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  1. Article ; Online: Leydig stem cells and future therapies for hypogonadism.

    Achua, Justin K / Frech, Fabio S / Ramasamy, Ranjith

    Current opinion in endocrinology, diabetes, and obesity

    2020  Volume 27, Issue 6, Page(s) 419–423

    Abstract: Purpose of review: In this review, we outline the most recent advances in the development of Leydig stem cells (LSCs) and summarize the current and upcoming treatments for hypogonadism.: Recent findings: In-vitro and in-vivo studies show that ... ...

    Abstract Purpose of review: In this review, we outline the most recent advances in the development of Leydig stem cells (LSCs) and summarize the current and upcoming treatments for hypogonadism.
    Recent findings: In-vitro and in-vivo studies show that inducing stem cells to differentiate into testosterone-producing adult Leydig cells is possible. In addition, LSCs can be grafted with Sertoli cells to increase testosterone levels in vivo. This therapy causes minimal effects on luteinizing hormone and follicle stimulating hormone levels. Novel therapies for hypogonadism include varying methods of testosterone delivery such as intranasal and oral agents, as well as novel selective estrogen and androgen receptor modulators.
    Summary: LSC therapies provide an effective way of increasing testosterone levels without detrimentally affecting gonadotropin levels. Next steps in developing viable Leydig cell grafting options for the treatment of hypogonadism should include the assessment of efficacy and potency of current animal models in human trials. Recently, both intranasal and oral testosterone have been made available and shown promising results in treating hypogonadism while maintaining fertility. Enclomiphene citrate and selective androgen receptor modulators have been suggested as future therapies for hypogonadism; however, further studies assessing efficacy and adverse effects are needed.
    MeSH term(s) Adult ; Animals ; Cell Differentiation/drug effects ; Fertility/physiology ; Humans ; Hypogonadism/therapy ; Leydig Cells/cytology ; Leydig Cells/physiology ; Leydig Cells/transplantation ; Male ; Stem Cell Transplantation/methods ; Stem Cell Transplantation/trends ; Stem Cells/physiology ; Testosterone/therapeutic use
    Chemical Substances Testosterone (3XMK78S47O)
    Language English
    Publishing date 2020-10-01
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2272017-0
    ISSN 1752-2978 ; 1752-296X
    ISSN (online) 1752-2978
    ISSN 1752-296X
    DOI 10.1097/MED.0000000000000580
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Strategies to Increase Testosterone in Men Seeking Fertility.

    Chu, Kevin Y / Achua, Justin K / Ramasamy, Ranjith

    Urology research & practice

    2019  Volume 49, Issue 1, Page(s) 2–6

    Abstract: Prevalence of testosterone deficiency is increasing in the adolescent and young adult male population. As the average paternal age rises, there is a significant population of men with hypogonadism seeking testosterone therapy wishing to achieve or ... ...

    Abstract Prevalence of testosterone deficiency is increasing in the adolescent and young adult male population. As the average paternal age rises, there is a significant population of men with hypogonadism seeking testosterone therapy wishing to achieve or maintain fertility potential. Identification of potential lifestyle modifications that may improve the testosterone deficiency is one of the initial interventions of the holistic strategy in treatment. This is followed by drug therapy; however, traditional testosterone therapy acts as a contraceptive by suppressing the hypothalamus-pituitary-gonadal (HPG) axis and therefore cannot be used as a treatment strategy. A solution has been the off-label use of selective estrogen receptor modulators, human chorionic gonadotropin (hCG), and anastrozole inhibitors to treat hypogonadal symptoms while increasing intratesticular testosterone, a necessity for spermatogenesis. Recently, a novel therapy, Natesto intranasal testosterone gel, has been shown to increase serum testosterone levels while maintaining semen parameters. This is hypothesized to be because of its short-acting properties having lesser effect on the HPG axis, in contrast to the long-acting properties of traditional testosterone therapy. It is important to differentiate hypogonadal men between those seeking to achieve or maintain fertility status because the drug therapy of choice differs. This can be accomplished by determining the levels of 17-hydroxyprogesterone (17-OHP), because it is a biomarker for intratesticular testosterone. Those with low 17-OHP may wish to initiate treatment with alternative therapies, whereas those with high 17-OHP may trial short-acting testosterone therapies. As the urologist's armamentarium continues to increase, better strategies to increase testosterone levels in men seeking fertility can be achieved.
    Language English
    Publishing date 2019-11-04
    Publishing country Turkey
    Document type Journal Article
    ISSN 2980-1478
    ISSN (online) 2980-1478
    DOI 10.5152/tud.2020.20436
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Correction: Neonatal Circumcision: What Are the Factors Affecting Parental Decision?

    Guevara, Christian G / Achua, Justin K / Blachman-Braun, Ruben / Cabrera-Valencia, Isabella / Ransford, George A / Gosalbez, Rafael / Labbie, Andrew S / Castellan, Miguel A / Alam, Alireza

    Cureus

    2023  Volume 15, Issue 10, Page(s) c137

    Abstract: This corrects the article DOI: 10.7759/cureus.19415.]. ...

    Abstract [This corrects the article DOI: 10.7759/cureus.19415.].
    Language English
    Publishing date 2023-10-13
    Publishing country United States
    Document type Published Erratum
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.c137
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: POST-MORTEM EXAMINATION OF THE EFFECTS OF SEVERE ACUTE RESPIRATORY SYNDROME (SARS) ASSOCIATED CORONAVIRUS (SARS-COV) ON TESTIS

    Achua, Justin K. / Chu, Kevin Y. / Arora, Himanshu / Lakymenko, Oleksii / Kryvenko, Oleksandr N. / Ramasamy, Ranjith

    Fertility and Sterility

    Keywords covid19
    Publisher Elsevier; PMC
    Document type Article ; Online
    DOI 10.1016/j.fertnstert.2020.08.289
    Database COVID19

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  5. Article ; Online: Rising Black voices in urology - the next generation.

    Achua, Justin K / Bilbrew, Jordan / Cooley, Keiko / Herbert, Amber / Matthew-Onabanjo, Asia N / Moghalu, Odinachi / Myrie, Akya / Odeluga, Nkiruka / Owens-Walton, Jeunice / Rieland, Arriana / Walker, Dyvon / Kaba, Aboubacar

    Nature reviews. Urology

    2021  Volume 18, Issue 6, Page(s) 327–335

    MeSH term(s) Humans ; Urology
    Language English
    Publishing date 2021-05-04
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 2493737-X
    ISSN 1759-4820 ; 1759-4812
    ISSN (online) 1759-4820
    ISSN 1759-4812
    DOI 10.1038/s41585-021-00461-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6030: Show issues Location:
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  6. Article ; Online: Long-term outcomes after surgery for catastrophic epilepsy in infants: institutional experience and review of the literature.

    Ye, Vincent C / Shah, Ashish H / Sur, Samir / Achua, Justin K / Wang, Shelly / Ibrahim, George M / Bhatia, Sanjiv / Ragheb, John

    Journal of neurosurgery. Pediatrics

    2020  Volume 26, Issue 2, Page(s) 157–164

    Abstract: Objective: Uncontrolled epilepsy is associated with serious deleterious effects on the neurological development of infants and has been described as "catastrophic epilepsy." Recently, there has been increased emphasis on early surgical interventions to ... ...

    Abstract Objective: Uncontrolled epilepsy is associated with serious deleterious effects on the neurological development of infants and has been described as "catastrophic epilepsy." Recently, there has been increased emphasis on early surgical interventions to preserve or rescue neurodevelopmental outcomes in infants with early intractable epilepsy. The enthusiasm for early treatments is often tempered by concerns regarding the morbidity of neurosurgical procedures in very young patients. Here, the authors report outcomes following the surgical management of infants (younger than 1 year).
    Methods: The authors performed a retrospective review of patients younger than 1 year of age who underwent surgery for epilepsy at Miami (Nicklaus) Children's Hospital and Jackson Memorial Hospital between 1994 and 2018. Patient demographics, including the type of interventions, were recorded. Seizure outcomes (at last follow-up and at 1 year postoperatively) as well as complications are reported.
    Results: Thirty-eight infants (median age 5.9 months) underwent a spectrum of surgical interventions, including hemispherectomy (n = 17), focal resection (n = 13), and multilobe resections (n = 8), with a mean follow-up duration of 9.1 years. Hemimegalencephaly and cortical dysplasia were the most commonly encountered pathologies. Surgery for catastrophic epilepsy resulted in complete resolution of seizures in 68% (n = 26) of patients, and 76% (n = 29) had a greater than 90% reduction in seizure frequency. Overall mortality and morbidity were 0% and 10%, respectively. The latter included infections (n = 2), infarct (n = 1), and immediate reoperation for seizures (n = 1).
    Conclusions: Surgical intervention for catastrophic epilepsy in infants remains safe, efficacious, and durable. The authors' work provides the longest follow-up of such a series on infants to date and compares favorably with previously published series.
    Language English
    Publishing date 2020-04-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2403985-8
    ISSN 1933-0715 ; 1933-0707
    ISSN (online) 1933-0715
    ISSN 1933-0707
    DOI 10.3171/2020.1.PEDS19537
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uk I Zs.135 -Pediatrics-: Show issues Location:
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  7. Article: Neonatal Circumcision: What Are the Factors Affecting Parental Decision?

    Guevara, Christian G / Achua, Justin K / Blachman-Braun, Ruben / Cabrera-Valencia, Isabella / Ransford, George A / Gosalbez, Rafael / Labbie, Andrew S / Castellan, Miguel A / Alam, Alireza

    Cureus

    2021  Volume 13, Issue 11, Page(s) e19415

    Abstract: Introduction: The American Academy of Pediatrics (AAP) guidelines state that the health benefits of circumcision outweigh the risks, but these benefits are not enough to recommend universal newborn circumcision. Therefore, it is the guardians' decision ... ...

    Abstract Introduction: The American Academy of Pediatrics (AAP) guidelines state that the health benefits of circumcision outweigh the risks, but these benefits are not enough to recommend universal newborn circumcision. Therefore, it is the guardians' decision to circumcise their son. In this study, we assess the factors that influence the decision-making process for newborn circumcision.
    Methods: A prospective study was done from January to April 2020 for newborn circumcision. AAP guidelines were used as an educational tool and given to the parents on the day of patient circumcision assessment. On procedure day, a self-reported survey regarding the reasons for circumcision and the usefulness of the guideline as an educational resource was given to guardians.
    Results:  A total of 265 parents completed the survey. Of the study variables, the future health of the child and the circumcision status of the father were considered extremely important factors influencing the decision-making process for 168 (63.4%) and 90 (34%) guardians, respectively. The study showed that 226 (85.3%) of the parents found the AAP guidelines helpful whereas 39 (14.7%) did not.
    Conclusion:  Overall results suggest that the health of the child and the father of the child being circumcised are the primary factors that influence the guardians' decision to circumcise their child. In addition, providing parents with an educational resource such as the AAP guidelines policy statement prior to circumcision may serve as a way to supplement the discussion between parents and providers.
    Language English
    Publishing date 2021-11-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.19415
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Perspectives of the Modern Black Urology Applicant.

    Kaba, Aboubacar / Achua, Justin / Herbert, Amber / Matthew-Onabanjo, Asia N / Moghalu, Odinachi / Odeluga, Nkiruka / Rieland, Arriana / Seideman, Casey / Cooley, Keiko

    Urology

    2021  Volume 162, Page(s) 114–115

    MeSH term(s) Humans ; Internship and Residency ; Personnel Selection ; Urology/education
    Language English
    Publishing date 2021-07-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 192062-5
    ISSN 1527-9995 ; 0090-4295
    ISSN (online) 1527-9995
    ISSN 0090-4295
    DOI 10.1016/j.urology.2021.07.006
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1142: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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    Zs.MO 275: Show issues

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  9. Article ; Online: Anxious behavior induces elevated hippocampal Cb

    Robertson, James M / Achua, Justin K / Smith, Justin P / Prince, Melissa A / Staton, Clarissa D / Ronan, Patrick J / Summers, Tangi R / Summers, Cliff H

    Neuroscience

    2017  Volume 352, Page(s) 273–284

    Abstract: Anxiety is differentially expressed across a continuum of stressful/fearful intensity, influenced by endocannabinoid systems and receptors. The hippocampus plays important roles in the regulation of affective behavior, emotion, and anxiety, as well as ... ...

    Abstract Anxiety is differentially expressed across a continuum of stressful/fearful intensity, influenced by endocannabinoid systems and receptors. The hippocampus plays important roles in the regulation of affective behavior, emotion, and anxiety, as well as memory. Location of Cb
    MeSH term(s) Acoustic Stimulation/adverse effects ; Animals ; Conditioning (Psychology)/physiology ; Disease Models, Animal ; Escape Reaction/physiology ; Fear/psychology ; Gene Expression Regulation/physiology ; Hippocampus/metabolism ; Interpersonal Relations ; Male ; Maze Learning/physiology ; Mice ; Mice, Inbred C57BL ; Physical Conditioning, Animal/physiology ; RNA, Messenger/metabolism ; Receptor, Cannabinoid, CB1/genetics ; Receptor, Cannabinoid, CB1/metabolism ; Receptor, Cannabinoid, CB2/genetics ; Receptor, Cannabinoid, CB2/metabolism ; Receptors, Transferrin/genetics ; Receptors, Transferrin/metabolism ; Stress, Psychological/pathology ; Stress, Psychological/physiopathology
    Chemical Substances RNA, Messenger ; Receptor, Cannabinoid, CB1 ; Receptor, Cannabinoid, CB2 ; Receptors, Transferrin ; Tfrc protein, mouse
    Language English
    Publishing date 2017-04-07
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 196739-3
    ISSN 1873-7544 ; 0306-4522
    ISSN (online) 1873-7544
    ISSN 0306-4522
    DOI 10.1016/j.neuroscience.2017.03.061
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  10. Article: Histopathology and Ultrastructural Findings of Fatal COVID-19 Infections on Testis.

    Achua, Justin K / Chu, Kevin Y / Ibrahim, Emad / Khodamoradi, Kajal / Delma, Katiana S / Iakymenko, Oleksii A / Kryvenko, Oleksandr N / Arora, Himanshu / Ramasamy, Ranjith

    The world journal of men's health

    2020  Volume 39, Issue 1, Page(s) 65–74

    Abstract: Purpose: To evaluate the presence and analyze the pathological changes within the testes of patients who died or recovered from severe acute respiratory syndrome coronavirus 2 (COVID-19) complications.: Materials and methods: Testis tissue was ... ...

    Abstract Purpose: To evaluate the presence and analyze the pathological changes within the testes of patients who died or recovered from severe acute respiratory syndrome coronavirus 2 (COVID-19) complications.
    Materials and methods: Testis tissue was collected from autopsies of COVID-19 positive (n=6) and negative men (n=3). Formalin-fixed paraffin-embedded tissues were stained with hematoxylin and eosin (H&E) and subjected to immunofluorescence for angiotensin-converting enzyme 2 (ACE-2) expression. Fluorescent-labeled tissue slides were imaged on a quantitative pathology scope with various zoom levels allowing for qualitative and quantitative interpretation. Tissue from four COVID-19 positive autopsy cases and a live seroconverted patient was imaged with transmission electron microscopy (TEM).
    Results: H&E histomorphology showed three of the six COVID-19 biopsies had normal spermatogenesis while the remaining three had impaired spermatogenesis. TEM showed the COVID-19 virus in testis tissue of one COVID-19 positive autopsy case and the live biopsy, H&E stain on the same autopsy case demonstrated interstitial macrophage and leukocyte infiltration. Immunofluorescent stained slides from six COVID-19 positive men demonstrated a direct association between increased quantitative ACE-2 levels and impairment of spermatogenesis.
    Conclusions: The novel COVID-19 has an affinity for ACE-2 receptors. Since ACE-2 receptor expression is high in the testes, we hypothesized that COVID-19 is prevalent in testes tissue of infected patients. This study suggests the male reproductive tract, specifically the testes, may be targets of COVID-19 infection. We found an inverse association between ACE-2 receptor levels and spermatogenesis, suggesting a possible mechanism of how COVID-19 can cause infertility.
    Keywords covid19
    Language English
    Publishing date 2020-11-03
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 2719786-4
    ISSN 2287-4690 ; 2287-4208
    ISSN (online) 2287-4690
    ISSN 2287-4208
    DOI 10.5534/wjmh.200170
    Database MEDical Literature Analysis and Retrieval System OnLINE

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