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  1. Article ; Online: Kikuchi-Fujimoto disease mimicking T-cell lymphoma after COVID-19 vaccination.

    Sumransub, Nuttavut / Bachanova, Veronika / Linden, Michael A

    American journal of clinical pathology

    2024  

    Language English
    Publishing date 2024-03-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 2944-0
    ISSN 1943-7722 ; 0002-9173
    ISSN (online) 1943-7722
    ISSN 0002-9173
    DOI 10.1093/ajcp/aqae016
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    In stock of ZB MED Cologne/Königswinter

    Ud II Zs.91: Show issues Location:
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  2. Article ; Online: Two for one? CAR-T therapy for lymphoma benefits concurrent autoimmune disorders.

    Bachanova, Veronika / Nachman, Patrick H

    Bone marrow transplantation

    2023  Volume 58, Issue 11, Page(s) 1175–1176

    MeSH term(s) Humans ; Receptors, Chimeric Antigen ; Immunotherapy, Adoptive ; Lymphoma/complications ; Lymphoma/therapy ; Autoimmune Diseases/complications ; Autoimmune Diseases/therapy ; Antigens, CD19 ; Lymphoma, Large B-Cell, Diffuse/therapy
    Chemical Substances Receptors, Chimeric Antigen ; Antigens, CD19
    Language English
    Publishing date 2023-08-19
    Publishing country England
    Document type Editorial
    ZDB-ID 632854-4
    ISSN 1476-5365 ; 0268-3369 ; 0951-3078
    ISSN (online) 1476-5365
    ISSN 0268-3369 ; 0951-3078
    DOI 10.1038/s41409-023-02084-3
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    Zs.A 2168: Show issues Location:
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  3. Article ; Online: A Conversational Agent for Early Detection of Neurotoxic Effects of Medications through Automated Intensive Observation.

    Pakhomov, Serguei / Solinsky, Jacob / Michalowski, Martin / Bachanova, Veronika

    Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing

    2023  Volume 29, Page(s) 24–38

    Abstract: We present a fully automated AI-based system for intensive monitoring of cognitive symptoms of neurotoxicity that frequently appear as a result of immunotherapy of hematologic malignancies. Early manifestations of these symptoms are evident in the ... ...

    Abstract We present a fully automated AI-based system for intensive monitoring of cognitive symptoms of neurotoxicity that frequently appear as a result of immunotherapy of hematologic malignancies. Early manifestations of these symptoms are evident in the patient's speech in the form of mild aphasia and confusion and can be detected and effectively treated prior to onset of more serious and potentially life-threatening impairment. We have developed the Automated Neural Nursing Assistant (ANNA) system designed to conduct a brief cognitive assessment several times per day over the telephone for 5-14 days following infusion of the immunotherapy medication. ANNA uses a conversational agent based on a large language model to elicit spontaneous speech in a semi-structured dialogue, followed by a series of brief language-based neurocognitive tests. In this paper we share ANNA's design and implementation, results of a pilot functional evaluation study, and discuss technical and logistic challenges facing the introduction of this type of technology in clinical practice. A large-scale clinical evaluation of ANNA will be conducted in an observational study of patients undergoing immunotherapy at the University of Minnesota Masonic Cancer Center starting in the Fall 2023.
    MeSH term(s) Humans ; Computational Biology ; Language
    Language English
    Publishing date 2023-12-30
    Publishing country United States
    Document type Journal Article
    ISSN 2335-6936
    ISSN (online) 2335-6936
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  4. Article ; Online: Advances in NK cell therapy for hematologic malignancies: NK source, persistence and tumor targeting.

    Merino, Aimee / Maakaron, Joseph / Bachanova, Veronika

    Blood reviews

    2023  Volume 60, Page(s) 101073

    Abstract: Natural Killer (NK) cells yield promise in therapy of hematologic malignancies. The clinical experience with adoptively transferred allogeneic NK cells over past two decades has revealed safety and minimal risk of CRS or ICANS. Unlike T cells which have ... ...

    Abstract Natural Killer (NK) cells yield promise in therapy of hematologic malignancies. The clinical experience with adoptively transferred allogeneic NK cells over past two decades has revealed safety and minimal risk of CRS or ICANS. Unlike T cells which have to be genetically altered to avoid graft vs host disease (GVHD), HLA mismatched NK cells can be infused without GVHD risk. This makes them ideal for the development of off-the-shelf products. In this review we focus on NK biology relevant to the cancer therapy, the trajectory of NK therapeutics for leukemia, lymphoma, and myeloma; and advantages of the NK cell platform. We will also discuss novel methods to enhance NK cell targeting, persistence, and function in the tumor microenvironment. The future of NK cell therapy depends on novel strategies to realize these qualities.
    MeSH term(s) Humans ; Hematologic Neoplasms/therapy ; Killer Cells, Natural/transplantation ; Immunotherapy, Adoptive/adverse effects ; Graft vs Host Disease ; Cell- and Tissue-Based Therapy ; Tumor Microenvironment
    Language English
    Publishing date 2023-03-12
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 639015-8
    ISSN 1532-1681 ; 0268-960X
    ISSN (online) 1532-1681
    ISSN 0268-960X
    DOI 10.1016/j.blre.2023.101073
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    Zs.A 2207: Show issues Location:
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  5. Article ; Online: Philadelphia-positive Acute Lymphoblastic Leukemia: Do We Still Need Allogeneic Transplantation? Argument "Pro".

    Bachanova, Veronika

    Clinical lymphoma, myeloma & leukemia

    2017  Volume 17S, Page(s) S10–S15

    MeSH term(s) Adult ; Age Factors ; Aged ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Child ; Fusion Proteins, bcr-abl/antagonists & inhibitors ; Fusion Proteins, bcr-abl/genetics ; Fusion Proteins, bcr-abl/metabolism ; Hematopoietic Stem Cell Transplantation/methods ; Humans ; Incidence ; Middle Aged ; Philadelphia Chromosome ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/epidemiology ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/genetics ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/pathology ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/therapy ; Protein Kinase Inhibitors/therapeutic use ; Transplantation Conditioning/methods ; Transplantation, Homologous/methods ; Treatment Outcome
    Chemical Substances BCR-ABL1 fusion protein, human ; Protein Kinase Inhibitors ; Fusion Proteins, bcr-abl (EC 2.7.10.2)
    Language English
    Publishing date 2017-01-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2540992-X
    ISSN 2152-2669 ; 2152-2650
    ISSN (online) 2152-2669
    ISSN 2152-2650
    DOI 10.1016/j.clml.2017.03.296
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    Zs.A 5903: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  6. Article ; Online: Deferring allogeneic transplantation for adult acute lymphoblastic leukemia: is there a second chance?

    Bachanova, Veronika

    Leukemia & lymphoma

    2016  Volume 57, Issue 9, Page(s) 1988–1990

    MeSH term(s) Adult ; Bone Marrow Transplantation ; Hematopoietic Stem Cell Transplantation ; Humans ; Precursor Cell Lymphoblastic Leukemia-Lymphoma ; Transplantation, Homologous
    Language English
    Publishing date 2016-07-12
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 1042374-6
    ISSN 1029-2403 ; 1042-8194
    ISSN (online) 1029-2403
    ISSN 1042-8194
    DOI 10.1080/10428194.2016.1205745
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    Zs.A 2997: Show issues Location:
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  7. Article ; Online: "Uncovering" the recovery of natural killer cells after reduced-intensity conditioning transplantation.

    Bachanova, Veronika

    Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation

    2015  Volume 21, Issue 3, Page(s) 383–384

    MeSH term(s) Cytokines/immunology ; Female ; Hematologic Neoplasms ; Hematopoietic Stem Cell Transplantation ; Humans ; Killer Cells, Natural/immunology ; Male ; Recovery of Function/immunology ; Transplantation Conditioning
    Chemical Substances Cytokines
    Language English
    Publishing date 2015-01-20
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 1474865-4
    ISSN 1523-6536 ; 1083-8791
    ISSN (online) 1523-6536
    ISSN 1083-8791
    DOI 10.1016/j.bbmt.2015.01.008
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    Zs.A 5082: Show issues Location:
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    Zs.MO 462: Show issues

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  8. Article ; Online: Novel Cell and Immune Engagers in Optimizing Tumor- Specific Immunity Post-Autologous Transplantation in Multiple Myeloma.

    Janakiram, Murali / Arora, Nivedita / Bachanova, Veronika / Miller, Jeffrey S

    Transplantation and cellular therapy

    2021  Volume 28, Issue 2, Page(s) 61–69

    Abstract: Autologous stem cell transplantation (ASCT) is an important component of treatment of multiple myeloma (MM). The post-ASCT setting offers a unique opportunity to increase myeloma specific immunity through enhancement of T and NK cell responses. The vast ... ...

    Abstract Autologous stem cell transplantation (ASCT) is an important component of treatment of multiple myeloma (MM). The post-ASCT setting offers a unique opportunity to increase myeloma specific immunity through enhancement of T and NK cell responses. The vast array of therapeutics being developed for MM, including cell-based therapies, dendritic vaccines, bispecific antibodies, and IL-15 agonists, provide the opportunity to increase tumor-specific immunity. Maintenance therapies, including immunomodulatory drugs, proteasome inhibitors, and daratumumab, exhibit a significant anti-myeloma response by modulating the immune system. Lenalidomide promotes an antitumoral immune microenvironment, whereas daratumumab can potentially cause NK cell fratricide. Thus, understanding the effects of commonly used maintenance drugs on the restoration of tumor specific immunity is important. In this review, we look at current and emerging therapeutics and their integration post-ASCT in the context of immune reconstitution to improve clinical responses in patients with MM. © 2021 American Society for Transplantation and Cellular Therapy. Published by Elsevier Inc.
    MeSH term(s) Hematopoietic Stem Cell Transplantation ; Humans ; Lenalidomide/therapeutic use ; Multiple Myeloma/therapy ; Proteasome Inhibitors/therapeutic use ; Transplantation, Autologous ; Tumor Microenvironment
    Chemical Substances Proteasome Inhibitors ; Lenalidomide (F0P408N6V4)
    Language English
    Publishing date 2021-10-08
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 3062231-1
    ISSN 2666-6367
    ISSN (online) 2666-6367
    DOI 10.1016/j.jtct.2021.10.001
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    Zs.A 5082: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: High Proliferating Regulatory T Cells Post-Transplantation Are Associated with Poor Survival in Lymphoma Patients Treated with Autologous Hematopoietic Stem Cell Transplantation.

    Sumransub, Nuttavut / Cao, Qing / Wangen, Rose / Brunstein, Claudio / Miller, Jeffrey S / Bachanova, Veronika

    Transplantation and cellular therapy

    2022  Volume 28, Issue 4, Page(s) 184.e1–184.e8

    Abstract: Autologous hematopoietic cell transplantation (AHCT) in lymphoma is well established and yields improved survival for patients with chemotherapy-sensitive disease. The patterns of immune cell reconstitution after AHCT have emerged as independent ... ...

    Abstract Autologous hematopoietic cell transplantation (AHCT) in lymphoma is well established and yields improved survival for patients with chemotherapy-sensitive disease. The patterns of immune cell reconstitution after AHCT have emerged as independent predictors of clinical outcomes. We sought to analyze the patterns of regulatory T cell (Treg) reconstitution after AHCT in non-Hodgkin lymphoma (NHL) and their correlations with clinical outcomes. In our prospective cohort study, we analyzed patterns of lymphocyte reconstitution and focused on T reg subsets for 41 patients who underwent AHCT for NHL between 2010 and 2016. Flow cytometry analysis was performed on blood samples collected prospectively at days +28, +60, and +100 post-AHCT. Patients' overall survival (OS) and progression-free survival (PFS) were correlated with Treg immune cell reconstitution. At day +28, Tregs comprised a median of 2.7% (range, 0.4% to 16.8%) of the total lymphocyte population. The proportion of proliferating Tregs (Ki67
    MeSH term(s) Hematopoietic Stem Cell Transplantation/adverse effects ; Humans ; Lymphoma/therapy ; Prospective Studies ; T-Lymphocytes, Regulatory ; Transplantation, Autologous
    Language English
    Publishing date 2022-01-23
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 3062231-1
    ISSN 2666-6367
    ISSN (online) 2666-6367
    DOI 10.1016/j.jtct.2022.01.016
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  10. Article ; Online: Temporal variation in oral microbiome composition of patients undergoing autologous hematopoietic cell transplantation with keratinocyte growth factor.

    Bohn, Bruno / Chalupova, Miroslava / Staley, Christopher / Holtan, Shernan / Maakaron, Joseph / Bachanova, Veronika / El Jurdi, Najla

    BMC microbiology

    2023  Volume 23, Issue 1, Page(s) 258

    Abstract: Introduction: Autologous hematopoietic cell transplantation (AHCT) is a well-established treatment for lymphoma. Unintended effects of this therapy include oral mucositis (OM) and gastrointestinal toxicities, resulting in poor clinical outcomes. The gut ...

    Abstract Introduction: Autologous hematopoietic cell transplantation (AHCT) is a well-established treatment for lymphoma. Unintended effects of this therapy include oral mucositis (OM) and gastrointestinal toxicities, resulting in poor clinical outcomes. The gut microbiome has been previously linked to transplant toxicities among allogeneic recipients, but little is known about the effects of AHCT on the oral microbiome.
    Methods: Seven patients with non-Hodgkin or Hodgkin lymphoma undergoing AHCT with palifermin (keratinocyte growth factor) were included. Buccal swab samples were collected at baseline and 14- and 28-days post-treatment. Oral microbial communities were characterized with 16 S rRNA amplicon sequencing. Temporal trends in community composition, alpha diversity, and beta diversity were investigated.
    Results: A significant reduction in the relative abundance of the genera Gemella and Actinomyces were observed from baseline. No significant temporal differences in alpha diversity were observed. Significant changes in beta diversity were recorded.
    Conclusion: Results of this pilot study suggest treatment with AHCT and palifermin affects the oral microbiome, resulting in temporal shifts in oral microbial community composition. Future studies are warranted to confirm these trends and further investigate the effects of AHCT on the oral microbiome and how these shifts may affect health outcomes.
    MeSH term(s) Humans ; Fibroblast Growth Factor 7 ; Pilot Projects ; Hematopoietic Stem Cell Transplantation/adverse effects ; Microbiota ; Gastrointestinal Microbiome
    Chemical Substances Fibroblast Growth Factor 7 (126469-10-1)
    Language English
    Publishing date 2023-09-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 2041505-9
    ISSN 1471-2180 ; 1471-2180
    ISSN (online) 1471-2180
    ISSN 1471-2180
    DOI 10.1186/s12866-023-03000-x
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