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  1. Article ; Online: Epigenetic and genetic changes in soft tissue sarcomas: a review.

    Soini, Ylermi

    APMIS : acta pathologica, microbiologica, et immunologica Scandinavica

    2016  Volume 124, Issue 11, Page(s) 925–934

    Abstract: Soft tissue sarcomas are a versatile group of tumors with a proposed origin from mesenchymal stem cells. During recent years, the molecular biologic mechanisms behind the histogenesis of these tumors have become clearer. In addition to translocations and ...

    Abstract Soft tissue sarcomas are a versatile group of tumors with a proposed origin from mesenchymal stem cells. During recent years, the molecular biologic mechanisms behind the histogenesis of these tumors have become clearer. In addition to translocations and other genomic changes, epigenetic mechanisms have been shown to be greatly involved in the histogenesis of sarcomas as well as other cancers. Even though the molecular mechanisms behind sarcomas appear to be more complex than previously expected, epigenetic mechanisms bring new opportunities and means for the treatment of these complex diseases.
    MeSH term(s) Animals ; Chromatin Assembly and Disassembly ; Epigenomics ; Humans ; RNA, Untranslated/genetics ; Sarcoma/genetics ; Sarcoma/pathology ; Sarcoma/physiopathology ; Sarcoma/virology
    Chemical Substances RNA, Untranslated
    Language English
    Publishing date 2016-11
    Publishing country Denmark
    Document type Journal Article ; Review
    ZDB-ID 93340-5
    ISSN 1600-0463 ; 0903-4641
    ISSN (online) 1600-0463
    ISSN 0903-4641
    DOI 10.1111/apm.12600
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    In stock of ZB MED Cologne/Königswinter

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  2. Article ; Online: Multimodal Imaging of Nitrogen-fixing Cyanobacteria in the Near-native State.

    Duersch, Bobby G / Soini, Steven A / Luo, Yanqi / Liu, Xiaoyang / Chen, Si / Merk, Vivian M

    Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada

    2023  Volume 29, Issue 29 Suppl 1, Page(s) 1953–1954

    Language English
    Publishing date 2023-08-23
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 1385710-1
    ISSN 1435-8115 ; 1431-9276
    ISSN (online) 1435-8115
    ISSN 1431-9276
    DOI 10.1093/micmic/ozad067.1011
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  3. Article: Etäpesäkkeistä emotuumorin etsintään.

    Soini, Ylermi

    Duodecim; laaketieteellinen aikakauskirja

    2013  Volume 129, Issue 10, Page(s) 1097–1101

    Abstract: A metastasis may be the first sign of a malignant tumor. Most commonly this is a pathologically enlarged lymph node, but other symptoms caused by metastases such as pathologic bone fractures may also produce the first symptom of the disease. When ... ...

    Title translation From metastases to the search of primary tumor.
    Abstract A metastasis may be the first sign of a malignant tumor. Most commonly this is a pathologically enlarged lymph node, but other symptoms caused by metastases such as pathologic bone fractures may also produce the first symptom of the disease. When searching for the primary tumor, the site of the metastasis and the patient's clinical data must be taken into consideration. Along with possible additional investigations, imaging studies and a biopsy taken from the metastasis lead to diagnosis in 90% of cases. The origin of metastasized tumors remains unraveled in approximately 3 to 5% of cases.
    MeSH term(s) Biopsy ; Humans ; Lymphatic Metastasis ; Neoplasm Metastasis/pathology ; Neoplasms, Unknown Primary/pathology
    Language Finnish
    Publishing date 2013
    Publishing country Finland
    Document type English Abstract ; Journal Article ; Review
    ZDB-ID 127604-9
    ISSN 0012-7183
    ISSN 0012-7183
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  4. Article: Claudin 6 is associated with a short survival and a short recurrent free interval in non-small cell lung carcinoma.

    Soini, Ylermi / Pirinen, Risto / Takasawa, Kumi / Osanai, Makoto / Takasawa, Akira

    Polish journal of pathology : official journal of the Polish Society of Pathologists

    2022  Volume 73, Issue 1, Page(s) 1–5

    Abstract: We investigated the expression of claudin 6 in non-small-cell lung carcinomas (NSCLC) by immunohistochemistry. Samples of 164 patients with NSCLC were studied by immunohistochemistry. Claudin 6 was expressed in 42 % of cases. Its expression was ... ...

    Abstract We investigated the expression of claudin 6 in non-small-cell lung carcinomas (NSCLC) by immunohistochemistry. Samples of 164 patients with NSCLC were studied by immunohistochemistry. Claudin 6 was expressed in 42 % of cases. Its expression was significantly more frequent in adeno- than in squamous cell carcinoma (p = 0.002). There was no association between the TNM status and claudin 6 expression. Claudin 6 associated with a poor prognosis of the patients and with a short recurrence-free interval (p = 0.002, p < 0.001). The association with survival had independent prognostic value (p = 0.011). The results show that claudin 6 can be regarded as a marker of poor prognosis in lung cancer. This is different to some other cancers, such as breast and cervical carcinoma suggesting that claudin 6 probably induces other cellular pathways in neoplastic lung cells than in those tumors. In lung cancer, adenocarcinomas were most abundantly positive indicating a higher linkage of claudin 6 to glandular differentiation.
    MeSH term(s) Biomarkers, Tumor ; Carcinoma, Non-Small-Cell Lung/metabolism ; Claudins ; Humans ; Lung Neoplasms/metabolism ; Prognosis
    Chemical Substances Biomarkers, Tumor ; Claudins ; claudin 6 (MRC5FX426I)
    Language English
    Publishing date 2022-07-17
    Publishing country Poland
    Document type Journal Article
    ZDB-ID 1283064-1
    ISSN 1233-9687 ; 0031-3114
    ISSN 1233-9687 ; 0031-3114
    DOI 10.5114/pjp.2022.117171
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  5. Article ; Online: The Influence of AA29504 on GABA

    Sikstus, Sylvia / Benkherouf, Ali Y / Soini, Sanna L / Uusi-Oukari, Mikko

    Neurochemical research

    2021  Volume 47, Issue 3, Page(s) 667–678

    Abstract: The unique pharmacological properties of δ-containing γ-aminobutyric acid type A receptors (δ- ... ...

    Abstract The unique pharmacological properties of δ-containing γ-aminobutyric acid type A receptors (δ-GABA
    MeSH term(s) Animals ; GABA-A Receptor Agonists/pharmacology ; HEK293 Cells ; Humans ; Ligands ; Mice ; Muscimol ; Receptors, GABA-A/metabolism
    Chemical Substances GABA-A Receptor Agonists ; Ligands ; Receptors, GABA-A ; Muscimol (2763-96-4)
    Language English
    Publishing date 2021-11-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 199335-5
    ISSN 1573-6903 ; 0364-3190
    ISSN (online) 1573-6903
    ISSN 0364-3190
    DOI 10.1007/s11064-021-03475-y
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  6. Article ; Online: Tight junctions in lung cancer and lung metastasis: a review.

    Soini, Ylermi

    International journal of clinical and experimental pathology

    2012  Volume 5, Issue 2, Page(s) 126–136

    Abstract: Tight junctions are structures located in the apicobasal region of the cell membranes. They regulate paracellular solute and electrical permeability of cell layers. Additionally, they influence cellular polarity, form a paracellular fence to molecules ... ...

    Abstract Tight junctions are structures located in the apicobasal region of the cell membranes. They regulate paracellular solute and electrical permeability of cell layers. Additionally, they influence cellular polarity, form a paracellular fence to molecules and pathogens and divide the cell membranes to apical and lateral compartments. Tight junctions adhere to the corresponding ones of neighbouring cells and by this way also mediate attachment of the cells to one other. Molecules forming the membranous part of tight junctions include occludin, claudins, tricellulin and junctional adhesion molecules. These molecules are attached to scaffolding proteins such as ZO-1, ZO-2 and ZO-3 through which signals are mediated to the cell interior. Expression of tight junction proteins, such as claudins, may be up- or downregulated in cancer and they are involved in EMT thus influencing tumor spread. Like in tumors of other sites, lung tumors show changes in the expression in tight junction proteins. In this review the significance of tight junctions and its proteins in lung cancer is discussed with a focus on the proteins forming the membranous part of these structures.
    MeSH term(s) Adenocarcinoma/metabolism ; Adenocarcinoma/secondary ; Down-Regulation ; Gene Expression Regulation, Neoplastic ; Humans ; Lung Neoplasms/metabolism ; Lung Neoplasms/pathology ; Membrane Proteins/genetics ; Membrane Proteins/metabolism ; Signal Transduction ; Tight Junctions/physiology ; Up-Regulation
    Chemical Substances Membrane Proteins
    Language English
    Publishing date 2012-02-12
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2418306-4
    ISSN 1936-2625 ; 1936-2625
    ISSN (online) 1936-2625
    ISSN 1936-2625
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  7. Article: Humulone Modulation of GABA

    Benkherouf, Ali Y / Eerola, Kim / Soini, Sanna L / Uusi-Oukari, Mikko

    Frontiers in neuroscience

    2020  Volume 14, Page(s) 594708

    Abstract: ... Humulus ... ...

    Abstract Humulus lupulus
    Language English
    Publishing date 2020-10-14
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2411902-7
    ISSN 1662-453X ; 1662-4548
    ISSN (online) 1662-453X
    ISSN 1662-4548
    DOI 10.3389/fnins.2020.594708
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  8. Article ; Online: Claudins in lung diseases.

    Soini, Ylermi

    Respiratory research

    2011  Volume 12, Page(s) 70

    Abstract: Tight junctions are the most apically localized part of the epithelial junctional complex. They regulate the permeability and polarity of cell layers and create compartments in cell membranes. Claudins are structural molecules of tight junctions. There ... ...

    Abstract Tight junctions are the most apically localized part of the epithelial junctional complex. They regulate the permeability and polarity of cell layers and create compartments in cell membranes. Claudins are structural molecules of tight junctions. There are 27 claudins known, and expression of different claudins is responsible for changes in the electrolyte and solute permeability in cells layers. Studies have shown that claudins and tight junctions also protect multicellular organisms from infections and that some infectious agents may use claudins as targets to invade and weaken the host's defense. In neoplastic diseases, claudin expression may be up- or downregulated. Since their expression is associated with specific tumor types or with specific locations of tumors to a certain degree, they can, in a restricted sense, also be used as tumor markers. However, the regulation of claudin expression is complex involving growth factors and integrins, protein kinases, proto-oncogens and transcription factors. In this review, the significance of claudins is discussed in lung disease and development.
    MeSH term(s) Cell Polarity ; Claudins/genetics ; Claudins/metabolism ; Epithelial Cells/metabolism ; Gene Expression Regulation ; Humans ; Lung/embryology ; Lung/metabolism ; Lung Diseases/genetics ; Lung Diseases/metabolism ; Male ; Permeability ; Signal Transduction ; Tight Junctions/metabolism
    Chemical Substances Claudins
    Keywords covid19
    Language English
    Publishing date 2011-05-27
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2041675-1
    ISSN 1465-993X ; 1465-9921
    ISSN (online) 1465-993X
    ISSN 1465-9921
    DOI 10.1186/1465-9921-12-70
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  9. Article ; Online: Expression of thioredoxin, 8Hydroxy-deguanosine and peroxiredoxins in placental tissues.

    Pirinen, Elina / Soini, Ylermi

    International journal of clinical and experimental pathology

    2017  Volume 10, Issue 8, Page(s) 8353–8360

    Abstract: In this study we analyzed the expression of 8-hydroxy-deguanosine (8OHdG), thioredoxin (Trx) and peroxiredoxins (Prx) 2, 3, 4, 5 and 6 in 80 cases of placental samples representing both normal and diseased placentas. The staining was evaluated separately ...

    Abstract In this study we analyzed the expression of 8-hydroxy-deguanosine (8OHdG), thioredoxin (Trx) and peroxiredoxins (Prx) 2, 3, 4, 5 and 6 in 80 cases of placental samples representing both normal and diseased placentas. The staining was evaluated separately in the stromal, trophoblastic and vascular components of the tissues. The results indicate that during the first trimester the level of reactive oxygen species (ROS) as indicated by 8OHdG was highest in the stromal component, which was also the case for Trx, Prx3, Prx4 and Prx6. In diseased placentas stromal 8OHdG was lower in cases with chromosomal aberrations but higher in molar disease in both trophoblastic and stromal cells. In chorioamnionitis stromal prx 5 and prx6 were high. Stromal prx4 and trophoblastic prx6 and stromal and endothelial Trx were also higher in molar disease. The results show that the oxidative stress is high in placentas during the first trimester. This probably reflects the oxidation burst of the placental tissues due to development of vascularity. In diseased placentas elevated levels of Prxs were seen in chorioamnionitis reflecting the ROS stress induced by inflammatory cells. The higher values of antioxidative enzymes in molar disease are possibly due to defective placentation. All in all, the results underline the importance on ROS associated mechanisms in placental development and the function of placenta to protect the developing fetus from harmful effects of reactive oxygen species as evidenced by their abundant expression in different cellular compartments of the placenta.
    Language English
    Publishing date 2017-08-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2418306-4
    ISSN 1936-2625 ; 1936-2625
    ISSN (online) 1936-2625
    ISSN 1936-2625
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  10. Article ; Online: Synchrotron-based X-ray fluorescence microscopy mapping the ionome of a toxic freshwater cyanobacterium.

    Duersch, Bobby G / Luo, Yanqi / Chen, Si / Soini, Steven A / Raja Somu, Dawn M / Merk, Vivian M

    Environmental pollution (Barking, Essex : 1987)

    2023  Volume 334, Page(s) 121781

    Abstract: Harmful algal blooms (HABs) pose a major environmental concern across the globe. In abundance, cyanobacteria, or so-called green-blue algae can produce extremely dangerous cyanotoxins that harm humans and animals. This study focused on the mapping and ... ...

    Abstract Harmful algal blooms (HABs) pose a major environmental concern across the globe. In abundance, cyanobacteria, or so-called green-blue algae can produce extremely dangerous cyanotoxins that harm humans and animals. This study focused on the mapping and distribution of intracellular macro-and micronutrients of the wide-spread freshwater cyanobacteria Microcystis aeruginosa (M. aeruginosa). Towards a better understanding of trace metal uptake and homeostasis throughout the cell cycle, we quantitatively mapped the spatial distribution of the elements P, K, Fe, Ca, Zn, Mn, and Cu across the ultrastructure of frozen-hydrated single cells using state-of-the-art X-ray nanofluorescence imaging at the Advanced Photon Source (APS) at Argonne National Laboratory. Bulk cellular nutrient and trace metal content correlated well with the total intracellular elemental content in individual cells obtained by quantitative synchrotron X-ray fluorescence measurements. Multi-dimensional mappings showed P and K atoms colocalized as discrete semicircular hotspots that were analyzed with respect to their stoichiometry. Elevated Cu and Ca concentrations were detected along division plane of cells. P and K were found to have similar spatial elemental distribution with about 65% and 69% of the total cellular P and K, respectively, located at the hotspots. The P and K colocalization were refined further using nanotomography, showing a K envelope surrounding the P core. Inorganic P and organic P compounds were specified using solution-state
    MeSH term(s) Humans ; Animals ; X-Rays ; Synchrotrons ; Trace Elements/analysis ; Cyanobacteria ; Fresh Water ; Chlorophyta ; Microscopy, Fluorescence
    Chemical Substances Trace Elements
    Language English
    Publishing date 2023-05-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 280652-6
    ISSN 1873-6424 ; 0013-9327 ; 0269-7491
    ISSN (online) 1873-6424
    ISSN 0013-9327 ; 0269-7491
    DOI 10.1016/j.envpol.2023.121781
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