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Article ; Online: Incorrect P Values in Two Articles by Ke-Xuan Liu, M.D., Ph.D., et al.

Liu, Ke-Xuan / Li, Cai / Yang, Wen-Han

2019 Volume 131, Issue 1, Page(s) 220

MeSH term(s)	Anesthetics ; Periodicals as Topic
Chemical Substances	Anesthetics
Language	English
Publishing date	2019-06-19
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	269-0
ISSN	1528-1175 ; 0003-3022
ISSN (online)	1528-1175
ISSN	0003-3022
DOI	10.1097/ALN.0000000000002792
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Article ; Online: Fu-Zheng-Xuan-Fei formula promotes macrophage polarization and Th17/Treg cell homeostasis against the influenza B virus (Victoria strain) infection.

Xiao, Yan / Zhang, Jinxin / Zhu, Xiangyu / Zhao, Wenxin / Li, Yiquan / Jin, Ningyi / Lu, Huijun / Han, Jicheng

Journal of ethnopharmacology

2023 Volume 312, Page(s) 116485

Abstract: Ethnopharmacological relevance: Fu-Zheng-Xuan-Fei formula (FF) is a prescription that has been ...

Abstract	Ethnopharmacological relevance: Fu-Zheng-Xuan-Fei formula (FF) is a prescription that has been clinically used through the basic theory of traditional Chinese medicine (TCM) for treating viral pneumonia. Although FF possesses a prominent clinical therapeutic effect, seldom pharmacological studies have been reported on its anti-influenza B virus (IBV) activity. Aim of the study: Influenza is an acute infectious respiratory disease caused by the influenza virus, which has high annual morbidity and mortality worldwide. With a global decline in the COVID-19 control, the infection rate of influenza virus is gradually increasing. Therefore, it is of great importance to develop novel drugs for the effective treatment of influenza virus. Apart from conventional antiviral drugs, TCM has been widely used in the clinical treatment of influenza in China. Therefore, studying the antiviral mechanism of TCM can facilitate the scientific development of TCM. Materials and methods: Madin-Darby canine kidney cells (MDCK) and BALB/c mice were infected with IBV, and FF was added to evaluate the anti-IBV effects of FF both in vitro and in vivo by Western blotting, immunofluorescence, flow cytometry, and pathological assessment. Results: It was found that FF exhibited anti-viral activity against IBV infection both in vivo and in vitro, while inducing macrophage activation and promoting M1 macrophage polarization. In addition, FF effectively regulated the signal transducer and activator of transcription (STAT) signaling pathway-mediated Th17/Treg balance to improve the lung tissue damage caused by IBV infection-induced inflammation. The findings provided the scientific basis for the antiviral mechanism of FF against IBV infection. Conclusions: This study shows that FF is a potentially effective antiviral drug against IBV infection.
MeSH term(s)	Mice ; Animals ; Dogs ; Humans ; Influenza B virus ; T-Lymphocytes, Regulatory ; Herpesvirus 1, Cercopithecine ; Macrophage Activation ; COVID-19 ; Antiviral Agents/pharmacology ; Antiviral Agents/therapeutic use ; Influenza, Human/drug therapy ; Orthomyxoviridae Infections ; Madin Darby Canine Kidney Cells
Chemical Substances	Antiviral Agents
Language	English
Publishing date	2023-04-10
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2023.116485
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Article: The therapeutic effect and mechanism of Chinese medicine Xuan-Yun-Ding on posterior circulation ischemia with vertigo in a rabbit model.

Chunhua, Liu / Zhixiong, Li / Dahua, Wu / Chunyun, Yuan / Haoqin, Deng / Sisi, Yuan / Fang, Liu / Yao, Xiao

Pakistan journal of pharmaceutical sciences

2021 Volume 34, Issue 3, Page(s) 843–854

Abstract: The aim of research is to unveil the mechanisms of the beneficial effects of XYD on PCIV in a rabbit model. 40 New Zealand white rabbits were randomly divided into 5 groups,including normal control group (NC), model control group (MC), low-dose of XYD ... ...

Abstract	The aim of research is to unveil the mechanisms of the beneficial effects of XYD on PCIV in a rabbit model. 40 New Zealand white rabbits were randomly divided into 5 groups,including normal control group (NC), model control group (MC), low-dose of XYD group (LXYD), high-dose of XYD group (HXYD) and Yang-Xue-Qin-Nao group (YXQN). PCIV rabbit model was established by feeding high-fat diet companied with paravertebral sclerotherapy and rotation exercise. The general observation, step-down test, rheoencephalogram, blood tests, histopathological detection and the plasma concentration of the effective component of XYD were investigated. After pharmacological intervening, the step-down time, REG, PL, IPL, blood viscosity, the levels of blood lipids, CRGP were significantly improved. Moreover, the vertebral artery showed the reduced stenosis of arterial lumen and less proliferation of fibrous tissue in the arterial wall in the LXYD, HXYD and YXQN group. Based on the LC-MS detection, the blood concentrations of puerarin in the LXYD and HXYD group were significantly increased after pharmacological intervening. XYD could ameliorate the symptoms of vertigo, Qi-deficiency and blood stasis in PCIV rabbits via effectively regulating the levels of blood lipids and vasoactive substances, decreasing blood viscosity, increasing CBF and protecting vestibular function.
MeSH term(s)	Animals ; Behavior, Animal/drug effects ; Disease Models, Animal ; Drugs, Chinese Herbal/pharmacology ; Evoked Potentials, Auditory, Brain Stem/drug effects ; Hemorheology ; Lipid Metabolism/drug effects ; Medicine, Chinese Traditional ; Rabbits ; Vertebral Artery/drug effects ; Vertebral Artery/pathology ; Vertebral Artery/ultrastructure ; Vertebrobasilar Insufficiency/physiopathology ; Vertigo/physiopathology ; Vestibular Nuclei/drug effects ; Vestibular Nuclei/pathology ; Vestibular Nuclei/ultrastructure
Chemical Substances	Drugs, Chinese Herbal
Language	English
Publishing date	2021-09-08
Publishing country	Pakistan
Document type	Journal Article
ZDB-ID	885131-1
ISSN	1011-601X
ISSN	1011-601X
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Zs.A 6588: Show issues

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Article ; Online: Fu-Zheng-Xuan-Fei formula promotes macrophage polarization and Th17/Treg cell homeostasis against the influenza B virus (Victoria strain) infection

Xiao, Yan / Zhang, Jinxin / Zhu, Xiangyu / Zhao, Wenxin / Li, Yiquan / Jin, Ningyi / Lu, Huijun / Han, Jicheng

Journal of Ethnopharmacology. 2023 Aug., v. 312 p.116485-

2023

Abstract: Fu-Zheng-Xuan-Fei formula (FF) is a prescription that has been clinically used through the basic ...

Abstract	Fu-Zheng-Xuan-Fei formula (FF) is a prescription that has been clinically used through the basic theory of traditional Chinese medicine (TCM) for treating viral pneumonia. Although FF possesses a prominent clinical therapeutic effect, seldom pharmacological studies have been reported on its anti-influenza B virus (IBV) activity. Influenza is an acute infectious respiratory disease caused by the influenza virus, which has high annual morbidity and mortality worldwide. With a global decline in the COVID-19 control, the infection rate of influenza virus is gradually increasing. Therefore, it is of great importance to develop novel drugs for the effective treatment of influenza virus. Apart from conventional antiviral drugs, TCM has been widely used in the clinical treatment of influenza in China. Therefore, studying the antiviral mechanism of TCM can facilitate the scientific development of TCM. Madin-Darby canine kidney cells (MDCK) and BALB/c mice were infected with IBV, and FF was added to evaluate the anti-IBV effects of FF both in vitro and in vivo by Western blotting, immunofluorescence, flow cytometry, and pathological assessment. It was found that FF exhibited anti-viral activity against IBV infection both in vivo and in vitro, while inducing macrophage activation and promoting M1 macrophage polarization. In addition, FF effectively regulated the signal transducer and activator of transcription (STAT) signaling pathway-mediated Th17/Treg balance to improve the lung tissue damage caused by IBV infection-induced inflammation. The findings provided the scientific basis for the antiviral mechanism of FF against IBV infection. This study shows that FF is a potentially effective antiviral drug against IBV infection.
Keywords	COVID-19 infection ; Influenza B virus ; Oriental traditional medicine ; antiviral agents ; antiviral properties ; dogs ; flow cytometry ; fluorescent antibody technique ; homeostasis ; inflammation ; influenza ; kidneys ; lungs ; macrophage activation ; macrophages ; morbidity ; mortality ; signal transduction ; therapeutics ; transactivators ; viral pneumonia ; viruses ; China ; Antiviral drugs ; Traditional Chinese medicines ; Macrophage polarization ; Th17/Treg homeostasis
Language	English
Dates of publication	2023-08
Publishing place	Elsevier B.V.
Document type	Article ; Online
Note	Use and reproduction
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2023.116485
Database	NAL-Catalogue (AGRICOLA)

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Article: Xuan Bi Tong Yu Fang Promotes Angiogenesis via VEGF-Notch1/Dll4 Pathway in Myocardial Ischemic Rats.

Li, Shuangdi / Dong, Jingrong / Ta, Guang / Liu, Yinghui / Cui, Junfeng / Li, Xiaohui / Song, Jing / Liu, Aidong / Cheng, Guangyu

Evidence-based complementary and alternative medicine : eCAM

2020 Volume 2020, Page(s) 5041629

Abstract: Objective: To investigate the effect of Xuan Bi Tong Yu Fang (XBTYF) on angiogenesis via ...

Abstract	Objective: To investigate the effect of Xuan Bi Tong Yu Fang (XBTYF) on angiogenesis via the vascular endothelial growth factor- (VEGF-) Notch1/delta-like 4 (Dll4) pathway. Results: XBTYF inhibited changes to the morphology and mitochondrial structure in cardiomyocyte and reduced cell apoptosis. Compared with the model group, XBTYF at all doses (3.2, 1.6, and 0.8 g/kg) reduced the expression of Notch1, Dll4, Bax, caspase 3, caspase 9, and Cyt-c, whereas expression of VEGF-A and Bcl2 was increased. Conclusion: XBTYF attenuated mitochondrial damage and cell apoptosis while promoting the angiogenesis of cardiomyocyte. The associated mechanism may be related to the VEGF-Notch1/Dll4 pathway.
Language	English
Publishing date	2020-02-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	2171158-6
ISSN	1741-4288 ; 1741-427X
ISSN (online)	1741-4288
ISSN	1741-427X
DOI	10.1155/2020/5041629
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Zs.A 5995: Show issues

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Article ; Online: Bituminous coal combustion and Xuan Wei Lung cancer: a review of the epidemiology, intervention, carcinogens, and carcinogenesis.

Li, Jinhui / Ran, Jinjun / Chen, Lung-Chi / Costa, Max / Huang, Yunchao / Chen, Xiao / Tian, Linwei

Archives of toxicology

2019 Volume 93, Issue 3, Page(s) 573–583

Abstract: ... lung cancer rates of nonsmoking women in Xuan Wei County, Yunnan Province, China. Venting the smoke outdoors ... farmers in central Xuan Wei. However, the lung cancer mortality rates in all 1.2 million residents of Xuan ... Province and China overall, with significant heterogeneities in the geographic patterns of Xuan Wei ...

Abstract	Indoor air pollution from bituminous coal combustion has been linked to the extremely high lung cancer rates of nonsmoking women in Xuan Wei County, Yunnan Province, China. Venting the smoke outdoors by installing chimneys was found to be effective at reducing the lung cancer risk in a cohort study of 21,232 farmers in central Xuan Wei. However, the lung cancer mortality rates in all 1.2 million residents of Xuan Wei have been increasing dramatically over the last four decades. It was higher than that in Yunnan Province and China overall, with significant heterogeneities in the geographic patterns of Xuan Wei. Intervention measures targeting certain types of coal or certain carcinogenic components in coal smoke need to be explored. To inform targeted intervention policies, it is essential to pinpoint the specific substance (particulate matter, organic extract, PAHs, free radicals, crystalline silica, and inorganic matter) that might account for the carcinogenicity of bituminous coal smoke. Exploring the underlying carcinogenesis mechanisms would also contribute to the intervention and control of the lung cancer epidemic in Xuan Wei, China. Here we review the suspected carcinogens and carcinogenesis mechanisms and discuss future research directions towards a better understanding of the etiology of lung cancer in Xuan Wei, China.
MeSH term(s)	Air Pollutants ; Air Pollution/statistics & numerical data ; China/epidemiology ; Coal ; Humans ; Lung Neoplasms/epidemiology
Chemical Substances	Air Pollutants ; Coal
Language	English
Publishing date	2019-01-16
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	124992-7
ISSN	1432-0738 ; 0340-5761
ISSN (online)	1432-0738
ISSN	0340-5761
DOI	10.1007/s00204-019-02392-y
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Article ; Online: A new kind of nanocomposite Xuan paper comprising ultralong hydroxyapatite nanowires and cellulose fibers with a unique ink wetting performance.

Shao, Yue-Ting / Zhu, Ying-Jie / Dong, Li-Ying / Zhang, Qiang-Qiang

RSC advances

2019 Volume 9, Issue 69, Page(s) 40750–40757

Abstract: In the history of civilization, Xuan paper with its superior texture, durability and suitable ... Xuan paper has won the reputation of "the king of paper that lasts for 1000 years" and was inscribed ... Organization of the United Nations in 2009. However, the surface of the commercial unprocessed Xuan paper has ...

Abstract	In the history of civilization, Xuan paper with its superior texture, durability and suitable characteristics for writing and painting, has played an important role in the dissemination of culture and art. Xuan paper has won the reputation of "the king of paper that lasts for 1000 years" and was inscribed on the Representative List of the Intangible Cultural Heritage of Humanity by the Educational, Scientific and Cultural Organization of the United Nations in 2009. However, the surface of the commercial unprocessed Xuan paper has a large number of large-sized pores with a poor resistance to water, allowing ink droplets to easily spread during the writing and painting process. In this study, we report a new kind of nanocomposite Xuan (HNXP) paper comprising ultralong hydroxyapatite (HAP) nanowires and plant cellulose fibers with unique ink wetting performance, high whiteness and excellent durability. The as-prepared HNXP paper sheets with various weight ratios of ultralong HAP nanowires ranging from 10% to 100% are all superhydrophilic with a water contact angle of zero. In contrast, the ink contact angle of the HNXP paper can be well controlled by adjusting the weight ratio of ultralong HAP nanowires, and the ink contact angle of the HNXP paper increases with increasing weight ratio of ultralong HAP nanowires. The experimental results show the unique ink wetting behavior of the as-prepared HNXP paper, which is absent in the traditional Xuan paper. This new kind of nanocomposite Xuan paper comprising ultralong hydroxyapatite nanowires and plant cellulose fibers is promising for applications in calligraphy and painting arts.
Language	English
Publishing date	2019-12-09
Publishing country	England
Document type	Journal Article
ISSN	2046-2069
ISSN (online)	2046-2069
DOI	10.1039/c9ra08349a
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Article ; Online: Five-year lung cancer mortality risk analysis and topography in Xuan Wei: a spatiotemporal correlation analysis.

Li, Jinhui / Guo, Wenbo / Ran, Jinjun / Tang, Robert / Lin, Hualiang / Chen, Xiao / Ning, Bofu / Li, Jihua / Zhou, Yongchun / Chen, Lung-Chi / Tian, Linwei / Huang, Yunchao

BMC public health

2019 Volume 19, Issue 1, Page(s) 173

Abstract: Background: In Xuan Wei, China, the lung cancer mortality rate is rising significantly more ... the lung cancer mortality rates differ within Xuan Wei and how these spatiotemporal patterns are linked with local ... geographically-weighted regression to test for correlations among different towns within Xuan Wei.: Results ...

Abstract	Background: In Xuan Wei, China, the lung cancer mortality rate is rising significantly more than that of the nation overall. However, it remains unclear 1) if improved diagnosis can just partially explain this observation and how other local risk factors may be correlated with the lung cancer mortality rate and 2) how the lung cancer mortality rates differ within Xuan Wei and how these spatiotemporal patterns are linked with local risk factors. To increase etiological knowledge, this study evaluated the spatial and temporal distributions of the health effects (the lung cancer mortality rates) from 2011 to 2015. Methods: Four steps of spatial analysis were applied, as follows: 1) hotspot analysis to determine the geographical patterns of lung cancer mortality, 2) spatially-weighted sum to identify areas with higher health risks, 3) bivariate statistical analysis to assess the overall correlation between coal mines and lung cancer mortality, and 4) geographically-weighted regression to test for correlations among different towns within Xuan Wei. Results: Women had higher lung cancer mortality rates than those in men, with an increasing trend in both sexes over time. The incidence rates in Laibin Town were the highest in Xuan Wei every year. Over the 5-year study period, the lung cancer mortality was increasingly concentrated in Laibin, Shuanglong, and Longchang, where the smoky coal mines are most concentrated. The population-level health risks from the coal mine in Xuan Wei were mapped and divided into five types of risk areas (Type I - Type IV). Correlation analysis revealed that there was no significant correlation between lung cancer mortality as a whole and coal mine distribution during the 5-year study period. However, the geographically-weighted regression revealed a stronger correlation in medium (Type III) and second-lowest (Type IV) health risks. Conclusions: Xuan Wei lung cancer mortality has increased continuously since the third national retrospective surveys on the causes of death by the Ministry of Health of the People's Republic of China (2004-2005), especially for local women and residents over 35 years of age. Geographically, lung cancer in Xuan Wei showed unique spatiotemporal clustering. The local lung cancer mortality was significantly correlated with the smoky coal mine geographically. Some specific towns (Laibin, Shuanglong, and Longchang) within Xuan Wei manifested high correlations between lung cancer mortality and coal mines. The effects of coal mines on lung cancer mortality rates also spread geographically outward from these areas. Public health concern regarding lung cancer in Xuan Wei should prioritize higher-risk towns surrounded by smoking coal mines. Intervention strategies for particular toxic coal types require further studies on their chemical characteristics and mechanisms of carcinogenesis. Additional studies are also warranted to systematically examine the local environmental health risks related to coal industries and combustion air pollution and eventually to conduct early screening of lung cancer for local people who are more exposed to smoky coal in high-risk areas.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; China/epidemiology ; Female ; Humans ; Lung Neoplasms/mortality ; Male ; Middle Aged ; Retrospective Studies ; Risk Factors ; Spatio-Temporal Analysis
Language	English
Publishing date	2019-02-11
Publishing country	England
Document type	Journal Article
ISSN	1471-2458
ISSN (online)	1471-2458
DOI	10.1186/s12889-019-6490-1
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Article ; Online: Protective Effect of the Traditional Chinese Patent Medicine Qing-Xuan Granule against Bleomycin-Induced Pulmonary Fibrosis in Mice.

Liu, Bei / Lü, Weichao / Ge, Haitao / Tang, Haitao / Li, Renshi / Zhang, Chaofeng

Chemistry & biodiversity

2019 Volume 16, Issue 12, Page(s) e1900467

Abstract: ... treatment. Qing-Xuan Granule (QX) as a traditional Chinese patent medicine is clinically used to cure ...

Abstract	Pulmonary fibrosis (PF) is a chronic obstructive pulmonary disease without effective clinical drug treatment. Qing-Xuan Granule (QX) as a traditional Chinese patent medicine is clinically used to cure children's cough. This study was designed to investigate the effects of QX and possible molecular mechanisms for bleomycin-induced PF. The work used Western blotting and Q-PCR to explore the vitro and vivo mechanisms of QX treatment, while using HPLC-TOF/MS to explore the composition of QX. QX was given daily orally for two weeks after bleomycin intratracheal instillation. The protective effects of QX on lung function, inflammation, growth factors, hydroxyproline content and deposition of extracellular matrix were investigated. QX decreased expression of Col I and α-SMA in lung tissues by down-regulating TGF-β1-Smad2/3 signaling and suppressed epithelial-mesenchymal transition and effectively reversed abnormal mRNA levels of MMP-1and TIMP-1 as well as LOXL-2 in lung tissues. HPLC-TOF/MS indicate that six substances could be the main active components, which were reported to protect against experimental lung disease.
MeSH term(s)	Amino Acid Oxidoreductases/genetics ; Amino Acid Oxidoreductases/metabolism ; Animals ; Bleomycin/toxicity ; Cell Line ; Cell Survival/drug effects ; Chromatography, High Pressure Liquid ; Disease Models, Animal ; Drugs, Chinese Herbal/analysis ; Drugs, Chinese Herbal/pharmacology ; Drugs, Chinese Herbal/therapeutic use ; Lung/drug effects ; Lung/metabolism ; Male ; Matrix Metalloproteinase 1/genetics ; Matrix Metalloproteinase 1/metabolism ; Medicine, Chinese Traditional ; Mice ; Mice, Inbred C57BL ; Protective Agents/chemistry ; Protective Agents/pharmacology ; Protective Agents/therapeutic use ; Pulmonary Fibrosis/chemically induced ; Pulmonary Fibrosis/drug therapy ; Signal Transduction/drug effects ; Smad2 Protein/metabolism ; Spectrometry, Mass, Electrospray Ionization ; Transforming Growth Factor beta1/genetics ; Transforming Growth Factor beta1/metabolism
Chemical Substances	Drugs, Chinese Herbal ; Protective Agents ; Smad2 Protein ; Transforming Growth Factor beta1 ; Bleomycin (11056-06-7) ; Amino Acid Oxidoreductases (EC 1.4.-) ; Loxl2 protein, mouse (EC 1.4.3.-) ; Matrix Metalloproteinase 1 (EC 3.4.24.7)
Language	English
Publishing date	2019-11-08
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2139001-0
ISSN	1612-1880 ; 1612-1872
ISSN (online)	1612-1880
ISSN	1612-1872
DOI	10.1002/cbdv.201900467
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Article ; Online: Mechanism of protective effect of xuan-bai-cheng-qi decoction on LPS-induced acute lung injury based on an integrated network pharmacology and RNA-sequencing approach.

Zhu, Huahe / Wang, Shun / Shan, Cong / Li, Xiaoqian / Tan, Bo / Chen, Qilong / Yang, Yunxiang / Yu, Hongji / Yang, Aidong

Respiratory research

2021 Volume 22, Issue 1, Page(s) 188

Abstract: Xuan-bai-cheng-qi decoction (XCD), a traditional Chinese medicine (TCM) prescription, has been ...

Abstract	Xuan-bai-cheng-qi decoction (XCD), a traditional Chinese medicine (TCM) prescription, has been widely used to treat a variety of respiratory diseases in China, especially to seriously infectious diseases such as acute lung injury (ALI). Due to the complexity of the chemical constituent, however, the underlying pharmacological mechanism of action of XCD is still unclear. To explore its protective mechanism on ALI, firstly, a network pharmacology experiment was conducted to construct a component-target network of XCD, which identified 46 active components and 280 predicted target genes. Then, RNA sequencing (RNA-seq) was used to screen differentially expressed genes (DEGs) between ALI model rats treated with and without XCD and 753 DEGs were found. By overlapping the target genes identified using network pharmacology and DEGs using RNA-seq, and subsequent protein-protein interaction (PPI) network analysis, 6 kernel targets such as vascular epidermal growth factor (VEGF), mammalian target of rapamycin (mTOR), AKT1, hypoxia-inducible factor-1α (HIF-1α), and phosphoinositide 3-kinase (PI3K) and gene of phosphate and tension homology deleted on chromsome ten (PTEN) were screened out to be closely relevant to ALI treatment. Verification experiments in the LPS-induced ALI model rats showed that XCD could alleviate lung tissue pathological injury through attenuating proinflammatory cytokines release such as tumor necrosis factor (TNF)-α, interleukin (IL)-6, and IL-1β. Meanwhile, both the mRNA and protein expression levels of PI3K, mTOR, HIF-1α, and VEGF in the lung tissues were down-regulated with XCD treatment. Therefore, the regulations of XCD on PI3K/mTOR/HIF-1α/VEGF signaling pathway was probably a crucial mechanism involved in the protective mechanism of XCD on ALI treatment.
MeSH term(s)	Acute Lung Injury/chemically induced ; Acute Lung Injury/genetics ; Acute Lung Injury/prevention & control ; Animals ; Drugs, Chinese Herbal/pharmacology ; Drugs, Chinese Herbal/therapeutic use ; Lipopolysaccharides/toxicity ; Male ; Network Pharmacology/methods ; Rats ; Rats, Wistar ; Sequence Analysis, RNA/methods
Chemical Substances	Drugs, Chinese Herbal ; Lipopolysaccharides ; xuanbai chengqi
Language	English
Publishing date	2021-06-28
Publishing country	England
Document type	Journal Article
ZDB-ID	2041675-1
ISSN	1465-993X ; 1465-9921
ISSN (online)	1465-993X
ISSN	1465-9921
DOI	10.1186/s12931-021-01781-1
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