LIVIVO - Search results -

Search results

Result 1 - 10 of total 10

Search options

Article ; Online: Breaking down barriers to identify hemorrhagic transformation in ischemic stroke.

Jickling, Glen C / Manolescu, Bogdan N

2012 Volume 79, Issue 16, Page(s) 1632–1633

MeSH term(s)	Biomarkers/analysis ; Blood Proteins/analysis ; Blood-Brain Barrier/pathology ; Brain Ischemia/blood ; Brain Ischemia/complications ; Cerebral Hemorrhage/blood ; Cerebral Hemorrhage/etiology ; Claudin-5/blood ; Disease Progression ; Humans ; Matrix Metalloproteinase 9/blood ; Occludin/blood ; Stroke/blood ; Stroke/complications ; Tight Junctions/metabolism
Chemical Substances	Biomarkers ; Blood Proteins ; Claudin-5 ; Occludin ; Matrix Metalloproteinase 9 (EC 3.4.24.35)
Language	English
Publishing date	2012-10-16
Publishing country	United States
Document type	Editorial ; Research Support, Non-U.S. Gov't
ZDB-ID	207147-2
ISSN	1526-632X ; 0028-3878
ISSN (online)	1526-632X
ISSN	0028-3878
DOI	10.1212/WNL.0b013e31826e9b9d
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Ui II Zs.153: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MG 18: Show issues
Zs.MO 374: Show issues

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾
- See ZB MED holdings
- Order with fees

Article: Effect of the nutritional supplement ALAnerv® on the serum PON1 activity in post-acute stroke patients.

Manolescu, Bogdan N / Berteanu, Mihai / Cintezã, Delia

Pharmacological reports : PR

2013 Volume 65, Issue 3, Page(s) 743–750

Abstract: Background: Paraoxonase-1 (PON1) is one of the HDL-associated proteins which contributes to the antioxidant properties of these lipoproteins. The aim of this pilot study was to evaluate the effect of the nutritional supplement ALAnerv® on serum PON1 ... ...

Abstract	Background: Paraoxonase-1 (PON1) is one of the HDL-associated proteins which contributes to the antioxidant properties of these lipoproteins. The aim of this pilot study was to evaluate the effect of the nutritional supplement ALAnerv® on serum PON1 activity in post-acute stroke patients undergoing rehabilitation. Methods: We enrolled 28 post-acute stroke patients and randomly divided them into (-) ALA or (+) ALA study groups. All the patients underwent the same rehabilitation program and received comparable standard medications. Moreover, (+) ALA patients received ALAnerv® for two weeks (2 pills/day). The serum PON1 activity was assessed on blood samples taken at the admission and at the discharge moments, respectively. We used paraoxon (paraoxonase activity, PONA), phenyl acetate (arylesterase activity, ARYLA) and dihydrocoumarin (lactonase activity, LACTA) as substrates, the latter activity being regarded as physiologically relevant. A control group of 14 apparently healthy subjects was also created. Results: In the (+) ALA group, LACTA significantly increased during the study period (17.6 ± 3.2 vs. 27.6 ± 3.5, p = 0.002). Moreover, the percentage of LACTA variation between (-) ALA and (+) ALA groups during the study was also statistically different (-11.7 ± 6.9% vs. +95.1 ± 29.7%, p < 0.0001). Conclusions: These preliminary results suggest that ALA nerv® could contribute to the improvement of the physiologically relevant LACTA of PON1 in post-acute stroke patients, enabling this enzyme to contribute to the redox correction. Also, this study raises the question about the effect of a longer treatment period over the other enzymatic activities of serum PON1.
MeSH term(s)	Aged ; Aryldialkylphosphatase/blood ; Dietary Supplements ; Female ; Humans ; Male ; Middle Aged ; Oxidation-Reduction/drug effects ; Pilot Projects ; Stroke/blood ; Stroke/metabolism ; Stroke Rehabilitation ; Thioctic Acid/pharmacology
Chemical Substances	Thioctic Acid (73Y7P0K73Y) ; Aryldialkylphosphatase (EC 3.1.8.1) ; PON1 protein, human (EC 3.1.8.1)
Language	English
Publishing date	2013-08-13
Publishing country	Switzerland
Document type	Journal Article ; Randomized Controlled Trial
ZDB-ID	2186248-5
ISSN	1734-1140
ISSN	1734-1140
DOI	10.1016/s1734-1140(13)71054-5
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 861: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article: Paraoxonases as protective agents against N-acyl homoserine lactone - producing pathogenic microorganisms.

Manolescu, Bogdan Nicolae

Maedica

2013 Volume 8, Issue 1, Page(s) 49–52

Abstract: ... the physiological substrate(s) of these enzymes. Recent data suggest that the N-acyl homoserine lactones (AHLs ...

Abstract	Abstract: Paraoxonases are a group of enzymes with a high "substrate-promiscuity", being able to act on many structurally different compounds. To date, there is no consensus regarding the physiological substrate(s) of these enzymes. Recent data suggest that the N-acyl homoserine lactones (AHLs) produced by different Gram-negative bacteria, including the opportunistic Pseudomonas aeruginosa, could be such substrates. Due to the ability of paraoxonases to hydrolyze AHLs, they represent an alternative mechanism of protection against pathogen microorganisms, interfering with the quorum sensing systems that allow these bacteria to respond in a coordinate manner to different changes in the extracellular environment. This mini-review presents some novel aspects regarding the relationship between paraoxonases and the aforementioned compounds, highlighting the potential role of these enzymes as a component of the humoral innate defence system.
Language	English
Publishing date	2013-04-03
Publishing country	Romania
Document type	Journal Article ; Review
ZDB-ID	2399972-X
ISSN	2069-6116 ; 1841-9038
ISSN (online)	2069-6116
ISSN	1841-9038
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: Testing five social-cognitive models to explain predictors of personal oral health behaviours and intention to improve them.

Dumitrescu, Alexandrina L / Dogaru, Beatrice C / Duta, Carmen / Manolescu, Bogdan N

Oral health & preventive dentistry

2014 Volume 12, Issue 4, Page(s) 345–355

Abstract: Purpose: To test the ability of several social-cognitive models to explain current behaviour and to predict intentions to engage in three different health behaviours (toothbrushing, flossing and mouthrinsing).: Materials and methods: Constructs from ... ...

Abstract	Purpose: To test the ability of several social-cognitive models to explain current behaviour and to predict intentions to engage in three different health behaviours (toothbrushing, flossing and mouthrinsing). Materials and methods: Constructs from the health belief model (HBM), theory of reasoned action (TRA), theory of planned behaviour (TPB) and the motivational process of the health action process approach (HAPA) were measured simultaneously in an undergraduate student sample of 172 first-year medical students. Results: Regarding toothbrushing, the TRA, TPB, HBM (without the inclusion of self-efficacy SE), HBM+SE and HAPA predictor models explained 7.4%, 22.7%, 10%, 10.2% and 10.1%, respectively, of the variance in behaviour and 7.5%, 25.6%, 12.1%, 17.5% and 17.2%, respectively, in intention. Regarding dental flossing, the TRA, TPB, HBM, HBM+SE and HAPA predictor models explained 39%, 50.6, 24.1%, 25.4% and 27.7%, respectively, of the variance in behaviour and 39.4%, 52.7%, 33.7%, 35.9% and 43.2%, respectively, in intention. Regarding mouthrinsing, the TRA, TPB, HBM, HBM+SE and HAPA predictor models explained 43.9%, 45.1%, 20%, 29% and 36%, respectively, of the variance in behaviour and 58%, 59.3%, 49.2%, 59.8% and 66.2%, respectively, in intention. The individual significant predictors for current behaviour were attitudes, barriers and outcome expectancy. Conclusion: Our findings revealed that the theory of planned behaviours and the health action process approach were the best predictor of intentions to engage in both behaviours.
MeSH term(s)	Attitude to Health ; Cognition ; Cross-Sectional Studies ; Dental Caries/prevention & control ; Dental Devices, Home Care ; Female ; Health Behavior ; Humans ; Intention ; Internal-External Control ; Male ; Models, Psychological ; Motivation ; Mouthwashes/therapeutic use ; Oral Health ; Psychometrics ; Reproducibility of Results ; Self Concept ; Self Efficacy ; Toothbrushing ; Young Adult
Chemical Substances	Mouthwashes
Language	English
Publishing date	2014-03-10
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2136786-3
ISSN	1757-9996 ; 1602-1622
ISSN (online)	1757-9996
ISSN	1602-1622
DOI	10.3290/j.ohpd.a31662
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 6526: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Homocysteine and vitamin therapy in stroke prevention and treatment: a review.

Manolescu, Bogdan N / Oprea, Eliza / Farcasanu, Ileana C / Berteanu, Mihai / Cercasov, Cornelia

Acta biochimica Polonica

2010 Volume 57, Issue 4, Page(s) 467–477

Abstract: Homocysteine (Hcy), a sulfur amino acid, is the only direct precursor for L-methionine synthesis through a reaction that requires vitamin B₁₂, representing a connection with "one-carbon" units metabolism. Hcy catabolism requires vitamin B₆ and as a ... ...

Abstract	Homocysteine (Hcy), a sulfur amino acid, is the only direct precursor for L-methionine synthesis through a reaction that requires vitamin B₁₂, representing a connection with "one-carbon" units metabolism. Hcy catabolism requires vitamin B₆ and as a consequence, alteration in folic acid and B vitamins status impairs Hcy biotransformation. Numerous studies have indicated that Hcy is an independent risk factor for cardio- and cerebrovascular diseases. In the last decade, several clinical trials have investigated the possible correlation between the use of folic acid and vitamins B₆ and B₁₂ for lowering Hcy plasma concentration and the reduced risk of stroke or its recurrence. This review is aimed to present some aspects of Hcy biochemistry, as well as the mechanisms through which it exerts the toxic effects on the vascular endothelium. We also discuss the results of some of the clinical trials developed to investigate the beneficial effects of vitamin therapy in the prevention and management of stroke.
MeSH term(s)	Homocysteine/blood ; Homocysteine/metabolism ; Humans ; Risk Factors ; Stroke/drug therapy ; Stroke/prevention & control ; Vitamin B Complex/therapeutic use ; Vitamins/therapeutic use
Chemical Substances	Vitamins ; Homocysteine (0LVT1QZ0BA) ; Vitamin B Complex (12001-76-2)
Language	English
Publishing date	2010
Publishing country	Poland
Document type	Journal Article ; Review
ZDB-ID	595762-x
ISSN	1734-154X ; 0001-527X
ISSN (online)	1734-154X
ISSN	0001-527X
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.B 232: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: A Retrospective Analysis Comparing VATS Cost Discrepancies and Outcomes in Primary Lung Cancer vs. Second Primary Lung Cancer Patients

Bogdan Cosmin Tanase / Alin Ionut Burlacu / Claudiu Eduard Nistor / Teodor Horvat / Cristian Oancea / Monica Marc / Emanuela Tudorache / Tudor Mateescu / Diana Manolescu

Healthcare, Vol 11, Iss 1745, p

2023 Volume 1745

Abstract: ... status that was matched by age and gender: the PLC group ( n = 62) and the SPLC group ( n = 62 ...

Abstract	This study aimed to compare the outcomes and cost differences between primary lung cancer (PLC) and second primary lung cancer (SPLC) patients who underwent video-assisted thoracoscopic surgery (VATS). This was a retrospective analysis of 124 patients with lung cancer stages I, II, and III who underwent VATS between January 2018 and January 2023. The patients were divided into two groups based on their cancer status that was matched by age and gender: the PLC group ( n = 62) and the SPLC group ( n = 62). The results showed that there was no significant difference in the clinical characteristics between the 2 groups, except for the Charlson Comorbidity Index (CCI), with a score above 3 in 62.9% of PLC patients and 80.6% among SPLC patients ( p = 0.028). Regarding the surgical outcomes, the operative time for the VATS intervention was significantly higher in the SPLC group, with a median of 300 min, compared with 260 min in the PLC group ( p = 0.001), varying by the cancer staging as well. The average duration of hospitalization was significantly longer before and after surgery among patients with SPLC (6.1 days after surgery), compared with 4.2 days after surgery in the PLC group (0.006). Regarding the cost analysis, the total hospitalization cost was significantly higher in the SPLC group (15,400 RON vs. 12,800 RON; p = 0.007). Lastly, there was a significant difference in the survival probability between the two patient groups (log-rank p -value = 0.038). The 2-year survival was 41.9% among PLC patients and only 24.2% among those with SPLC. At the 5-year follow-up, there were only 1.6% survivors in the SPLC group, compared with 11.3% in the PLC group ( p -value = 0.028). In conclusion, this study found that VATS is a safe and effective surgical approach for both PLC and SPLC patients. However, SPLC patients have a higher VATS operating time and require more healthcare resources than PLC patients, resulting in higher hospitalization costs. These findings suggest that careful pre-operative evaluation and ...
Keywords	lung cancer ; pulmonary disease ; video-assisted thoracoscopic surgery ; Medicine ; R
Subject code	610
Language	English
Publishing date	2023-06-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Dynamic of oxidative and nitrosative stress markers during the convalescent period of stroke patients undergoing rehabilitation.

Manolescu, Bogdan Nicolae / Berteanu, M / Oprea, E / Chiriac, N / Dumitru, L / Vladoiu, S / Popa, O / Ianas, O

Annals of clinical biochemistry

2011 Volume 48, Issue Pt 4, Page(s) 338–343

Abstract: Background: Stroke patients have a redox imbalance, a consequence of both the cerebrovascular event and the associated pathological conditions. Our study was aimed to investigate the dynamic of some oxidative and nitrosative markers during the ... ...

Abstract	Background: Stroke patients have a redox imbalance, a consequence of both the cerebrovascular event and the associated pathological conditions. Our study was aimed to investigate the dynamic of some oxidative and nitrosative markers during the convalescent phase of postacute stroke patients undergoing rehabilitation. Methods: We assessed thiol, advanced oxidation protein product, protein carbonyl, 3-nitro-l-tyrosine, ceruloplasmin and oxidized LDL concentrations, as well as gamma-glutamyltranspeptidase (GGT) activity in 20 patients at the beginning of the hospitalization and at the discharge moment, respectively, and 24 apparently healthy controls. Results: We found significantly increased values for GGT (P = 0.04), ceruloplasmin (P = 0.01) and protein carbonyl (P = 0.04) in stroke patients at the hospitalization moment when compared with healthy controls, while total thiols were significantly decreased (P = 0.002). Rehabilitation was associated with a significant decrease of protein carbonyl (P = 0.03) and oxidized LDL particle concentrations (P = 0.03), as well as GGT activity (P = 0.02). At the hospitalization moment, both GGT and ceruloplasmin were significantly negatively correlated with non-proteic thiols (r = -0.44, P = 0.049, and r = -0.53, P = 0.015, respectively) and significantly positively with protein carbonyls (r = +0.80, P < 0.001, and r = +0.69, P < 0.001, respectively) suggesting putative roles of GGT and ceruloplasmin in the redox imbalance. Conclusions: These results highlight the existence of a redox imbalance in postacute stroke patients, and the possible benefits of an antioxidant-based therapy for the recovery of these patients.
MeSH term(s)	Aged ; Biomarkers/blood ; Ceruloplasmin/analysis ; Convalescence ; Female ; Humans ; Male ; Middle Aged ; Nitrogen/metabolism ; Oxidation-Reduction ; Oxidative Stress ; Stroke/blood ; Stroke Rehabilitation ; Sulfhydryl Compounds/blood ; gamma-Glutamyltransferase/blood
Chemical Substances	Biomarkers ; Sulfhydryl Compounds ; Ceruloplasmin (EC 1.16.3.1) ; gamma-Glutamyltransferase (EC 2.3.2.2) ; gamma-glutamyltransferase, human (EC 2.3.2.2) ; Nitrogen (N762921K75)
Language	English
Publishing date	2011-07
Publishing country	England
Document type	Journal Article
ZDB-ID	390309-6
ISSN	1758-1001 ; 0004-5632
ISSN (online)	1758-1001
ISSN	0004-5632
DOI	10.1258/acb.2011.010243
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 889: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: All-trans retinoic acid stimulates gene expression of the cardioprotective natriuretic peptide system and prevents fibrosis and apoptosis in cardiomyocytes of obese ob/ob mice

Manolescu, Daniel-Constantin / Bogdan A. Danalache / Donghao Wang / Jean-Louis Chiasson / Jolanta Gutkowska / Marek Jankowski / Tom L. Broderick

Applied Physiology, Nutrition, and Metabolism. 2014 Apr. 30, v. 39, no. 10

2014

Abstract: ... insulin resistance. Female 9-week-old B6.V-Lep/J ob/ob mice (n = 16) were divided into 2 groups: 1 group (n = 8 ... body weightâÂ¹Â·dayâÂ¹) by stomach intubation for 16 days, and 1 group (n = 8) that received the vehicle ... alone. A group of nonobese littermate mice (n = 9) served as controls. Ob/ob mice exhibited obesity ...

Abstract	In hypertensive rodents, retinoic acid (RA) prevents adverse cardiac remodelling and improves myocardial infarction outcome, but its role in obesity-related changes of cardiac tissue are unclear. We hypothesized that all-trans RA (ATRA) treatment will improve the cardioprotective oxytocin-natriuretic peptides (OT-NP) system, preventing apoptosis and collagen accumulation in hearts of ob/ob mice, a mouse model of obesity and insulin resistance. Female 9-week-old B6.V-Lep/J ob/ob mice (n = 16) were divided into 2 groups: 1 group (n = 8) treated with 100 Î¼g of ATRA dissolved in 100 Î¼L of corn oil (vehicle) delivered daily (â¼2 Î¼gÂ·g body weightâÂ¹Â·dayâÂ¹) by stomach intubation for 16 days, and 1 group (n = 8) that received the vehicle alone. A group of nonobese littermate mice (n = 9) served as controls. Ob/ob mice exhibited obesity, hyperglycaemia, and downregulation of the cardiac OT-NP system, including the mRNA for the transcription factor GATA4, OT receptor and brain NP, and the protein expression for endothelial nitric oxide synthase. Hearts from ob/ob mice also demonstrated increased apoptosis and collagen accumulation. ATRA treatment induced weight loss and decreased adipocytes diameter in the visceral fat, thus reducing visceral obesity, which is associated with a high risk for cardiovascular disease. RA treatment was associated with a reduction in hyperglycemia and a normalization of the OT-NP systemâs expression in the hearts of ob/ob mice. Furthermore, ATRA treatment prevented apoptosis and collagen accumulation in hearts of ob/ob mice. The present study indicates that ATRA treatment was effective in restoring the cardioprotective OT-NP system and in preventing abnormal cardiac remodelling in the ob/ob mice.
Keywords	adipocytes ; animal models ; apoptosis ; brain ; cardiomyocytes ; collagen ; corn oil ; endothelial nitric oxide synthase ; females ; fibrosis ; GATA transcription factors ; gene expression ; gene expression regulation ; hyperglycemia ; insulin resistance ; messenger RNA ; mice ; myocardial infarction ; natriuretic peptides ; nutrition ; obesity ; protein synthesis ; retinoic acid ; risk ; stomach ; visceral fat ; weight loss
Language	English
Dates of publication	2014-0430
Size	p. 1127-1136.
Publishing place	NRC Research Press
Document type	Article
ZDB-ID	2236708-1
ISSN	1715-5320 ; 1715-5312
ISSN (online)	1715-5320
ISSN	1715-5312
DOI	10.1139/apnm-2014-0005
Database	NAL-Catalogue (AGRICOLA)

In stock of ZB MED Cologne/Königswinter

Zs.A 1717: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: All-trans retinoic acid stimulates gene expression of the cardioprotective natriuretic peptide system and prevents fibrosis and apoptosis in cardiomyocytes of obese ob/ob mice.

Manolescu, Daniel-Constantin / Jankowski, Marek / Danalache, Bogdan A / Wang, Donghao / Broderick, Tom L / Chiasson, Jean-Louis / Gutkowska, Jolanta

Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme

2014 Volume 39, Issue 10, Page(s) 1127–1136

Abstract: ... insulin resistance. Female 9-week-old B6.V-Lep/J ob/ob mice (n = 16) were divided into 2 groups: 1 group (n = 8 ... 1)·day(-1)) by stomach intubation for 16 days, and 1 group (n = 8) that received the vehicle alone ... A group of nonobese littermate mice (n = 9) served as controls. Ob/ob mice exhibited obesity ...

Abstract	In hypertensive rodents, retinoic acid (RA) prevents adverse cardiac remodelling and improves myocardial infarction outcome, but its role in obesity-related changes of cardiac tissue are unclear. We hypothesized that all-trans RA (ATRA) treatment will improve the cardioprotective oxytocin-natriuretic peptides (OT-NP) system, preventing apoptosis and collagen accumulation in hearts of ob/ob mice, a mouse model of obesity and insulin resistance. Female 9-week-old B6.V-Lep/J ob/ob mice (n = 16) were divided into 2 groups: 1 group (n = 8) treated with 100 μg of ATRA dissolved in 100 μL of corn oil (vehicle) delivered daily (∼2 μg·g body weight(-1)·day(-1)) by stomach intubation for 16 days, and 1 group (n = 8) that received the vehicle alone. A group of nonobese littermate mice (n = 9) served as controls. Ob/ob mice exhibited obesity, hyperglycaemia, and downregulation of the cardiac OT-NP system, including the mRNA for the transcription factor GATA4, OT receptor and brain NP, and the protein expression for endothelial nitric oxide synthase. Hearts from ob/ob mice also demonstrated increased apoptosis and collagen accumulation. ATRA treatment induced weight loss and decreased adipocytes diameter in the visceral fat, thus reducing visceral obesity, which is associated with a high risk for cardiovascular disease. RA treatment was associated with a reduction in hyperglycemia and a normalization of the OT-NP system's expression in the hearts of ob/ob mice. Furthermore, ATRA treatment prevented apoptosis and collagen accumulation in hearts of ob/ob mice. The present study indicates that ATRA treatment was effective in restoring the cardioprotective OT-NP system and in preventing abnormal cardiac remodelling in the ob/ob mice.
MeSH term(s)	Animals ; Apoptosis/genetics ; Female ; Fibrosis/prevention & control ; Gene Expression Regulation ; Mice ; Mice, Obese ; Myocytes, Cardiac/metabolism ; Myocytes, Cardiac/pathology ; Natriuretic Peptides/genetics ; Obesity/metabolism ; Obesity/pathology ; Tretinoin/physiology
Chemical Substances	Natriuretic Peptides ; Tretinoin (5688UTC01R)
Language	English
Publishing date	2014-10
Publishing country	Canada
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2236708-1
ISSN	1715-5320 ; 1715-5312
ISSN (online)	1715-5320
ISSN	1715-5312
DOI	10.1139/apnm-2014-0005
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1717: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Dynamics of inflammatory markers in post-acute stroke patients undergoing rehabilitation.

Manolescu, Bogdan Nicolae / Berteanu, Mihai / Dumitru, Luminița / Dinu, Horațiu / Iliescu, Alina / Fărcășanu, Ileana Cornelia / Oprea, Eliza / Vlădoiu, Suzana / Popa, Oana / Ianăș, Olga

Inflammation

2010 Volume 34, Issue 6, Page(s) 551–558

Abstract: ... of post-acute stroke patients (n = 20), in parallel with control subjects (n = 24). Stroke patients had ...

Abstract	Stroke is a pathological condition associated with an enhanced inflammatory response that has a multifactorial etiology. We evaluated the dynamic of plasma concentrations of IL-1α, IL-6, IL-8, TNF-α, soluble form of intercellular adhesion molecule 1, and lipoprotein (a) [Lp(a)] during the rehabilitation of post-acute stroke patients (n = 20), in parallel with control subjects (n = 24). Stroke patients had significantly increased concentrations of IL-6, TNF-α, and Lp(a) when compared to healthy controls. It was found that the changes in the IL-6, IL-8, and TNF-α concentrations associated with the pathological condition were statistically significant (χ2 = 4.81, p = 0.028, χ2 = 10.40, p = 0.005 and χ2 = 6.73, p = 0.034, respectively). The decrease of Lp(a) during the rehabilitation had statistical significance (p = 0.043), while the decrease of IL-1α had marginal significance (p = 0.071). IL-1α, TNF-α, and Lp(a) concentrations were significantly negatively correlated with the Barthel index values, suggesting that the decrease of these inflammatory markers was beneficial for patients' recovery.
MeSH term(s)	Biomarkers/blood ; Case-Control Studies ; Female ; Humans ; Inflammation/blood ; Inflammation/diagnosis ; Interleukin-1alpha/blood ; Interleukin-6/blood ; Lipoprotein(a)/blood ; Male ; Prognosis ; Rehabilitation ; Stroke/blood ; Stroke/diagnosis ; Tumor Necrosis Factor-alpha/blood
Chemical Substances	Biomarkers ; Interleukin-1alpha ; Interleukin-6 ; Lipoprotein(a) ; Tumor Necrosis Factor-alpha
Language	English
Publishing date	2010-09-30
Publishing country	United States
Document type	Journal Article
ZDB-ID	434408-x
ISSN	1573-2576 ; 0360-3997
ISSN (online)	1573-2576
ISSN	0360-3997
DOI	10.1007/s10753-010-9262-8
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 1401: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

To top

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito