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  1. Book: Immunology laboratory testing

    Mahajan, Vinay S.

    (Clinics in laboratory medicine ; volume 39, number 4 (December 2019))

    2019  

    Author's details editor Vinay S. Mahajan
    Series title Clinics in laboratory medicine ; volume 39, number 4 (December 2019)
    Collection
    Language English
    Size xii Seiten, Seite 514-708, Illustrationen
    Publisher Elsevier
    Publishing place Philadelphia, Pennsylvania
    Publishing country United States
    Document type Book
    HBZ-ID HT020315723
    ISBN 978-0-323-71157-9 ; 0-323-71157-X
    Database Catalogue ZB MED Medicine, Health

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    Zs A 1695 -39,4- not available for loan Zeitschriften-Lesesaal

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  2. Article ; Online: Update on Clinical Immunology Laboratory Testing.

    Mahajan, Vinay S

    Clinics in laboratory medicine

    2019  Volume 39, Issue 4, Page(s) xi–xii

    MeSH term(s) Flow Cytometry ; Genetic Techniques ; Humans ; Immune System Diseases/diagnosis ; Immunologic Tests
    Language English
    Publishing date 2019-10-03
    Publishing country United States
    Document type Editorial ; Introductory Journal Article
    ZDB-ID 604580-7
    ISSN 1557-9832 ; 0272-2712
    ISSN (online) 1557-9832
    ISSN 0272-2712
    DOI 10.1016/j.cll.2019.09.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Alternative Methods to Detect Severe Acute Respiratory Syndrome Coronavirus 2 Antibodies.

    Patel, Rashmi / Khare, Siddharth / Mahajan, Vinay S

    Clinics in laboratory medicine

    2021  Volume 42, Issue 1, Page(s) 57–73

    Abstract: The COVID-19 pandemic has resulted in the development, validation, and rapid adoption of multiple novel diagnostic approaches. Hundreds of SARS-CoV-2 serologic assays have been developed and deployed to contain the spread of the virus, and to supply ... ...

    Abstract The COVID-19 pandemic has resulted in the development, validation, and rapid adoption of multiple novel diagnostic approaches. Hundreds of SARS-CoV-2 serologic assays have been developed and deployed to contain the spread of the virus, and to supply timely and important health information. Most of these serologic assays were based on a conventional enzyme-linked immunosorbent assay or the lateral flow assay format. The immunoassays that were developed were based on alternative technologies and are highlighted in this article with a brief discussion of the assay principle and the pros and cons for each assay. Measurement of neutralizing antibodies is also discussed.
    MeSH term(s) Antibodies, Neutralizing ; Antibodies, Viral ; COVID-19 ; Enzyme-Linked Immunosorbent Assay ; Humans ; Pandemics ; SARS-CoV-2 ; Sensitivity and Specificity
    Chemical Substances Antibodies, Neutralizing ; Antibodies, Viral
    Language English
    Publishing date 2021-11-03
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 604580-7
    ISSN 1557-9832 ; 0272-2712
    ISSN (online) 1557-9832
    ISSN 0272-2712
    DOI 10.1016/j.cll.2021.10.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Molecular Diagnosis of Inherited Immune Disorders.

    Farmer, Jocelyn R / Mahajan, Vinay S

    Clinics in laboratory medicine

    2019  Volume 39, Issue 4, Page(s) 685–697

    Abstract: Primary immunodeficiency diseases are a heterogeneous group of rare inherited disorders of innate or adaptive immune system function. Patients with primary immunodeficiencies typically present with recurrent and severe infections in infancy or young ... ...

    Abstract Primary immunodeficiency diseases are a heterogeneous group of rare inherited disorders of innate or adaptive immune system function. Patients with primary immunodeficiencies typically present with recurrent and severe infections in infancy or young adulthood. More recently, the co-occurrence of autoimmune, benign lymphoproliferative, atopic, and malignant complications has been described. The diagnosis of a primary immunodeficiency disorder requires a thorough assessment of a patient's underlying immune system function. Historically, this has been accomplished at the time of symptomatic presentation by measuring immunoglobulins, complement components, protective antibody titers, or immune cell counts in the peripheral blood. Although these data can be used to critically assess the degree of immune dysregulation in the patient, this approach fall short in at least 2 regards. First, this assessment often occurs after the patient has suffered life-threatening infectious or autoinflammatory complications. Second, these data fail to uncover an underlying molecular cause of the patient's primary immune dysfunction, prohibiting the use of molecularly targeted therapeutic interventions. Within the last decade, the field of primary immunodeficiency diagnostics has been revolutionized by 2 major molecular advancements: (1) the onset of newborn screening in 2008, and (2) the onset of next-generation sequencing in 2010. In this article, the techniques of newborn screening and next-generation sequencing are reviewed and their respective impacts on the field of primary immunodeficiency disorders are discussed with a specific emphasis on severe combined immune deficiency and common variable immune deficiency.
    MeSH term(s) High-Throughput Nucleotide Sequencing ; Humans ; Molecular Diagnostic Techniques ; Primary Immunodeficiency Diseases/diagnosis ; Primary Immunodeficiency Diseases/genetics ; Whole Exome Sequencing
    Language English
    Publishing date 2019-09-26
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 604580-7
    ISSN 1557-9832 ; 0272-2712
    ISSN (online) 1557-9832
    ISSN 0272-2712
    DOI 10.1016/j.cll.2019.07.013
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Permanent, Antimicrobial Coating to Rapidly Kill and Prevent Transmission of Bacteria, Fungi, Influenza, and SARS-CoV-2.

    Ghosh, Sreyan / Mukherjee, Riya / Mahajan, Vinay S / Boucau, Julie / Pillai, Shiv / Haldar, Jayanta

    ACS applied materials & interfaces

    2022  Volume 14, Issue 37, Page(s) 42483–42493

    Abstract: Microbial adhesion and contamination on shared surfaces can lead to life-threatening infections with serious impacts on public health, economy, and clinical practices. The traditional use of chemical disinfectants for sanitization of surfaces, however, ... ...

    Abstract Microbial adhesion and contamination on shared surfaces can lead to life-threatening infections with serious impacts on public health, economy, and clinical practices. The traditional use of chemical disinfectants for sanitization of surfaces, however, comes with its share of health risks, such as hazardous effects on the eyes, skin, and respiratory tract, carcinogenicity, as well as environmental toxicity. To address this, we have developed a nonleaching quaternary small molecule (QSM)-based sprayable coating which can be fabricated on a wide range of surfaces such as nylon, polyethylene, surgical mask, paper, acrylate, and rubber in a one-step, photocuring technique. This contact-active coating killed pathogenic bacteria and fungi including drug-resistant strains of
    MeSH term(s) Acrylates/pharmacology ; Anti-Bacterial Agents/chemistry ; Anti-Infective Agents/pharmacology ; Bacteria ; COVID-19/prevention & control ; Disinfectants/pharmacology ; Fungi ; Humans ; Influenza A Virus, H1N1 Subtype ; Influenza, Human ; Nylons/pharmacology ; Polyethylenes/pharmacology ; Rubber ; SARS-CoV-2
    Chemical Substances Acrylates ; Anti-Bacterial Agents ; Anti-Infective Agents ; Disinfectants ; Nylons ; Polyethylenes ; Rubber (9006-04-6)
    Language English
    Publishing date 2022-09-08
    Publishing country United States
    Document type Journal Article
    ISSN 1944-8252
    ISSN (online) 1944-8252
    DOI 10.1021/acsami.2c11915
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Studies on intra-ocular vaccination of adult cattle with reduced dose

    Saidu, A S / Singh, Mahavir / Kumar, Aman / Mahajan, N K / Mittal, Dinesh / Chhabra, Rajesh / Joshi, Vinay G / Musallam, Imadidden I / Sadiq, Usman

    Heliyon

    2022  Volume 8, Issue 2, Page(s) e08937

    Abstract: ... Brucella ... ...

    Abstract Brucella abortus
    Language English
    Publishing date 2022-02-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2022.e08937
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Predictive association of gut microbiome and NLR in anemic low middle-income population of Odisha- a cross-sectional study.

    Venugopal, Giriprasad / Khan, Zaiba Hasan / Dash, Rishikesh / Tulsian, Vinay / Agrawal, Siwani / Rout, Sudeshna / Mahajan, Preetam / Ramadass, Balamurugan

    Frontiers in nutrition

    2023  Volume 10, Page(s) 1200688

    Abstract: ... and 43 non-anemic participants using 16 s rRNA sequencing, followed by the Bioinformatics analysis ...

    Abstract Background: Iron is abundant on earth but not readily available for colonizing bacteria due to its low solubility in the human body. Hosts and microbiota compete fiercely for iron. <15% Supplemented Iron is absorbed in the small bowel, and the remaining iron is a source of dysbiosis. The gut microbiome signatures to the level of predicting anemia among low-middle-income populations are unknown. The present study was conducted to identify gut microbiome signatures that have predictive potential in association with Neutrophil to lymphocytes ratio (NLR) and Mean corpuscular volume (MCV) in anemia.
    Methods: One hundred and four participants between 10 and 70 years were recruited from Odisha's Low Middle-Income (LMI) rural population. Hematological parameters such as Hemoglobin (HGB), NLR, and MCV were measured, and NLR was categorized using percentiles. The microbiome signatures were analyzed from 61 anemic and 43 non-anemic participants using 16 s rRNA sequencing, followed by the Bioinformatics analysis performed to identify the diversity, correlations, and indicator species. The Multi-Layered Perceptron Neural Network (MLPNN) model were applied to predict anemia.
    Results: Significant microbiome diversity among anemic participants was observed between the lower, middle, and upper Quartile NLR groups. For anemic participants with NLR in the lower quartile, alpha indices indicated bacterial overgrowth, and consistently, we identified
    Conclusion: These findings strongly associate anemic hematological parameters and microbiome. Such predictive association between the gut microbiome and NLR could be further evaluated and utilized to design precision nutrition models and to predict Iron supplementation and dietary intervention responses in both community and clinical settings.
    Language English
    Publishing date 2023-07-13
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2776676-7
    ISSN 2296-861X
    ISSN 2296-861X
    DOI 10.3389/fnut.2023.1200688
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Disseminated filiform hyperkeratosis - a variant of porokeratosis?

    Kaushik, A / Handa, S / Chatterjee, D / Vinay, K / Mahajan, R

    Journal of the European Academy of Dermatology and Venereology : JEADV

    2018  Volume 32, Issue 11, Page(s) e419–e421

    MeSH term(s) Chronic Disease ; Facial Dermatoses/diagnostic imaging ; Facial Dermatoses/pathology ; Humans ; Male ; Porokeratosis/diagnostic imaging ; Porokeratosis/pathology ; Torso ; Young Adult
    Language English
    Publishing date 2018-05-24
    Publishing country England
    Document type Case Reports ; Letter
    ZDB-ID 1128828-0
    ISSN 1468-3083 ; 0926-9959
    ISSN (online) 1468-3083
    ISSN 0926-9959
    DOI 10.1111/jdv.15008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: The Future of Clinical Immunology Laboratory Testing.

    Allard-Chamard, Hugues / Mahajan, Vinay S

    Clinics in laboratory medicine

    2019  Volume 39, Issue 4, Page(s) 699–708

    Abstract: For decades, autoantibody detection has comprised the bulk of clinical laboratory immunology. However, most immune disorders are caused by imbalances in both humoral and cellular immunity. Our knowledge of the immune system has grown exponentially, ... ...

    Abstract For decades, autoantibody detection has comprised the bulk of clinical laboratory immunology. However, most immune disorders are caused by imbalances in both humoral and cellular immunity. Our knowledge of the immune system has grown exponentially, resulting in new treatment paradigms in immunology. Extensive functional characterization of lymphocyte subsets is routinely carried out in a research laboratories, facilitated by the emergence of high-dimensional analysis technologies for low cell numbers. It will not be long before these approaches enter the diagnostic realm. This chapter outlines emerging trends in laboratory immunology testing with a focus on deep immune profiling or high-dimensional testing modalities.
    MeSH term(s) Gene Expression Profiling ; High-Throughput Nucleotide Sequencing ; Humans ; Immunologic Tests/methods ; Immunologic Tests/trends ; Immunophenotyping ; Point-of-Care Systems ; Transcriptome/immunology
    Language English
    Publishing date 2019-10-03
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 604580-7
    ISSN 1557-9832 ; 0272-2712
    ISSN (online) 1557-9832
    ISSN 0272-2712
    DOI 10.1016/j.cll.2019.07.014
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  10. Article: Permanent, Antimicrobial Coating to Rapidly Kill and Prevent Transmission of Bacteria, Fungi, Influenza, and SARS-CoV-2

    Ghosh, Sreyan / Mukherjee, Riya / Mahajan, Vinay S. / Boucau, Julie / Pillai, Shiv / Haldar, Jayanta

    ACS applied materials & interfaces. 2022 Sept. 08, v. 14, no. 37

    2022  

    Abstract: Microbial adhesion and contamination on shared surfaces can lead to life-threatening infections with serious impacts on public health, economy, and clinical practices. The traditional use of chemical disinfectants for sanitization of surfaces, however, ... ...

    Abstract Microbial adhesion and contamination on shared surfaces can lead to life-threatening infections with serious impacts on public health, economy, and clinical practices. The traditional use of chemical disinfectants for sanitization of surfaces, however, comes with its share of health risks, such as hazardous effects on the eyes, skin, and respiratory tract, carcinogenicity, as well as environmental toxicity. To address this, we have developed a nonleaching quaternary small molecule (QSM)-based sprayable coating which can be fabricated on a wide range of surfaces such as nylon, polyethylene, surgical mask, paper, acrylate, and rubber in a one-step, photocuring technique. This contact-active coating killed pathogenic bacteria and fungi including drug-resistant strains of Staphylococcus aureus and Candida albicans within 15–30 min of contact. QSM coatings withstood multiple washes, highlighting their durability. Interestingly, the coated surfaces exhibited rapid killing of pathogens, leading to the prevention of their transmission upon contact. The coating showed membrane disruption of bacterial cells in fluorescence and electron microscopic investigations. Along with bacteria and fungi, QSM-coated surfaces also showed the complete killing of high loads of influenza (H1N1) and SARS-CoV-2 viruses within 30 min of exposure. To our knowledge, this is the first report of a coating for multipurpose materials applied in high-touch public places, hospital equipment, and clinical consumables, rapidly killing drug-resistant bacteria, fungi, influenza virus, and SARS-CoV-2.
    Keywords Candida albicans ; Orthomyxoviridae ; Severe acute respiratory syndrome coronavirus 2 ; Staphylococcus aureus ; carcinogenicity ; drug resistance ; durability ; ecotoxicology ; electron microscopy ; equipment ; fluorescence ; hospitals ; influenza ; microbial adhesion ; nylon ; paper ; polyethylene ; public health ; respiratory system ; rubber
    Language English
    Dates of publication 2022-0908
    Size p. 42483-42493.
    Publishing place American Chemical Society
    Document type Article
    ISSN 1944-8252
    DOI 10.1021/acsami.2c11915
    Database NAL-Catalogue (AGRICOLA)

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