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  1. Article ; Online: Prognostic value and immunological role of CSNK1D in human cancers.

    Wang, Jianguo / Hu, Baohong / Wang, Weixing

    Aging

    2023  Volume 15, Issue 17, Page(s) 8948–8975

    Abstract: CSNK1D, also known as CK1δ, is a crucial gene involved in various biological processes such as cell cycle, transcriptional regulation, apoptosis, cell polarity, and cell motility. It is associated with different cancers and neurodegenerative diseases. ... ...

    Abstract CSNK1D, also known as CK1δ, is a crucial gene involved in various biological processes such as cell cycle, transcriptional regulation, apoptosis, cell polarity, and cell motility. It is associated with different cancers and neurodegenerative diseases. This study aimed to investigate the role of CSNK1D in multiple human cancers, particularly hepatocellular carcinoma (HCC), through
    MeSH term(s) Humans ; Apoptosis ; Biological Assay ; Carcinoma, Hepatocellular/genetics ; Liver Neoplasms/genetics ; Prognosis ; Casein Kinase Idelta/metabolism
    Chemical Substances Casein Kinase Idelta (EC 2.7.11.1)
    Language English
    Publishing date 2023-09-08
    Publishing country United States
    Document type Journal Article
    ISSN 1945-4589
    ISSN (online) 1945-4589
    DOI 10.18632/aging.205009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: RBP-J regulates homeostasis and function of circulating Ly6C

    Kou, Tiantian / Kang, Lan / Zhang, Bin / Li, Jiaqi / Zhao, Baohong / Zeng, Wenwen / Hu, Xiaoyu

    eLife

    2024  Volume 12

    Abstract: Notch-RBP-J signaling plays an essential role in the maintenance of myeloid homeostasis. However, its role in monocyte cell fate decisions is not fully understood. Here, we showed that conditional deletion of transcription factor RBP-J in myeloid cells ... ...

    Abstract Notch-RBP-J signaling plays an essential role in the maintenance of myeloid homeostasis. However, its role in monocyte cell fate decisions is not fully understood. Here, we showed that conditional deletion of transcription factor RBP-J in myeloid cells resulted in marked accumulation of blood Ly6C
    MeSH term(s) Monocytes ; Myeloid Cells ; Macrophages ; Bone Marrow Transplantation ; Homeostasis ; Receptors, Chemokine
    Chemical Substances Receptors, Chemokine
    Language English
    Publishing date 2024-02-26
    Publishing country England
    Document type Journal Article
    ZDB-ID 2687154-3
    ISSN 2050-084X ; 2050-084X
    ISSN (online) 2050-084X
    ISSN 2050-084X
    DOI 10.7554/eLife.88135
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  3. Article: Comparative Transcriptomics Analysis Reveals Unique Immune Response to Grass Carp Reovirus Infection in Barbel Chub (

    Huang, Yuhong / Wang, Xiaodong / Lv, Zhao / Hu, Xudong / Xu, Baohong / Yang, Hong / Xiao, Tiaoyi / Liu, Qiaolin

    Biology

    2024  Volume 13, Issue 4

    Abstract: Grass carp ( ...

    Abstract Grass carp (
    Language English
    Publishing date 2024-03-25
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2661517-4
    ISSN 2079-7737
    ISSN 2079-7737
    DOI 10.3390/biology13040214
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  4. Article ; Online: Jagged1 Acts as an RBP-J Target and Feedback Suppresses TNF-Mediated Inflammatory Osteoclastogenesis.

    Ng, Courtney / Qin, Yongli / Xia, Yuhan / Hu, Xiaoyu / Zhao, Baohong

    Journal of immunology (Baltimore, Md. : 1950)

    2023  Volume 211, Issue 9, Page(s) 1340–1347

    Abstract: TNF plays a crucial role in inflammation and bone resorption in various inflammatory diseases, including rheumatoid arthritis (RA). However, its direct ability to drive macrophages to differentiate into osteoclasts is limited. Although RBP-J is ... ...

    Abstract TNF plays a crucial role in inflammation and bone resorption in various inflammatory diseases, including rheumatoid arthritis (RA). However, its direct ability to drive macrophages to differentiate into osteoclasts is limited. Although RBP-J is recognized as a key inhibitor of TNF-mediated osteoclastogenesis, the precise mechanisms that restrain TNF-induced differentiation of macrophages into osteoclasts are not fully elucidated. In this study, we identified that the Notch ligand Jagged1 is a previously unrecognized RBP-J target. The expression of Jagged1 is significantly induced by TNF mainly through RBP-J. The TNF-induced Jagged1 in turn functions as a feedback inhibitory regulator of TNF-mediated osteoclastogenesis. This feedback inhibition of osteoclastogenesis by Jagged1 does not exist in RANKL-induced mouse osteoclast differentiation, as RANKL does not induce Jagged1 expression. The Jagged1 level in peripheral blood monocytes/osteoclast precursors is decreased in RA compared with the nonerosive inflammatory disease systemic lupus erythematosus, suggesting a mechanism that contributes to increased osteoclast formation in RA. Moreover, recombinant Jagged1 suppresses human inflammatory osteoclastogenesis. Our findings identify Jagged1 as an RBP-J direct target that links TNF and Notch signaling pathways and restrains TNF-mediated osteoclastogenesis. Given that Jagged1 has no effect on TNF-induced expression of inflammatory genes, its use may present a new complementary therapeutic approach to mitigate inflammatory bone loss with little impact on the immune response in disease conditions.
    MeSH term(s) Humans ; Animals ; Mice ; Osteogenesis ; Feedback ; Osteoclasts/metabolism ; Bone Resorption ; Macrophages ; Arthritis, Rheumatoid/metabolism ; RANK Ligand/metabolism ; Cell Differentiation ; Tumor Necrosis Factor-alpha/metabolism
    Chemical Substances RANK Ligand ; Tumor Necrosis Factor-alpha
    Language English
    Publishing date 2023-09-23
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 3056-9
    ISSN 1550-6606 ; 0022-1767 ; 1048-3233 ; 1047-7381
    ISSN (online) 1550-6606
    ISSN 0022-1767 ; 1048-3233 ; 1047-7381
    DOI 10.4049/jimmunol.2300317
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ud II Zs.37: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 28: Show issues

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  5. Article: Quantitative proteomic analysis and verification identify global protein profiling dynamics in pig during the estrous cycle.

    Xin, Haiyun / Li, Baohong / Meng, Fanming / Hu, Bin / Wang, Sutian / Wang, Ying / Li, Jianhao

    Frontiers in veterinary science

    2023  Volume 10, Page(s) 1247561

    Abstract: The current estrus detection method is generally time-consuming and has low accuracy. As such, a deeper understanding of the physiological processes during the estrous cycle accelerates the development of estrus detection efficiency and accuracy. In this ...

    Abstract The current estrus detection method is generally time-consuming and has low accuracy. As such, a deeper understanding of the physiological processes during the estrous cycle accelerates the development of estrus detection efficiency and accuracy. In this study, the label-free acquisition mass spectrometry was used to explore salivary proteome profiles during the estrous cycle (day -3, day 0, day 3, and day 8) in pigs, and the parallel reaction monitoring (PRM) was applied to verify the relative profiles of protein expression. A total of 1,155 proteins were identified in the label-free analysis, of which 115 were identified as differentially expressed proteins (DEPs) among different groups (
    Language English
    Publishing date 2023-09-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2834243-4
    ISSN 2297-1769
    ISSN 2297-1769
    DOI 10.3389/fvets.2023.1247561
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  6. Article ; Online: Effect and mechanism of mir-574-5p regulating mpegs on drug resistance of pC9/h1993 cells.

    Xin, Chunxia / Hu, Baohong / Sui, Minghua

    Panminerva medica

    2021  Volume 64, Issue 2, Page(s) 300–302

    MeSH term(s) Carcinoma, Non-Small-Cell Lung/genetics ; Cell Line, Tumor ; Drug Resistance ; Gene Expression Regulation, Neoplastic ; Humans ; Lung Neoplasms/genetics ; MicroRNAs/genetics
    Chemical Substances MIRN574 microRNA, human ; MicroRNAs
    Language English
    Publishing date 2021-10-19
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 123572-2
    ISSN 1827-1898 ; 0031-0808
    ISSN (online) 1827-1898
    ISSN 0031-0808
    DOI 10.23736/S0031-0808.21.04464-5
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    In stock of ZB MED Cologne/Königswinter

    Zs.B 179: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Microbial community evolution and individual-based model validation of biofilms in single-stage partial nitrification/anammox system.

    Han, Baohong / Xing, Wei / Hu, Zhifeng / Tian, Qianqian / Zhang, Jingjing / Han, Xiangyu / Mei, Ning / Zhao, Xingcheng / Yao, Hong

    Bioresource technology

    2024  Volume 397, Page(s) 130463

    Abstract: In this study, matrix degradation, microbial community development, and distribution using an individual-based model during biofilm formation on carriers at varying depths within a single-stage partial nitrification/anammox system were simulated. The ... ...

    Abstract In this study, matrix degradation, microbial community development, and distribution using an individual-based model during biofilm formation on carriers at varying depths within a single-stage partial nitrification/anammox system were simulated. The findings from the application of individual-based model fitting, fluorescence in situ hybridization, and high-throughput sequencing reveal the presence of aerobic bacteria, specifically ammonia-oxidizing bacteria, as discrete particles within the outer layer of the carrier. Facultative anaerobic bacteria exemplified by anaerobic ammonia-oxidizing bacteria, are observed as aggregates within the middle layer. Conversely, anaerobic bacteria, represented by denitrifiers, are enveloped by extracellular polymeric substances within the inner layer. The present study extends the application of individual-based model to the formation of polyurethane-supported biofilms and presents valuable avenues for the design and advancement of pragmatic engineering carriers.
    MeSH term(s) Nitrification ; Ammonia/metabolism ; Anaerobic Ammonia Oxidation ; In Situ Hybridization, Fluorescence ; Biofilms ; Microbiota ; Bioreactors/microbiology ; Oxidation-Reduction ; Nitrogen/metabolism ; Denitrification
    Chemical Substances Ammonia (7664-41-7) ; Nitrogen (N762921K75)
    Language English
    Publishing date 2024-02-17
    Publishing country England
    Document type Journal Article
    ZDB-ID 1065195-0
    ISSN 1873-2976 ; 0960-8524
    ISSN (online) 1873-2976
    ISSN 0960-8524
    DOI 10.1016/j.biortech.2024.130463
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    In stock of ZB MED Bonn / Germany

    Z 3258: Show issues

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  8. Article ; Online: Mutations in the

    Qi, Youpeng / Wang, Xiangyan / Zhu, Chune / Mi, Baohong / Cui, Changze / Chen, Shaopeng / Zhao, Zhidong / Zhao, Fangfang / Liu, Xiu / Wang, Jiqing / Shi, Bingang / Hu, Jiang

    International journal of molecular sciences

    2024  Volume 25, Issue 4

    Abstract: ... ...

    Abstract The
    MeSH term(s) Animals ; Cattle ; Meat ; Phenotype ; Genotype ; Quantitative Trait Loci ; Mutation ; Polymorphism, Single Nucleotide ; Muscle, Skeletal/physiology
    Language English
    Publishing date 2024-02-06
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25041948
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  9. Article ; Online: Pramipexole Inhibits Neuronal Apoptosis in Rats with Parkinson's Disease.

    Sun, Yongqi / Cui, Baohong / Ye, Lin / Hu, Yunxin / Pan, Yujun

    publication RETRACTED

    Journal of healthcare engineering

    2022  Volume 2022, Page(s) 7002630

    Abstract: To explore the inhibition of pramipexole on the neuronal apoptosis and its influences on the expressions of brain tissue brain-derived neurotrophic factor (BDNF), and serum miR-103a and miR-30b and inflammatory factors in rats with Parkinson's disease. A ...

    Abstract To explore the inhibition of pramipexole on the neuronal apoptosis and its influences on the expressions of brain tissue brain-derived neurotrophic factor (BDNF), and serum miR-103a and miR-30b and inflammatory factors in rats with Parkinson's disease. A total of 36 Sprague-Dawley rats were randomly divided into normal group (
    MeSH term(s) Animals ; Apoptosis/physiology ; Brain-Derived Neurotrophic Factor ; MicroRNAs/metabolism ; Parkinson Disease/drug therapy ; Pramipexole/pharmacology ; Proto-Oncogene Proteins c-bcl-2 ; Rats ; Rats, Sprague-Dawley ; bcl-2-Associated X Protein
    Chemical Substances Brain-Derived Neurotrophic Factor ; MicroRNAs ; Proto-Oncogene Proteins c-bcl-2 ; bcl-2-Associated X Protein ; Pramipexole (83619PEU5T)
    Language English
    Publishing date 2022-04-13
    Publishing country England
    Document type Journal Article ; Retracted Publication
    ZDB-ID 2545054-2
    ISSN 2040-2309 ; 2040-2295
    ISSN (online) 2040-2309
    ISSN 2040-2295
    DOI 10.1155/2022/7002630
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  10. Article ; Online: RBP-J imposes a requirement for ITAM-mediated costimulation of osteoclastogenesis

    Susan Li / Christine H. Miller / Eugenia Giannopoulou / Xiaoyu Hu / Lionel B. Ivashkiv / Baohong Zhao

    The Journal of Clinical Investigation, Vol 132, Iss

    2022  Volume 10

    Keywords Medicine ; R
    Language English
    Publishing date 2022-05-01T00:00:00Z
    Publisher American Society for Clinical Investigation
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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