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  1. Article: A Review and Comparative Analysis of Transoral Surgical Treatment versus Conservative Management in Early-Stage Oropharyngeal Cancer.

    Rujan, Simona Andreea / Bertesteanu, Serban Vifor Gabriel / Grigore, Raluca / Popescu, Bogdan / Condeescu-Cojocarita, Mihnea / Alexandru, Nicolaescu / Bertesteanu, Gloria Simona / Schipor-Diaconu, Teodora Elena / Cirstea, Anca Ionela / Tudosie, Mihai Dumitru / Popescu, Irina-Doinita / Taher, Bianca Petra

    Journal of personalized medicine

    2024  Volume 14, Issue 3

    Abstract: Introduction: Oropharyngeal cancer requires a comprehensive evaluation of treatment options, including surgery, radiation therapy, and chemotherapy. It is crucial to customize these treatments based on the stage of the tumor and the overall health of ... ...

    Abstract Introduction: Oropharyngeal cancer requires a comprehensive evaluation of treatment options, including surgery, radiation therapy, and chemotherapy. It is crucial to customize these treatments based on the stage of the tumor and the overall health of the patient, enabling personalized or combined approaches. Transoral surgical techniques have regained popularity due to the advancements and limitations of non-surgical strategies. The potential influence of surgical procedures on patients' quality of life highlights the need for careful intervention selection; among them, the transoral approach has proven to be especially beneficial for early-stage oropharyngeal neoplasms.
    Methods: To explore potential treatments for early-stage oropharyngeal malignancies, this study carefully reviews the literature, using information from papers, current research, and global databases. The review protocol commenced on November 2023. A comprehensive search of the PUBMED database was undertaken, employing pertinent terms associated with oropharyngeal, transoral surgery or radiotherapy, robotic surgery, and chemotherapy.
    Results: Treating early-stage oropharyngeal neoplasms is particularly intriguing due to the multitude of variables influencing treatment decisions, leading to ongoing debates in specialized literature. Regardless of the chosen approach, maintaining a high quality of life is crucial. To assess this, standardized questionnaires from the European Organization for Research and Treatment of Cancer were employed, revealing superior outcomes for patients solely undergoing surgical intervention. Additionally, in the realm of specialized literature, cases of HPV-positive oropharyngeal neoplasms are recognized for their heightened radiosensitivity and more favorable long-term prognosis.
    Conclusions: Surgical intervention and radiotherapy are the main treatment options for oropharyngeal cancer, and they can be used separately or together for maximum effectiveness. Amid ongoing discussions, determining the superior effectiveness between the two options continues to be a matter of debate. This study provides a comprehensive analysis, offering valuable perspectives for future discussions. Neoplasm in the oropharynx can be effectively treated using transoral microsurgery.
    Language English
    Publishing date 2024-03-04
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662248-8
    ISSN 2075-4426
    ISSN 2075-4426
    DOI 10.3390/jpm14030283
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Management of Locally Advanced Laryngeal Cancer-From Risk Factors to Treatment, the Experience of a Tertiary Hospital from Eastern Europe.

    Cîrstea, Anca-Ionela / Berteșteanu, Șerban Vifor Gabriel / Scăunașu, Răzvan-Valentin / Popescu, Bogdan / Bejenaru, Paula Luiza / Simion-Antonie, Catrinel Beatrice / Berteșteanu, Gloria Simona / Diaconu, Teodora Elena / Taher, Petra Bianca / Rujan, Simona-Andreea / Oașă, Irina-Doinița / Grigore, Raluca

    International journal of environmental research and public health

    2023  Volume 20, Issue 6

    Abstract: Laryngeal cancer is an important oncological entity in which prognosis depends on the establishment of appropriate preventive and diagnostic measures, especially in high-risk populations. We present a retrospective two-year study (January 2021 to ... ...

    Abstract Laryngeal cancer is an important oncological entity in which prognosis depends on the establishment of appropriate preventive and diagnostic measures, especially in high-risk populations. We present a retrospective two-year study (January 2021 to December 2022) with 152 patients diagnosed with laryngeal cancer from a tertiary hospital in Romania. The average age of the patients was 62 years old for both sexes, with a range from 44 to 83 years. The most frequent symptom was dysphonia with or without dyspnea in 142 cases (93.42%), followed by dyspnea alone in nine patients (5.92%) and dysphagia in one case (0.66%). Surgical treatment in this study consisted of partial laryngectomy (CO
    MeSH term(s) Male ; Female ; Humans ; Adult ; Middle Aged ; Aged ; Aged, 80 and over ; Laryngeal Neoplasms/epidemiology ; Laryngeal Neoplasms/surgery ; Retrospective Studies ; Tertiary Care Centers ; Laryngectomy/methods ; Risk Factors ; Treatment Outcome
    Language English
    Publishing date 2023-03-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2175195-X
    ISSN 1660-4601 ; 1661-7827
    ISSN (online) 1660-4601
    ISSN 1661-7827
    DOI 10.3390/ijerph20064737
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  3. Article: Antimicrobial therapy in complicated rhinosinusitis.

    Beatrice, Simion-Antonie Catrinel / Luiza, Bejenaru Paula / Bogdan, Popescu / Simona, Berteșteanu Gloria / Mihnea, Condeescu-Cojocărița / Ionela, Cîrstea Anca / Elena, Diaconu Teodora / Petra, Taher Bianca / Simona-Andreea, Rujan / Doinița, Oașă Irina / Gabriel, Berteșteanu Șerban Vifor / Raluca, Grigore

    Frontiers in microbiology

    2022  Volume 13, Page(s) 960319

    Abstract: Introduction: Complicated rhinosinusitis is a rare but life-threatening pathology that requires both medical and surgical treatment as soon as possible. The spread of the infection from the paranasal sinuses affects, most often, the orbit, patients ... ...

    Abstract Introduction: Complicated rhinosinusitis is a rare but life-threatening pathology that requires both medical and surgical treatment as soon as possible. The spread of the infection from the paranasal sinuses affects, most often, the orbit, patients presenting diplopia, preseptal cellulitis, orbital cellulitis, or even blindness alongside exteriorization of puss from the middle meatus and nasal obstruction.
    Materials and methods: We carried out a retrospective review of 32 patients that were diagnosed in our clinic with complicated rhinosinusitis from 2015 to 2022. All the patients received at least one intravenous antibiotic, and some also received antifungal drugs. All patients underwent surgery, either endoscopically or combined approach. Nasal washout or nasal swabs during surgery were sent for laboratory examination in all patients, and we studied the microbial etiology in these extensive infections. A database with all the information regarding demographic and medical data was established.
    Results: 78% of the patients were male, with a mean age of 50.55. A wide range of antibiotics were used, while some patients, diagnosed with mucormycosis also received antifungal drugs. The mean hospitalization period was 12 days. We correlated the type of antibiotic with the hospitalization period and the outcome but also the degree of involvement of the orbit and the microbial strains identified.
    Discussion: The management of patients with complicated rhinosinusitis is complex and dynamic and it must be tailored to every patient, after an interdisciplinary meeting with the infectious disease specialist, ophthalmologist, and rhinologist. The microbial strains that produce such important infections are sometimes multi-resistant or combined, patients usually already had followed a course of antibiotics at home, and choosing the right treatment is sometimes challenging.
    Language English
    Publishing date 2022-08-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2022.960319
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Management of Locally Advanced Laryngeal Cancer—From Risk Factors to Treatment, the Experience of a Tertiary Hospital from Eastern Europe

    Anca-Ionela Cîrstea / Șerban Vifor Gabriel Berteșteanu / Răzvan-Valentin Scăunașu / Bogdan Popescu / Paula Luiza Bejenaru / Catrinel Beatrice Simion-Antonie / Gloria Simona Berteșteanu / Teodora Elena Diaconu / Petra Bianca Taher / Simona-Andreea Rujan / Irina-Doinița Oașă / Raluca Grigore

    International Journal of Environmental Research and Public Health, Vol 20, Iss 4737, p

    2023  Volume 4737

    Abstract: Laryngeal cancer is an important oncological entity in which prognosis depends on the establishment of appropriate preventive and diagnostic measures, especially in high-risk populations. We present a retrospective two-year study (January 2021 to ... ...

    Abstract Laryngeal cancer is an important oncological entity in which prognosis depends on the establishment of appropriate preventive and diagnostic measures, especially in high-risk populations. We present a retrospective two-year study (January 2021 to December 2022) with 152 patients diagnosed with laryngeal cancer from a tertiary hospital in Romania. The average age of the patients was 62 years old for both sexes, with a range from 44 to 83 years. The most frequent symptom was dysphonia with or without dyspnea in 142 cases (93.42%), followed by dyspnea alone in nine patients (5.92%) and dysphagia in one case (0.66%). Surgical treatment in this study consisted of partial laryngectomy (CO 2 laser transoral tumor ablation, supraglottic horizontal laryngectomy or hemilaryngectomy), or total laryngectomy. The main treatment was total laryngectomy (63%). For the eight patients with initial organ preservation treatment, the average time of recurrence was about two-and-a-half years. For the four patients who underwent a total circular pharyngo-laryngectomy, the upper digestive tract needed to be rebuilt with a salivary bypass tube or with a tubed myocutaneous flap from the major pectoralis muscle. One strong point is characteristic of the study group in gathering patients with advanced stages of laryngeal carcinoma candidates for salvage surgery and extended reconstruction methods. The development of new prevention protocols is mandatory in Eastern European countries.
    Keywords laryngeal cancer ; risk factors ; advanced cancer ; Medicine ; R
    Subject code 610 ; 616
    Language English
    Publishing date 2023-03-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Histopathological findings in the advanced natural evolution of the SARS-CoV-2 infection.

    Cîrstea, Andreea Elena / Buzulică, Radu Lucian / Pirici, Daniel / Ceauşu, Mihail Constantin / Iman, Radu Vasile / Gheorghe, Ovidiu Mircea / Neamţu, Simona Daniela / Stanca, Liliana / Ene, Răzvan / Kumar-Singh, Samir / Mogoantă, Laurenţiu

    Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie

    2020  Volume 61, Issue 1, Page(s) 209–218

    Abstract: We are reporting a case of natural evolution and pathological data from a young person that was diagnosed with coronavirus disease 2019 (COVID-19). All data has been collected from the autopsy of a 30-year-old female, which was performed by the ... ...

    Abstract We are reporting a case of natural evolution and pathological data from a young person that was diagnosed with coronavirus disease 2019 (COVID-19). All data has been collected from the autopsy of a 30-year-old female, which was performed by the Department of Forensic Medicine from Emergency County Hospital, Drobeta Turnu Severin, Mehedinţi County, Romania. The infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was confirmed by reverse transcription polymerase chain reaction (RT-PCR) on the lung tissue which was obtained during autopsy. This case provides the opportunity to study the natural evolution of COVID-19 pneumonia in a young person with clinical signs of pneumonia but without associated comorbidities. The patient had not received any treatment. The histopathological examination of the lung revealed a process of productive proliferation, proteinaceous and fibrin-macrophagic interalveolar spaces exudate, and lesions consistent with vasculitis. In the heart, we identified a cardiac thrombus. These changes are likely to suggest an advanced natural evolution of SARS-CoV-2 virus infection.
    MeSH term(s) Adult ; Autopsy ; Betacoronavirus ; COVID-19 ; COVID-19 Testing ; Clinical Laboratory Techniques ; Coronavirus Infections/diagnosis ; Coronavirus Infections/physiopathology ; Coronavirus Infections/virology ; Female ; Humans ; Kidney/pathology ; Liver/pathology ; Lung/pathology ; Lung/virology ; Myocardium/pathology ; Pancreas/pathology ; Pandemics ; Pneumonia, Viral/physiopathology ; Pneumonia, Viral/virology ; Reverse Transcriptase Polymerase Chain Reaction ; Romania ; SARS-CoV-2 ; Thrombosis/pathology ; Thrombosis/virology
    Keywords covid19
    Language English
    Publishing date 2020-10-19
    Publishing country Romania
    Document type Case Reports ; Journal Article
    ZDB-ID 1062519-7
    ISSN 2066-8279 ; 1220-0522 ; 0035-4007
    ISSN (online) 2066-8279
    ISSN 1220-0522 ; 0035-4007
    DOI 10.47162/RJME.61.1.23
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1105: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article: The immunoexpression of EGFR, HER2 and HER3 in malignant serous ovarian tumors.

    Cîrstea, Andreea Elena / Stepan, Alex Emilian / Mărgăritescu, Claudiu / Zăvoi, Roxana Eugenia / Olimid, Daniel Alin / Simionescu, Cristiana Eugenia

    Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie

    2018  Volume 58, Issue 4, Page(s) 1269–1273

    Abstract: The expression of epidermal growth factor (EGF) receptors is common in human carcinomas and the proteins are used as therapeutics targets. In this study, we analyzed the immunoexpression of EGFR, HER2 (EGFR2) and HER3 (EGFR3) in 41 cases of serous ... ...

    Abstract The expression of epidermal growth factor (EGF) receptors is common in human carcinomas and the proteins are used as therapeutics targets. In this study, we analyzed the immunoexpression of EGFR, HER2 (EGFR2) and HER3 (EGFR3) in 41 cases of serous borderline ovarian tumors and carcinomas, in relation to the degree of differentiation and tumor stage. The quantification of the results was done using the final staining score (FSS), which took into account the number of labeled cells and the intensity of immunoreactions. For all the receptors, the FSS values corresponding to the high-grade serous carcinomas were significantly superior compared with low-grade carcinomas and borderline tumors. Also, the FSS values associated with advanced stages ovarian tumors were significantly superior compared to those in the initial stages. In this study, we found positive linear correlations between the values associated with the expression of EGF receptors. The relation of EGFR, HER2 and HER3 immunoexpression with the lesion subtype, tumor grade and stage, designates the EGF receptors system as possible therapeutic target in ovarian serous tumors.
    MeSH term(s) Cystadenocarcinoma, Serous/enzymology ; Cystadenocarcinoma, Serous/genetics ; Cystadenocarcinoma, Serous/pathology ; Female ; Humans ; Immunohistochemistry ; Neoplasm Staging ; Ovarian Neoplasms/enzymology ; Ovarian Neoplasms/genetics ; Ovarian Neoplasms/pathology ; Receptor, Epidermal Growth Factor/biosynthesis ; Receptor, Epidermal Growth Factor/genetics ; Receptor, ErbB-2/biosynthesis ; Receptor, ErbB-2/genetics ; Receptor, ErbB-3/biosynthesis ; Receptor, ErbB-3/genetics
    Chemical Substances EGFR protein, human (EC 2.7.10.1) ; ERBB2 protein, human (EC 2.7.10.1) ; ERBB3 protein, human (EC 2.7.10.1) ; Receptor, Epidermal Growth Factor (EC 2.7.10.1) ; Receptor, ErbB-2 (EC 2.7.10.1) ; Receptor, ErbB-3 (EC 2.7.10.1)
    Language English
    Publishing date 2018-03-16
    Publishing country Romania
    Document type Journal Article
    ZDB-ID 1062519-7
    ISSN 2066-8279 ; 1220-0522 ; 0035-4007
    ISSN (online) 2066-8279
    ISSN 1220-0522 ; 0035-4007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1105: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article: Histopathological findings in the advanced natural evolution of the SARS-CoV-2 infection

    Cîrstea, Andreea Elena / Buzulica, Radu Lucian / Pirici, Daniel / Ceausu, Mihail Constantin / Iman, Radu Vasile / Gheorghe, Ovidiu Mircea / Neamtu, Simona Daniela / Stanca, Liliana / Ene, Razvan / Kumar-Singh, Samir / Mogoanta, Laurentiu

    Rom J Morphol Embryol

    Abstract: We are reporting a case of natural evolution and pathological data from a young person that was diagnosed with coronavirus disease 2019 (COVID-19). All data has been collected from the autopsy of a 30-year-old female, which was performed by the ... ...

    Abstract We are reporting a case of natural evolution and pathological data from a young person that was diagnosed with coronavirus disease 2019 (COVID-19). All data has been collected from the autopsy of a 30-year-old female, which was performed by the Department of Forensic Medicine from Emergency County Hospital, Drobeta Turnu Severin, Mehedinti County, Romania. The infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was confirmed by reverse transcription polymerase chain reaction (RT-PCR) on the lung tissue which was obtained during autopsy. This case provides the opportunity to study the natural evolution of COVID-19 pneumonia in a young person with clinical signs of pneumonia but without associated comorbidities. The patient had not received any treatment. The histopathological examination of the lung revealed a process of productive proliferation, proteinaceous and fibrin-macrophagic interalveolar spaces exudate, and lesions consistent with vasculitis. In the heart, we identified a cardiac thrombus. These changes are likely to suggest an advanced natural evolution of SARS-CoV-2 virus infection.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #693877
    Database COVID19

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