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  1. Book ; Online ; E-Book: The autoimmune diseases

    Rose, Noel R. / Mackay, Ian R.

    2020  

    Author's details edited by Noel R. Rose, Ian R. Mackay
    Keywords Electronic books
    Language English
    Size 1 Online-Ressource (xxiii, 1508 Seiten), Illustrationen
    Edition Sixth edition
    Publisher Elsevier Academic Press
    Publishing place London
    Publishing country Great Britain
    Document type Book ; Online ; E-Book
    Note Description based on publisher supplied metadata and other sources
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT020363737
    ISBN 978-0-12-812242-6 ; 9780128121023 ; 0-12-812242-0 ; 0128121025
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book ; Online: Encyclopedia of medical immunology

    Mackay, Ian R.

    (Springer Reference)

    2014  

    Author's details Ian R. Mackay ... ed.-in-chief
    Series title Springer Reference
    Language German
    Dates of publication 2014-9999
    Publisher Springer
    Publishing place New York u.a.
    Publishing country Germany
    Document type Book ; Online
    HBZ-ID HT018444065
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  4. Book: The autoimmune diseases

    Rose, Noel R. / Mackay, Ian R.

    2014  

    Author's details ed. by Noel R. Rose ; Ian R. MacKay
    Keywords Autoimmune diseases
    Subject code 616.978
    Language English
    Size XXXIII, 1267 S. : Ill., graph. Darst.
    Edition 5. ed.
    Publisher Elsevier AP
    Publishing place Amsterdam u.a.
    Publishing country Netherlands
    Document type Book
    HBZ-ID HT018169864
    ISBN 978-0-12-384929-8 ; 9780123849304 ; 0-12-384929-2 ; 0123849306
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2014 A 720 available for loan (reading room) Lesesaal EG

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  5. Article: Historical reflections on autoimmune hepatitis.

    Mackay, Ian-R

    World journal of gastroenterology

    2008  Volume 14, Issue 21, Page(s) 3292–3300

    Abstract: Autoimmune hepatitis (AIH), initially known as chronic active or active chronic hepatitis (and by various other names), first came under clinical notice in the late 1940s. However, quite likely, chronic active hepatitis (CAH) had been observed prior to ... ...

    Abstract Autoimmune hepatitis (AIH), initially known as chronic active or active chronic hepatitis (and by various other names), first came under clinical notice in the late 1940s. However, quite likely, chronic active hepatitis (CAH) had been observed prior to this and was attributed to a persistently destructive virus infection of the liver. An earlier (and controversial) designation in 1956 as lupoid hepatitis was derived from associated L.E. cell test positivity and emphasized accompanying multisystem features and immunological aberrations. Young women featured prominently in early descriptions of CAH. AIH was first applied in 1965 as a descriptive term. Disease-characteristic autoantibodies were defined from the early 1960s, notably antinuclear antibody (ANA), smooth muscle antibody (SMA) and liver-kidney microsomal (LKM) antibody. These are still widely used diagnostically but their relationship to pathogenesis is still not evident. A liver and disease specific autoantigen has long been searched for but unsuccessfully. Prolonged immunosuppressive therapy with predisolone and azathioprine in the 1960s proved beneficial and remains standard therapy today. AIH like many other autoimmune diseases is associated with particular HLA alleles especially with the "ancestral" B8, DR3 haplotype, and also with DR4. Looking forwards, AIH is one of the several enigmatic autoimmune diseases that, despite being (relatively) organ specific, are marked by autoimmune reactivities with non-organ-specific autoantigens. New paradigms are needed to explain the occurrence, expressions and pathogenesis of such diseases.
    MeSH term(s) Autoantibodies/blood ; Chronic Disease ; Genetic Predisposition to Disease ; HLA Antigens/immunology ; Hepatitis, Autoimmune/diagnosis ; Hepatitis, Autoimmune/drug therapy ; Hepatitis, Autoimmune/genetics ; Hepatitis, Autoimmune/history ; Hepatitis, Autoimmune/immunology ; History, 20th Century ; History, 21st Century ; Humans ; Immunosuppressive Agents/therapeutic use ; Predictive Value of Tests ; Risk Factors ; T-Lymphocytes/immunology ; Terminology as Topic ; Treatment Outcome
    Chemical Substances Autoantibodies ; HLA Antigens ; Immunosuppressive Agents
    Language English
    Publishing date 2008-06-06
    Publishing country United States
    Document type Historical Article ; Journal Article ; Portrait ; Review
    ZDB-ID 2185929-2
    ISSN 2219-2840 ; 1007-9327
    ISSN (online) 2219-2840
    ISSN 1007-9327
    DOI 10.3748/wjg.14.3292
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  6. Book: Intolerant bodies

    Anderson, Warwick / Mackay, Ian R.

    a short history of autoimmunity

    (Johns Hopkins biographies of disease)

    2014  

    Author's details Warwick Anderson and Ian R. Mackay
    Series title Johns Hopkins biographies of disease
    Keywords Autoimmune Diseases / history
    Language English
    Size XII, 250 S.
    Publisher Johns Hopkins Univ. Press
    Publishing place Baltimore
    Publishing country United States
    Document type Book
    Note Includes bibliographical references and index ; Physiology with obstacles -- Immunological thought styles -- A sense of unlimited possibilities -- The science of self -- Doing biographical work -- Reframing self
    HBZ-ID HT018389807
    ISBN 978-1-4214-1533-8 ; 1-4214-1533-X ; 1421415348 ; 9781421415345
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2015 A 608 available for loan (reading room) Lesesaal EG

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  7. Book ; Conference proceedings: Mechanisms of autoimmunity: a tribute to Professor Ian Mackay

    Mackay, Ian R. / Kitching, A. Richard

    a selection of papers presented at the 11th Australasian Autoimmunity Workshop ; [6 - 8 July 2007, Melbourne]

    (Journal of autoimmunity ; 31,3 = Special issue)

    2008  

    Event/congress Australasian Autoimmunity Workshop (11, 2007, Melbourne)
    Author's details guest ed.: A. Richard Kitching
    Series title Journal of autoimmunity ; 31,3 = Special issue
    Collection
    Language English
    Size S. 197 - 310: Ill., graph. Darst.
    Publisher Elsevier
    Publishing place Oxford
    Publishing country Great Britain
    Document type Book ; Conference proceedings
    HBZ-ID HT015850498
    Database Catalogue ZB MED Medicine, Health

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    Zs A 2368 -31- not available for loan Zeitschriften-Lesesaal

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  8. Article: Autoimmune liver diseases.

    Invernizzi, Pietro / Mackay, Ian-R

    World journal of gastroenterology

    2008  Volume 14, Issue 21, Page(s) 3290–3291

    Abstract: The liver was one of the earliest recognized sites among autoimmune diseases yet autoimmune hepatitis, primary biliary cirrhosis, primary sclerosing cholangitis, and their overlap forms, are still problematic in diagnosis and causation. The contributions ...

    Abstract The liver was one of the earliest recognized sites among autoimmune diseases yet autoimmune hepatitis, primary biliary cirrhosis, primary sclerosing cholangitis, and their overlap forms, are still problematic in diagnosis and causation. The contributions herein comprise 'pairs of articles' on clinical characteristics, and concepts of etiopathogenesis, for each of the above diseases, together with childhood autoimmune liver disease, overlaps, interpretations of diagnostic serology, and liver transplantation. This issue is timely, since we are witnessing an ever increasing applicability of immunology to a wide variety of chronic diseases, hepatic and non-hepatic, in both developed and developing countries. The 11 invited expert review articles capture the changing features over recent years of the autoimmune liver diseases, the underlying immunomolecular mechanisms of development, the potent albeit still unexplained genetic influences, the expanding repertoire of immunoserological diagnostic markers, and the increasingly effective therapeutic possibilities.
    MeSH term(s) Animals ; Autoimmune Diseases/diagnosis ; Autoimmune Diseases/immunology ; Autoimmune Diseases/therapy ; Humans ; Liver Diseases/diagnosis ; Liver Diseases/immunology ; Liver Diseases/therapy
    Language English
    Publishing date 2008-06-05
    Publishing country United States
    Document type Editorial ; Introductory Journal Article
    ZDB-ID 2185929-2
    ISSN 2219-2840 ; 1007-9327
    ISSN (online) 2219-2840
    ISSN 1007-9327
    DOI 10.3748/wjg.14.3290
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Autoimmune liver serology: current diagnostic and clinical challenges.

    Bogdanos, Dimitrios-P / Invernizzi, Pietro / Mackay, Ian-R / Vergani, Diego

    World journal of gastroenterology

    2008  Volume 14, Issue 21, Page(s) 3374–3387

    Abstract: Liver-related autoantibodies are crucial for the correct diagnosis and classification of autoimmune liver diseases (AiLD), namely autoimmune hepatitis types 1 and 2 (AIH-1 and 2), primary biliary cirrhosis (PBC), and the sclerosing cholangitis variants ... ...

    Abstract Liver-related autoantibodies are crucial for the correct diagnosis and classification of autoimmune liver diseases (AiLD), namely autoimmune hepatitis types 1 and 2 (AIH-1 and 2), primary biliary cirrhosis (PBC), and the sclerosing cholangitis variants in adults and children. AIH-1 is specified by anti-nuclear antibody (ANA) and smooth muscle antibody (SMA). AIH-2 is specified by antibody to liver kidney microsomal antigen type-1 (anti-LKM1) and anti-liver cytosol type 1 (anti-LC1). SMA, ANA and anti-LKM antibodies can be present in de-novo AIH following liver transplantation. PBC is specified by antimitochondrial antibodies (AMA) reacting with enzymes of the 2-oxo-acid dehydrogenase complexes (chiefly pyruvate dehydrogenase complex E2 subunit) and disease-specific ANA mainly reacting with nuclear pore gp210 and nuclear body sp100. Sclerosing cholangitis presents as at least two variants, first the classical primary sclerosing cholangitis (PSC) mostly affecting adult men wherein the only (and non-specific) reactivity is an atypical perinuclear antineutrophil cytoplasmic antibody (p-ANCA), also termed perinuclear anti-neutrophil nuclear antibodies (p-ANNA) and second the childhood disease called autoimmune sclerosing cholangitis (ASC) with serological features resembling those of type 1 AIH. Liver diagnostic serology is a fast-expanding area of investigation as new purified and recombinant autoantigens, and automated technologies such as ELISAs and bead assays, become available to complement (or even compete with) traditional immunofluorescence procedures. We survey for the first time global trends in quality assurance impacting as it does on (1) manufacturers/purveyors of kits and reagents, (2) diagnostic service laboratories that fulfill clinicians' requirements, and (3) the end-user, the physician providing patient care, who must properly interpret test results in the overall clinical context.
    MeSH term(s) Australia ; Autoantibodies/blood ; Autoantigens/immunology ; Cholangitis, Sclerosing/diagnosis ; Cholangitis, Sclerosing/immunology ; Europe ; Fluorescent Antibody Technique ; Hepatitis, Autoimmune/diagnosis ; Hepatitis, Autoimmune/immunology ; Humans ; Liver Cirrhosis, Biliary/diagnosis ; Liver Cirrhosis, Biliary/immunology ; New Zealand ; Practice Guidelines as Topic ; Predictive Value of Tests ; Program Development ; Quality Assurance, Health Care ; Quality Control ; Reagent Kits, Diagnostic ; Serologic Tests/methods ; Serologic Tests/standards ; United States
    Chemical Substances Autoantibodies ; Autoantigens ; Reagent Kits, Diagnostic
    Language English
    Publishing date 2008-06-05
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2185929-2
    ISSN 2219-2840 ; 1007-9327
    ISSN (online) 2219-2840
    ISSN 1007-9327
    DOI 10.3748/wjg.14.3374
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  10. Article: Etiopathogenesis of primary biliary cirrhosis.

    Lleo, Ana / Invernizzi, Pietro / Mackay, Ian-R / Prince, Harry / Zhong, Ren-Qian / Gershwin, M-Eric

    World journal of gastroenterology

    2008  Volume 14, Issue 21, Page(s) 3328–3337

    Abstract: Primary biliary cirrhosis (PBC) is an autoimmune disease of the liver characterized by progressive bile duct destruction eventually leading to cirrhosis and liver failure. The serological hallmark of the disease is the presence of circulating ... ...

    Abstract Primary biliary cirrhosis (PBC) is an autoimmune disease of the liver characterized by progressive bile duct destruction eventually leading to cirrhosis and liver failure. The serological hallmark of the disease is the presence of circulating antimitochondrial antibodies (AMA). These reflect the presence of autoreactive T and B cells to the culprit antigens, the E2 subunits of mitochondrial 2-oxo-acid dehydrogenase enzymes, chiefly pyruvate dehydrogenase (PDC-E2). The disease results from a combination of genetic and environmental risk factors. Genetic predisposition is indicated by the higher familial incidence of the disease particularly among siblings and the high concordance rate among monozygotic twins. Environmental triggering events appear crucial to disrupt a pre-existing unstable immune tolerance of genetic origin allowing, after a long latency, the emergence of clinical disease. Initiating mimetopes of the vulnerable epitope of the PDC-E2 autoantigen can be derived from microbes that utilize the PDC enzyme or, alternatively, environmental xenobiotics/chemical compounds that modify the structure of native proteins to make them immunogenic. A further alternative as a source of antigen is PDC-E2 derived from apoptotic cells. In the effector phase the biliary ductular cell, by reason of its proclivity to express the antigen PDC-E2 in the course of apoptosis, undergoes a multilineage immune attack comprised of CD4(+) and CD8(+) T cells and antibody. In this article, we critically review the available evidence on etiopathogenesis of PBC and present interpretations of complex data, new developments and theories, and nominate directions for future research.
    MeSH term(s) Animals ; Apoptosis/immunology ; Autoantibodies/blood ; Autoimmune Diseases/genetics ; Autoimmune Diseases/immunology ; Autoimmune Diseases/pathology ; B-Lymphocytes/immunology ; Bile Ducts, Intrahepatic/immunology ; Cytokines/metabolism ; Disease Models, Animal ; Environment ; Epithelial Cells/immunology ; Genetic Predisposition to Disease ; Humans ; Immunity, Innate ; Liver Cirrhosis, Biliary/genetics ; Liver Cirrhosis, Biliary/immunology ; Liver Cirrhosis, Biliary/pathology ; Risk Factors ; T-Lymphocytes/immunology
    Chemical Substances Autoantibodies ; Cytokines
    Language English
    Publishing date 2008-06-05
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2185929-2
    ISSN 2219-2840 ; 1007-9327
    ISSN (online) 2219-2840
    ISSN 1007-9327
    DOI 10.3748/wjg.14.3328
    Database MEDical Literature Analysis and Retrieval System OnLINE

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