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Article ; Online: "I think that the small peptides are the best for healthy ageing...", an interview with Vladimir Khavinson. Interview by Suresh I. S. Rattan.

Khavinson, Vladimir

2013 Volume 14, Issue 1, Page(s) 1–8

Abstract: ... providing an insight into the history of ideas in modern biogerontology. Here we present Vladimir Khavinson ...

Abstract	Since its inception in 2000, Biogerontology has published interviews with some of the most renowned and intellectually influential biogerontologists, including Len Hayflick, Robin Holliday, Denham Harman, Vincent Cristofalo, Claudio Franceschi, Leslie Robert, Ken Kitani, Geroge Martin, Zhores Medvedev and John Maynard Smith. These interviews have explored the minds of these scientists in all aspects of their lives combining the private and the professional. Together, this series is a remarkable document providing an insight into the history of ideas in modern biogerontology. Here we present Vladimir Khavinson talking about his life and work in Russia during and after the Soviet times, his ideas on stress and health, his discoveries of the healthy ageing promoting small peptides, and other anti-ageing interventions.
MeSH term(s)	Aged ; Aging/physiology ; Animals ; Geriatrics/history ; History, 20th Century ; History, 21st Century ; Humans ; Peptides/physiology ; Russia
Chemical Substances	Peptides
Language	English
Publishing date	2013-02
Publishing country	Netherlands
Document type	Autobiography ; Biography ; Historical Article ; Interview
ZDB-ID	2047160-9
ISSN	1573-6768 ; 1389-5729
ISSN (online)	1573-6768
ISSN	1389-5729
DOI	10.1007/s10522-013-9414-y
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Article ; Online: Peptide regulation of plant cells differentiation and growth

Khavinson Vladimir / Linkova Natalia / Diatlova Anastasiia / Dudkov and Aleksandr

BIO Web of Conferences, Vol 82, p

2024 Volume 02003

Abstract: The main task of agriculture is to increase the productivity of cultivated plants, and therefore the development of methods that regulate the growth and development of agricultural crops is becoming increasingly important. It is known that plant ... ...

Abstract	The main task of agriculture is to increase the productivity of cultivated plants, and therefore the development of methods that regulate the growth and development of agricultural crops is becoming increasingly important. It is known that plant development in response to external stimuli is regulated by peptide phytohormones. In addition, peptides are considered as antimicrobial agents. The review examines peptides of the CLE, EPF, PSY, PSK, RGF, CIF families, dipeptide KE, tripeptide EDR and tetrapeptides AEDL, KEDG, AEDR, KEDP and their role in the regulation of plant differentiation and growth. The wide range of biological activity of peptides allows us to propose their use to increase the productivity of new generation plants.
Keywords	Microbiology ; QR1-502 ; Physiology ; QP1-981 ; Zoology ; QL1-991
Language	English
Publishing date	2024-01-01T00:00:00Z
Publisher	EDP Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Book: Gerontological aspects of genome peptide regulation

Khavinson, Vladimir Kh / Malinin, Vladimir V.

16 tables

2005

Author's details	Vladimir Kh. Khavinson ; Vladimir V. Malinin
Keywords	Gene Expression Regulation / physiology ; Aging ; Peptides / physiology ; Altern ; Peptide ; Regulation ; Genexpression
Subject	Alterungsprozess ; Altwerden ; Seneszenz ; Alterung
Language	English
Size	IX, 104 S. : Ill., graph. Darst., 245 mm x 175 mm
Publisher	Karger
Publishing place	Basel u.a.
Publishing country	Switzerland
Document type	Book
HBZ-ID	HT014358198
ISBN	3-8055-7895-4 ; 978-3-8055-7895-0
Database	Catalogue ZB MED Medicine, Health

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2005 A 1610	order for loan	Magazin

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Article ; Online: Peptide Regulation of Chondrogenic Stem Cell Differentiation.

Linkova, Natalia / Khavinson, Vladimir / Diatlova, Anastasiia / Myakisheva, Svetlana / Ryzhak, Galina

International journal of molecular sciences

2023 Volume 24, Issue 9

Abstract: The search for innovative ways to treat osteoarthritis (OA) is an urgent task for molecular medicine and biogerontology. OA leads to disability in persons of middle and older age, while safe and effective methods of treating OA have not yet been ... ...

Abstract	The search for innovative ways to treat osteoarthritis (OA) is an urgent task for molecular medicine and biogerontology. OA leads to disability in persons of middle and older age, while safe and effective methods of treating OA have not yet been discovered. The directed differentiation of mesenchymal stem cells (MSCs) into chondrocytes is considered one of the possible methods to treat OA. This review describes the main molecules involved in the chondrogenic differentiation of MSCs. The peptides synthesized on the basis of growth factors' structures (SK2.1, BMP, B2A, and SSPEPS) and components of the extracellular matrix of cartilage tissue (LPP, CFOGER, CMP, RDG, and N-cadherin mimetic peptide) offer the greatest promise for the regulation of the chondrogenic differentiation of MSCs. These peptides regulate the WNT, ERK-p38, and Smad 1/5/8 signaling pathways, gene expression, and the synthesis of chondrogenic differentiation proteins such as COL2, SOX9, ACAN, etc.
MeSH term(s)	Cartilage/metabolism ; Cell Differentiation/genetics ; Chondrocytes/metabolism ; Extracellular Matrix ; Peptides/pharmacology ; Peptides/metabolism ; Chondrogenesis/genetics ; Cells, Cultured
Chemical Substances	Peptides
Language	English
Publishing date	2023-05-08
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms24098415
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Feasibility of Transport of 26 Biologically Active Ultrashort Peptides via LAT and PEPT Family Transporters.

Khavinson, Vladimir Khatskelevich / Linkova, Natalia Sergeevna / Rudskoy, Andrey Ivanovich / Petukhov, Michael Gennadievich

Biomolecules

2023 Volume 13, Issue 3

Abstract: The aim of this work is to verify the possibility of transport of 26 biologically active ultrashort peptides (USPs) into cells via LAT and PEPT family transporters. Molecular modeling and computer-assisted docking of peptide ligands revealed that the ... ...

Abstract	The aim of this work is to verify the possibility of transport of 26 biologically active ultrashort peptides (USPs) into cells via LAT and PEPT family transporters. Molecular modeling and computer-assisted docking of peptide ligands revealed that the size and structure of ligand-binding sites of the amino acid transporters LAT1, LAT2, and of the peptide transporter PEPT1 are sufficient for the transport of the 26 biologically active di-, tri-, and tetra-peptides. Comparative analysis of the binding of all possible di- and tri-peptides (8400 compounds) at the binding sites of the LAT and PEPT family transporters has been carried out. The 26 biologically active USPs systematically showed higher binding scores to LAT1, LAT2, and PEPT1, as compared with di- and tri-peptides, for which no biological activity has been established. This indicates an important possible role which LAT and PEPT family transporters may play in a variety of biological activities of the 26 biologically active peptides under investigation in this study. Most of the 26 studied USPs were found to bind to the LAT1, LAT2, and PEPT1 transporters more efficiently than the known substrates or inhibitors of these transporters. Peptides ED, DS, DR, EDR, EDG, AEDR, AEDL, KEDP, and KEDG, and peptoids DS7 and KE17 with negatively charged Asp
MeSH term(s)	Feasibility Studies ; Amino Acids/metabolism ; Peptides/metabolism ; Membrane Transport Proteins/metabolism ; Biological Transport
Chemical Substances	1,10-phenanthroline-platinum(II)-ethylenediamine (54831-91-3) ; Amino Acids ; Peptides ; Membrane Transport Proteins
Language	English
Publishing date	2023-03-17
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2701262-1
ISSN	2218-273X ; 2218-273X
ISSN (online)	2218-273X
ISSN	2218-273X
DOI	10.3390/biom13030552
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Article ; Online: Neuroepigenetic Mechanisms of Action of Ultrashort Peptides in Alzheimer's Disease.

Ilina, Anastasiia / Khavinson, Vladimir / Linkova, Natalia / Petukhov, Mikhael

International journal of molecular sciences

2022 Volume 23, Issue 8

Abstract: Epigenetic regulation of gene expression is necessary for maintaining higher-order cognitive functions (learning and memory). The current understanding of the role of epigenetics in the mechanism of Alzheimer's disease (AD) is focused on DNA methylation, ...

Abstract	Epigenetic regulation of gene expression is necessary for maintaining higher-order cognitive functions (learning and memory). The current understanding of the role of epigenetics in the mechanism of Alzheimer's disease (AD) is focused on DNA methylation, chromatin remodeling, histone modifications, and regulation of non-coding RNAs. The pathogenetic links of this disease are the misfolding and aggregation of tau protein and amyloid peptides, mitochondrial dysfunction, oxidative stress, impaired energy metabolism, destruction of the blood-brain barrier, and neuroinflammation, all of which lead to impaired synaptic plasticity and memory loss. Ultrashort peptides are promising neuroprotective compounds with a broad spectrum of activity and without reported side effects. The main aim of this review is to analyze the possible epigenetic mechanisms of the neuroprotective action of ultrashort peptides in AD. The review highlights the role of short peptides in the AD pathophysiology. We formulate the hypothesis that peptide regulation of gene expression can be mediated by the interaction of short peptides with histone proteins, cis- and transregulatory DNA elements and effector molecules (DNA/RNA-binding proteins and non-coding RNA). The development of therapeutic agents based on ultrashort peptides may offer a promising addition to the multifunctional treatment of AD.
MeSH term(s)	Alzheimer Disease/drug therapy ; Alzheimer Disease/genetics ; Alzheimer Disease/metabolism ; Amyloid beta-Peptides/metabolism ; DNA/metabolism ; DNA Methylation ; Epigenesis, Genetic ; Humans ; Peptides/metabolism ; tau Proteins/metabolism
Chemical Substances	Amyloid beta-Peptides ; Peptides ; tau Proteins ; DNA (9007-49-2)
Language	English
Publishing date	2022-04-12
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms23084259
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Article ; Online: Neuroepigenetic Mechanisms of Action of Ultrashort Peptides in Alzheimer’s Disease

Anastasiia Ilina / Vladimir Khavinson / Natalia Linkova / Mikhael Petukhov

International Journal of Molecular Sciences, Vol 23, Iss 4259, p

2022 Volume 4259

Abstract	Epigenetic regulation of gene expression is necessary for maintaining higher-order cognitive functions (learning and memory). The current understanding of the role of epigenetics in the mechanism of Alzheimer’s disease (AD) is focused on DNA methylation, chromatin remodeling, histone modifications, and regulation of non-coding RNAs. The pathogenetic links of this disease are the misfolding and aggregation of tau protein and amyloid peptides, mitochondrial dysfunction, oxidative stress, impaired energy metabolism, destruction of the blood–brain barrier, and neuroinflammation, all of which lead to impaired synaptic plasticity and memory loss. Ultrashort peptides are promising neuroprotective compounds with a broad spectrum of activity and without reported side effects. The main aim of this review is to analyze the possible epigenetic mechanisms of the neuroprotective action of ultrashort peptides in AD. The review highlights the role of short peptides in the AD pathophysiology. We formulate the hypothesis that peptide regulation of gene expression can be mediated by the interaction of short peptides with histone proteins, cis- and transregulatory DNA elements and effector molecules (DNA/RNA-binding proteins and non-coding RNA). The development of therapeutic agents based on ultrashort peptides may offer a promising addition to the multifunctional treatment of AD.
Keywords	ultrashort peptides ; DNA ; promotors ; histones ; nucleosome ; DNA-binding proteins ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Subject code	612
Language	English
Publishing date	2022-04-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Transport of Biologically Active Ultrashort Peptides Using POT and LAT Carriers.

Khavinson, Vladimir / Linkova, Natalia / Kozhevnikova, Ekaterina / Dyatlova, Anastasiia / Petukhov, Mikhael

International journal of molecular sciences

2022 Volume 23, Issue 14

Abstract: Ultrashort peptides (USPs), consisting of 2-7 amino-acid residues, are a group of signaling molecules that regulate gene expression and protein synthesis under normal conditions in various diseases and ageing. USPs serve as a basis for the development of ...

Abstract	Ultrashort peptides (USPs), consisting of 2-7 amino-acid residues, are a group of signaling molecules that regulate gene expression and protein synthesis under normal conditions in various diseases and ageing. USPs serve as a basis for the development of drugs with a targeted mechanism of action. The purpose of this review is to systematize the available data on USP transport involving POT and LAT transporters in various organs and tissues under normal, pathological and ageing conditions. The carriers of the POT family (PEPT1, PEPT2, PHT1, PHT2) transport predominantly di- and tripeptides into the cell. Methods of molecular modeling and physicochemistry have demonstrated the ability of LAT1 to transfer not only amino acids but also some di- and tripeptides into the cell and out of it. LAT1 and 2 are involved in the regulation of the antioxidant, endocrine, immune and nervous systems' functions. Analysis of the above data allows us to conclude that, depending on their structure, di- and tripeptides can be transported into the cells of various tissues by POT and LAT transporters. This mechanism is likely to underlie the tissue specificity of peptides, their geroprotective action and effectiveness in the case of neuroimmunoendocrine system disorders.
MeSH term(s)	Amino Acids/metabolism ; Biological Transport/physiology ; Membrane Transport Proteins/metabolism ; Organ Specificity ; Peptides/metabolism ; Symporters/metabolism
Chemical Substances	Amino Acids ; Membrane Transport Proteins ; Peptides ; Symporters
Language	English
Publishing date	2022-07-13
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms23147733
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Senescence-Associated Secretory Phenotype of Cardiovascular System Cells and Inflammaging: Perspectives of Peptide Regulation.

Khavinson, Vladimir / Linkova, Natalia / Dyatlova, Anastasiia / Kantemirova, Raisa / Kozlov, Kirill

Cells

2022 Volume 12, Issue 1

Abstract: A senescence-associated secretory phenotype (SASP) and a mild inflammatory response characteristic of senescent cells (inflammaging) form the conditions for the development of cardiovascular diseases: atherosclerosis, coronary heart disease, and ... ...

Abstract	A senescence-associated secretory phenotype (SASP) and a mild inflammatory response characteristic of senescent cells (inflammaging) form the conditions for the development of cardiovascular diseases: atherosclerosis, coronary heart disease, and myocardial infarction. The purpose of the review is to analyze the pool of signaling molecules that form SASP and inflammaging in cells of the cardiovascular system and to search for targets for the action of vasoprotective peptides. The SASP of cells of the cardiovascular system is characterized by a change in the synthesis of anti-proliferative proteins (p16, p19, p21, p38, p53), cytokines characteristic of inflammaging (IL-1α,β, IL-4, IL-6, IL-8, IL-18, TNFα, TGFβ1, NF-κB, MCP), matrix metalloproteinases, adhesion molecules, and sirtuins. It has been established that peptides are physiological regulators of body functions. Vasoprotective polypeptides (liraglutide, atrial natriuretic peptide, mimetics of relaxin, Ucn1, and adropin), KED tripeptide, and AEDR tetrapeptide regulate the synthesis of molecules involved in inflammaging and SASP-forming cells of the cardiovascular system. This indicates the prospects for the development of drugs based on peptides for the treatment of age-associated cardiovascular pathology.
MeSH term(s)	Cellular Senescence/physiology ; Senescence-Associated Secretory Phenotype ; Cytokines/metabolism ; NF-kappa B/metabolism ; Cardiovascular System/metabolism
Chemical Substances	Cytokines ; NF-kappa B
Language	English
Publishing date	2022-12-27
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2661518-6
ISSN	2073-4409 ; 2073-4409
ISSN (online)	2073-4409
ISSN	2073-4409
DOI	10.3390/cells12010106
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Article ; Online: Homology between SARS CoV-2 and human proteins.

Khavinson, Vladimir / Terekhov, Alexander / Kormilets, Dmitry / Maryanovich, Alexander

Scientific reports

2021 Volume 11, Issue 1, Page(s) 17199

Abstract: An extremely high contagiousness of SARS CoV-2 indicates that the virus developed the ability to deceive the innate immune system. The virus could have included in its outer protein domains some motifs that are structurally similar to those that the ... ...

Abstract	An extremely high contagiousness of SARS CoV-2 indicates that the virus developed the ability to deceive the innate immune system. The virus could have included in its outer protein domains some motifs that are structurally similar to those that the potential victim's immune system has learned to ignore. The similarity of the primary structures of the viral and human proteins can provoke an autoimmune process. Using an open-access protein database Uniprot, we have compared the SARS CoV-2 proteome with those of other organisms. In the SARS CoV-2 spike (S) protein molecule, we have localized more than two dozen hepta- and octamers homologous to human proteins. They are scattered along the entire length of the S protein molecule, while some of them fuse into sequences of considerable length. Except for one, all these n-mers project from the virus particle and therefore can be involved in providing mimicry and misleading the immune system. All hepta- and octamers of the envelope (E) protein, homologous to human proteins, are located in the viral transmembrane domain and form a 28-mer protein E
MeSH term(s)	Cell Line ; Humans ; Proteomics ; SARS-CoV-2/metabolism ; SARS-CoV-2/physiology ; Sequence Homology, Amino Acid ; Spike Glycoprotein, Coronavirus/chemistry ; Spike Glycoprotein, Coronavirus/metabolism ; Viral Proteins/chemistry ; Viral Proteins/metabolism
Chemical Substances	Spike Glycoprotein, Coronavirus ; Viral Proteins
Language	English
Publishing date	2021-08-25
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-021-96233-7
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