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  1. Article ; Online: Holistic rehabilitation for children with cancer: The Chilean model.

    Celedón, Vera / Rossell, Nuria / Zubieta, Marcela

    Cancer reports (Hoboken, N.J.)

    2021  Volume 5, Issue 6, Page(s) e1515

    Abstract: The increasingly positive outcomes of childhood cancer treatments are among the most inspiring stories in modern medicine. Many of the children and adolescents surviving cancer will have a healthy life; however, many others will suffer from physical, ... ...

    Abstract The increasingly positive outcomes of childhood cancer treatments are among the most inspiring stories in modern medicine. Many of the children and adolescents surviving cancer will have a healthy life; however, many others will suffer from physical, cognitive, psychological, and social sequelae. During treatment, many children experience multiple temporary and permanent side effects which negatively impact their quality of life. Low- and middle-income countries where childhood cancer treatment outcomes are improving are facing the reality of a growing population of teenagers and young adults suffering from long-term disease- and treatment-related consequences. In Chile, 500 children are diagnosed with cancer each year. Treatment is granted for all through public health policies and NGO collaboration. In order to address the complex problems from acute and long-term consequences of disease and treatment, the Oncological Rehabilitation Center Fundación Nuestros Hijos (CROFNH) provides multidisciplinary attention to an extensive variety of rehabilitation needs for children and adolescents with cancer. With its integrated services in the medical treatment of children and adolescents with cancer, the CROFNH helps reduce the impact of treatment-related side effects in children's daily lives, improves quality of life, and aims at contributing to these children becoming independent and functional adults to the maximum of their capacities. The aim of this article is to show the experience of the Chilean Oncological Rehabilitation Centre and its unique multidisciplinary approach. In addition, we discuss the successful telerehabilitation strategy implemented in response to the COVID-19 pandemic in order to secure continuity of treatment.
    MeSH term(s) Adolescent ; COVID-19/epidemiology ; Child ; Chile ; Humans ; Neoplasms/therapy ; Pandemics ; Quality of Life ; Young Adult
    Language English
    Publishing date 2021-07-26
    Publishing country United States
    Document type Journal Article
    ISSN 2573-8348
    ISSN (online) 2573-8348
    DOI 10.1002/cnr2.1515
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Factores determinantes para el acceso a la educación superior en el Municipio San Juan del Cesar-La Guajira desde la gestión pedagógica

    Julio Guillermo Otero Celedón / María Martha Daza Mejía / Yamelys Navarro Becerra

    Clío, Iss

    2023  Volume 6

    Abstract: ... comunidad-escuela-universidad. Escenario pedagógico-curricular, que se verá expuesto, a ...

    Abstract El escenario de la gestión pedagógica y de la pertinencia curricular, como base en la interacción comunidad-escuela-universidad. Escenario pedagógico-curricular, que se verá expuesto, a través de los factores determinantes-académico-curriculares. Los cuales, permiten abordar la evaluación del rendimiento escolar, desde estándares no convencionales. Desde el máximo aprovechamiento, en relación al desarrollo del pensamiento formal y desarrollo de la creatividad en la escuela, como uno de los cuatro factores determinantes que se establecieron desde la gestión pedagógica. Ello, para el acceso a la educación superior en el municipio San Juan del Cesar-La Guajira.
    Keywords gestión pedagógica ; factores determinantes-académico-curriculares ; acceso a la educación superior ; Anthropology ; GN1-890 ; Auxiliary sciences of history ; C
    Language English
    Publishing date 2023-07-01T00:00:00Z
    Publisher Ediciones Clío
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Maintenance Peritoneal Dialysis in Children With Autosomal Recessive Polycystic Kidney Disease: A Comparative Cohort Study of the International Pediatric Peritoneal Dialysis Network Registry.

    Akarkach, Abdelaziz / Burgmaier, Kathrin / Sander, Anja / Hooman, Nakysa / Sever, Lale / Cano, Francisco / Zambrano, Pedro / Bilge, Ilmay / Flynn, Joseph T / Yavascan, Onder / Vallés, Patricia G / Munarriz, Reyner Loza / Patel, Hiren P / Serdaroglu, Erkin / Koch, Vera H / Suarez, Angela Del Carmen / Galanti, Monica / Celedon, Claudia Gonzalez / Rébori, Anabella /
    Kari, Jameela A / Wong, Cynthia J / Elenberg, Ewa / Rojas, Luisa F / Warady, Bradley A / Liebau, Max C / Schaefer, Franz

    American journal of kidney diseases : the official journal of the National Kidney Foundation

    2020  Volume 75, Issue 3, Page(s) 460–464

    MeSH term(s) Child ; Child, Preschool ; Female ; Follow-Up Studies ; Humans ; Infant ; Male ; Peritoneal Dialysis/methods ; Polycystic Kidney, Autosomal Recessive/complications ; Polycystic Kidney, Autosomal Recessive/therapy ; Registries ; Renal Insufficiency/etiology ; Renal Insufficiency/prevention & control ; Time Factors ; Treatment Outcome
    Language English
    Publishing date 2020-01-23
    Publishing country United States
    Document type Comparative Study ; Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 604539-x
    ISSN 1523-6838 ; 0272-6386
    ISSN (online) 1523-6838
    ISSN 0272-6386
    DOI 10.1053/j.ajkd.2019.10.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Correction: High accuracy of an ELISA test based in a flagella antigen of Leishmania in serodiagnosis of canine visceral leishmaniasis with potential to improve the control measures in Brazil-A Phase II study.

    Borja, Lairton Souza / Coelho, Lívia Brito / de Jesus, Matheus Silva / de Queiroz, Artur Trancoso Lopo / Celedon, Paola Alejandra Fiorani / Zanchin, Nilson Ivo Tonin / Silva, Edimilson Domingos / Ferreira, Antônio Gomes Pinto / Krieger, Marco Aurélio / Veras, Patrícia Sampaio Tavares / Fraga, Deborah Bittencourt Mothé

    PLoS neglected tropical diseases

    2020  Volume 14, Issue 5, Page(s) e0008346

    Abstract: This corrects the article DOI: 10.1371/journal.pntd.0006871.]. ...

    Abstract [This corrects the article DOI: 10.1371/journal.pntd.0006871.].
    Language English
    Publishing date 2020-05-20
    Publishing country United States
    Document type Journal Article ; Published Erratum
    ZDB-ID 2429704-5
    ISSN 1935-2735 ; 1935-2727
    ISSN (online) 1935-2735
    ISSN 1935-2727
    DOI 10.1371/journal.pntd.0008346
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: High accuracy of an ELISA test based in a flagella antigen of Leishmania in serodiagnosis of canine visceral leishmaniasis with potential to improve the control measures in Brazil - A Phase II study.

    Borja, Lairton Souza / Coelho, Lívia Brito / Jesus, Matheus Silva de / de Queiroz, Artur Trancoso Lopo / Celedon, Paola Alejandra Fiorani / Zanchin, Nilson Ivo Tonin / Silva, Edimilson Domingos / Ferreira, Antônio Gomes Pinto / Krieger, Marco Aurélio / Veras, Patrícia Sampaio Tavares / Fraga, Deborah Bittencourt Mothé

    PLoS neglected tropical diseases

    2018  Volume 12, Issue 10, Page(s) e0006871

    Abstract: Background: Canine Visceral leishmaniasis (CVL) is a serious public health problem, thus for its control, the Ministry of Health in Brazil recommends the rapid diagnosis and euthanasia of seropositive dogs in endemic areas. Therefore, our group had ... ...

    Abstract Background: Canine Visceral leishmaniasis (CVL) is a serious public health problem, thus for its control, the Ministry of Health in Brazil recommends the rapid diagnosis and euthanasia of seropositive dogs in endemic areas. Therefore, our group had previously selected six recombinant proteins (rLci1, rLci2, rLci4, rLci5, rLci8, and rLci12) due to their high potential for CVL diagnostic testing. The present study aims to produce an immunodiagnostic test using the aforementioned antigens, to improve the performance of the diagnosis of CVL recommended by Brazilian Ministry of Health.
    Methodology/principal findings: To evaluate the recombinant proteins in the serological assays, positive and negative samples were selected based on parasitological test (culture) and molecular test (qPCR) of splenic aspirate. Initially, we selected 135 dog serum samples, 73 positives (symptomatic and asymptomatic) and 62 negatives to screen recombinant proteins on ELISA platform. Then, for rLci5 ELISA validation, 361 serum samples collected in a cross-sectional study were selected, being 183 positives (symptomatic and asymptomatic) and 178 negatives. In the screening of the recombinant proteins, rLci5 was the only protein to present a performance statistically higher than the performance presented by EIE-LVC test, presenting 96% (IC 95%; 85-99%) vs. 83% (IC 95%; 69-92%) of sensitivity for symptomatic dogs, 71% (IC 95%; 49-97%) vs. 54% (IC 95%; 33-74%) for asymptomatic dogs and 94% (IC 95%; 83-99%) vs, 88% (IC 95%; 76-95% of specificity. Thus, the rLci5 protein was selected to compose a final ELISA test. Validation of rLci5 ELISA showed 87% (IC 81-91%) of sensitivity, 94% (IC 95%; 90-97%) of specificity and 90% accuracy. Testing the EIE-LVC with the same validation panel, we observed a lower performance when compared to ELISA rLci5 (sensitivity of 67% (IC 95%; 59-74%), specificity of 87% (IC 95%; 81-92%), and accuracy of 77%). Finally, the performance of current CVL diagnostic protocol recommended by Brazilian Ministry of Health, using DPP-LVC as screening test and EIE-LVC as confirmatory test, was compared with a modified protocol, replacing EIE-LVC by rLci5 ELISA. The current protocol presented a sensitivity of 59% (IC 95%; 52-66%), specificity of 98% (IC 95%; 95-99%) and accuracy of 80% (IC 95%; 76-84%), while the modified protocol presented a sensitivity of 71% (IC 95%; 63-77%), specificity of 99% (IC 95%; 97-100%) and accuracy of 86% (IC 95%; 83-89%).
    Conclusion: Thus, we concluded that rLci5 ELISA is a promising test to replace EIE-LVC test and increase the diagnostic performance of CVL in Brazil.
    MeSH term(s) Animals ; Antigens, Protozoan/immunology ; Brazil ; Cross-Sectional Studies ; Dog Diseases/diagnosis ; Dogs ; Enzyme-Linked Immunosorbent Assay/methods ; Flagella/immunology ; Leishmania/immunology ; Leishmaniasis, Visceral/diagnosis ; Leishmaniasis, Visceral/veterinary ; Recombinant Proteins/immunology ; Sensitivity and Specificity ; Serologic Tests/methods
    Chemical Substances Antigens, Protozoan ; Recombinant Proteins
    Language English
    Publishing date 2018-10-26
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Validation Study
    ZDB-ID 2429704-5
    ISSN 1935-2735 ; 1935-2727
    ISSN (online) 1935-2735
    ISSN 1935-2727
    DOI 10.1371/journal.pntd.0006871
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Correction

    Lairton Souza Borja / Lívia Brito Coelho / Matheus Silva de Jesus / Artur Trancoso Lopo de Queiroz / Paola Alejandra Fiorani Celedon / Nilson Ivo Tonin Zanchin / Edimilson Domingos Silva / Antônio Gomes Pinto Ferreira / Marco Aurélio Krieger / Patrícia Sampaio Tavares Veras / Deborah Bittencourt Mothé Fraga

    PLoS Neglected Tropical Diseases, Vol 14, Iss 5, p e

    High accuracy of an ELISA test based in a flagella antigen of Leishmania in serodiagnosis of canine visceral leishmaniasis with potential to improve the control measures in Brazil-A Phase II study.

    2020  Volume 0008346

    Abstract: This corrects the article DOI:10.1371/journal.pntd.0006871.]. ...

    Abstract [This corrects the article DOI:10.1371/journal.pntd.0006871.].
    Keywords Arctic medicine. Tropical medicine ; RC955-962 ; Public aspects of medicine ; RA1-1270
    Language English
    Publishing date 2020-05-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: High accuracy of an ELISA test based in a flagella antigen of Leishmania in serodiagnosis of canine visceral leishmaniasis with potential to improve the control measures in Brazil - A Phase II study.

    Lairton Souza Borja / Lívia Brito Coelho / Matheus Silva de Jesus / Artur Trancoso Lopo de Queiroz / Paola Alejandra Fiorani Celedon / Nilson Ivo Tonin Zachin / Edimilson Domingos Silva / Antônio Gomes Pinto Ferreira / Marco Aurélio Krieger / Patrícia Sampaio Tavares Veras / Deborah Bittencourt Mothé Fraga

    PLoS Neglected Tropical Diseases, Vol 12, Iss 10, p e

    2018  Volume 0006871

    Abstract: BACKGROUND:Canine Visceral leishmaniasis (CVL) is a serious public health problem, thus for its control, the Ministry of Health in Brazil recommends the rapid diagnosis and euthanasia of seropositive dogs in endemic areas. Therefore, our group had ... ...

    Abstract BACKGROUND:Canine Visceral leishmaniasis (CVL) is a serious public health problem, thus for its control, the Ministry of Health in Brazil recommends the rapid diagnosis and euthanasia of seropositive dogs in endemic areas. Therefore, our group had previously selected six recombinant proteins (rLci1, rLci2, rLci4, rLci5, rLci8, and rLci12) due to their high potential for CVL diagnostic testing. The present study aims to produce an immunodiagnostic test using the aforementioned antigens, to improve the performance of the diagnosis of CVL recommended by Brazilian Ministry of Health. METHODOLOGY/PRINCIPAL FINDINGS:To evaluate the recombinant proteins in the serological assays, positive and negative samples were selected based on parasitological test (culture) and molecular test (qPCR) of splenic aspirate. Initially, we selected 135 dog serum samples, 73 positives (symptomatic and asymptomatic) and 62 negatives to screen recombinant proteins on ELISA platform. Then, for rLci5 ELISA validation, 361 serum samples collected in a cross-sectional study were selected, being 183 positives (symptomatic and asymptomatic) and 178 negatives. In the screening of the recombinant proteins, rLci5 was the only protein to present a performance statistically higher than the performance presented by EIE-LVC test, presenting 96% (IC 95%; 85-99%) vs. 83% (IC 95%; 69-92%) of sensitivity for symptomatic dogs, 71% (IC 95%; 49-97%) vs. 54% (IC 95%; 33-74%) for asymptomatic dogs and 94% (IC 95%; 83-99%) vs, 88% (IC 95%; 76-95% of specificity. Thus, the rLci5 protein was selected to compose a final ELISA test. Validation of rLci5 ELISA showed 87% (IC 81-91%) of sensitivity, 94% (IC 95%; 90-97%) of specificity and 90% accuracy. Testing the EIE-LVC with the same validation panel, we observed a lower performance when compared to ELISA rLci5 (sensitivity of 67% (IC 95%; 59-74%), specificity of 87% (IC 95%; 81-92%), and accuracy of 77%). Finally, the performance of current CVL diagnostic protocol recommended by Brazilian Ministry of Health, using ...
    Keywords Arctic medicine. Tropical medicine ; RC955-962 ; Public aspects of medicine ; RA1-1270
    Subject code 150
    Language English
    Publishing date 2018-10-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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