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  1. Article ; Online: Diagnostic Testing Procedures and Challenges for Primary Immunodeficiencies.

    Kraft, Antigone / Ciaccio, Christina E

    Pediatric annals

    2022  Volume 51, Issue 12, Page(s) e480–e484

    Abstract: Primary immunodeficiencies are rare but are often on the differential diagnosis list when patients present with recurrent or atypical infections. Patients with primary immunodeficiencies can present with a variety of symptoms and can present providers ... ...

    Abstract Primary immunodeficiencies are rare but are often on the differential diagnosis list when patients present with recurrent or atypical infections. Patients with primary immunodeficiencies can present with a variety of symptoms and can present providers with diagnostic challenges given this variability, and the severe implications of immunodeficiencies can sometimes lead providers to pursue broad workups that may not be necessary. However, there are certain symptom patterns providers can look out for and diagnostic steps that can be taken to triage these presentations. We have used the practice modeled in the "Five Fingers of the Immune Workup" to outline common laboratory tests for clinicians to order when they are concerned for immunodeficiencies while remembering that these diagnoses are often rare, and true concern for this pathology would warrant referral to a specialist.
    MeSH term(s) Humans ; Diagnostic Techniques and Procedures
    Language English
    Publishing date 2022-12-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 195430-1
    ISSN 1938-2359 ; 0090-4481
    ISSN (online) 1938-2359
    ISSN 0090-4481
    DOI 10.3928/19382359-20221006-07
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1347: Show issues Location:
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  2. Article ; Online: Modulating the microbiome: The future of allergy therapeutics?

    Ciaccio, Christina E

    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology

    2018  Volume 122, Issue 3, Page(s) 233–235

    MeSH term(s) Fatty Acids, Volatile/therapeutic use ; Humans ; Hypersensitivity/microbiology ; Hypersensitivity/therapy ; Microbiota ; Prebiotics ; Probiotics/therapeutic use
    Chemical Substances Fatty Acids, Volatile ; Prebiotics
    Language English
    Publishing date 2018-12-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1228189-x
    ISSN 1534-4436 ; 0003-4738 ; 1081-1206
    ISSN (online) 1534-4436
    ISSN 0003-4738 ; 1081-1206
    DOI 10.1016/j.anai.2018.12.006
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  3. Article ; Online: New and emerging concepts and therapies for the treatment of food allergy.

    Hwang, David W / Nagler, Cathryn R / Ciaccio, Christina E

    Immunotherapy advances

    2022  Volume 2, Issue 1, Page(s) ltac006

    Abstract: Food allergy is an increasingly common disease that often starts in early childhood and lasts throughout life. Self-reported food allergy has risen at a rate of 1.2% per decade since 1988, and by 2018, the prevalence of food allergy in the United States ... ...

    Abstract Food allergy is an increasingly common disease that often starts in early childhood and lasts throughout life. Self-reported food allergy has risen at a rate of 1.2% per decade since 1988, and by 2018, the prevalence of food allergy in the United States was estimated to be 8% in children and 11% in adults.
    Language English
    Publishing date 2022-02-04
    Publishing country England
    Document type Journal Article ; Review
    ISSN 2732-4303
    ISSN (online) 2732-4303
    DOI 10.1093/immadv/ltac006
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  4. Article ; Online: Pediatric Allergy and Immunology.

    Makhija, Melanie M / Ciaccio, Christina E

    Pediatric annals

    2019  Volume 48, Issue 12, Page(s) e466–e467

    MeSH term(s) Adolescent ; Allergy and Immunology ; Child ; Child, Preschool ; Female ; Food Hypersensitivity/epidemiology ; Food Hypersensitivity/prevention & control ; Humans ; Hypersensitivity/diagnosis ; Hypersensitivity/epidemiology ; Hypersensitivity/therapy ; Journal Impact Factor ; Male ; Pediatrics ; Periodicals as Topic ; Rhinitis, Allergic/diagnosis ; Rhinitis, Allergic/epidemiology ; Rhinitis, Allergic/therapy
    Language English
    Publishing date 2019-12-12
    Publishing country United States
    Document type Editorial ; Review
    ZDB-ID 195430-1
    ISSN 1938-2359 ; 0090-4481
    ISSN (online) 1938-2359
    ISSN 0090-4481
    DOI 10.3928/19382359-20191114-02
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  5. Article ; Online: Topical steroid withdrawal and atopic dermatitis.

    Marshall, Hannah F / Leung, Donald Y M / Lack, Gideon / Sindher, Sayantani / Ciaccio, Christina E / Chan, Susan / Nadeau, Kari C / Brough, Helen A

    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology

    2023  Volume 132, Issue 4, Page(s) 423–425

    MeSH term(s) Humans ; Dermatitis, Atopic/drug therapy ; Steroids/adverse effects ; Administration, Topical
    Chemical Substances Steroids
    Language English
    Publishing date 2023-12-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1228189-x
    ISSN 1534-4436 ; 0003-4738 ; 1081-1206
    ISSN (online) 1534-4436
    ISSN 0003-4738 ; 1081-1206
    DOI 10.1016/j.anai.2023.12.022
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Increase in Epinephrine Administration for Food-Induced Anaphylaxis in Pediatric Emergency Departments From 2007 to 2015.

    Kim, So Lim / Suresh, Ragha / Mayampurath, Anoop / Ciaccio, Christina E

    The journal of allergy and clinical immunology. In practice

    2021  Volume 10, Issue 1, Page(s) 200–205.e1

    Abstract: Background: Epinephrine is underused in the treatment of anaphylaxis, despite being the first-line treatment, which reflects the challenges in diagnosing anaphylaxis and understanding the appropriate therapy.: Objective: To describe trends in ... ...

    Abstract Background: Epinephrine is underused in the treatment of anaphylaxis, despite being the first-line treatment, which reflects the challenges in diagnosing anaphylaxis and understanding the appropriate therapy.
    Objective: To describe trends in epinephrine administration for patients visiting the pediatric emergency department (ED) with food-induced anaphylaxis (FIA) from 2007 to 2015.
    Methods: This retrospective cohort study included children 0 to 17 years of age with FIA from 46 children's hospitals in the United States between 2007 and 2015. Multivariable regression was used to identify factors associated with epinephrine administration.
    Results: A total of 15,318 cases of FIA cases were seen in the pediatric EDs from 2007 to 2015. Among these ED visits, 7,600 (49.6%) had at least 1 dose of epinephrine administered in the ED. Administration of epinephrine for anaphylaxis in the pediatric ED increased by 4% each year (odds ratio [OR] 1.04; 95% CI 1.03-1.05; P < .001). Sensitivity analysis by census region demonstrated that hospitals in the Northeast and the West were associated with an increase in epinephrine administration per year (Northeast OR 1.18, 95% CI 1.13-1.22, P < .001; West OR 1.14, 95% CI 1.10-1.18, P < .001).
    Conclusions: Epinephrine administration for FIA in the pediatric ED has increased over time, reflecting the need for continued advocacy for the optimal management of FIA. Further research is warranted to identify optimal strategies for proper recognition and early administration of epinephrine for anaphylaxis.
    MeSH term(s) Anaphylaxis/drug therapy ; Anaphylaxis/epidemiology ; Child ; Emergency Service, Hospital ; Epinephrine/therapeutic use ; Food Hypersensitivity/drug therapy ; Food Hypersensitivity/epidemiology ; Humans ; Retrospective Studies ; United States/epidemiology
    Chemical Substances Epinephrine (YKH834O4BH)
    Language English
    Publishing date 2021-09-23
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2843237-X
    ISSN 2213-2201 ; 2213-2198
    ISSN (online) 2213-2201
    ISSN 2213-2198
    DOI 10.1016/j.jaip.2021.09.024
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    Zs.A 7086: Show issues Location:
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  7. Article ; Online: Food OIT: What do we know, what don't we know, and what do we need to know?

    Ciaccio, Christina E / Bauer, Maureen Egan / Nowak-Wegrzyn, Anna

    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology

    2019  Volume 123, Issue 2, Page(s) 118–119

    MeSH term(s) Allergens/administration & dosage ; Allergens/immunology ; Desensitization, Immunologic/methods ; Egg Hypersensitivity/therapy ; Egg Proteins, Dietary/administration & dosage ; Egg Proteins, Dietary/immunology ; Food ; Humans ; Immune Tolerance/drug effects ; Peanut Hypersensitivity/therapy
    Chemical Substances Allergens ; Egg Proteins, Dietary
    Language English
    Publishing date 2019-07-31
    Publishing country United States
    Document type Editorial
    ZDB-ID 1228189-x
    ISSN 1534-4436 ; 0003-4738 ; 1081-1206
    ISSN (online) 1534-4436
    ISSN 0003-4738 ; 1081-1206
    DOI 10.1016/j.anai.2019.06.015
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  8. Article: Angioedema: an overview and update.

    Ciaccio, Christina E

    Missouri medicine

    2011  Volume 108, Issue 5, Page(s) 354–357

    Abstract: Angioedema is an increasing cause of hospitalizations in the United States. This syndrome presents with non-pitting, asymmetric swelling of the face, lips, tongue, larynx, genitalia, and extremities, although any part of the body can be involved. Common ... ...

    Abstract Angioedema is an increasing cause of hospitalizations in the United States. This syndrome presents with non-pitting, asymmetric swelling of the face, lips, tongue, larynx, genitalia, and extremities, although any part of the body can be involved. Common causes of angioedema include allergic reactions and ACE inhibitors. Hereditary angioedema is a rare form of angioedema that can be diagnosed by screening with a C4 level. In 2009, three new treatments for hereditary angioedema were approved for use in the United States, revolutionizing management of this rare disease.
    MeSH term(s) Angioedema/diagnosis ; Angioedema/etiology ; Angioedema/immunology ; Angioedemas, Hereditary/diagnosis ; Angioedemas, Hereditary/immunology ; Complement C1 Inactivator Proteins/immunology ; Complement C4/analysis ; Humans ; Urticaria/immunology
    Chemical Substances Complement C1 Inactivator Proteins ; Complement C4
    Language English
    Publishing date 2011-09-22
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 427362-x
    ISSN 0026-6620
    ISSN 0026-6620
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 182: Show issues Location:
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  9. Article ; Online: Skin as the target for allergy prevention and treatment.

    Marques-Mejias, Andreina / Bartha, Irene / Ciaccio, Christina E / Chinthrajah, R Sharon / Chan, Susan / Hershey, Gurjit K Khurana / Hui-Beckman, Jessica W / Kost, Laurie / Lack, Gideon / Layhadi, Janice A / Leung, Donald Y M / Marshall, Hannah F / Nadeau, Kari C / Radulovic, Suzana / Rajcoomar, Reena / Shamji, Mohamed H / Sindher, Sayantani / Brough, Helen A

    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology

    2024  

    Abstract: The fact that genetic and environmental factors could trigger disruption of the epithelial barrier and subsequently initiate a ... ...

    Abstract The fact that genetic and environmental factors could trigger disruption of the epithelial barrier and subsequently initiate a T
    Language English
    Publishing date 2024-01-20
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1228189-x
    ISSN 1534-4436 ; 0003-4738 ; 1081-1206
    ISSN (online) 1534-4436
    ISSN 0003-4738 ; 1081-1206
    DOI 10.1016/j.anai.2023.12.030
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Potential new targets for drug development in severe asthma.

    Zhu, Linda / Ciaccio, Christina E / Casale, Thomas B

    The World Allergy Organization journal

    2018  Volume 11, Issue 1, Page(s) 30

    Abstract: In recent years there has been increasing recognition of varying asthma phenotypes that impact treatment response. This has led to the development of biological therapies targeting specific immune cells and cytokines in the inflammatory cascade. ... ...

    Abstract In recent years there has been increasing recognition of varying asthma phenotypes that impact treatment response. This has led to the development of biological therapies targeting specific immune cells and cytokines in the inflammatory cascade. Currently, there are two primary asthma phenotypes, Type 2 hi and Type 2 lo, which are defined by eosinophilic and neutrophilic/pauci- granulocytic pattern of inflammation respectively. Most biologics focus on Type 2 hi asthma, including all four biologics approved for treatment of uncontrolled asthma in the United States - omalizumab, mepolizumab, reslizumab, and benralizumab. Potential new targets for drug development are being investigated, such as IL-13, IL-4α receptor, CRTH2, TSLP, IL-25, IL-13, IL-17A receptor, and CXCR2/IL-8. This review will discuss the role of these molecules on the inflammatory response in uncontrolled asthma and the emerging biologics that address them. Through the delineation of distinct immunological mechanisms in severe asthma, targeted biologics are promising new therapies that have the potential to improve asthma control and quality of life.
    Language English
    Publishing date 2018-10-25
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2581968-9
    ISSN 1939-4551
    ISSN 1939-4551
    DOI 10.1186/s40413-018-0208-1
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