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  1. Article ; Online: Pillars Article: T-Cell Apoptosis Detected In Situ during Positive and Negative Selection in the Thymus.

    Surh, Charles D / Sprent, Jonathan

    Journal of immunology (Baltimore, Md. : 1950)

    2018  Volume 201, Issue 1, Page(s) 7–10

    MeSH term(s) Animals ; Apoptosis/immunology ; History, 20th Century ; In Situ Nick-End Labeling/history ; Major Histocompatibility Complex/immunology ; Mice ; Mice, Inbred C57BL ; T-Lymphocytes/cytology ; Thymus Gland/cytology
    Language English
    Publishing date 2018-06-18
    Publishing country United States
    Document type Classical Article ; Historical Article ; Journal Article
    ZDB-ID 3056-9
    ISSN 1550-6606 ; 0022-1767 ; 1048-3233 ; 1047-7381
    ISSN (online) 1550-6606
    ISSN 0022-1767 ; 1048-3233 ; 1047-7381
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ud II Zs.37: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 28: Show issues

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  2. Article ; Online: Writer's block: preventing m

    Sprent, Jonathan / Surh, Charles D

    Immunology and cell biology

    2017  Volume 95, Issue 10, Page(s) 855–856

    MeSH term(s) Methylation ; RNA, Messenger ; T-Lymphocytes
    Chemical Substances RNA, Messenger
    Language English
    Publishing date 2017-09-18
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 284057-1
    ISSN 1440-1711 ; 0818-9641
    ISSN (online) 1440-1711
    ISSN 0818-9641
    DOI 10.1038/icb.2017.67
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  3. Article ; Online: Microbial Colonization at Early Life Promotes the Development of Diet-Induced CD8αβ Intraepithelial T Cells.

    Jung, Jisun / Surh, Charles D / Lee, You Jeong

    Molecules and cells

    2019  Volume 42, Issue 4, Page(s) 313–320

    Abstract: Intraepithelial lymphocytes (IELs) develop through the continuous interaction with intestinal antigens such as commensal microbiome and diet. However, their respective roles and mutual interactions in the development of IELs are largely unknown. Here, we ...

    Abstract Intraepithelial lymphocytes (IELs) develop through the continuous interaction with intestinal antigens such as commensal microbiome and diet. However, their respective roles and mutual interactions in the development of IELs are largely unknown. Here, we showed that dietary antigens regulate the development of the majority of CD8αβ IELs in the small intestine and the absence of commensal microbiota particularly during the weaning period, delay the development of IELs. When we tested specific dietary components, such as wheat or combined corn, soybean and yeast, they were dependent on commensal bacteria for the timely development of diet-induced CD8αβ IELs. In addition, supplementation of intestinal antigens later in life was inefficient for the full induction of CD8αβ IELs. Overall, our findings suggest that early exposure to commensal bacteria is important for the proper development of dietary antigen-dependent immune repertoire in the gut.
    MeSH term(s) Animals ; Animals, Newborn ; CD8 Antigens/metabolism ; Cell Differentiation ; Diet ; Gastrointestinal Microbiome ; Intestine, Small/immunology ; Intestine, Small/microbiology ; Intraepithelial Lymphocytes/immunology ; Intraepithelial Lymphocytes/metabolism ; Mice ; Mice, Inbred C57BL ; Microbiota/immunology ; Glycine max/immunology ; Triticum/immunology ; Weaning ; Yeasts/immunology ; Zea mays/immunology
    Chemical Substances CD8 Antigens ; CD8alphabeta antigen
    Language English
    Publishing date 2019-02-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1148964-9
    ISSN 0219-1032 ; 1016-8478
    ISSN (online) 0219-1032
    ISSN 1016-8478
    DOI 10.14348/molcells.2019.2431
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4713: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article: Induction of Immune Tolerance to Dietary Antigens.

    Kim, Kwang Soon / Surh, Charles D

    Advances in experimental medicine and biology

    2015  Volume 850, Page(s) 93–118

    Abstract: The intestinal immune system is continuously exposed to massive amounts of diverse antigens derived from both food and intestinal microbes. Immunological tolerance to these enteric antigens is critical for ensuring intestinal and systemic immune ... ...

    Abstract The intestinal immune system is continuously exposed to massive amounts of diverse antigens derived from both food and intestinal microbes. Immunological tolerance to these enteric antigens is critical for ensuring intestinal and systemic immune homeostasis. Oral tolerance is a specific type of peripheral tolerance induced by the exposure of antigen via the oral route, emphasizing the role of intestinal immune system for preventing unnecessary hypersensitivity reactions to innocuous dietary and microbial antigens. Here, we discuss how dietary antigens are recognized by intestinal immune systems and highlight the role of Foxp3(+) regulatory CD4(+) T cells (Tregs) in establishment of oral tolerance, the tolerogenic features of intestinal dendritic cells that induce development of Foxp3(+) Tregs, and the factors that promote development of the intestinal dendritic cells.
    MeSH term(s) Animals ; Antigens, CD/genetics ; Antigens, CD/immunology ; Cell Movement ; Dendritic Cells/cytology ; Dendritic Cells/immunology ; Diet ; Dietary Proteins/immunology ; Forkhead Transcription Factors/genetics ; Forkhead Transcription Factors/immunology ; Gene Expression ; Humans ; Immunity, Innate ; Integrin alpha Chains/genetics ; Integrin alpha Chains/immunology ; Intestines/cytology ; Intestines/immunology ; Lymph Nodes/cytology ; Lymph Nodes/immunology ; Mice ; Peripheral Tolerance ; T-Lymphocytes, Regulatory/cytology ; T-Lymphocytes, Regulatory/immunology
    Chemical Substances Antigens, CD ; Dietary Proteins ; FOXP3 protein, human ; Forkhead Transcription Factors ; Integrin alpha Chains ; alpha E integrins
    Language English
    Publishing date 2015
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ISSN 2214-8019 ; 0065-2598
    ISSN (online) 2214-8019
    ISSN 0065-2598
    DOI 10.1007/978-3-319-15774-0_8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Beyond Hygiene: Commensal Microbiota and Allergic Diseases.

    Hong, Sung-Wook / Kim, Kwang Soon / Surh, Charles D

    Immune network

    2017  Volume 17, Issue 1, Page(s) 48–59

    Abstract: Complex communities of microorganisms, termed commensal microbiota, inhabit mucosal surfaces and profoundly influence host physiology as well as occurrence of allergic diseases. Perturbing factors such as the mode of delivery, dietary fibers and ... ...

    Abstract Complex communities of microorganisms, termed commensal microbiota, inhabit mucosal surfaces and profoundly influence host physiology as well as occurrence of allergic diseases. Perturbing factors such as the mode of delivery, dietary fibers and antibiotics can influence allergic diseases by altering commensal microbiota in affected tissues as well as in intestine. Here, we review current findings on the relationship between commensal microbiota and allergic diseases, and discuss the underlying mechanisms that contribute to the regulation of allergic responses by commensal microbiota.
    Language English
    Publishing date 2017-02-23
    Publishing country Korea (South)
    Document type Journal Article ; Review
    ZDB-ID 2536191-0
    ISSN 2092-6685 ; 1598-2629
    ISSN (online) 2092-6685
    ISSN 1598-2629
    DOI 10.4110/in.2017.17.1.48
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Self-gratification yields not-so-naive T cells.

    Martin, Christopher E / Surh, Charles D

    Nature immunology

    2014  Volume 15, Issue 3, Page(s) 217–219

    MeSH term(s) Animals ; Autoantigens/immunology ; CD4-Positive T-Lymphocytes/immunology ; Humans ; Lymphocyte Activation/immunology ; Major Histocompatibility Complex/immunology ; Receptors, Antigen, T-Cell/immunology
    Chemical Substances Autoantigens ; Receptors, Antigen, T-Cell
    Language English
    Publishing date 2014-02-19
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2016987-5
    ISSN 1529-2916 ; 1529-2908
    ISSN (online) 1529-2916
    ISSN 1529-2908
    DOI 10.1038/ni.2832
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5294: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 42: Show issues

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  7. Article ; Online: Listeria monocytogenes

    Cho, Kyungjin / Spasova, Darina / Hong, Sung-Wook / O, Eunju / Surh, Charles D / Im, Sin-Hyeog / Kim, Kwang Soon

    Frontiers in immunology

    2021  Volume 12, Page(s) 666088

    Abstract: The intestine harbors a complex community of bacterial species collectively known as commensal microbiota. Specific species of resident bacteria, as known as pathobiont, have pathogenic potential and can induce apparent damage to the host and intestinal ... ...

    Abstract The intestine harbors a complex community of bacterial species collectively known as commensal microbiota. Specific species of resident bacteria, as known as pathobiont, have pathogenic potential and can induce apparent damage to the host and intestinal inflammation in a certain condition. However, the host immune factors that permit its commensalism under steady state conditions are not clearly understood. Here, we studied the gut fitness of
    MeSH term(s) Animals ; CD8-Positive T-Lymphocytes/immunology ; Gastrointestinal Tract/immunology ; Gastrointestinal Tract/microbiology ; Gene Expression Regulation, Bacterial ; Germ-Free Life/immunology ; Host Microbial Interactions ; Intestinal Mucosa/immunology ; Intestinal Mucosa/microbiology ; Listeria monocytogenes/genetics ; Listeria monocytogenes/pathogenicity ; Listeria monocytogenes/physiology ; Mice ; Pore Forming Cytotoxic Proteins/metabolism ; Symbiosis ; Virulence/genetics
    Chemical Substances Pore Forming Cytotoxic Proteins
    Language English
    Publishing date 2021-05-03
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2021.666088
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Blowing on embers: commensal microbiota and our immune system.

    Spasova, Darina S / Surh, Charles D

    Frontiers in immunology

    2014  Volume 5, Page(s) 318

    Abstract: Vertebrates have co-evolved with microorganisms resulting in a symbiotic relationship, which plays an important role in health and disease. Skin and mucosal surfaces are colonized with a diverse population of commensal microbiota, over 1000 species, ... ...

    Abstract Vertebrates have co-evolved with microorganisms resulting in a symbiotic relationship, which plays an important role in health and disease. Skin and mucosal surfaces are colonized with a diverse population of commensal microbiota, over 1000 species, outnumbering the host cells by 10-fold. In the past 40 years, studies have built on the idea that commensal microbiota is in constant contact with the host immune system and thus influence immune function. Recent studies, focusing on mutualism in the gut, have shown that commensal microbiota seems to play a critical role in the development and homeostasis of the host immune system. In particular, the gut microbiota appears to direct the organization and maturation of lymphoid tissues and acts both locally and systemically to regulate the recruitment, differentiation, and function of innate and adaptive immune cells. While the pace of research in the area of the mucosal-immune interface has certainly intensified over the last 10 years, we are still in the early days of this field. Illuminating the mechanisms of how gut microbes shape host immunity will enhance our understanding of the causes of immune-mediated pathologies and improve the design of next-generation vaccines. This review discusses the recent advances in this field, focusing on the close relationship between the adaptive immune system and commensal microbiota, a constant and abundant source of foreign antigens.
    Language English
    Publishing date 2014-07-28
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2606827-8
    ISSN 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2014.00318
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Interleukin 7, maestro of the immune system.

    Sprent, Jonathan / Surh, Charles D

    Seminars in immunology

    2012  Volume 24, Issue 3, Page(s) 149–150

    MeSH term(s) Animals ; Humans ; Immune System ; Interleukin-7/immunology ; Periodicals as Topic
    Chemical Substances Interleukin-7
    Language English
    Publishing date 2012-06
    Publishing country England
    Document type Editorial ; Introductory Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1018141-6
    ISSN 1096-3618 ; 1044-5323
    ISSN (online) 1096-3618
    ISSN 1044-5323
    DOI 10.1016/j.smim.2012.04.011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2843: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  10. Article ; Online: Epithelial HVEM maintains intraepithelial T cell survival and contributes to host protection.

    Seo, Goo-Young / Takahashi, Daisuke / Wang, Qingyang / Mikulski, Zbigniew / Chen, Angeline / Chou, Ting-Fang / Marcovecchio, Paola / McArdle, Sara / Sethi, Ashu / Shui, Jr-Wen / Takahashi, Masumi / Surh, Charles D / Cheroutre, Hilde / Kronenberg, Mitchell

    Science immunology

    2022  Volume 7, Issue 73, Page(s) eabm6931

    Abstract: Intraepithelial T cells (IETs) are in close contact with intestinal epithelial cells and the underlying basement membrane, and they detect invasive pathogens. How intestinal epithelial cells and basement membrane influence IET survival and function, at ... ...

    Abstract Intraepithelial T cells (IETs) are in close contact with intestinal epithelial cells and the underlying basement membrane, and they detect invasive pathogens. How intestinal epithelial cells and basement membrane influence IET survival and function, at steady state or after infection, is unclear. The herpes virus entry mediator (HVEM), a member of the TNF receptor superfamily, is constitutively expressed by intestinal epithelial cells and is important for protection from pathogenic bacteria. Here, we showed that at steady-state LIGHT, an HVEM ligand, binding to epithelial HVEM promoted the survival of small intestine IETs. RNA-seq and addition of HVEM ligands to epithelial organoids indicated that HVEM increased epithelial synthesis of basement membrane proteins, including collagen IV, which bound to β
    MeSH term(s) Animals ; Collagen ; Epithelial Cells/metabolism ; Integrins/metabolism ; Intraepithelial Lymphocytes ; Ligands ; Mice
    Chemical Substances Integrins ; Ligands ; Collagen (9007-34-5)
    Language English
    Publishing date 2022-07-29
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ISSN 2470-9468
    ISSN (online) 2470-9468
    DOI 10.1126/sciimmunol.abm6931
    Database MEDical Literature Analysis and Retrieval System OnLINE

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