
    Methods: We present 11 cases of non-infectious granulomatous disorders of the upper lip, 8 women and 3 men with an age range of 29-84 years, who have been attended at the Oral Medicine Department of the IUCT (France) and the Oral Medicine Unit of the UPV/EHU (Spain). All clinicopathological data were collected in a specific protocol.
    Results: We recognized 4 different subtypes of non-infectious granulomatous disorders of the upper lip: (1) associated with Crohn's disease (1 case), (2) associated with foreign body (2 cases), (3) associated with gingivitis lichenoid-like (4 cases), (4) idiopathic (4 cases).
    Conclusions: Clinicopathological differences were identified between these subtypes. A good differential diagnosis is necessary in all cases to rule out the presence of local or systemic etiopathogenic factors.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Diagnosis, Differential ; Female ; France ; Gingivitis/etiology ; Humans ; Lip ; Male ; Middle Aged ; Mouth Mucosa
    Language English
    Publishing date 2022-05-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 2091511-1
    ISSN 1472-6831 ; 1472-6831
    ISSN (online) 1472-6831
    ISSN 1472-6831
    DOI 10.1186/s12903-022-02189-z
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  3. Article: Angina bullosa hemorrhagica, an uncommon oral disorder. Report of 4 cases.

    Alberdi-Navarro, Javier / García-García, Abel / Cardona-Tortajada, Francisco / Gainza-Cirauqui, María-Luisa / Aguirre-Urizar, José-Manuel

    Journal of clinical and experimental dentistry

    2020  Volume 12, Issue 5, Page(s) e509–e513

    Abstract: Angina bullosa hemorrhagica (ABH) is a rare oral disorder characterized by blood-filled bullous lesions in the oral cavity and the oropharynx in the absence of an underlying systemic, haematological or mucocutaneous condition. The presentation of the ... ...

    Abstract Angina bullosa hemorrhagica (ABH) is a rare oral disorder characterized by blood-filled bullous lesions in the oral cavity and the oropharynx in the absence of an underlying systemic, haematological or mucocutaneous condition. The presentation of the lesions is acute and located on the lining mucosa, mainly on the soft palate. Often, these lesions are single and rupture easily leaving an ulcerated area. In this study, we present 4 ABH cases in 3 women and 1 man and we discuss the main clinicopathological characteristics. The characteristics of this disorder are important to recognize in order to differentiate the lesions from other oral bullous conditions of the oral cavity such as mucocutaneous disorders or blood coagulation disorders.
    Language English
    Publishing date 2020-05-01
    Publishing country Spain
    Document type Case Reports
    ZDB-ID 2586647-3
    ISSN 1989-5488
    ISSN 1989-5488
    DOI 10.4317/jced.56840
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  4. Article: Therapeutic management of the odontogenic keratocyst. An energetic approach with a conservative perspective and review of the current therapeutic options.

    Borrás-Ferreres, Jordi / Sánchez-Torres, Alba / Alberdi-Navarro, Javier / Aguirre-Urizar, José-Manuel / Mosqueda-Taylor, Adalberto / Gay-Escoda, Cosme

    Journal of clinical and experimental dentistry

    2020  Volume 12, Issue 8, Page(s) e794–e799

    Abstract: Background: Odontogenic keratocysts (OKC) are cystic lesions appearing in the jaws, usually asymptomatic with a progressive growth into the bone. Many of them are diagnosed by a routine radiological examination.: Material and methods: This study ... ...

    Abstract Background: Odontogenic keratocysts (OKC) are cystic lesions appearing in the jaws, usually asymptomatic with a progressive growth into the bone. Many of them are diagnosed by a routine radiological examination.
    Material and methods: This study reports a 12-year-old girl that presented an asymptomatic large radiolucent unilocular lesion associated to the crown of 3.8 that caused displacement of the molar and the inferior alveolar canal. Differential diagnosis included OKC, unicystic ameloblastoma, ameloblastic fibroma, dentigerous cyst and orthokeratinized odontogenic cyst. Two surgical interventions were performed; first, a marsupialization, and 10 months after, the third molar extraction plus cyst enucleation, mucosa excision and the application of Carnoy's solution.
    Results: The anatomopathological exam confirmed diagnosis of OKC. There was no evidence of recurrence after 2 years of follow-up.
    Conclusions: Marsupialization followed by surgical enucleation with mucosa excision and Carnoy's solution can help manage treatment of OKC, a lesion characterized by an aggressive behavior.
    Language English
    Publishing date 2020-08-01
    Publishing country Spain
    Document type Case Reports
    ZDB-ID 2586647-3
    ISSN 1989-5488
    ISSN 1989-5488
    DOI 10.4317/jced.56722
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  5. Article: Peripheral giant cell granuloma associated with a dental implant: A case report.

    Sánchez-Torres, Alba / Pérez-Amate, Berta / Javier, Alberdi-Navarro / Cercadillo-Ibarguren, Iñaki / Figueiredo, Rui / Valmaseda-Castellón, Eduard

    Journal of clinical and experimental dentistry

    2021  Volume 13, Issue 10, Page(s) e1049–e1052

    Abstract: Peripheral giant cell granuloma (PGCG) is a reactive exophytic lesion classified as a benign tumor of the oral mucosa. Although its etiology is not clear, it may be a consequence of local chronic irritation or persistent trauma. The objective of this ... ...

    Abstract Peripheral giant cell granuloma (PGCG) is a reactive exophytic lesion classified as a benign tumor of the oral mucosa. Although its etiology is not clear, it may be a consequence of local chronic irritation or persistent trauma. The objective of this case report was to document the main clinical and histopathological characteristics of a patient with a PGCG associated with a dental implant. A 36 years-old man presented a partly-ulcerated violet-colored sessile-based tumor in the buccal aspect of an implant placed in the fourth quadrant. Radiographically, the implant had one third of marginal bone loss. Differential diagnosis included PGCG and pyogenic granuloma. The implant and the lesion were removed and the histopathological diagnosis was PGCG. After 6 months, there was no evidence of relapse. Peripheral giant cell granulomas may appear in implants that have suffered bone loss. When facing with peri-implant soft tissue lesions, it is advisable to perform an anatomopathological study to obtain a correct diagnosis, to establish an adequate treatment plan, and to rule out malignant lesions.
    Language English
    Publishing date 2021-10-01
    Publishing country Spain
    Document type Case Reports
    ZDB-ID 2586647-3
    ISSN 1989-5488
    ISSN 1989-5488
    DOI 10.4317/jced.57189
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  6. Article ; Online: Detection of Microparticles of Different Origins in Implant Prostheses and Abutments.

    Del Valle, Asier Eguia / López-Vicente, Jose / Alberdi-Navarro, Javier / Marichalar, Xabier / Laña, Joana / Martínez-Conde, Rafael

    The International journal of prosthodontics

    2019  Volume 32, Issue 5, Page(s) 420–422

    Abstract: Purpose: To assess whether particles from metal and other alloplastic materials detected in tissues surrounding dental implants could have other sources of origin besides biotribocorrosion or detachment from the implant surface.: Materials and methods! ...

    Abstract Purpose: To assess whether particles from metal and other alloplastic materials detected in tissues surrounding dental implants could have other sources of origin besides biotribocorrosion or detachment from the implant surface.
    Materials and methods: A total of 52 prostheses were randomly tested at various stages of manufacture. Identification of the detached microparticles was performed using light field microscopy and comparison with previously obtained microscopic images.
    Results: Microparticles of metallic, ceramic, plaster, polishers, or unidentifiable origin were detected in 49 prostheses (94%).
    Conclusion: Without an exhaustive decontamination protocol, prostheses and abutments carry metal microparticles and microparticles of other origins that could contribute to the development of peri-implant pathologies.
    MeSH term(s) Crowns ; Dental Abutments ; Dental Implants ; Dental Prosthesis, Implant-Supported ; Dental Restoration Failure
    Chemical Substances Dental Implants
    Language English
    Publishing date 2019-09-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 645046-5
    ISSN 1942-4426 ; 0893-2174
    ISSN (online) 1942-4426
    ISSN 0893-2174
    DOI 10.11607/ijp.6026
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  7. Article ; Online: Characterization of juvenile spongiotic gingival hyperplasia as an entity of odontogenic origin.

    Lafuente-Ibáñez de Mendoza, Irene / Alberdi-Navarro, Javier / Marichalar-Mendia, Xabier / Mosqueda-Taylor, Adalberto / Aguirre-Urizar, Jose Manuel

    Journal of periodontology

    2019  Volume 90, Issue 12, Page(s) 1490–1495

    Abstract: Background: Juvenile spongiotic gingival hyperplasia (JSGH) is a distinct clinicopathological entity of the buccal gingiva of young patients which has been related to several factors such as plaque formation, hormonal modifications, and viral infections; ...

    Abstract Background: Juvenile spongiotic gingival hyperplasia (JSGH) is a distinct clinicopathological entity of the buccal gingiva of young patients which has been related to several factors such as plaque formation, hormonal modifications, and viral infections; however, its true etiopathogenesis remains unsolved. Several immunohistochemical studies have demonstrated the similarity between the junctional epithelium (JE) and the hyperplasic epithelium of JSGH. The objective of this study is to analyze the clinicopathological and immunohistochemical characteristics of JSGH to explain its origin.
    Methods: Clinicopathlogical data of 10 cases of JSGH (five men and five women) with a mean age of 13 years (range: 9 to 17 years) were collected. CK7, CK14, CK19, CD3, CD20, S100, and Ki-67 antibodies were used for comparative immunohistochemical study.
    Results: All the lesions showed hyperplasic epithelium in its central portion, exhibiting marked spongiosis, vascular proliferation, and a chronic inflammatory infiltrate on the subepithelial connective tissue. CK19 was positive in the whole hyperplasic epithelium of JSGH and the basal layer of the marginal gingiva, while expression of CK14 was present in all epithelial layers of both the JSGH and that of the marginal gingiva. The subepithelial inflammatory infiltrate has a larger amount of CD20 positive cells.
    Conclusion: JSGH is a reactive tumor of the gingiva that may have an odontogenic etiology, whose origin seems to be the remnants of JE.
    MeSH term(s) Adolescent ; Child ; Epithelial Attachment ; Epithelium ; Female ; Gingiva ; Gingival Hyperplasia ; Humans ; Hyperplasia ; Male
    Language English
    Publishing date 2019-09-15
    Publishing country United States
    Document type Case Reports ; Research Support, Non-U.S. Gov't
    ZDB-ID 390921-9
    ISSN 1943-3670 ; 0022-3492 ; 1049-8885 ; 0095-960X
    ISSN (online) 1943-3670
    ISSN 0022-3492 ; 1049-8885 ; 0095-960X
    DOI 10.1002/JPER.19-0022
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  8. Article: Inflammatory fibro-epithelial hyperplasia related to a fixed implant-supported prosthesis: A case report.

    Sánchez-Torres, Alba / Mota, Inês / Alberdi-Navarro, Javier / Cercadillo-Ibarguren, Iñaki / Figueiredo, Rui / Valmaseda-Castellón, Eduard

    Journal of clinical and experimental dentistry

    2018  Volume 10, Issue 9, Page(s) e945–e948

    Abstract: The gingival overgrowth is a common finding in the clinical practice with a diverse etiology. There are no treatment guidelines defined for this oral lesions. These can provoke discomfort to the patient and often, can alter the function of the ... ...

    Abstract The gingival overgrowth is a common finding in the clinical practice with a diverse etiology. There are no treatment guidelines defined for this oral lesions. These can provoke discomfort to the patient and often, can alter the function of the stomatologic system. This article presents a case report of a bilateral gingival overgrowth in a 68 years old woman wearing a fixed upper-arch implant-supported prosthesis placed five years ago. The clinical exam after removing the prosthesis showed an intense accumulation of plaque around the intermediate abutments associated to a mucosal enlargement with suppuration on touching the buccal area of the implant in position 1.5 and a probing depth of 8mm. The 2.4 and 2.5 implants also showed vestibular mucosal enlargement and a probing depth of 6mm. No changes were observed in the peri-implant bone level measured in the periapical radiographs. An incisional biopsy was made on second quadrant and sent for the histopathological study. The definitive diagnosis was inflammatory fibro-epithelial hyperplasia. No recurrence has been reported after a 6 month follow-up.
    Language English
    Publishing date 2018-09-01
    Publishing country Spain
    Document type Case Reports
    ZDB-ID 2586647-3
    ISSN 1989-5488
    ISSN 1989-5488
    DOI 10.4317/jced.54921
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  9. Article: Maxillary peripheral keratocystic odontogenic tumor. A clinical case report.

    Vázquez-Romero, María Del Carmen / Serrera-Figallo, María de Los Angeles / Alberdi-Navarro, Javier / Cabezas-Talavero, Javier / Romero-Ruiz, Manuel-María / Torres-Lagares, Daniel / Aguirre-Urizar, Jose-Manuel / Gutiérrez-Pérez, Jose-Luis

    Journal of clinical and experimental dentistry

    2017  Volume 9, Issue 1, Page(s) e167–e171

    Abstract: The keratocystic odontogenic tumor is a benign odontogenic cystic neoplasia characterized by its thin, squamous epithelium with superficial parakeratosis. It has the potential for infiltration and local aggressiveness and has a high rate of recurrence. ... ...

    Abstract The keratocystic odontogenic tumor is a benign odontogenic cystic neoplasia characterized by its thin, squamous epithelium with superficial parakeratosis. It has the potential for infiltration and local aggressiveness and has a high rate of recurrence. This neoplasia is predominantly found in males and people of white origin. The mandible is the most frequently involved site, in particular the third molar region, mandibular angle, and ramus. It has a mandible-maxilla ratio of 2:1. Only about twenty cases of peripheral keratocystic odontogenic tumors (PKCOT) have been reported in the international literature. This study presents a case of PKCOT localized in the anterior region of the maxilla, on the vestibular side of the upper left lateral incisor and the upper left canine. The diagnosis and treatment procedures, as based on the literature, are also discussed.
    Language English
    Publishing date 2017-01-01
    Publishing country Spain
    Document type Case Reports
    ZDB-ID 2586647-3
    ISSN 1989-5488
    ISSN 1989-5488
    DOI 10.4317/jced.53438
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  10. Article ; Online: Central odontogenic fibroma: an international multicentric study of 62 cases.

    Roza, Ana Luiza Oliveira Corrêa / Sousa, Emanuel Mendes / Leite, Amanda Almeida / Amaral-Silva, Gleyson Kleber / Morais, Thayná Melo de Lima / Wagner, Vivian Petersen / Schuch, Lauren Frenzel / Vasconcelos, Ana Carolina Uchoa / de Arruda, José Alcides Almeida / Mesquita, Ricardo Alves / Fonseca, Felipe Paiva / Abrahão, Aline Corrêa / Agostini, Michelle / de Andrade, Bruno Augusto Benevenuto / da Silveira, Ericka Janine Dantas / Martínez-Flores, René / Rondanelli, Benjamin Martínez / Alberdi-Navarro, Javier / Robinson, Liam /
    Marin, Constanza / Assunção Júnior, José Narciso Rosa / Valiati, Renato / Fregnani, Eduardo Rodrigues / Santos-Silva, Alan Roger / Lopes, Marcio Ajudarte / Hunter, Keith D / Khurram, Syed Ali / Speight, Paul M / Mosqueda-Taylor, Adalberto / van Heerden, Willie F P / Carlos, Román / Wright, John M / de Almeida, Oslei Paes / Romañach, Mário José / Vargas, Pablo Agustin

    Oral surgery, oral medicine, oral pathology and oral radiology

    2020  Volume 131, Issue 5, Page(s) 549–557

    Abstract: Objective: The aim of this study was to report the clinicopathologic features of 62 cases of central odontogenic fibroma (COdF).: Study design: Clinical and radiographic data were collected from the records of 13 oral pathology laboratories. All ... ...

    Abstract Objective: The aim of this study was to report the clinicopathologic features of 62 cases of central odontogenic fibroma (COdF).
    Study design: Clinical and radiographic data were collected from the records of 13 oral pathology laboratories. All cases were microscopically reviewed, considering the current World Health Organization classification of tumors and were classified according to histopathologic features.
    Results: There were 43 females and 19 males (average age 33.9 years; range 8-63 years). Clinically, COdF lesions appeared as asymptomatic swellings, occurring similarly in the maxilla (n = 33) and the mandible (n = 29); 9 cases exhibited palatal depression. Imaging revealed well-defined, interradicular unilocular (n = 27), and multilocular (n = 12) radiolucencies, with displacement of contiguous teeth (55%) and root resorption (46.4%). Microscopically, classic features of epithelial-rich (n = 33), amyloid (n = 10), associated giant cell lesion (n = 7), ossifying (n = 6), epithelial-poor (n = 3), and granular cell (n = 3) variants were seen. Langerhans cells were highlighted by CD1a staining in 17 cases. Most patients underwent conservative surgical treatments, with 1 patient experiencing recurrence.
    Conclusions: To the best of our knowledge, this study represents the largest clinicopathologic study of COdF. Most cases appeared as locally aggressive lesions located in tooth-bearing areas in middle-aged women. Inactive-appearing odontogenic epithelium is usually observed within a fibrous/fibromyxoid stroma, occasionally exhibiting amyloid deposits, multinucleated giant cells, or granular cells.
    MeSH term(s) Adolescent ; Adult ; Child ; Female ; Fibroma/diagnostic imaging ; Fibroma/surgery ; Humans ; Male ; Mandible ; Maxilla ; Middle Aged ; Neoplasm Recurrence, Local ; Odontogenic Tumors/diagnostic imaging ; Odontogenic Tumors/surgery ; Young Adult
    Language English
    Publishing date 2020-08-27
    Publishing country United States
    Document type Journal Article ; Multicenter Study
    ZDB-ID 2650843-6
    ISSN 2212-4411 ; 2212-4403
    ISSN (online) 2212-4411
    ISSN 2212-4403
    DOI 10.1016/j.oooo.2020.08.022
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