Article ; Online: Diagnostic and prognostic value of H-ficolin for functionally relevant coronary artery disease.
Clinica chimica acta; international journal of clinical chemistry
2023 Volume 551, Page(s) 117582
Abstract: Background: We aimed to test the diagnostic and prognostic ability of H-ficolin, an initiator ... myocardial perfusion imaging single-photon emission tomography and coronary angiography. H-ficolin levels were measured ... by a sandwich-type immunoassay at rest, peak stress-test, and 2 h after stress-test. Cardiovascular death and ...
| Abstract | Background: We aimed to test the diagnostic and prognostic ability of H-ficolin, an initiator of the lectin pathway of the complement system, for functionally relevant coronary artery disease (fCAD), and explore its determinants. Methods: The presence of fCAD was adjudicated using myocardial perfusion imaging single-photon emission tomography and coronary angiography. H-ficolin levels were measured by a sandwich-type immunoassay at rest, peak stress-test, and 2 h after stress-test. Cardiovascular death and non-fatal myocardial infarction were assessed during 5-year follow-up. Results: Among 1,571 patients (32.3 % women), fCAD was detected in 462 patients (29.4 %). H-ficolin concentration at rest was 18.6 (15.3-21.8) µg/ml in patients with fCAD versus 17.8 (15.4-21.5) µg/ml, p = 0.33, in patients without fCAD, resulting in an AUC of 0.53 (95 %CI 0.48-0.56). During follow-up, 107 patients (6.8 %) had non-fatal myocardial infarction and 99 patients (6.3 %) experienced cardiovascular death. In Cox regression analysis, H-ficolin was not a predictor of events in the overall cohort. Subgroup analysis suggested a potential link between H-ficolin and non-fatal myocardial infarction in patients without fCAD (adjusted HR 1.03, 95 % CI 1.02-1.15, p = 0.005). H-ficolin concentration showed a weak positive correlation with systolic (r = 0.069, p < 0.001) and diastolic blood pressure (r = 0.111, p < 0.001). Conclusion: H-ficolin concentration did not have diagnostic and/or prognostic value in patients referred for fCAD work-up. |
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| MeSH term(s) | Humans ; Female ; Male ; Coronary Artery Disease/diagnosis ; Prognosis ; Lectins ; Coronary Angiography ; Myocardial Infarction/diagnosis ; Ficolins |
| Chemical Substances | Lectins |
| Language | English |
| Publishing date | 2023-10-05 |
| Publishing country | Netherlands |
| Document type | Journal Article |
| ZDB-ID | 80228-1 |
| ISSN | 1873-3492 ; 0009-8981 |
| ISSN (online) | 1873-3492 |
| ISSN | 0009-8981 |
| DOI | 10.1016/j.cca.2023.117582 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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