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Article ; Online: Diabetic kidney disease: the onset of a new era?

Fioretto, Paola

2020 Volume 33, Issue 5, Page(s) 899–900

MeSH term(s)	Diabetes Mellitus ; Diabetic Nephropathies/diagnosis ; Diabetic Nephropathies/epidemiology ; Diabetic Nephropathies/etiology ; Graft Survival ; Humans ; Kidney ; Kidney Transplantation
Language	English
Publishing date	2020-08-18
Publishing country	Italy
Document type	Editorial
ZDB-ID	1093991-x
ISSN	1724-6059 ; 1120-3625 ; 1121-8428
ISSN (online)	1724-6059
ISSN	1120-3625 ; 1121-8428
DOI	10.1007/s40620-020-00849-3
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Zs.A 3369: Show issues

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Article ; Online: Expanding the therapy options for diabetic kidney disease.

Fioretto, Paola / Pontremoli, Roberto

Nature reviews. Nephrology

2021 Volume 18, Issue 2, Page(s) 78–79

MeSH term(s)	Diabetes Mellitus, Type 2 ; Diabetic Nephropathies/drug therapy ; Humans ; Kidney Failure, Chronic/therapy
Language	English
Publishing date	2021-12-01
Publishing country	England
Document type	Journal Article
ZDB-ID	2490366-8
ISSN	1759-507X ; 1759-5061
ISSN (online)	1759-507X
ISSN	1759-5061
DOI	10.1038/s41581-021-00522-3
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Zs.A 6334: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MG 107: Show issues

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Article: SGLT2 Inhibitors and the Clinical Implications of Associated Weight Loss in Type 2 Diabetes: A Narrative Review.

Janež, Andrej / Fioretto, Paola

Diabetes therapy : research, treatment and education of diabetes and related disorders

2021 Volume 12, Issue 8, Page(s) 2249–2261

Abstract: Introduction: The obesity epidemic is closely linked to the rising prevalence of type 2 diabetes (T2D). Body weight reduction remains an important challenge in patients with T2D, as it requires changing their overall metabolic control. Of all glucose- ... ...

Abstract	Introduction: The obesity epidemic is closely linked to the rising prevalence of type 2 diabetes (T2D). Body weight reduction remains an important challenge in patients with T2D, as it requires changing their overall metabolic control. Of all glucose-lowering therapies, only sodium-glucose cotransporter 2 inhibitors (SGLT2is) and glucagon-like peptide 1 receptor agonists (GLP-1 RAs) consistently result in weight improvement. Moreover, the same two classes have important cardiovascular and renal benefits. We summarize the key available information related to the weight loss effect of SGLT2is in T2D, focusing on the unexploited potential of these drugs. Methods: Data on weight change with SGLT2is in patients with T2D were extracted from published cardiovascular outcomes trials (CVOTs). A discussion on patient perspectives about weight change is based on key preclinical and clinical trials, meta-analyses, and reviews and is supplemented by the authors' clinical judgment and research experience in the field. Results: SGLT2is have a unique mode of action resulting in caloric loss through glycosuria. The anticipated weight loss with SGLT2is is not reflected in clinical trial results. There is a discrepancy between the magnitude of improvement in glycemic control and the weight loss, cardiovascular, and renal benefits obtained in large clinical trials. Conclusion: The relationships between the magnitude of weight loss, improvement in glycemic control, and cardiorenal benefits with SGLT2i are still unclear. Potential mechanisms other than simple glycemic efficacy should be revealed and explained. Better weight control may be achieved if adequately intensive lifestyle changes are implemented and monitored in the T2D population treated with SGLT2is.
Language	English
Publishing date	2021-07-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	2566702-6
ISSN	1869-6961 ; 1869-6953
ISSN (online)	1869-6961
ISSN	1869-6953
DOI	10.1007/s13300-021-01104-z
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Article ; Online: Ultraviolet Resonant Raman Scattering of Electrolyte Solutions.

Sassi, Paola / Comez, Lucia / D'Amico, Francesco / Rossi, Barbara / Bartolini, Gabriele / Fioretto, Daniele / Paolantoni, Marco

Applied spectroscopy

2024 , Page(s) 37028241245443

Abstract: Saltwater stands as the most prevalent liquid on Earth. Consequently, substantial interest has been directed toward its characterization, both as an independent system and as a solvent for complex structures such as biomacromolecules. In the last few ... ...

Abstract	Saltwater stands as the most prevalent liquid on Earth. Consequently, substantial interest has been directed toward its characterization, both as an independent system and as a solvent for complex structures such as biomacromolecules. In the last few decades, special emphasis was placed on the investigation of the hydration properties of ions for the fundamental role they play in numerous chemical processes. In this study, we employed multi-wavelength Raman spectroscopy to examine the hydration shell surrounding bromide ions in solutions of simple electrolytes, specifically lithium bromide, potassium bromide, and cesium bromide, at two different concentrations. Cation-induced differences among electrolytes were observed in connection to their tendency to form ion pairs. An increased sensitivity to reveal the structure of the first hydration shell was evidenced when employing ultraviolet excitation in the 228-266 nm range, under resonance conditions with the charge transfer transition to the solvent peaked at about 200 nm. Other than a significant increase in the Raman cross-section for the OH stretching band when shifting from pure water to the solution, a larger enhancement for the Raman signal of the H-O-H bending mode over the stretching vibration was observed. Thus, the bending band plays a crucial role in monitoring the H-bond structure of water around the anions related to the charge distribution within the first hydration shell of anions, being an effective probe of hydration phenomena.
Language	English
Publishing date	2024-04-18
Publishing country	United States
Document type	Journal Article
ISSN	1943-3530
ISSN (online)	1943-3530
DOI	10.1177/00037028241245443
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Article ; Online: High-protein diet: A barrier to the nephroprotective effects of sodium-glucose co-transporter-2 inhibitors?

Mazzucato, Marta / Fioretto, Paola / Avogaro, Angelo

Diabetes, obesity & metabolism

2020 Volume 22, Issue 9, Page(s) 1511–1515

Abstract: Glomerular hyperfiltration is a common finding in patients with diabetes and poor glycaemic control; whole-kidney hyperfiltration, with glomerular filtration rate (GFR) values above normal, should be differentiated from single nephron hyperfiltration, ... ...

Abstract	Glomerular hyperfiltration is a common finding in patients with diabetes and poor glycaemic control; whole-kidney hyperfiltration, with glomerular filtration rate (GFR) values above normal, should be differentiated from single nephron hyperfiltration, consequent to nephron loss and compensatory hyperfiltration of the remnant nephrons. This is the result of an imbalance between the vascular tone of the afferent and efferent arterioles. Hormonal influences and/or an impaired tubuloglomerular feedback (TGF) system, because of excessive sodium (Na
MeSH term(s)	Diabetes Mellitus, Type 2/drug therapy ; Diet, High-Protein ; Glomerular Filtration Rate ; Glucose ; Humans ; Sodium/metabolism ; Sodium-Glucose Transporter 2 ; Sodium-Glucose Transporter 2 Inhibitors/therapeutic use
Chemical Substances	Sodium-Glucose Transporter 2 ; Sodium-Glucose Transporter 2 Inhibitors ; Sodium (9NEZ333N27) ; Glucose (IY9XDZ35W2)
Language	English
Publishing date	2020-05-20
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1454944-x
ISSN	1463-1326 ; 1462-8902
ISSN (online)	1463-1326
ISSN	1462-8902
DOI	10.1111/dom.14071
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Zs.A 5442: Show issues

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Article ; Online: Sodium-glucose co-transporter-2 inhibitors in patients with type 2 diabetes: Barriers and solutions for improving uptake in routine clinical practice.

Khunti, Kamlesh / Jabbour, Serge / Cos, Xavier / Mudaliar, Sunder / Mende, Christian / Bonaca, Marc / Fioretto, Paola

Diabetes, obesity & metabolism

2022 Volume 24, Issue 7, Page(s) 1187–1196

Abstract: Recent advances in type 2 diabetes (T2D) research have highlighted the benefits of sodium-glucose co-transporter-2 (SGLT-2) inhibitors, including cardiovascular and renal protection. However, uptake rates of these drugs remain low in patients with T2D, ... ...

Abstract	Recent advances in type 2 diabetes (T2D) research have highlighted the benefits of sodium-glucose co-transporter-2 (SGLT-2) inhibitors, including cardiovascular and renal protection. However, uptake rates of these drugs remain low in patients with T2D, particularly in subpopulations most likely to benefit from them. This review considers the potential barriers to prescribing SGLT-2 inhibitors in T2D in clinical practice and outlines potential multidisciplinary recommendations to overcome these barriers. Safety concerns and a lack of clarity in and divergence of guidelines around the introduction of SGLT-2 inhibitors into treatment regimens may represent a barrier to uptake from the clinicians' perspective, including a general lack of understanding of the benefits associated with SGLT-2 inhibitors. Patient characteristics, such as socioeconomic status, may influence uptake because of the cost of SGLT-2 inhibitors, especially in the United States, where health insurance coverage could be a concern. SGLT-2 inhibitor prescription rates vary between clinical specialty (endocrinology, primary care, cardiology, and nephrology) and country, with cardiologists the lowest prescribers, and endocrinologists the highest. Primary care practitioners may experience more challenges in following SGLT-2 inhibitor-related guidelines than diabetes specialists as there may be fewer opportunities for education on how this drug class improves cardiovascular and renal outcomes in patients with T2D. Uptake rates appear to vary between countries because of differences in guidelines and health insurance systems. The amendment of SGLT-2 inhibitor-related guidelines for more multidisciplinary use and the implementation of patient and clinician education may encourage uptake of these drugs, potentially improving long-term health outcomes among patients with T2D.
MeSH term(s)	Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/drug therapy ; Glucose/therapeutic use ; Humans ; Hypoglycemic Agents/therapeutic use ; Sodium ; Sodium-Glucose Transporter 2 Inhibitors/therapeutic use ; Symporters
Chemical Substances	Hypoglycemic Agents ; Sodium-Glucose Transporter 2 Inhibitors ; Symporters ; Sodium (9NEZ333N27) ; Glucose (IY9XDZ35W2)
Language	English
Publishing date	2022-03-30
Publishing country	England
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	1454944-x
ISSN	1463-1326 ; 1462-8902
ISSN (online)	1463-1326
ISSN	1462-8902
DOI	10.1111/dom.14684
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Zs.A 5442: Show issues

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Article ; Online: SGLT2 inhibitors to prevent diabetic kidney disease.

Fioretto, Paola / Vettor, Roberto / Pontremoli, Roberto

The lancet. Diabetes & endocrinology

2019 Volume 8, Issue 1, Page(s) 4–5

MeSH term(s)	Diabetes Mellitus, Type 2/complications ; Diabetic Nephropathies/prevention & control ; Humans ; Observational Studies as Topic ; Sodium-Glucose Transporter 2 Inhibitors/therapeutic use ; Treatment Outcome
Chemical Substances	Sodium-Glucose Transporter 2 Inhibitors
Language	English
Publishing date	2019-12-20
Publishing country	England
Document type	Journal Article
ISSN	2213-8595
ISSN (online)	2213-8595
DOI	10.1016/S2213-8587(19)30387-0
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Article: Hydration Dynamics of Model Peptides with Different Hydrophobic Character.

Lupi, Laura / Bracco, Brenda / Sassi, Paola / Corezzi, Silvia / Morresi, Assunta / Fioretto, Daniele / Comez, Lucia / Paolantoni, Marco

Life (Basel, Switzerland)

2022 Volume 12, Issue 4

Abstract: The multi-scale dynamics of aqueous solutions of the hydrophilic ... ...

Abstract	The multi-scale dynamics of aqueous solutions of the hydrophilic peptide
Language	English
Publishing date	2022-04-12
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662250-6
ISSN	2075-1729
ISSN	2075-1729
DOI	10.3390/life12040572
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Article ; Online: Dapagliflozin: potential beneficial effects in the prevention and treatment of renal and cardiovascular complications in patients with type 2 diabetes.

Fioretto, Paola / Avogaro, Angelo

Expert opinion on pharmacotherapy

2017 Volume 18, Issue 5, Page(s) 517–527

Abstract: Introduction: Diabetic kidney disease is the leading cause of end-stage renal disease, a significant contributor to cardiovascular (CV) disease, responsible for much of the morbidity and mortality in patients with type 2 diabetes (T2DM). Strategies to ... ...

Abstract	Introduction: Diabetic kidney disease is the leading cause of end-stage renal disease, a significant contributor to cardiovascular (CV) disease, responsible for much of the morbidity and mortality in patients with type 2 diabetes (T2DM). Strategies to slow or prevent the onset and progression of diabetic kidney disease are critical for effectively managing T2DM and reducing CV risk. Sodium-glucose cotransporter 2 (SGLT2) inhibitors are effective antidiabetic agents, which may provide nephroprotective and CV protective effects. Areas covered: This review examines the role of the kidney in glucose homeostasis, discusses renal hemodynamic changes in diabetes, and outlines the major hypotheses regarding the mechanisms underlying renal injury in diabetes. The potential benefits of SGLT2 inhibitors in the prevention and treatment of CV complications in patients with T2DM are reviewed, with particular focus on dapagliflozin. Expert opinion: Dapagliflozin and other SGLT2 inhibitors have the capacity to decrease hyperglycemia and visceral fat, components of the metabolic syndrome particularly associated with the progression of CV disease. However, the mechanisms of action of SGLT2 inhibitors resulting in their positive CV effects remain unclear. Furthermore, the mechanism of action of SGLT2 inhibitors on heart function in non-diabetic patients with decompensated heart failure remains to be explored.
MeSH term(s)	Benzhydryl Compounds/therapeutic use ; Cardiovascular Diseases/prevention & control ; Diabetes Mellitus, Type 2/drug therapy ; Diabetic Nephropathies/prevention & control ; Glucosides/therapeutic use ; Humans ; Hyperglycemia/drug therapy ; Hypoglycemic Agents/therapeutic use ; Kidney Failure, Chronic/prevention & control ; Sodium-Glucose Transporter 2 ; Sodium-Glucose Transporter 2 Inhibitors
Chemical Substances	Benzhydryl Compounds ; Glucosides ; Hypoglycemic Agents ; SLC5A2 protein, human ; Sodium-Glucose Transporter 2 ; Sodium-Glucose Transporter 2 Inhibitors ; dapagliflozin (1ULL0QJ8UC)
Language	English
Publishing date	2017-03-20
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2001535-5
ISSN	1744-7666 ; 1465-6566
ISSN (online)	1744-7666
ISSN	1465-6566
DOI	10.1080/14656566.2017.1300253
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Zs.A 5130: Show issues

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Article ; Online: Bringing door-to-needle times within the European benchmarks results in better stroke patients outcomes in a spoke hospital from the Apulian Region.

Giorelli, Maurizio / Leone, Ruggiero / Aniello, Maria Stella / Altomare, Sergio / Colonna, Isabella / Liuzzi, Daniele / Plasmati, Immacolata / Sardaro, Michele / Fioretto, Nicola / Di Paola, Giuseppe / Tatò, Emanuele / Scelzi, Alessandro

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology

2023 Volume 44, Issue 9, Page(s) 3199–3207

Abstract: Introduction: Door-to-needle time (DNT) is a key factor in acute stroke treatment success. We retrospectively analysed the effects of a new protocol aimed at reducing treatment delays in our single-centre observational series over a 1-year period (from ... ...

Abstract	Introduction: Door-to-needle time (DNT) is a key factor in acute stroke treatment success. We retrospectively analysed the effects of a new protocol aimed at reducing treatment delays in our single-centre observational series over a 1-year period (from October 1st 2021 to September 30th 2022). Methods: The time frame was divided into two semesters as a new protocol was started at the beginning of the second semester to ensure a rapid evaluation, imaging, and intravenous thrombolysis in all stroke patients attending our spoke-hospital serving 200,000 inhabitants. Logistics and outcome measures were obtained for each patient and compared before and after implementation of the new protocol. Results: A total of 215 patients with ischemic stroke attended our hospital within a 1-year period (109 in the first semester, 96 in the second semester). Seventeen percent and 21% of all patients underwent acute stroke thrombolysis in the first and second semesters, respectively. DNTs were strongly reduced in the second semester (from 90 to 55 min), bringing this value below the Italian and European benchmarks. This resulted in better short-term outcomes (an average of 20%) as measured by both Δ NIHSS scores at 24 h and at discharge with respect to baseline.
MeSH term(s)	Humans ; Child ; Thrombolytic Therapy/methods ; Retrospective Studies ; Benchmarking ; Stroke/drug therapy ; Hospitals ; Treatment Outcome ; Time-to-Treatment ; Fibrinolytic Agents ; Tissue Plasminogen Activator/therapeutic use
Chemical Substances	Fibrinolytic Agents ; Tissue Plasminogen Activator (EC 3.4.21.68)
Language	English
Publishing date	2023-05-06
Publishing country	Italy
Document type	Journal Article
ZDB-ID	2016546-8
ISSN	1590-3478 ; 1590-1874
ISSN (online)	1590-3478
ISSN	1590-1874
DOI	10.1007/s10072-023-06828-3
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