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  1. Article ; Online: Nonalcoholic fatty liver disease and the ongoing role of liver biopsy evaluation.

    Brunt, Elizabeth M

    Hepatology communications

    2017  Volume 1, Issue 5, Page(s) 370–378

    Abstract: Nonalcoholic fatty liver disease (NAFLD) is one of the most common underlying causes of chronically elevated liver tests and liver disease in adults and children worldwide and may be strongly suspected if not diagnosed by ever evolving and available ... ...

    Abstract Nonalcoholic fatty liver disease (NAFLD) is one of the most common underlying causes of chronically elevated liver tests and liver disease in adults and children worldwide and may be strongly suspected if not diagnosed by ever evolving and available serologic and imaging-based noninvasive tests. However, the definitive diagnosis of the most progressive form of NAFLD, nonalcoholic steatohepatitis, and the identification of fibrosis stage still require liver biopsy evaluation as noninvasive testing has not replaced some of the specifics or the totality of information obtainable from liver biopsy. In this review, both the role and value of a liver biopsy evaluation in NAFLD/ nonalcoholic steatohepatitis are examined from publications related to a selected variety of settings. Details of the most commonly used semiquantitative methods of analysis are discussed, and some useful potential pitfalls for differential diagnostic consideration in liver biopsy interpretation are given. (
    Language English
    Publishing date 2017-06-07
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2471-254X
    ISSN (online) 2471-254X
    DOI 10.1002/hep4.1055
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Hepatocellular adenomas: the expanding epidemiology.

    Brunt, Elizabeth M / Sempoux, Christine / Bioulac-Sage, Paulette

    Histopathology

    2021  Volume 79, Issue 1, Page(s) 20–22

    MeSH term(s) Adenoma, Liver Cell/epidemiology ; Carcinoma, Hepatocellular/epidemiology ; Humans ; Liver Neoplasms/epidemiology
    Language English
    Publishing date 2021-01-11
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 131914-0
    ISSN 1365-2559 ; 0309-0167
    ISSN (online) 1365-2559
    ISSN 0309-0167
    DOI 10.1111/his.14343
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1328: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Nonalcoholic Fatty Liver Disease: Pros and Cons of Histologic Systems of Evaluation.

    Brunt, Elizabeth M

    International journal of molecular sciences

    2016  Volume 17, Issue 1

    Abstract: The diagnostic phenotype of nonalcoholic fatty liver disease (NAFLD)--in particular, the most significant form in terms of prognosis, nonalcoholic steatohepatitis (NASH)--continues to rely on liver tissue evaluation, in spite of remarkable advances in ... ...

    Abstract The diagnostic phenotype of nonalcoholic fatty liver disease (NAFLD)--in particular, the most significant form in terms of prognosis, nonalcoholic steatohepatitis (NASH)--continues to rely on liver tissue evaluation, in spite of remarkable advances in non-invasive algorithms developed from serum-based tests and imaging-based or sonographically-based tests for fibrosis or liver stiffness. The most common tissue evaluation remains percutaneous liver biopsy; considerations given to the needle size and the location of the biopsy have the potential to yield the most representative tissue for evaluation. The pathologist's efforts are directed to not only global diagnosis, but also assessment of severity of injury. Just as in other forms of chronic liver disease, these assessments can be divided into necroinflammatory activity, and fibrosis with parenchymal remodeling, in order to separately analyze potentially reversible (grade) and non-reversible (stage) lesions. These concepts formed the bases for current methods of evaluating the lesions that collectively comprise the phenotypic spectra of NAFLD. Four extant methods have specific applications; there are pros and cons to each, and this forms the basis of the review.
    MeSH term(s) Biopsy, Needle/methods ; Biopsy, Needle/standards ; Fibrosis ; Humans ; Non-alcoholic Fatty Liver Disease/pathology
    Language English
    Publishing date 2016-01-13
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms17010097
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  4. Article: Histopathologic features of hepatocellular carcinoma.

    Brunt, Elizabeth M

    Clinical liver disease

    2013  Volume 1, Issue 6, Page(s) 194–199

    Language English
    Publishing date 2013-01-23
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2657644-2
    ISSN 2046-2484
    ISSN 2046-2484
    DOI 10.1002/cld.98
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Challenges in the hepatic histopathology in non-alcoholic fatty liver disease.

    Brunt, Elizabeth M / Kleiner, David E

    Gut

    2017  Volume 66, Issue 9, Page(s) 1539–1540

    Language English
    Publishing date 2017-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 80128-8
    ISSN 1468-3288 ; 0017-5749
    ISSN (online) 1468-3288
    ISSN 0017-5749
    DOI 10.1136/gutjnl-2016-313379
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 160: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: A novel genetic marker of liver disease aetiology in hepatocellular carcinoma: culling the metabolic syndrome.

    Brunt, Elizabeth M

    Gut

    2013  Volume 62, Issue 6, Page(s) 808–809

    MeSH term(s) Carcinoma, Hepatocellular/genetics ; Chromosome Aberrations ; Chromosomes, Human, Pair 6/genetics ; Cullin Proteins/genetics ; Female ; Humans ; Liver Neoplasms/genetics ; Male ; Metabolic Syndrome/complications
    Chemical Substances CUL7 protein, human ; Cullin Proteins
    Language English
    Publishing date 2013-06
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 80128-8
    ISSN 1468-3288 ; 0017-5749
    ISSN (online) 1468-3288
    ISSN 0017-5749
    DOI 10.1136/gutjnl-2012-303451
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 160: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Surgical assessment of significant steatosis in donor livers: the beginning of the end for frozen-section analysis?

    Brunt, Elizabeth M

    Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society

    2013  Volume 19, Issue 4, Page(s) 360–361

    MeSH term(s) Donor Selection ; Fatty Liver/pathology ; Female ; Humans ; Liver Transplantation ; Male ; Pathology, Surgical/methods ; Tissue Donors
    Language English
    Publishing date 2013-04
    Publishing country United States
    Document type Comment ; Editorial
    ZDB-ID 2006866-9
    ISSN 1527-6473 ; 1527-6465
    ISSN (online) 1527-6473
    ISSN 1527-6465
    DOI 10.1002/lt.23609
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    Zs.A 4702: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  8. Article ; Online: Liver pathology in retinal vasculopathy with cerebral leukoencephalopathy and systemic manifestations: vasculopathic disease beyond nodular regenerative hyperplasia.

    Khonde, Pooja / Chatterjee, Deyali / Bogacki, Madonna / Liszewski, M Kathryn / Ford, Andria L / Miner, Jonathan J / Atkinson, John P / Brunt, Elizabeth M

    Human pathology

    2023  Volume 135, Page(s) 22–34

    Abstract: Retinal vasculopathy with cerebral leukoencephalopathy and systemic manifestations (RVCL-S) is a rare autosomal dominant disease resulting from a frame-shift mutation in TREX1, an intracellular 3'-5' exonuclease 1. Hepatic findings include an elevated ... ...

    Abstract Retinal vasculopathy with cerebral leukoencephalopathy and systemic manifestations (RVCL-S) is a rare autosomal dominant disease resulting from a frame-shift mutation in TREX1, an intracellular 3'-5' exonuclease 1. Hepatic findings include an elevated alkaline phosphatase (ALP) and nodular regenerative hyperplasia (NRH). Affected individuals typically succumb to brain lesions before clinically apparent hepatic manifestations; thus, little else is known about the hepatic pathology. Autopsy reports and a liver section from each (n = 11) of three unrelated kindreds with the most common mutation in TREX1 (V235Gfs∗6) were studied with standard and immunohistochemical stains. Cases were compared with "normal liver" controls from similar autopsy years. Cases consisted of six men and five women who died at a median age of 50 yr (range, 41-60 yr.). Seven had elevated ALP. Two had liver atrophy. Foci of NRH were variably detected in all. Inhomogeneous distribution of other findings included patternless parenchymal fibrous bands, approximation of vascular structures, and commonly, architectural changes of vascular structures. Only bile duct epithelia were unaffected. In addition, small trichrome-positive nodules were found along vein walls or isolated in the parenchyma. Rare foci of non-NRH hepatocytic nodules were noted in 3. Increased CD34 and altered α-SMA IHC expression were variably noted. Periportal ductules and perivenular K7 IHC expression were increased to unpredictable degrees. The extensive but inhomogeneous histopathologic findings in livers of autopsied patients with RVCL-S appear to involve hepatic vascular structures. These findings validate inclusion of vascular liver involvement beyond NRH in this complex hereditary disorder.
    MeSH term(s) Male ; Humans ; Female ; Hyperplasia/pathology ; Liver/pathology ; Leukoencephalopathies/genetics ; Leukoencephalopathies/pathology ; Vascular Diseases/genetics ; Vascular Diseases/pathology ; Liver Diseases/genetics ; Liver Diseases/pathology
    Language English
    Publishing date 2023-03-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 207657-3
    ISSN 1532-8392 ; 0046-8177
    ISSN (online) 1532-8392
    ISSN 0046-8177
    DOI 10.1016/j.humpath.2023.02.013
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    Zs.A 722: Show issues Location:
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  9. Article: Histological assessment of nonalcoholic fatty liver disease in adults and children.

    Brunt, Elizabeth M

    Clinical liver disease

    2012  Volume 1, Issue 4, Page(s) 108–111

    Language English
    Publishing date 2012-09-25
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2657644-2
    ISSN 2046-2484
    ISSN 2046-2484
    DOI 10.1002/cld.31
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  10. Article ; Online: Inhibition of chylomicron assembly leads to dissociation of hepatic steatosis from inflammation and fibrosis.

    Xie, Yan / Newberry, Elizabeth P / Brunt, Elizabeth M / Ballentine, Samuel J / Soleymanjahi, Saeed / Molitor, Elizabeth A / Davidson, Nicholas O

    Journal of lipid research

    2021  Volume 62, Page(s) 100123

    Abstract: Regulating dietary fat absorption may impact progression of nonalcoholic fatty liver disease (NAFLD). Here, we asked if inducible inhibition of chylomicron assembly, as observed in intestine-specific microsomal triglyceride (TG) transfer protein knockout ...

    Abstract Regulating dietary fat absorption may impact progression of nonalcoholic fatty liver disease (NAFLD). Here, we asked if inducible inhibition of chylomicron assembly, as observed in intestine-specific microsomal triglyceride (TG) transfer protein knockout mice (Mttp-IKO), could retard NAFLD progression and/or reverse established fibrosis in two dietary models. Mttp-IKO mice fed a methionine/choline-deficient (MCD) diet exhibited reduced hepatic TGs, inflammation, and fibrosis, associated with reduced oxidative stress and downstream activation of c-Jun N-terminal kinase and nuclear factor kappa B signaling pathways. However, when Mttp
    MeSH term(s) Animals ; Choline Deficiency ; Chylomicrons/antagonists & inhibitors ; Chylomicrons/metabolism ; Diet/adverse effects ; Fatty Liver/metabolism ; Female ; Fibrosis/metabolism ; Inflammation/metabolism ; Intestines/drug effects ; Intestines/metabolism ; Male ; Methionine/deficiency ; Mice ; Mice, Knockout ; Mice, Transgenic ; Non-alcoholic Fatty Liver Disease/metabolism
    Chemical Substances Chylomicrons ; Methionine (AE28F7PNPL)
    Language English
    Publishing date 2021-09-24
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 80154-9
    ISSN 1539-7262 ; 0022-2275
    ISSN (online) 1539-7262
    ISSN 0022-2275
    DOI 10.1016/j.jlr.2021.100123
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 175: Show issues Location:
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